Metabolic shock in elderly pertrochanteric or intertrochanteric surgery. Comparison of three surgical methods. Is there a much safer?

Trend of procalcitonin changes (n_v_ <0_05 ng/ML) during 1 year of follow-up in the three groups_

Time	Average procalcitonin (ng/mL) RIMN	Average procalcitonin (ng/mL) UINM	Average procalcitonin (ng/mL)DHS
0	0.01	0.01	0.01
Before surgery	0.03	0.04	0.05
After surgery	0.50	0.50	0.50
1st month	0.02	0.01	0.02
3rd month	0.01	0.01	0.01
6th month	0.02	0.01	0.01
12th month	0.01	0.01	0.02

Description of population

	RIMN	UINM	DHS
Numbers	15	15	13
Average age (years)	83.5	84.9	82.4
Range of age (years)	75-100	75-102	75-96
Sex	12 M; 18 F	11 M; 12 F	8 M; 18 F
Antiplatelet used for thromboembolic prophylaxis	Enoxaparin: 15	Enoxaparin: 15	Enoxaparin: 13
Average score of thromboembolic risk according to card TVP Tuscany Region	5,7	5,9	5,5
Anesthetic risk (ASA)	III	III	III
Number of patients on therapy for osteoporosis before trauma	21	22	19
Average time of surgery (min)	23.6	18.6	45.3
Length of surgical wound (cm)	9.3	9.2	12.2

Trend of D-dimer changes (n_v_ 50-500 ng/mL) during 1 year of follow-up in the three groups_

Time	Average D-dimer (ng/mL) RIMN	Average D-dimer (ng/mL) UINM	Average D-dimer (ng/mL)DHS
0	724.3	726.9	727.5
Before surgery	798.3	795.4	789.6
After surgery	803.5	804.7	808.3
1st month	526.3	528.4	630.3
3rd month	182.4	180.3	184.2
6th month	78.3	79.5	80.5
12th month	77.3	78.8	79.5

Comorbidities in the three investigated groups_

Comorbidity	RIMN	UIMN	DHS
Cardiovascular disease	6	7	6
Stroke	4	3	2
Respiratory disease	6	8	5
Renal disease	8	6	5
Diabetes mellitus	4	5	3
Rheumatoid disease	2	1	2
Parkinson’s disease	1	2	1
Severe mental deterioration in old age	8	8	5
Paget’s disease	1	1	0
Current smokers	5	4	2
No. of comorbidities
1	5 (16.67%)	4 (15.33%)	4 (15.38%)
2	10 (33.33%)	11 (30.67%)	8 (30.76%)
≥3	15 (50%)	15 (50%)	14 (53.86%)

Trend of LDH changes (n_v_ 0-600 U/L) during 1 year of follow-up in the three groups_

Time	Average LDH (U/L) RIMN	Average LDH (U/L) UIMN	Average LDH (U/L) DHS
0	787.3	786.2	788.1
Before surgery	370.5	376.3	368.8
After surgery	701.2	702.3	929.5
1st month	326.5	327.3	338.9
3rd month	250.6	284.4	256.7
6th month	232.5	237.9	236.4
12th month	372.6	377.1	382.3

Trend of IL-1β changes (n_v_<1pg/mL) during 1 year of follow-up in the three groups_

Time	Average IL-1β (pg/mL) RIMN	Average IL-1β (pg/mL) UINM	Average IL-1β (pg/mL) DHS
0	2.1	2.3	2.1
Before surgery	2.3	2.6	2.4
After surgery	3.8	3.9	4.4
1st month	2.7	2.7	3.1
3rd month	1.8	1.9	2.9
6th month	1.6	1.4	1.5
12th month	1.7	1.7	1.6

Trend of IL-8 changes (n_v_<11 pg/mL) during 1 year of follow-up in the three groups_

