Hypertension-mediated Cardiac Damage Among Romanian Adult Hypertensive Patients: A Post-hoc Echocardiographic Analysis of the SEPHAR IV Epidemiological Survey

1. Kearney PM, Whelton M, Reynolds K et al. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217-23. Kearney PM Whelton M Reynolds K et al .  Global burden of hypertension: analysis of worldwide data . Lancet .  2005 ;365 ( 9455 ): 217 - 23 . Search in Google Scholar

2. Forouzanfar MH, Liu P, Roth GA et al. Global burden of hypertension and systolic blood pressure of at least 110 to 115mmHg, 1990-2015. JAMA. 2017;317(2):165-82. Forouzanfar MH Liu P Roth GA et al .  Global burden of hypertension and systolic blood pressure of at least 110 to 115mmHg, 1990-2015 .  JAMA .  2017 ; 317 ( 2 ): 165 - 82 . Search in Google Scholar

3. Zhou B, Perel P, Mensah GA et al. Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nat Rev Cardiol. 2021;18(11):785-802. Zhou B Perel P Mensah GA et al .  Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension .  Nat Rev Cardiol .  2021 ; 18 ( 11 ): 785 - 802 . Search in Google Scholar

4. Ettehad D, Emdin CA, Kiran A et al. Blood pressure lowering for prevention of cardiovascular disease and death: A systematic review and meta-analysis. Lancet. 2016;387(10022):957-67. Ettehad D Emdin CA Kiran A et al .  Blood pressure lowering for prevention of cardiovascular disease and death: A systematic review and meta-analysis .  Lancet .  2016 ; 387 ( 10022 ): 957 - 67 . Search in Google Scholar

5. Nadar SK, Lip GYH. The heart in hypertension. J Hum Hypertens. 2021;35(5):383-6. Nadar SK Lip GYH .  The heart in hypertension .  J Hum Hypertens .  2021 ; 35 ( 5 ): 383 - 6 . Search in Google Scholar

6. Dorobantu M, Tautu OF, Dimulescu D et al. Perspectives on hypertension’s prevalence, treatment and control in a high cardiovascular risk East European country: Data from the SEPHAR III survey. J Hypertens. 2018;36(3):690-700. Dorobantu M Tautu OF Dimulescu D et al .  Perspectives on hypertension’s prevalence, treatment and control in a high cardiovascular risk East European country: Data from the SEPHAR III survey .  J Hypertens .  2018 ; 36 ( 3 ): 690 - 700 . Search in Google Scholar

7. Dorobanţu M, Darabont R, Ghiorghe S et al. Hypertension prevalence and control in Romania at a seven-year interval. Comparison of SEPHAR I and II surveys. J Hypertens. 2014;32(1):39-47. Dorobanţu M Darabont R Ghiorghe S et al .  Hypertension prevalence and control in Romania at a seven-year interval .  Comparison of SEPHAR I and II surveys. J Hypertens .  2014 ; 32 ( 1 ): 39 - 47 . Search in Google Scholar

8. Williams B, Mancia G, Spiering W et al. 2018 ESC/ESH Guidelines for themanagement of arterial hypertension. Eur Heart J. 2018; 39:3021-310. Williams B Mancia G Spiering W et al .  2018 ESC/ESH Guidelines for themanagement of arterial hypertension .  Eur Heart J .  2018 ;  39 : 3021 - 310 . Search in Google Scholar

9. Lang RM, Badano LP, Mor-Avi V et al. Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American society of echocardiography and the European association of cardiovascular imaging. Eur Heart J Cardiovasc Imaging. 2015;16(3):233- 71. Lang RM Badano LP Mor-Avi V et al .  Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American society of echocardiography and the European association of cardiovascular imaging .  Eur Heart J Cardiovasc Imaging .  2015 ; 16 ( 3 ): 233 - 71 . Search in Google Scholar

10. Nagueh SF, Smiseth OA, Appleton CP et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277-314. Nagueh SF Smiseth OA Appleton CP et al .  Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging .  J Am Soc Echocardiogr .  2016 ; 29 ( 4 ): 277 - 314 . Search in Google Scholar

11. Guo G, Wang H, Bell D et al. KNN model-based approach in classification. Lect Notes Comput Sci. 2003;2888:986-96. Guo G Wang H Bell D et al .  KNN model-based approach in classification .  Lect Notes Comput Sci .  2003 ; 2888 : 986 - 96 . Search in Google Scholar

