[
1. Threatt J, Williamson JF, Huynh K, Davis RM, Hermayer K. Ocular disease, knowledge and technology applications in patients with diabetes. Am J Med Sci. 2013;345(4):266-270.10.1097/MAJ.0b013e31828aa6fb363815523531956
]Search in Google Scholar
[
2. Bikbova G, Oshitari T, Baba T, Bikbov M, Yamamoto S. Diabetic corneal neuropathy: clinical perspectives. Clin Ophthalmol. 2018;12:981-987.10.2147/OPTH.S145266597336529872257
]Search in Google Scholar
[
3. Rosenberg ME, Tervo TM, Immonen IJ, Müller LJ, Grönhagen-Riska C, Vesaluoma MH. Corneal structure and sensitivity in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci. 2000;41(10):2915-2921.
]Search in Google Scholar
[
4. Mocan MC, Durukan I, Irkec M, Orhan M. Morphologic alterations of both the stromal and subbasal nerves in the corneas of patients with diabetes. Cornea. 2006;25(7):769-773.10.1097/01.ico.0000224640.58848.5417068451
]Search in Google Scholar
[
5. Edwards K, Pritchard N, Vagenas D, Russell A, Malik RA, Efron N. Utility of corneal confocal microscopy for assessing mild diabetic neuropathy: baseline findings of the LANDMark study. Clin Exp Optom. 2012;95(3):348-354.10.1111/j.1444-0938.2012.00740.x22540156
]Search in Google Scholar
[
6. Szalai E, Deák E, Módis L Jr, Németh G, Berta A, Nagy A, Felszeghy E, Káposzta R, Malik RA, Csutak A. Early corneal cellular and nerve fiber pathology in young patients with type 1 diabetes mellitus identified using corneal confocal microscopy. Invest Oph. Vis Sci. 2016;57(3):853-858
]Search in Google Scholar
[
7. Kallinikos P, Berhanu M, O’Donnell C, Boulton AJ, Efron N, Malik RA. Corneal nerve tortuosity in diabetic patients with neuropathy. Invest Ophthalmol Vis Sci. 2004;45(2):418-422.10.1167/iovs.03-063714744880
]Search in Google Scholar
[
8. Patel DV, McGhee CN. In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: a review. Br J Ophthalmol. 2009;93(7):853-860.10.1136/bjo.2008.15061519019923
]Search in Google Scholar
[
9. He JC, Bazan HE. Mapping the nerve architecture of diabetic human corneas. Ophthalmology. 2012;119(5):956-964.10.1016/j.ophtha.2011.10.036348008022325488
]Search in Google Scholar
[
10. Madonna R, Balistreri CR, Geng YJ, De Caterina R. Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches. Vascul Pharmacol. 2017;90:1-7.10.1016/j.vph.2017.01.00428137665
]Search in Google Scholar
[
11. Bikbova G, Oshitari T, Baba T, Yamamoto S. Mechanisms of neuronal cell death in AGE-exposed retinas-research and literature review. Curr Diabetes Rev. 2017;13(3):280-288.10.2174/157339981266616051911133327193899
]Search in Google Scholar
[
12. Kim J, Kim CS, Sohn E, Jeong IH, Kim H, Kim JS. Involvement of advanced glycation end products, oxidative stress and nuclear factor-kappaB in the development of diabetic keratopathy. Graefes Arch Clin Exp Ophthalmol. 2011;249(4):529-536.10.1007/s00417-010-1573-921104267
]Search in Google Scholar
[
13. Babizhayev MA, Strokov IA, Nosikov VV, Savel’yeva EL, Sitnikov VF, Yegorov YE, Lankin VZ. The role of oxidative stress in diabetic neuropathy: generation of free radical species in the glycation reaction and gene polymorphisms encoding antioxidant enzymes to genetic susceptibility to diabetic neuropathy in population of type I diabetic patients. Cell Biochem Biophys. 2015;71(3):1425-1443.10.1007/s12013-014-0365-y25427889
]Search in Google Scholar
[
14. Yagihashi S, Mizukami H, Sugimoto K. Mechanism of diabetic neuropathy: Where are we now and where to go? J Diabetes Investig. 2011;2(1):18-32.10.1111/j.2040-1124.2010.00070.x400801124843457
]Search in Google Scholar
[
15. Leppin K, Behrendt AK, Reichard M, Stachs O, Guthoff RF, Baltrusch S, Eule JC, Vollmar B. Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the Cornea. Invest Ophthalmol. Vis Sci 2014;55(6): 3603-3615.
