Apolipoprotein E polymorphism in a Romanian population

1. Liehn EA, Ponomariov V, Diaconu R, Streata I, Ioana M, Crespo-Avilan GE, et al. Apolipoprotein E in cardiovascular diseases: novel aspects of an old-fashioned enigma. Arch Med Res. 2018;49(8):522–9. Liehn EA Ponomariov V Diaconu R Streata I Ioana M Crespo-Avilan GE Apolipoprotein E in cardiovascular diseases: novel aspects of an old-fashioned enigma . Arch Med Res. 2018 ; 49 ( 8 ): 522 – 9 . Search in Google Scholar

2. Marais AD. Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease. Pathology. 2019;51(2):165–76. Marais AD . Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease . Pathology. 2019 ; 51 ( 2 ): 165 – 76 . Search in Google Scholar

3. Liehn EA, Lupan A-M, Diaconu R, Ioana M, Streata I, Manole C, et al. Heart function assessment during aging in apolipoprotein E knock-out mice. Discoveries. 2021;9(3):e136. Liehn EA Lupan A-M Diaconu R Ioana M Streata I Manole C Heart function assessment during aging in apolipoprotein E knock-out mice . Discoveries. 2021 ; 9 ( 3 ): e136 . Search in Google Scholar

4. Kharrazi H, Vaisi Raygani A, Sabokroh AR, Pourmotabbed T. Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. Clin Biochem. 2006;39(6): 613–6. Kharrazi H Vaisi Raygani A Sabokroh AR Pourmotabbed T . Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran . Clin Biochem. 2006 ; 39 ( 6 ): 613 – 6 . Search in Google Scholar

5. Grundy SM, Pasternak R, Greenland P, Smith S, Fuster V. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation. 1999;100(13):1,481–92. Grundy SM Pasternak R Greenland P Smith S Fuster V . Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology . Circulation. 1999 ; 100 ( 13 ): 1,481 – 92 . Search in Google Scholar

6. Cohn JS, Tremblay M, Boulet L, Jacques H, Davignon J, Roy M, et al. Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism. Atherosclerosis. 2003;169(1):63–70. Cohn JS Tremblay M Boulet L Jacques H Davignon J Roy M Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism . Atherosclerosis. 2003 ; 169 ( 1 ): 63 – 70 . Search in Google Scholar

7. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8(1):1–21. Davignon J Gregg RE Sing CF . Apolipoprotein E polymorphism and atherosclerosis . Arteriosclerosis. 1988 ; 8 ( 1 ): 1 – 21 . Search in Google Scholar

8. Dallongeville J, Roy M, Leboeuf N, Xhignesse M, Davignon J, Lussier-Cacan S. Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia. Arterioscler Thromb. 1991;11(2):272–8. Dallongeville J Roy M Leboeuf N Xhignesse M Davignon J Lussier-Cacan S . Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia . Arterioscler Thromb. 1991 ; 11 ( 2 ): 272 – 8 . Search in Google Scholar

9. Yamamura T. Apolipoprotein E. Nihon Rinsho. (in Japanese) 1994;52(12):3,124–32. Yamamura T . Apolipoprotein E . Nihon Rinsho. (in Japanese) 1994 ; 52 ( 12 ): 3,124 – 32 . Search in Google Scholar

10. Végh C, Langmár Z, Szerzo M, Agota A, Marosi K, Szabolcs Z, et al. Connections between apolipoprotein E genotypes and the development of cardiovascular diseases. (in Hungarian) Orv Hetil. 2012;153(52):2,070–6. Végh C Langmár Z Szerzo M Agota A Marosi K Szabolcs Z Connections between apolipoprotein E genotypes and the development of cardiovascular diseases. (in Hungarian) Orv Hetil. 2012 ; 153 ( 52 ): 2,070 – 6 . Search in Google Scholar

11. Wang XL, McCredie RM, Wilcken DEL. Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography. Arterioscler Thromb Vasc Biol. 1995;15(8):1,030–4. Wang XL McCredie RM Wilcken DEL . Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography . Arterioscler Thromb Vasc Biol. 1995 ; 15 ( 8 ): 1,030 – 4 . Search in Google Scholar