12. Buuren S van, Oudshoorn K. Flexible multivariate imputation by MICE. TNO Prev Heal. 1999;1-20. Buuren S van Oudshoorn K .  Flexible multivariate imputation by MICE .  TNO Prev Heal .  1999 ; 1 - 20 . Search in Google Scholar

13. Dempster AP, Laird NM, Rubin DB. Maximum Likelihood from Incomplete Data Via the EM Algorithm. J R Stat Soc Ser B. 1977;39(1):1-22. Dempster AP Laird NM Rubin DB .  Maximum Likelihood from Incomplete Data Via the EM Algorithm .  J R Stat Soc Ser B .  1977 ; 39 ( 1 ): 1 - 22 . Search in Google Scholar

14. https://scikit-learn.org/stable/modules/generated/sklearn.impute. IterativeImputer.html https://scikit-learn.org/stable/modules/generated/sklearn.impute.IterativeImputer.html Search in Google Scholar

15. Bießmann F, Rukat T, Schmidt P et al. DataWig: Missing value imputation for tables. J Mach Learn Res. 2019;20:1-6. Bießmann F Rukat T Schmidt P et al .  DataWig: Missing value imputation for tables .  J Mach Learn Res .  2019 ; 20 : 1 - 6 . Search in Google Scholar

16. Correll RN, Eder P, Burr AR et al. Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodelling. Circ Res. 2014;114(2):249-56. Correll RN Eder P Burr AR et al .  Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodelling .  Circ Res .  2014 ; 114 ( 2 ): 249 - 56 . Search in Google Scholar

17. Schlaich MP, Kaye DM, Lambert E et al. Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy. Circulation. 2003;108(5):560-5. Schlaich MP Kaye DM Lambert E et al .  Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy .  Circulation .  2003 ; 108 ( 5 ): 560 - 5 . Search in Google Scholar

18. Ichikawa KI, Hidai C, Okuda C et al. Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium. J Am Coll Cardiol. 1996;27(5):1286-91. Ichikawa KI Hidai C Okuda C et al .  Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium .  J Am Coll Cardiol .  1996 ; 27 ( 5 ): 1286 - 91 . Search in Google Scholar

19. Seko Y, Kato T, Shiba M et al. Staging cardiac damage in patients with hypertension. Hypertension. 2019;74(6):1357-65. Seko Y Kato T Shiba M et al .  Staging cardiac damage in patients with hypertension .  Hypertension .  2019 ; 74 ( 6 ): 1357 - 65 . Search in Google Scholar

20. Marwick TH, Gillebert TC, Aurigemma G et al. Recommendations on the use of echocardiography in adult hypertension: A report from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE). Eur Heart J Cardiovasc Imaging. 2015;16(6):577-605. Marwick TH Gillebert TC Aurigemma G et al .  Recommendations on the use of echocardiography in adult hypertension: A report from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE) .  Eur Heart J Cardiovasc Imaging .  2015 ; 16 ( 6 ): 577 - 605 . Search in Google Scholar

21. Milani RV, Lavie CJ, Mehra MR et al. Left ventricular geometry and survival in patients with normal left ventricular ejection fraction. Am J Cardiol. 2006;97:959-63. Milani RV Lavie CJ Mehra MR et al .  Left ventricular geometry and survival in patients with normal left ventricular ejection fraction .  Am J Cardiol .  2006 ; 97 : 959 - 63 . Search in Google Scholar

22. Koren MJ, Devereux RB, Casale PN et al. Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med. 1991;114(5):345-52. Koren MJ Devereux RB Casale PN et al .  Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension .  Ann Intern Med .  1991 ; 114 ( 5 ): 345 - 52 . Search in Google Scholar

23. Cuspidi C, Sala C, Negri F et al. Prevalence of left-ventricular hypertrophy in hypertension: An updated review of echocardiographic studies. J Hum Hypertens. 2012;26(6):343-9. Cuspidi C Sala C Negri F et al .  Prevalence of left-ventricular hypertrophy in hypertension: An updated review of echocardiographic studies .  J Hum Hypertens .  2012 ; 26 ( 6 ): 343 - 9 . Search in Google Scholar

24. Cramariuc D, Gerdts E. Epidemiology of left ventricular hypertrophy in hypertension: implications for the clinic. Expert Rev Cardiovasc Ther. 2016;14(8):915-26. Cramariuc D Gerdts E .  Epidemiology of left ventricular hypertrophy in hypertension: implications for the clinic .  Expert Rev Cardiovasc Ther .  2016 ; 14 ( 8 ): 915 - 26 . Search in Google Scholar

