<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Chronic Hepatitis C virus (HCV) infection is defined as persistence of HCV RNA in the blood for more than six months. HCV is a major cause of chronic liver disease and cirrhosis. It’s serious public health problem, affects about 71 million people worldwide. HCV doesn’t destroy hepatocytes directly. It activates the host's innate and acquired immune system and causes liver injury indirectly. Behind hepatic, HCV can cause extra-hepatic manifestations. One of them is renal disease which can lead to end-stage renal disease, ESRD. The prevalence of HCV infection in patients on hemodialysis is high, ranging from 5% to 60%. HCV infection is a significant cause of morbidity and mortality in patients with ESRD on hemodialysis. In this review, we discuss HCV infection and chronic renal disease as comorbidities, their severity and outcome.</p></abstract>

Chronic Hepatitis C virus (HCV) infection is defined as persistence of HCV RNA in the blood for more than six months. HCV is a major cause of chronic liver disease and cirrhosis. It’s serious public health problem, affects about 71 million people worldwide. HCV doesn’t destroy hepatocytes directly. It activates the host's innate and acquired immune system and causes liver injury indirectly. Behind hepatic, HCV can cause extra-hepatic manifestations. One of them is renal disease which can lead to end-stage renal disease, ESRD. The prevalence of HCV infection in patients on hemodialysis is high, ranging from 5% to 60%. HCV infection is a significant cause of morbidity and mortality in patients with ESRD on hemodialysis. In this review, we discuss HCV infection and chronic renal disease as comorbidities, their severity and outcome.

HCV Infection and Chronic Renal Disease

Department of Infectious diseases, Faculty of Medical Sciences

Department of Internal medicine, Faculty of Medical Sciences

Department of Microbiology, Faculty of Medicine Foca

Department of Otorhinolaryngology, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"HCV Infection and Chronic Renal Disease"}

Chronic Hepatitis C virus (HCV) infection is defined as persistence of HCV RNA in the blood for more than six months. HCV is a major cause of chronic liver...

HCV Infection and Chronic Renal Disease

Data publikacji: 26 maj 2021

Zakres stron: -

Otrzymano: 26 sty 2021

Przyjęty: 22 lut 2021

DOI: https://doi.org/10.2478/sjecr-2021-0010

Słowa kluczowe
HCV, infection, chronic renal disease, comorbidity

© 2021 Sofija Sekulic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

HCV Infection and Chronic Renal Disease

Data publikacji: 26 maj 2021

Zakres stron: -

Otrzymano: 26 sty 2021

Przyjęty: 22 lut 2021

DOI: https://doi.org/10.2478/sjecr-2021-0010

Słowa kluczoweHCV, infection, chronic renal disease, comorbidity

© 2021 Sofija Sekulic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
HCV, infection, chronic renal disease, comorbidity