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Radiographic and pathologic response of myxoid liposarcoma treated with preoperative radiotherapy

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16 cze 2025

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FIGURE 1.

Percentage change in volume during radiotherapy. Dotted lines represent individual tumors. Bold line indicates mean. Gray bar indicates 95% confidence interval.
Percentage change in volume during radiotherapy. Dotted lines represent individual tumors. Bold line indicates mean. Gray bar indicates 95% confidence interval.

FIGURE 2.

Percentage change in greatest dimension during radiotherapy. Dotted lines represent individual tumors. Bold line indicates mean. Gray bar indicates 95% confidence interval.
Percentage change in greatest dimension during radiotherapy. Dotted lines represent individual tumors. Bold line indicates mean. Gray bar indicates 95% confidence interval.

FIGURE 3.

Volumetric change in tumor size from (A) prior to treatment to (B) following 13 fractions in a patient who underwent mid-radiotherapy replanning. Red contour indicates gross tumor volume. The gross tumor volume decreased from 1780 cc prior to treatment to 1287 cc on the replanning scan.
Volumetric change in tumor size from (A) prior to treatment to (B) following 13 fractions in a patient who underwent mid-radiotherapy replanning. Red contour indicates gross tumor volume. The gross tumor volume decreased from 1780 cc prior to treatment to 1287 cc on the replanning scan.

Dosimetric comparison of original plan and replan for an individual patient

Original plan Replan
Soft tissue avoid
  V30Gy(%) 10.3% 0.3%
Large bowel V45Gy(%)
  V45Gy(%) 5.4% 1.5%
  V50Gy(%) 1.8% 0.4%
Small bowel
  V30Gy(cc) 101 cc 82 cc
  V45Gy(cc) 13 cc 6 cc
  V50Gy(cc) 2 cc 1 cc
Rectum
  Mean dose 23 Gy 16 Gy
Genitalia
  Mean dose 10 Gy 6 Gy

Radiographic and pathologic characteristics

N = 20
Intratumoral enhancement
  Stable 4 (20%)
  Decrease 16 (80%)
Peritumoral enhancement
  Increase 1 (5%)
  Not present 15 (75%)
  Decrease 4 (20%)
Peritumoral edema
  Increase 4 (20%)
  Stable 5 (25%)
  Decrease 11 (55%)
Fat
  Increase 11 (55%)
  Stable 9 (45%)
Biopsy grade
  Low 18 (90%)
  High 2 (10%)
Margin status
  Negative 18 (90%)
  Positive 2 (10%)
Greatest pathologic dimension (cm)
  Median (IQR) 9 (7–15)
Percentage viable tumor
  Median (IQR) 5 (5–35)
Extensive pathologic response
  Median (IQR) 16 (80%)

Patient and radiotherapy characteristics

N = 20
Sex
  Female 8 (40%)
  Male 12 (60%)
Age (years)
  Median (IQR) 51 (39–60)
Tumor site
  Lower extremity, proximal 13 (65%)
  Lower extremity, distal 3 (15%)
  Trunk 4 (20%)
Recurrence 1 (5%)
Chemotherapy
  Neoadjuvant 1 (5%)
  Adjuvant 1 (5%)
RT modality
  3D conformal 11 (55%)
  IMRT 8 (40%)
  IMPT 1 (5%)
RT dose
  36 Gy 3 (15%)
  50 Gy 16 (80%)
  56.25 Gy 1 (5%)
IORT 1 (5%)
Brachytherapy 1 (5%)
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medycyna, Medycyna kliniczna, Medycyna wewnętrzna, Hematologia, onkologia, Radiologia