25. Levy D, Savage DD, Garrison RJ et al. Echocardiographic criteria for left ventricular hypertrophy: The Framingham heart study. Am J Cardiol. 1987;59(9):956-60. Levy D Savage DD Garrison RJ et al .  Echocardiographic criteria for left ventricular hypertrophy: The Framingham heart study .  Am J Cardiol .  1987 ; 59 ( 9 ): 956 - 60 . Search in Google Scholar

26. Gerdts E, Izzo R, Mancusi C et al. Left ventricular hypertrophy offsets the sex difference in cardiovascular risk. Int J Cardiol. 2018;258:257-61. Gerdts E Izzo R Mancusi C et al .  Left ventricular hypertrophy offsets the sex difference in cardiovascular risk .  Int J Cardiol .  2018 ; 258 : 257 - 61 . Search in Google Scholar

27. Ruilope LM, Schmieder RE. Left ventricular hypertrophy and clinical outcomes in hypertensive patients. Am J Hypertens. 2008;21(5):500-8. Ruilope LM Schmieder RE .  Left ventricular hypertrophy and clinical outcomes in hypertensive patients .  Am J Hypertens .  2008 ; 21 ( 5 ): 500 - 8 . Search in Google Scholar

28. Li H, Pei F, Shao L et al. Prevalence and risk factors of abnormal left ventricular geometrical patterns in untreated hypertensive patients. BMC Cardiovasc Disord. 2014;14(1):1-7. Li H Pei F Shao L et al .  Prevalence and risk factors of abnormal left ventricular geometrical patterns in untreated hypertensive patients .  BMC Cardiovasc Disord .  2014 ; 14 ( 1 ): 1 - 7 . Search in Google Scholar

29. Ngabea MA, Ojji DB, Umar H et al. Prevalence of echocardiographic left ventricular hypertrophy among hypertensives in a tertiary health institution in Nigeria. Ann Med Res Pract. 2022;3(3):1–5. Ngabea MA Ojji DB Umar H et al .  Prevalence of echocardiographic left ventricular hypertrophy among hypertensives in a tertiary health institution in Nigeria .  Ann Med Res Pract .  2022 ; 3 ( 3 ): 1 – 5 . Search in Google Scholar

30. Dorobantu M, Vijiiac A, Scafa-Udriste A et al.. Cardiac damage in hypertensive patients.The Romanian experience. AρτηρIακη Yρρδαραση. 2021;30(2):100–4. Dorobantu M Vijiiac A Scafa-Udriste A et al ..  Cardiac damage in hypertensive patients.The Romanian experience .  AρτηρIακη Yρρδαραση .  2021 ; 30 ( 2 ): 100 – 4 . Search in Google Scholar

31. Kuznetsova T, Herbots L, López B et al. Prevalence of left ventricular diastolic dysfunction in a general population. Circ Hear Fail. 2009;2(2):105– 12. Kuznetsova T Herbots L López B et al .  Prevalence of left ventricular diastolic dysfunction in a general population .  Circ Hear Fail .  2009 ; 2 ( 2 ): 105 – 12 . Search in Google Scholar

32. Kloch-Badelek M, Kuznetsova T, Sakiewicz W et al. Prevalence of left ventricular diastolic dysfunction in European populations based on crossvalidated diagnostic thresholds. Cardiovasc Ultrasound. 2012;10(1):1–9. Kloch-Badelek M Kuznetsova T Sakiewicz W et al .  Prevalence of left ventricular diastolic dysfunction in European populations based on crossvalidated diagnostic thresholds .  Cardiovasc Ultrasound .  2012 ; 10 ( 1 ): 1 – 9 . Search in Google Scholar

33. Pavlopoulos H, Grapsa J, Stefanadi E et al. The evolution of diastolic dysfunction in the hypertensive disease. Eur J Echocardiogr. 2008;9(6):772–8. Pavlopoulos H Grapsa J Stefanadi E et al .  The evolution of diastolic dysfunction in the hypertensive disease .  Eur J Echocardiogr .  2008 ; 9 ( 6 ): 772 – 8 . Search in Google Scholar

34. Zhou D, Yan M, Cheng Q et al. Prevalence and prognosis of left ventricular diastolic dysfunction in community hypertension patients. BMC Cardiovasc Disord. 2022;22(1):1–9. Zhou D Yan M Cheng Q et al .  Prevalence and prognosis of left ventricular diastolic dysfunction in community hypertension patients .  BMC Cardiovasc Disord .  2022 ; 22 ( 1 ): 1 – 9 . Search in Google Scholar