]Search in Google Scholar
[
16. Markoulli M, You JJ, Kim J, Duong CL, Tolentino JB, Karras J, Lum E. Corneal nerve morphology and tear film substance P in diabetes. Optom Vis Sci. 2017;94(7):726-731.10.1097/OPX.000000000000109628650386
]Search in Google Scholar
[
17. Dana MR. Corneal antigen-presenting cells: diversity, plasticity, and disguise: the Cogan lecture. Invest Ophthalmol Vis Sci. 2004;45(3):722-727; 721.10.1167/iovs.03-080314985280
]Search in Google Scholar
[
18. Qu JH, Li L, Tian L, Zhang XY, Thomas R, Sun XG. Epithelial changes with corneal punctate epitheliopathy in type 2 diabetes mellitus and their correlation with time to healing. BMC Ophthalmol. 2018;18(1):1.10.1186/s12886-017-0645-6575351729301512
]Search in Google Scholar
[
19. Cai D, Zhu MF, Petroll WM, Koppaka V, Robertson DM. The impact of type 1 diabetes mellitus on corneal epithelial nerve morphology and the corneal epithelium. Am J Pathol. 2014;184(10):2662-2670.10.1016/j.ajpath.2014.06.016418887225102563
]Search in Google Scholar
[
20. Chang PY, Carrel H, Huang JS, Wang IJ, Hou YC, Chen WL, Wang JY, Hu FR. Decreased density of corneal basal epithelium and subbasal corneal nerve bundle changes in patients with diabetic retinopathy. Am J Ophthalmol. 2006;142(3):488-490.10.1016/j.ajo.2006.04.03316935596
]Search in Google Scholar
[
21. Di GH, Qi X, Zhao XW, Zhang SM, Danielson P, Zhou QJ. Corneal epithelium-derived neurotrophic factors promote nerve regeneration. Invest Ophthalmol Vis Sci. 2017;58(11):4695-4702.10.1167/iovs.16-2137228910445
]Search in Google Scholar
[
22. Zhou QJ, Chen P, Di GH, Zhang YY, Wang Y, Qi X, Duan HY, Xie LX. Ciliary neurotrophic factor promotes the activation of corneal epithelial stem/progenitor cells and accelerates corneal epithelial wound healing. Stem Cells. 2015;33(5):1566-1576.10.1002/stem.194225546438
]Search in Google Scholar
[
23. Park JH, Kang SS, Kim JY, Tchah H. Nerve growth factor attenuates apoptosis and inflammation in the diabetic Cornea. Invest Ophthalmol Vis Sci. 2016;57(15):6767-6775.10.1167/iovs.16-1974727978558
]Search in Google Scholar
[
24. Morishige N, Uemura A, Morita Y, Nishida T. Promotion of corneal epithelial wound healing in diabetic rats by the fibronectin-derived peptide PHSRN. Cornea. 2017;36(12):1544-1548.10.1097/ICO.0000000000001344
]Search in Google Scholar
[
25. Hu JZ, Hu XY, Kan T. MiR-34c participates in diabetic corneal neuropathy via regulation of autophagy. Invest Ophthalmol Vis Sci. 2019;60(1):16-25.10.1167/iovs.18-24968
]Search in Google Scholar
[
26. Taylor HR, Kimsey RA. Corneal epithelial basement membrane changes in diabetes. Invest Ophthalmol Vis Sci. 1981;20(4):548-553.