Time	Average IL-8 (pg/mL) RIMN	Average IL-8 (pg/mL) UINM	Average IL-8 (pg/mL) DHS
0	18.3	17.6	16.9
Before surgery	24.5	23.3	22.5
After surgery	38.3	28.3	46.4
1st month	33.4	24.5	28.8
3rd month	24.5	23.3	27.6
6th month	16.6	14.8	17.8
12th month	13.2	13.3	14.2

Trend of alpha-1-acid glycoprotein changes (n_v_ 55-120 mg/dL) during 1 year of follow-up in the three groups_

Time	Average alpha-1-acid glycoprotein (mg/dL) RIMN	Average alpha-1-acid glycoprotein (mg/dL) UINM	Average alpha-1-acid glycoprotein (mg/dL) DHS
0	237.5	245.6	248.2
Before surgery	280.2	288.5	274.6
After surgery	296.3	289.1	303.4
1st month	184.4	168.7	209.1
3rd month	156.8	148.9	178.2
6th month	193.8	198.1	199.2
12th month	181.4	182.6	185.7

Trend of CPK changes (n_v 60-190 U/L) during 1 year of follow-up in the three groups_

Time	Average CPK (U/L) RIMN	Average CPK (U/L) UIMN	Average DHS CPK (U/L)
0	308.7	315.5	299.8
Before surgery	270.3	271.8	268.3
After surgery	388.3	368.2	408.2
1st month	202.3	198.3	199.4
3rd month	199.7	197.3	198.2
6th month	163.3	168.3	172.4
12th month	102.3	106.4	105.3

Trend of ESR changes (n_v_ fino a 10 mm/h) during 1 year of follow-up in the three groups_

Time	Average ESR (mm/h) RIMN	Average ESR (mm/h) UINM	Average ESR (mm/h) DHS
0	54.2	56.3	55.2
Before surgery	64.3	68.4	64.9
After surgery	78.3	78.5	77.2
1st month	20.4	19.5	21.8
3rd month	16.3	17.8	20.3
6th month	12.3	11.8	12.2
12th month	11.9	12.3	11.4

Trend of fibrinogen changes (n_v_ 200-400 mg/dL) during 1 year of follow-up in the three groups_

Time	Average fibrinogen (mg/dL) RIMN	Average fibrinogen (mg/dL) UINM	Average fibrinogen (mg/dL) DHS
0	670.3	668.3	667.4
Before surgery	653.9	651.3	652.8
After surgery	710.3	711.3	708.9
1st month	458.3	459.4	600.5
3rd month	234.2	233.4	236.4
6th month	202.4	202.5	207.4
12th month	223.6	237.4	238.5

Trend of CRP changes (n_v_<5 mg/dL) during 1 year of follow-up in the three groups_

Time	Average CRP (mg/dL) RIMN	Average CRP (mg/dL) UINM	Average CRP (mg/dL) DHS
0	25.8	26.3	23.3
Before surgery	45.8	45.4	43.2
After surgery	59.5	59.3	51.8
1st month	12.1	12.8	12.2
3rd month	8.5	8.3	7.6
6th month	6.1	6.3	5.9
12th month	5.6	5.4	5.8

Trend of mortality during 1 year of follow-up in the three groups_

Time	Mortality RIMN	Mortality UINM	Mortality DHS
0	0	0	0
Before surgery	0	0	0
After surgery	0	0	1
1st month	2	1	4
3rd month	3	3	2
6th month	1	2	2
12th month	2	1	0
Total	8 (26.67%)	7 (23.33)	9 (34.61)

Trend of IL-6 changes (n_v_<1_4pg/mL) during 1 year of follow-up in the three groups_

Time	Average IL-6 (pg/mL) RIMN	AverageIL-6 (pg/mL) UINM	AverageIL-6 (pg/mL) DHS
0	4.5	4.6	4.5
Before surgery	3.8	4.2	4.4
After surgery	6.5	5.6	6.7
1st month	2.4	2.9	4.4
3rd month	2.3	2.2	4.2
6th month	1.9	1.6	1.8
12th month	1.8	1.6	1.8