12. Stengård JH, Weiss KM, Sing CF. An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E. Hum Genet. 1998;103(2):234–41. Stengård JH Weiss KM Sing CF . An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E . Hum Genet. 1998 ; 103 ( 2 ): 234 – 41 . Search in Google Scholar

13. Lehtinen S, Lehtimäki T, Sisto T, Salenius JP, Nikkilä M, Jokela H, et al. Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women. Atherosclerosis. 1995;114(1):83–91. Lehtinen S Lehtimäki T Sisto T Salenius JP Nikkilä M Jokela H Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women . Atherosclerosis. 1995 ; 114 ( 1 ): 83 – 91 . Search in Google Scholar

14. Stengård JH, Zerba KE, Pekkanen J, Ehnholm C, Nissinen A, Sing CF. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation. 1995;91(2):265–9. Stengård JH Zerba KE Pekkanen J Ehnholm C Nissinen A Sing CF . Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men . Circulation. 1995 ; 91 ( 2 ): 265 – 9 . Search in Google Scholar

15. Liu C-C, Liu C-C, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature reviews Neurology. 2013;9(2):106–18. Liu C-C Liu C-C Kanekiyo T Xu H Bu G . Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy . Nature reviews Neurology. 2013 ; 9 ( 2 ): 106 – 18 . Search in Google Scholar

16. Ward A, Crean S, Mercaldi CJ, Collins JM, Boyd D, Cook MN, et al. Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer’s disease: a systematic review and meta-analysis. Neuroepidemiology. 2012;38(1):1–17. Ward A Crean S Mercaldi CJ Collins JM Boyd D Cook MN Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer’s disease: a systematic review and meta-analysis . Neuroepidemiology. 2012 ; 38 ( 1 ): 1 – 17 . Search in Google Scholar

17. Anuurad E, Rubin J, Lu G, Pearson TA, Holleran S, Ramakrishnan R, et al. Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol. J Lipid Res. 2006;47(11):2,475–81. Anuurad E Rubin J Lu G Pearson TA Holleran S Ramakrishnan R Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol . J Lipid Res. 2006 ; 47 ( 11 ): 2,475 – 81 . Search in Google Scholar

18. Howard B V, Gidding SS, Liu K. Association of apolipoprotein E phenotype with plasma lipoproteins in African-American and white young adults. The CARDIA study. Coronary artery risk development in young adults. Am J Epidemiol. 1998;148(9):859–68. Howard B V Gidding SS Liu K . Association of apolipoprotein E phenotype with plasma lipoproteins in African-American and white young adults. The CARDIA study. Coronary artery risk development in young adults . Am J Epidemiol. 1998 ; 148 ( 9 ): 859 – 68 . Search in Google Scholar

19. Simionescu M, Bilan S, Gavurova B, Bordea EN. Health policies in Romania to reduce the mortality caused by cardiovascular diseases. Int J Environ Res Public Health. 2019;16(17):3,080. Simionescu M Bilan S Gavurova B Bordea EN . Health policies in Romania to reduce the mortality caused by cardiovascular diseases . Int J Environ Res Public Health. 2019 ; 16 ( 17 ): 3,080 . Search in Google Scholar

20. Sima A, Iordan A, Stancu C. Apolipoprotein E polymorphism-a risk factor for metabolic syndrome. Clin Chem Lab Med. 2007;45(9):1,149–53. Sima A Iordan A Stancu C . Apolipoprotein E polymorphism-a risk factor for metabolic syndrome . Clin Chem Lab Med. 2007 ; 45 ( 9 ): 1,149 – 53 . Search in Google Scholar

21. Main BF, Jones PJH, MacGillivray RTA, Banfield DK. Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide primers. J Lipid Res. 1991;32(1):183–7. Main BF Jones PJH MacGillivray RTA Banfield DK . Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide primers . J Lipid Res. 1991 ; 32 ( 1 ): 183 – 7 . Search in Google Scholar

22. Diaconu R, Schaaps N, Afify M, Boor P, Cornelissen A, Florescu RA, et al. Apolipoprotein e4 is associated with right ventricular dysfunction in dilated cardiomyopathy–an animal and in-human comparative study. Int J Mol Sci. 2021;22(18):9,688. Diaconu R Schaaps N Afify M Boor P Cornelissen A Florescu RA Apolipoprotein e4 is associated with right ventricular dysfunction in dilated cardiomyopathy–an animal and in-human comparative study . Int J Mol Sci. 2021 ; 22 ( 18 ): 9,688 . Search in Google Scholar