]Search in Google Scholar
[
27. Ljubimov AV, Huang ZS, Huang GH, Burgeson RE, Gullberg D, Miner JH, Ninomiya Y, Sado Y, Kenney MC. Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy. J Histochem Cytochem. 1998;46(9):1033-1041.10.1177/002215549804600907
]Search in Google Scholar
[
28. Tomomatsu T, Takamura Y, Kubo, Akagi Y. Aldose reductase inhibitorcounteracts the attenuated adhesion of human corneal epithelial cells induced by high glucose through modulation of MMP-10 expression. Diabetes Res Clin Pract. 2009;86(1):16-23.10.1016/j.diabres.2009.07.007
]Search in Google Scholar
[
29. Takahashi H, Akiba K, Noguchi T, Ohmura T, Takahashi R, Ezure Y, Ohara K, Zieske JD. Matrix metalloproteinase activity is enhanced during corneal wound repair in high glucose condition. Curr Eye Res. 2000;21(2):608-615.10.1076/0271-3683(200008)2121-VFT608
]Search in Google Scholar
[
30. Ishida M, Yokoi N, Okuzawa J, Maeda K, Kinoshita S. Corneal autofluorescence in patients with diabetic retinopathy. Nippon Ganka Gakkai Zasshi. 1995;99(3):308-311.
]Search in Google Scholar
[
31. Mishima S. Clinical investigations on the corneal endothelium. Ophthalmology. 1982;89(6):525-530.10.1016/S0161-6420(82)34755-7
]Search in Google Scholar
[
32. Sato E, Mori F, Igarashi S, Abiko T, Takeda M, Ishiko S, Yoshida A. Corneal advanced glycation end products increase in patients with proliferative diabetic retinopathy. Diabetes Care. 2001;24(3):479-482.10.2337/diacare.24.3.47911289471
]Search in Google Scholar
[
33. Torricelli AA, Wilson SE. Cellular and extracellular matrix modulation of corneal stromal opacity. Exp Eye Res. 2014;129:151-160.10.1016/j.exer.2014.09.013425985725281830
]Search in Google Scholar
[
34. Kumar N, Pop-Busui R, Musch DC, Reed DM, Momont AC, Hussain M, Raval N, Moroi SE, Shtein R. Central corneal thickness increase due to stromal thickening with diabetic peripheral neuropathy severity. Cornea. 2018;37(9):1138-1142.10.1097/ICO.0000000000001668608125229923859
]Search in Google Scholar
[
35. Kowalczuk L, Latour G, Bourges JL, Savoldelli M, Jeanny JC, Plamann K, Schanne-Klein MC, Behar-Cohen F. Multimodal highlighting of structural abnormalities in diabetic rat and human corneas. Transl Vis Sci Technol. 2013;2(2):3.10.1167/tvst.2.2.3376389024049714
]Search in Google Scholar
[
36. Zou CL, Wang SY, Huang F, Zhang YA. Advanced glycation end products and ultrastructural changes in corneas of long-term streptozotocin-induced diabetic monkeys. Cornea. 2012;31(12):1455-1459.10.1097/ICO.0b013e318249090722695699
]Search in Google Scholar
[
37. Priyadarsini S, Rowsey TG, Ma JX, Karamichos D. Unravelling the stromal-nerve interactions in the human diabetic Cornea. Exp Eye Res. 2017;164:22-30.10.1016/j.exer.2017.08.003615545628827027
]Search in Google Scholar
[
38. Todorovic D, Sarenac Vulovic T, Sreckovic S, Jovanovic S, Janicijevic K, Todorovic Z. Updates on the treatment of pterygium. Ser J Exp Clin Res. 2016; 17 (3): 257-261 doi: 10.1515/SJECR-2016-0012.10.1515/sjecr-2016-0012
]Search in Google Scholar
[
39. Saghizadeh M, Kramerov AA, Tajbakhsh J, Aoki AM, Wang C, Chai NN, Ljubimova JY, Sasaki T, Sosne G, Carlson MR, Nelson SF, Ljubimov AV. Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas. Invest Ophthalm. 2005;46(10):3604-3615.10.1167/iovs.04-1507145910516186340
]Search in Google Scholar
