<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background:</bold> The primary goal was to estimate the seroprevalence of autochthonous hepatitis E virus (HEV) infection in adult Romanian population. Additionally, we aimed to identify the risk factors associated with the HEV seropositive status.<bold>Methods</bold>: Between January 2015 and December 2016, 201 adult patients were tested for antiHEV-IgG. Multivariate logistic regression was used to examine for factors associated with a positive HEV-IgG test. The level of significance was set at α = 0.05.<bold>Results</bold>: The final analysis included 175 patients who followed the study protocol. Forty-sex (26.3%) had positive, 121 (69.1%) had negative, and 8 (4.6%) had indeterminate antiHEV-IgG results. Patients with positive anti-HEV-IgG were older [median age: 54.5 years (IQR 43-65)] compared to patients with negative anti-HEV-IgG [median age: 37.5 years (IQR 28-57.5)], p &lt;0.001. A positive HEV-IgG was more common in patients with history of blood transfusions [n=10 (22.7%) versus (vs) n=11 (9.4%), p=0.025], in those with immunosuppressive conditions [n=18 (40.9%) vs n=27 (23.1%), p=0.025] and in patients with positive hepatitis B surface antigen (HBsAg) [n=14 (31.1%) vs n=10 (10.3%), p=0.002].<bold>Conclusions</bold>: In conclusion, we found that autochthonous HEV seropositivity is common in our study population, especially in older patients, previous blood transfusions, presence of immunosuppressive conditions, and positive HBsAg.</abstract>

Background: The primary goal was to estimate the seroprevalence of autochthonous hepatitis E virus (HEV) infection in adult Romanian population. Additionally, we aimed to identify the risk factors associated with the HEV seropositive status.Methods: Between January 2015 and December 2016, 201 adult patients were tested for antiHEV-IgG. Multivariate logistic regression was used to examine for factors associated with a positive HEV-IgG test. The level of significance was set at α = 0.05.Results: The final analysis included 175 patients who followed the study protocol. Forty-sex (26.3%) had positive, 121 (69.1%) had negative, and 8 (4.6%) had indeterminate antiHEV-IgG results. Patients with positive anti-HEV-IgG were older [median age: 54.5 years (IQR 43-65)] compared to patients with negative anti-HEV-IgG [median age: 37.5 years (IQR 28-57.5)], p <0.001. A positive HEV-IgG was more common in patients with history of blood transfusions [n=10 (22.7%) versus (vs) n=11 (9.4%), p=0.025], in those with immunosuppressive conditions [n=18 (40.9%) vs n=27 (23.1%), p=0.025] and in patients with positive hepatitis B surface antigen (HBsAg) [n=14 (31.1%) vs n=10 (10.3%), p=0.002].Conclusions: In conclusion, we found that autochthonous HEV seropositivity is common in our study population, especially in older patients, previous blood transfusions, presence of immunosuppressive conditions, and positive HBsAg.

Seroprevalence and risk factors for hepatitis E virus infection in the Romanian adult population: a cross-sectional study in a tertiary hospital

“Carol Davila” University of Medicine and Pharmacy

“Dr. Carol Davila”; ‟Titu Maiorescu” University

Biomedical Research and Training Institute

National Institute for Infectious Diseases“Prof. Dr. Matei Balș”

National Institute for Infectious Diseases “Prof. Dr. Matei Balș”

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: The primary goal was to estimate the seroprevalence of autochthonous hepatitis E virus (HEV) infection in adult Romanian population. Additionally,...

Seroprevalence and risk factors for hepatitis E virus infection in the Romanian adult population: a cross-sectional study in a tertiary hospital

Data publikacji: 02 maj 2019

Zakres stron: 199 - 208

Otrzymano: 24 gru 2018

Przyjęty: 03 mar 2019

DOI: https://doi.org/10.2478/rrlm-2019-0018

Słowa kluczowe
hepatitis E, HEV, risk factors, Romanian population, seroprevalence

© 2019 Valeriu Gheorghiță et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Seroprevalence and risk factors for hepatitis E virus infection in the Romanian adult population: a cross-sectional study in a tertiary hospital

Data publikacji: 02 maj 2019

Zakres stron: 199 - 208

Otrzymano: 24 gru 2018

Przyjęty: 03 mar 2019

DOI: https://doi.org/10.2478/rrlm-2019-0018

Słowa kluczowehepatitis E, HEV, risk factors, Romanian population, seroprevalence

© 2019 Valeriu Gheorghiță et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
hepatitis E, HEV, risk factors, Romanian population, seroprevalence