23. Vučinić N, Djan I, Stokić E, Božin B, Obreht D, Stankov K, et al. Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia). Mol Biol Rep. 2014;41(8):5,221–7. Vučinić N Djan I Stokić E Božin B Obreht D Stankov K Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia) . Mol Biol Rep. 2014 ; 41 ( 8 ): 5,221 – 7 . Search in Google Scholar

24. Hallman DM, Boerwinkle E, Saha N, Sandholzer C, Menzel HJ, Csazar A, et al. The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. Am J Hum Genet. 1991;49(2):338–49. Hallman DM Boerwinkle E Saha N Sandholzer C Menzel HJ Csazar A The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations . Am J Hum Genet. 1991 ; 49 ( 2 ): 338 – 49 . Search in Google Scholar

25. Kalina A, Szalai C, Prohászka Z, Reiber I, Császár A. Association of plasma lipid levels with apolipoprotein E polymorphism in Type 2 diabetes. Diabetes Res Clin Pract. 2002;56(1):63–8. Kalina A Szalai C Prohászka Z Reiber I Császár A . Association of plasma lipid levels with apolipoprotein E polymorphism in Type 2 diabetes . Diabetes Res Clin Pract. 2002 ; 56 ( 1 ): 63 – 8 . Search in Google Scholar

26. Borinskaia SA, Kal’ina NR, Sanina ED, Kozhekbaeva ZM, Gupalo EI, Garmash I V, et al. Polymorphism of the apolipoprotein E gene (APOE) in the populations of Russia and neighboring countries. (in Russian) Genetika. 2007;43(10):1,434–40. Borinskaia SA Kal’ina NR Sanina ED Kozhekbaeva ZM Gupalo EI Garmash I V Polymorphism of the apolipoprotein E gene (APOE) in the populations of Russia and neighboring countries. (in Russian) Genetika. 2007 ; 43 ( 10 ): 1,434 – 40 . Search in Google Scholar

27. Siváková D, Zacharová M, Gasparovic J, Raslová K, Wsólová L, Basistová Z, et al. Apolipoprotein E polymorphism in relation to plasma lipid levels and other risk factors of atherosclerosis in two ethnic groups from Slovakia. Coll Antropol. 2006;30(2):387–94. Siváková D Zacharová M Gasparovic J Raslová K Wsólová L Basistová Z Apolipoprotein E polymorphism in relation to plasma lipid levels and other risk factors of atherosclerosis in two ethnic groups from Slovakia . Coll Antropol. 2006 ; 30 ( 2 ): 387 – 94 . Search in Google Scholar

28. Borilova Linhartova P, Bartova J, Poskerova H, Machal J, Vokurka J, Fassmann A, et al. Apolipoprotein E gene polymorphisms in relation to chronic periodontitis, periodontopathic bacteria, and lipid levels. Arch Oral Biol. 2015;60(3):456–62. Borilova Linhartova P Bartova J Poskerova H Machal J Vokurka J Fassmann A Apolipoprotein E gene polymorphisms in relation to chronic periodontitis, periodontopathic bacteria, and lipid levels . Arch Oral Biol. 2015 ; 60 ( 3 ): 456 – 62 . Search in Google Scholar

29. Kowalska A, Wiechmann I, Walter H. Genetic variability of apolipoprotein E in a Polish population. Hum Biol;70(6):1,093–9. Kowalska A Wiechmann I Walter H . Genetic variability of apolipoprotein E in a Polish population . Hum Biol ; 70 ( 6 ): 1,093 – 9 . Search in Google Scholar

30. Pedersen JC, Berg K. Gene-gene interaction between the low density lipoprotein receptor and apolipoprotein E loci affects lipid levels. Clin Genet. 1990;38(4):287–94. Pedersen JC Berg K . Gene-gene interaction between the low density lipoprotein receptor and apolipoprotein E loci affects lipid levels . Clin Genet. 1990 ; 38 ( 4 ): 287 – 94 . Search in Google Scholar

