The aim of the study was to predict the fatigue life of metallic bone plates employing SIMULIA fe-safe software. Two materials commonly used for surgical implants were subjected to investigation: 1.4441 (ASTM F138) stainless steel for implants and Ti6Al4V ELI (ASTM F136) titanium alloy. The material parameters of the two materials were determined from experimental research. Four-point bending fatigue testing was conducted on two generations of bone plates in order to allow for the comparison of the prediction results with the measured data from the experiments.