Ketamine Versus Tramadol as an Adjunct to PCA Morphine for Postoperative Analgesia after Major Upper Abdominal Surgery: A Prospective, Comparative, Randomized Trial

[1]Tilleul P, Aissou M, Bocquet F, Thiriat N, le Grelle O, Burke MJ, et al. Cost-effectiveness analysis comparing epidural, patient-controlled intravenous morphine, and continuous wound infiltration for postoperative pain management after open abdominal surgery. Br J Anaesth 2012; 108: 998–1005TilleulPAissouMBocquetFThiriatNle GrelleOBurkeMJCost-effectiveness analysis comparing epidural, patient-controlled intravenous morphine, and continuous wound infiltration for postoperative pain management after open abdominal surgeryBr J Anaesth2012108998100510.1093/bja/aes09122466819Search in Google Scholar

[2]Page A, Rostad B, Staley CA, Levy JH, Park J, Goodman M, et al. Epidural analgesia in hepatic resection. J Am Coll Surg 2008; 206: 1184–1192PageARostadBStaleyCALevyJHParkJGoodmanMEpidural analgesia in hepatic resectionJ Am Coll Surg20082061184119210.1016/j.jamcollsurg.2007.12.04118501817Search in Google Scholar

[3]Elterman KG, Xiong Z. Coagulation profile changes and safety of epidural analgesia after hepatectomy: a retrospective study. J Anesth 2015; 29: 367–372EltermanKGXiongZCoagulation profile changes and safety of epidural analgesia after hepatectomy: a retrospective studyJ Anesth20152936737210.1007/s00540-014-1933-425391365Search in Google Scholar

[4]Shen L, Huang YG. Role of Postoperative Multimodal Analgesia in Abdominal and Pelvic Enhanced Recovery after Surgery. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2016; 38: 458–463ShenLHuangYGRole of Postoperative Multimodal Analgesia in Abdominal and Pelvic Enhanced Recovery after SurgeryZhongguo Yi Xue Ke Xue Yuan Xue Bao201638458463Search in Google Scholar

[5]Ide S, Minami M, Ishihara K, Uhl GR, Sora I, Ikeda K. Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology 2006; 51: 651–658IdeSMinamiMIshiharaKUhlGRSoraIIkedaKMu opioid receptor-dependent and independent components in effects of tramadolNeuropharmacology20065165165810.1016/j.neuropharm.2006.05.00816793069Search in Google Scholar

[6]Minami K, Sudo Y, Miyano K, Murphy RS, Uezono Y. μ-Opioid receptor activation by tramadol and O-desmethyltramadol (M1). J Anesth 2015; 29: 475–479MinamiKSudoYMiyanoKMurphyRSUezonoYμ-Opioid receptor activation by tramadol and O-desmethyltramadol (M1)J Anesth20152947547910.1007/s00540-014-1946-z25394761Search in Google Scholar

[7]Cohen SP, Liao W, Gupta A, Plunkett A. Ketamine in pain management. Adv Psychosom Med 2011; 30: 139–161CohenSPLiaoWGuptaAPlunkettAKetamine in pain managementAdv Psychosom Med20113013916110.1159/00032407121508630Search in Google Scholar

[8]Mion G, Villevieille T. Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings). CNS Neurosci Ther 2013; 19: 370–380MionGVillevieilleTKetamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings)CNS Neurosci Ther20131937038010.1111/cns.12099649335723575437Search in Google Scholar

[9]Pacheco Dda F, Romero TR, Duarte ID. Central antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptors. Brain Res 2014; 1562: 69–75Pacheco DdaFRomeroTRDuarteIDCentral antinociception induced by ketamine is mediated by endogenous opioids and μ- and δ-opioid receptorsBrain Res20141562697510.1016/j.brainres.2014.03.02624675031Search in Google Scholar

[10]Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Clin Pharmacokinet 2016; 55: 1059–1077PeltoniemiMAHagelbergNMOlkkolaKTSaariTIKetamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain TherapyClin Pharmacokinet2016551059107710.1007/s40262-016-0383-627028535Search in Google Scholar