31. Roussos L, Ekström U, Ehle PN, Öqvist B, Floren CH. Apolipoprotein E polymorphism in 385 patients on renal replacement therapy in Sweden. Scand J Urol Nephrol. 2004;38(6):504–10. Roussos L Ekström U Ehle PN Öqvist B Floren CH . Apolipoprotein E polymorphism in 385 patients on renal replacement therapy in Sweden . Scand J Urol Nephrol. 2004 ; 38 ( 6 ): 504 – 10 . Search in Google Scholar

32. Eggertsen G, Tegelman R, Ericsson S, Angelin B, Berglund L. Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clin Chem. 1993;39(10):2,125–9. Eggertsen G Tegelman R Ericsson S Angelin B Berglund L . Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations . Clin Chem. 1993 ; 39 ( 10 ): 2,125 – 9 . Search in Google Scholar

33. Lehtimaki T, Uibu T, Roto P, Koivula T, Jokela H, Ehnholm C, et al. Apolipoprotein E and A-IV polymorphisms in the Estonian population. Clin Genet. 1998;54(1):106–7. Lehtimaki T Uibu T Roto P Koivula T Jokela H Ehnholm C Apolipoprotein E and A-IV polymorphisms in the Estonian population . Clin Genet. 1998 ; 54 ( 1 ): 106 – 7 . Search in Google Scholar

34. Petkeviciene J, Smalinskiene A, Luksiene DI, Jureniene K, Ramazauskiene V, Klumbiene J, et al. Associations between apolipoprotein E genotype, diet, body mass index, and serum lipids in Lithuanian adult population. PLoS One. 2012;7(7):e41525. Petkeviciene J Smalinskiene A Luksiene DI Jureniene K Ramazauskiene V Klumbiene J Associations between apolipoprotein E genotype, diet, body mass index, and serum lipids in Lithuanian adult population . PLoS One. 2012 ; 7 ( 7 ): e41525 . Search in Google Scholar

35. Gerdes LU, Klausen IC, Sihm I, Faergeman O, Vogler GP. Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet Epidemiol. 1992;9(3):155–67. Gerdes LU Klausen IC Sihm I Faergeman O Vogler GP . Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world . Genet Epidemiol. 1992 ; 9 ( 3 ): 155 – 67 . Search in Google Scholar

36. Sheehan D, Bennett T, Cashman K. Apolipoprotein E gene polymorphisms and serum cholesterol in healthy Irish adults: a proposed genetic marker for coronary artery disease risk. Ir J Med Sci. 2000;169(1):50–4. Sheehan D Bennett T Cashman K . Apolipoprotein E gene polymorphisms and serum cholesterol in healthy Irish adults: a proposed genetic marker for coronary artery disease risk . Ir J Med Sci. 2000 ; 169 ( 1 ): 50 – 4 . Search in Google Scholar

37. Adler G, Adler MA, Urbańska A, Skonieczna-Żydecka K, Kiseljakovic E, Valjevac A, et al. Bosnian study of APOE distribution (BOSAD): a comparison with other European populations. Ann Hum Biol. 2017;44(6):568–73. Adler G Adler MA Urbańska A Skonieczna-Żydecka K Kiseljakovic E Valjevac A Bosnian study of APOE distribution (BOSAD): a comparison with other European populations . Ann Hum Biol. 2017 ; 44 ( 6 ): 568 – 73 . Search in Google Scholar

38. Mustapic M, Popovic Hadzija M, Pavlovic M, Pavkovic P, Presecki P, Mrazovac D, et al. Alzheimer’s disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes. Metab Brain Dis. 2012;27(4):507–12. Mustapic M Popovic Hadzija M Pavlovic M Pavkovic P Presecki P Mrazovac D Alzheimer’s disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes . Metab Brain Dis. 2012 ; 27 ( 4 ): 507 – 12 . Search in Google Scholar

39. Gialeraki A, Politou M, Rallidis L, Merkouri E, Markatos C, Kremastinos D, et al. Prevalence of prothrombotic polymorphisms in Greece. Genet Test. 2008;12(4):541–7. Gialeraki A Politou M Rallidis L Merkouri E Markatos C Kremastinos D Prevalence of prothrombotic polymorphisms in Greece . Genet Test. 2008 ; 12 ( 4 ): 541 – 7 . Search in Google Scholar