[
40. Schwarz C, Aldrich BT, Burckart KA, Schmidt GA, Zimmerman MB, Reed CR, Greiner MA, Sander EA. Descemet membrane adhesion strength is greater in diabetics with advanced disease compared to healthy donor corneas. Exp Eye Res. 2016;153:152-158.10.1016/j.exer.2016.10.01527777123
]Search in Google Scholar
[
41. Priyadarsini S, McKay TB, Sarker-Nag A, Allegood J, Chalfant C, Ma JX, Karamichos D. Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma. Exp Eye Res. 2016;153:90-100.10.1016/j.exer.2016.10.010531720527742548
]Search in Google Scholar
[
42. Liaboe CA, Aldrich BT, Carter PC, Skeie JM, Burckart KA, Schmidt of diabetes mellitus on donor corneal endothelial cell density. Cornea. 2017;36(5):561-566.10.1097/ICO.000000000000117428306601
]Search in Google Scholar
[
43. El-Agamy A, Alsubaie S. Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus. Clin Ophthalmol. 2017;11: 481-486.10.2147/OPTH.S126217533898428280298
]Search in Google Scholar
[
44. Sahu PK, Das GK, Agrawal S, Kumar S. Comparative evaluation of corneal endothelium in patients with diabetes undergoing phacoemulsification. Middle East Afr J Ophthalmol. 2017;24(2):74-80.10.4103/meajo.MEAJO_242_15559830628936050
]Search in Google Scholar
[
45. Storr-Paulsen A, Singh A, Jeppesen H, Norregaard JC, Thulesen J. Corneal endothelial morphology and central thickness in patients with type II diabetes mellitus. Acta Ophthalmol 2014;92(2):158-160.10.1111/aos.1206423387877
]Search in Google Scholar
[
46. Shenoy R, Khandekar R, Bialasiewicz A, Al Muniri A. Corneal endothelium in patients with diabetes mellitus: a historical cohort study. Eur J Ophthalmol. 2009;19(3):369-375.10.1177/11206721090190030719396780
]Search in Google Scholar
[
47. González-Méijome JM, Jorge J, Queirós A, Peixoto-de- Matos SC,Parafita MA. Two single descriptors of endothelial polymegethism and pleomorphism. Graefes Arch Clin Exp Ophthalmol. 2010;248(8):1159-1166.10.1007/s00417-010-1337-620224952
]Search in Google Scholar
[
48. Mathew PT, David S, Thomas N. Endothelial cell loss and central corneal thickness in patients with and without diabetes after manual small incision cataract surgery. Cornea. 2011;30(4):424-428.10.1097/ICO.0b013e3181eadb4b20885307
]Search in Google Scholar
[
49. Kaji Y, Amano S, Usui T, Suzuki K, Tanaka S, Oshika T, Nagai R, Horiuchi S. Advanced glycation end products in Descemet’s membrane and their effect on corneal endothelial cell. Curr Eye Res. 2001;23(6):469-477.10.1076/ceyr.23.6.469.696812045898
]Search in Google Scholar
[
50. Aldrich BT, Schlötzer-Schrehardt U, Skeie JM, Burckart KA, Schmidt GA, Reed CR, Zimmerman MB, Kruse FE, Greiner MA. Mitochondrial and morphologic alterations in native human corneal endothelial cells associated with diabetes mellitus. Invest Ophthalmol Vis Sci. 2017;58(4):2130-213810.1167/iovs.16-2109428395029
]Search in Google Scholar
[
51. Eghrari AO, Riazuddin SA, Gottsch JD. Overview of the cornea: structure, function, and development. Prog Mol Biol Transl Sci. 2015;134: 7-23.10.1016/bs.pmbts.2015.04.00126310146
]Search in Google Scholar
[
52. Latour G, Kowalczuk L, Savoldelli M, Bourges JL, Plamann K, Behar-Cohen F, Schanne-Klein MC. Hyperglycemia- induced abnormalities in rat and human corneas: the potential of second harmonic generation microscopy. PLoS One. 2012;7(11):e48388.10.1371/journal.pone.0048388348967023139780