[11]Eng J. Sample size estimation: How many individuals should be studied? Radiology 2003; 227: 309–313EngJSample size estimation: How many individuals should be studied?Radiology200322730931310.1148/radiol.227201205112732691Search in Google Scholar

[12]Unlügenç H, Gündüz M, Ozalevli M, Akman H. A comparative study on the analgesic effect of tramadol, tramadol plus magnesium, and tramadolplus ketamine for postoperative pain management after major abdominal surgery. Acta Anaesthesiol Scand 2002; 46: 1025–1030UnlügençHGündüzMOzalevliMAkmanHA comparative study on the analgesic effect of tramadol, tramadol plus magnesium, and tramadolplus ketamine for postoperative pain management after major abdominal surgeryActa Anaesthesiol Scand2002461025103010.1034/j.1399-6576.2002.460817.xSearch in Google Scholar

[13]Lepri A, Sia S, Catinelli S, Casali R, Novelli G. Patient-controlled analgesia with tramadol versus tramadol plus ketorolac. Minerva Anestesiol 2006; 72: 59–67LepriASiaSCatinelliSCasaliRNovelliGPatient-controlled analgesia with tramadol versus tramadol plus ketorolacMinerva Anestesiol2006725967Search in Google Scholar

[14]Unlugenc H, Tetiker S, Büyükkurt S, Guler T, Isik G. Comparison of the effect of adding remifentanil to patient-controlled tramadol or morphine for postoperative analgesia after major abdominal surgery. J Opioid Manag 2009; 5: 247–255UnlugencHTetikerSBüyükkurtSGulerTIsikGComparison of the effect of adding remifentanil to patient-controlled tramadol or morphine for postoperative analgesia after major abdominal surgeryJ Opioid Manag2009524725510.5055/jom.2009.0027Search in Google Scholar

[15]Murphy JD, Yan D, Hanna MN, Bravos ED, Isaac GR, Eng CA, et al. Comparison of the postoperative analgesic efficacy of intravenous patient-controlled analgesia with tramadol to intravenous patient-controlled analgesia with opioids. J Opioid Manag 2010; 6: 141–147MurphyJDYanDHannaMNBravosEDIsaacGREngCAComparison of the postoperative analgesic efficacy of intravenous patient-controlled analgesia with tramadol to intravenous patient-controlled analgesia with opioidsJ Opioid Manag2010614114710.5055/jom.2010.0014Search in Google Scholar

[16]Shen X, Wang F, Xu S, Ma L, Liu Y, Feng S, et al. Comparison of the analgesic efficacy of preemptive and preventive tramadol after lumpectomy. Pharmacol Rep 2008; 60: 415–421ShenXWangFXuSMaLLiuYFengSComparison of the analgesic efficacy of preemptive and preventive tramadol after lumpectomyPharmacol Rep200860415421Search in Google Scholar

[17]Wang F, Shen X, Xu S, Liu Y. Preoperative tramadol combined with postoperative small-dose tramadol infusion after total abdominal hysterectomy: a double-blind, randomized, controlled trial. Pharmacol Rep 2009; 61: 1198–1205WangFShenXXuSLiuYPreoperative tramadol combined with postoperative small-dose tramadol infusion after total abdominal hysterectomy: a double-blind, randomized, controlled trialPharmacol Rep2009611198120510.1016/S1734-1140(09)70184-7Search in Google Scholar

[18]Stiller CO, Lundblad H, Weidenhielm L, Tullberg T, Grantinger B, Lafolie P, et al. The addition of tramadol to morphine via patient-controlled analgesia does not lead to better post-operative pain relief after total knee arthroplasty. Acta Anaesthesiol Scand 2007; 51: 322–330StillerCOLundbladHWeidenhielmLTullbergTGrantingerBLafoliePThe addition of tramadol to morphine via patient-controlled analgesia does not lead to better post-operative pain relief after total knee arthroplastyActa Anaesthesiol Scand20075132233010.1111/j.1399-6576.2006.01191.x17096666Search in Google Scholar