35. Al-Ghamdi S, Alzubaidi FK, Alharthai SA et al. Prevalence and correlates of diastolic dysfunction in patients with hypertension: A cross-sectional study from in the kingdom of Saudi Arabia. Pan Afr Med J. 2021;40:159. Al-Ghamdi S Alzubaidi FK Alharthai SA et al .  Prevalence and correlates of diastolic dysfunction in patients with hypertension: A cross-sectional study from in the kingdom of Saudi Arabia .  Pan Afr Med J .  2021 ; 40 : 159 . Search in Google Scholar

36. Leão RN, da Silva PM, Pocinho RM et al. Determinants of left ventricular diastolic dysfunction in hypertensive patients. Hipertens y Riesgo Vasc. 2018;35(4):160–8. Leão RN da Silva PM Pocinho RM et al .  Determinants of left ventricular diastolic dysfunction in hypertensive patients .  Hipertens y Riesgo Vasc .  2018 ; 35 ( 4 ): 160 – 8 . Search in Google Scholar

37. Świerblewska E, Wolf J, Kunicka K et al. Prevalence and distribution of left ventricular diastolic dysfunction in treated patients with long-lasting hypertension. Blood Press. 2018;27(6):376–84. Świerblewska E Wolf J Kunicka K et al .  Prevalence and distribution of left ventricular diastolic dysfunction in treated patients with long-lasting hypertension .  Blood Press .  2018 ; 27 ( 6 ): 376 – 84 . Search in Google Scholar

38. Vasan RS, Xanthakis V, Lyass A et al. Epidemiology of Left Ventricular Systolic Dysfunction and Heart Failure in the Framingham Study: An Echocardiographic Study Over 3 Decades. JACC Cardiovasc Imaging. 2018;11(1):1–11. Vasan RS Xanthakis V Lyass A et al .  Epidemiology of Left Ventricular Systolic Dysfunction and Heart Failure in the Framingham Study: An Echocardiographic Study Over 3 Decades .  JACC Cardiovasc Imaging .  2018 ; 11 ( 1 ): 1 – 11 . Search in Google Scholar

39. van Riet EES, Hoes AW, Wagenaar KP et al. Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review. Eur J Heart Fail. 2016;18:242–52. van Riet EES Hoes AW Wagenaar KP et al .  Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time .  A systematic review. Eur J Heart Fail .  2016 ; 18 : 242 – 52 . Search in Google Scholar

40. Messerli FH, Rimoldi SF, Bangalore S. The Transition From Hypertension to Heart Failure: Contemporary Update. JACC Hear Fail. 2017;5(8):543–51. Messerli FH Rimoldi SF Bangalore S .  The Transition From Hypertension to Heart Failure: Contemporary Update .  JACC Hear Fail .  2017 ; 5 ( 8 ): 543 – 51 . Search in Google Scholar

41. Verdecchia P, Angeli F, Gattobigio R et al. Asymptomatic left ventricular systolic dysfunction in essential hypertension: Prevalence, determinants, and prognostic value. Hypertension. 2005;45(3):412–8. Verdecchia P Angeli F Gattobigio R et al .  Asymptomatic left ventricular systolic dysfunction in essential hypertension: Prevalence, determinants, and prognostic value .  Hypertension .  2005 ; 45 ( 3 ): 412 – 8 . Search in Google Scholar

42. Ojji D, Atherton J, Sliwa K et al. Left ventricular systolic dysfunction in asymptomatic black hypertensive subjects. Am J Hypertens. 2015;28(7):924-9 Ojji D Atherton J Sliwa K et al .  Left ventricular systolic dysfunction in asymptomatic black hypertensive subjects .  Am J Hypertens .  2015 ; 28 ( 7 ): 924 - 9 . Search in Google Scholar

43. Mitsutake R, Miura SI, Shiga Y et al. Association Between Hypertension and Coronary Artery Disease as Assessed by Coronary Computed Tomography. J Clin Hypertens. 2011;13(3):198–204. Mitsutake R Miura SI Shiga Y et al .  Association Between Hypertension and Coronary Artery Disease as Assessed by Coronary Computed Tomography .  J Clin Hypertens .  2011 ; 13 ( 3 ): 198 – 204 . Search in Google Scholar