]Search in Google Scholar
[
53. Akimoto Y, Sawada H, Ohara-Imaizumi M, Nagamatsu S, Kawakami H. Change in long-spacing collagen in Descemet’s membrane of diabetic Goto-Kakizaki rats and its suppression by antidiabetic agents. Exp Diabetes Res. 2008;2008:818341.10.1155/2008/818341252806118779868
]Search in Google Scholar
[
54. Nubile M, Lanzini M, Miri A, Pocobelli A, Calienno R, Curcio C, Mastropasqua R, Dua HS, Mastropasqua L. In vivo confocal microscopy in diagnosis of limbal stem cell deficiency. Am J Ophthalmol. 2013;155(2):220-232.10.1016/j.ajo.2012.08.01723127748
]Search in Google Scholar
[
55. Ueno H, Hattori T, Kumagai Y, Suzuki N, Ueno S, Takagi H.Alterations in the corneal nerve and stem/progenitor cells in diabetes: preventive effects of insulin-like growth factor-1 treatment. Int J Endocrinol. 2014;2014:312401.10.1155/2014/312401394859324696681
]Search in Google Scholar
[
56. Stuard WL, Titone R, Robertson DM. Tear levels of insulin- like growth factor binding protein 3 correlate with subbasal nerve plexus changes in patients with type 2 diabetes mellitus. Invest Ophthalmol Vis Sci. 2017;58(14):6105-6112.10.1167/iovs.17-22425
]Search in Google Scholar
[
57. Sarenac Vulovic T, Pavlovic S, Janicijevic K, Todorovic D, Lutovac M, Paunovic S, et al. Tear film stability in patients with pseudexfoliation. Ser J Exp Clin Res. 2018; 19 (3): 243-246. doi: 10.1515/SJECR-2017-0002.10.1515/sjecr-2017-0002
]Search in Google Scholar
[
58. Rocha EM, Alves M, Rios JD, Dartt DA. The aging lacrimal gland: changes in structure and function. Ocul Surf 2008;6(4):162-174.10.1016/S1542-0124(12)70177-5
]Search in Google Scholar
[
59. Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004;18(12):1450-1452.10.1096/fj.03-1476fje15231732
]Search in Google Scholar
[
60. Massingale ML, Li XH, Vallabhajosyula M, Chen DM, Wei Y, Asbell PA. Analysis of inflammatory cytokines in the tears of dry eye patients. Cornea. 2009;28(9):1023-1027.10.1097/ICO.0b013e3181a1657819724208
]Search in Google Scholar
[
61. Kaufman HE. The practical detection of MMP-9 diagnoses ocular surface disease and may help prevent its complications. Cornea. 2013; 32(2):211-216.10.1097/ICO.0b013e3182541e9a22673852
]Search in Google Scholar
[
62. Liu H, Sheng M, Liu Y, Wang P, Chen Y, Chen L, Wang W, Li B. Expression of SIRT1 and oxidative stress in diabetic dry eye. Int J Clin Exp Pathol. 2015;8(6):7644-7653.
]Search in Google Scholar
[
63. Eissa IM, Khalil NM, El-Gendy HA. A controlled study on the correlation between tear film volume and tear film stability in diabetic patients. J Ophthalmol. 2016;2016:5465272.10.1155/2016/5465272478947427034823
]Search in Google Scholar
[
64. Cousen P, Cackett P, Bennett H, Swa K, Dhillon B. Tear production and corneal sensitivity in diabetes. J Diabetes Complicat. 2007;21(6):371-373.10.1016/j.jdiacomp.2006.05.00817967709
]Search in Google Scholar
[
65. Ding J, Liu Y, Sullivan DA. Effects of insulin and high glucose on human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci. 2015;56(13):7814-7820.10.1167/iovs.15-18049468248726658502
]Search in Google Scholar
[
66. Sayin N, Kara N, Pekel G. Ocular complications of diabetes mellitus. World J Diabetes. 2015; 6(1): 92–108.10.4239/wjd.v6.i1.92431732125685281
]Search in Google Scholar
