<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Interleukin-33 (IL-33) is a member of IL-1 family of cytokines, produced constitutively by fibroblasts, endothelial cells, and epithelial cells. IL-33 can be released passively from cells during tissue damage and cell necrosis, suggesting that it may act as an alarmin. Function of IL-33 is mediated by its interaction with ST2 molecule that is expressed on many immune cells: Th2 lymphocytes, NK, NKT and mast cells, monocytes, dendritic cells and granulocytes. IL-33/ST2 pathway plays, often dual, roles in different physiological and inflammatory processes, mediating both, pathological immune responses and tissue repair. Expression of IL-33 in the central nervous system (CNS) is significantly enhanced during various pathological processes, indicating its important role in the pathogenesis of neurological inflammatory and degenerative diseases. In this review the biological features, expression of IL-33 and its ligand ST2 in CNS, and the role of IL- 33/ST2 pathway in development of Alzheimer’s disease and multiple sclerosis are discussed.</p>
</abstract>

Interleukin-33 (IL-33) is a member of IL-1 family of cytokines, produced constitutively by fibroblasts, endothelial cells, and epithelial cells. IL-33 can be released passively from cells during tissue damage and cell necrosis, suggesting that it may act as an alarmin. Function of IL-33 is mediated by its interaction with ST2 molecule that is expressed on many immune cells: Th2 lymphocytes, NK, NKT and mast cells, monocytes, dendritic cells and granulocytes. IL-33/ST2 pathway plays, often dual, roles in different physiological and inflammatory processes, mediating both, pathological immune responses and tissue repair. Expression of IL-33 in the central nervous system (CNS) is significantly enhanced during various pathological processes, indicating its important role in the pathogenesis of neurological inflammatory and degenerative diseases. In this review the biological features, expression of IL-33 and its ligand ST2 in CNS, and the role of IL- 33/ST2 pathway in development of Alzheimer’s disease and multiple sclerosis are discussed.

Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss

University of Kragujevac, Faculty of Medical Sciences

Department of Medical statistics and informatics

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss"}

Interleukin-33 (IL-33) is a member of IL-1 family of cytokines, produced constitutively by fibroblasts, endothelial cells, and epithelial cells. IL-33 can be...

Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss

Data publikacji: 08 gru 2021

Zakres stron: -

Otrzymano: 25 sie 2020

Przyjęty: 10 wrz 2020

DOI: https://doi.org/10.2478/sjecr-2020-0038

Słowa kluczowe
IL-33, ST2, Alzheimer’s disease, Multiple Sclerosis, EAE

© 2021 Jelena Dimitrijevic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss

Data publikacji: 08 gru 2021

Zakres stron: -

Otrzymano: 25 sie 2020

Przyjęty: 10 wrz 2020

DOI: https://doi.org/10.2478/sjecr-2020-0038

Słowa kluczoweIL-33, ST2, Alzheimer’s disease, Multiple Sclerosis, EAE

© 2021 Jelena Dimitrijevic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
IL-33, ST2, Alzheimer’s disease, Multiple Sclerosis, EAE