40. Haddy N, De Bacquer D, Chemaly MM, Maurice M, Ehnholm C, Evans A, et al. The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe. Eur J Hum Genet. 2002;10(12):841–50. Haddy N De Bacquer D Chemaly MM Maurice M Ehnholm C Evans A The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe . Eur J Hum Genet. 2002 ; 10 ( 12 ): 841 – 50 . Search in Google Scholar

41. Muros M, Rodríguez-Ferrer C. Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4. Atherosclerosis. 1996;121(1):13–21. Muros M Rodríguez-Ferrer C . Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4 . Atherosclerosis. 1996 ; 121 ( 1 ): 13 – 21 . Search in Google Scholar

42. Schmidt R, Schmidt H, Fazekas F, Schumacher M, Niederkorn K, Kapeller P, et al. Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention Study. Stroke. 1997;28(5):951–6. Schmidt R Schmidt H Fazekas F Schumacher M Niederkorn K Kapeller P Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention Study . Stroke. 1997 ; 28 ( 5 ): 951 – 6 . Search in Google Scholar

43. Corbo RM, Scacchi R. Apolipoprotein E (APOE) allele distribution in the world. Is APOE * 4 a ‘thrifty’ allele? Ann Hum Genet. 1999;63(4):301–10. Corbo RM Scacchi R . Apolipoprotein E (APOE) allele distribution in the world. Is APOE * 4 a ‘thrifty’ allele? Ann Hum Genet. 1999 ; 63 ( 4 ): 301 – 10 . Search in Google Scholar

44. Bailleul S, Couderc R, Landais V, Lefèvre G, Raichvarg D, Etienne J. Direct phenotyping of human apolipoprotein E in plasma: application to population frequency distribution in Paris (France). Hum Hered. 1993;43(3):159–65. Bailleul S Couderc R Landais V Lefèvre G Raichvarg D Etienne J . Direct phenotyping of human apolipoprotein E in plasma: application to population frequency distribution in Paris (France) . Hum Hered. 1993 ; 43 ( 3 ): 159 – 65 . Search in Google Scholar

45. Klasen EC, Smit M, Knijff P De, Leuven JG, Kempen-Voogd R, Havekes L. Apolipoprotein E phenotype and gene distribution in The Netherlands. Hum Hered. 1987;37(6):340–4. Klasen EC Smit M Knijff P De Leuven JG Kempen-Voogd R Havekes L . Apolipoprotein E phenotype and gene distribution in The Netherlands . Hum Hered. 1987 ; 37 ( 6 ): 340 – 4 . Search in Google Scholar

46. Cavalli-Sforza LL, Piazza A. Human genomic diversity in Europe: a summary of recent research and prospects for the future. Eur J Hum Genet. 1993;1(1):3–18. Cavalli-Sforza LL Piazza A . Human genomic diversity in Europe: a summary of recent research and prospects for the future . Eur J Hum Genet. 1993 ; 1 ( 1 ): 3 – 18 . Search in Google Scholar

47. Veeramah KR, Novembre J. Demographic events and evolutionary forces shaping European genetic diversity. Cold Spring Harb Perspect Biol. 2014;6(9):a008516. Veeramah KR Novembre J . Demographic events and evolutionary forces shaping European genetic diversity . Cold Spring Harb Perspect Biol. 2014 ; 6 ( 9 ): a008516 . Search in Google Scholar

48. Atadzhanov M, Mwaba MH, Mukomena PN, Lakhi S, Mwaba P, Rayaprolu S, et al. Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population. BMC Res Notes. 2014;7:194. Atadzhanov M Mwaba MH Mukomena PN Lakhi S Mwaba P Rayaprolu S Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population . BMC Res Notes. 2014 ; 7 : 194 . Search in Google Scholar

49. Cocoş R, Schipor S, Hervella M, Cianga P, Popescu R, Banescu C, et al. Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis. BMC Genet. 2017;18(1):20. Cocoş R Schipor S Hervella M Cianga P Popescu R Banescu C Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis . BMC Genet. 2017 ; 18 ( 1 ): 20 . Search in Google Scholar