[19]Webb AR, Leong S, Myles PS, Burn SJ. The addition of a tramadol infusion to morphine patient-controlled analgesia after abdominal surgery: a double-blinded, placebo-controlled randomized trial. Anesth Analg 2002; 95: 1713–1718WebbARLeongSMylesPSBurnSJThe addition of a tramadol infusion to morphine patient-controlled analgesia after abdominal surgery: a double-blinded, placebo-controlled randomized trialAnesth Analg2002951713171810.1097/00000539-200212000-0004512456445Search in Google Scholar

[20]Kocabas S, Karaman S, Uysallar E, Firat V. The use of tramadol and morphine for pain relief after abdominal hysterectomy. Clin Exp Obstet Gynecol 2005; 32: 45–48KocabasSKaramanSUysallarEFiratVThe use of tramadol and morphine for pain relief after abdominal hysterectomyClin Exp Obstet Gynecol2005324548Search in Google Scholar

[21]De Witte JL, Schoenmaekers B, Sessler DI, Deloof T. The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron. Anesth Analg 2001; 92: 1319–1321De WitteJLSchoenmaekersBSesslerDIDeloofTThe analgesic efficacy of tramadol is impaired by concurrent administration of ondansetronAnesth Analg2001921319132110.1097/00000539-200105000-0004511323369Search in Google Scholar

[22]Arcioni R, della Rocca M, Romanò S, Romano R, Pietropaoli P, Gasparetto A. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans. Anesth Analg 2002; 94: 1553–1557ArcioniRdella RoccaMRomanòSRomanoRPietropaoliPGasparettoAOndansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humansAnesth Analg20029415531557Search in Google Scholar

[23]Carstensen M, Møller AM. Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials. Br J Anaesth 2010; 104: 401–406CarstensenMMøllerAMAdding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trialsBr J Anaesth201010440140610.1093/bja/aeq04120207747Search in Google Scholar

[24]Reeves M, Lindholm DE, Myles PS, Fletcher H, Hunt JO. Adding ketamine to morphine for patient-controlled analgesia after major abdominal surgery: a double-blinded, randomized controlled trial. Anesth Analg 2001; 93: 116–120ReevesMLindholmDEMylesPSFletcherHHuntJOAdding ketamine to morphine for patient-controlled analgesia after major abdominal surgery: a double-blinded, randomized controlled trialAnesth Analg20019311612010.1097/00000539-200107000-0002511429351Search in Google Scholar

[25]Murdoch CJ, Crooks BA, Miller CD. Effect of the addition of ketamine to morphine in patient-controlled analgesia. Anaesthesia 2002; 57: 484–488MurdochCJCrooksBAMillerCDEffect of the addition of ketamine to morphine in patient-controlled analgesiaAnaesthesia20025748448810.1046/j.0003-2409.2001.02409.x12004808Search in Google Scholar

[26]Adriaenssens G, Vermeyen KM, Hoffmann VL, Mertens E, Adriaensen HF. Postoperative analgesia with i.v. patient-controlled morphine: effect of adding ketamine. Br J Anaesth 1999; 83: 393–396AdriaenssensGVermeyenKMHoffmannVLMertensEAdriaensenHFPostoperative analgesia with i.v. patient-controlled morphine: effect of adding ketamineBr J Anaesth19998339339610.1093/bja/83.3.39310655908Search in Google Scholar

[27]Guillou N, Tanguy M, Seguin P, Branger B, Campion JP, Mallédant Y. The effects of small-dose ketamine on morphine consumption in surgical intensive care unit patients after major abdominal surgery. Anesth Analg 2003; 97: 843–847GuillouNTanguyMSeguinPBrangerBCampionJPMallédantYThe effects of small-dose ketamine on morphine consumption in surgical intensive care unit patients after major abdominal surgeryAnesth Analg20039784384710.1213/01.ANE.0000075837.67275.3612933413Search in Google Scholar