50. Hedenstierna-Jonson C, Kjellström A, Zachrisson T, Krzewińska M, Sobrado V, Price N, et al. A female Viking warrior confirmed by genomics. Am J Phys Anthropol. 2017;164(4):853–60. Hedenstierna-Jonson C Kjellström A Zachrisson T Krzewińska M Sobrado V Price N A female Viking warrior confirmed by genomics . Am J Phys Anthropol. 2017 ; 164 ( 4 ): 853 – 60 . Search in Google Scholar

51. Hellenthal G, Busby GBJ, Band G, Wilson JF, Capelli C, Falush D, et al. A genetic atlas of human admixture history. Science. 2014;343(6,172):747–51. Hellenthal G Busby GBJ Band G Wilson JF Capelli C Falush D A genetic atlas of human admixture history . Science . 2014 ; 343 ( 6,172 ): 747 – 51 . Search in Google Scholar

52. Gaiţǎ D, Moşteoru S. Cardiometabolic prevention in Romania: a midsummer night’s dream? Cardiovasc Endocrinol. 2017;6(1):45–7. Gaiţǎ D Moşteoru S . Cardiometabolic prevention in Romania: a midsummer night’s dream? Cardiovasc Endocrinol. 2017 ; 6 ( 1 ): 45 – 7 . Search in Google Scholar

53. Serrano-Pozo A, Das S, Hyman BT. APOE and Alzheimer’s disease: advances in genetics, pathophysiology, and therapeutic approaches. Lancet Neurol. 2021;20(1):68–80. Serrano-Pozo A Das S Hyman BT . APOE and Alzheimer’s disease: advances in genetics, pathophysiology, and therapeutic approaches . Lancet Neurol. 2021 ; 20 ( 1 ): 68 – 80 . Search in Google Scholar

54. Kurki SN, Kantonen J, Kaivola K, Hokkanen L, Mäyränpää MI, Puttonen H, et al. APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study. Acta Neuropathol Commun. 2021;9(1):199. Kurki SN Kantonen J Kaivola K Hokkanen L Mäyränpää MI Puttonen H APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study . Acta Neuropathol Commun. 2021 ; 9 ( 1 ): 199 . Search in Google Scholar

55. Villeneuve S, Brisson D, Marchant NL, Gaudet D. The potential applications of Apolipoprotein E in personalized medicine. Front Aging Neurosci. 2014;6:154. Villeneuve S Brisson D Marchant NL Gaudet D . The potential applications of Apolipoprotein E in personalized medicine . Front Aging Neurosci. 2014 ; 6 : 154 . Search in Google Scholar

56. Donnelly LA, Palmer CN, Whitley AL, Lang CC, Doney AS, Morris AD, Donnan PT. Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study. Pharmacogenet Genomics. 2008;18(4):279–87. Donnelly LA Palmer CN Whitley AL Lang CC Doney AS Morris AD Donnan PT . Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study . Pharmacogenet Genomics. 2008 ; 18 ( 4 ): 279 – 87 . Search in Google Scholar

57. Cai C, Wen Z, Li L. The relationship between ApoE gene polymorphism and the efficacy of statins controlling hyperlipidemia. Am J Transl Res. 2021;13(6):6,772–7. Cai C Wen Z Li L . The relationship between ApoE gene polymorphism and the efficacy of statins controlling hyperlipidemia . Am J Transl Res. 2021 ; 13 ( 6 ): 6,772 – 7 . Search in Google Scholar

58. Norwitz NG, Saif N, Ariza IE, Isaacson RS. Precision nutrition for Alzheimer’s prevention in ApoE4 carriers. Nutrients. 2021;13:1,362. Norwitz NG Saif N Ariza IE Isaacson RS . Precision nutrition for Alzheimer’s prevention in ApoE4 carriers . Nutrients. 2021 ; 13 : 1,362 . Search in Google Scholar

59. Dagliati A, Peek N, Brinton RD, Geifman N. Sex and APOE genotype differences related to statin use in the aging population. Alzheimers Dement (N Y). 2021;7:e12156. Dagliati A Peek N Brinton RD Geifman N . Sex and APOE genotype differences related to statin use in the aging population . Alzheimers Dement (N Y). 2021 ; 7 : e12156 . Search in Google Scholar