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Whole-body PET/MRI to detect bone metastases: comparison of the diagnostic performance of the sequences

Onur Levent Ulusoy

Onur Levent Ulusoy

  • Demiroglu Bilim Universityİstanbul, Turkey
  • Derpartment of Radiology, Florence Nigtingale Hospitalsİstanbul, Turkey
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Ulusoy, Onur Levent
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Sadık Server

Sadık Server

  • Demiroglu Bilim Universityİstanbul, Turkey
  • Derpartment of Radiology, Florence Nigtingale Hospitalsİstanbul, Turkey
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Server, Sadık
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Murat Yesilova

Murat Yesilova

Demiroglu Bilim Universityİstanbul, Turkey
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Yesilova, Murat
 oraz 
Nagihan İnan

Nagihan İnan

  • Demiroglu Bilim Universityİstanbul, Turkey
  • Derpartment of Radiology, Florence Nigtingale Hospitalsİstanbul, Turkey
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İnan, Nagihan
  
28 lis 2024
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Kategoria artykułu: Research Article
Data publikacji: 28 lis 2024
Zakres stron: 494 - 500
Otrzymano: 02 cze 2024
Przyjęty: 24 paź 2024
DOI: https://doi.org/10.2478/raon-2024-0062
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© 2024 Onur Levent Ulusoy et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

FIGURE 1.

A 53-year-old woman with breast cancer. A metastasis can be observed in the L2 vertebral body (arrows) on the precontrast T1 weighted (W) image (A), contrast enhanced (CE) T1W image (B), and CE T1W VIBE-PET fused image (C). The AC PET axial image (D) does not show FDG uptake. CT yielded false-negative results (E).AC PET = attenuation-corrected raw data positron-emission tomography; FDG = fluorodeoxyglucose; VIBE = volume-interpolated breath-hold examination
A 53-year-old woman with breast cancer. A metastasis can be observed in the L2 vertebral body (arrows) on the precontrast T1 weighted (W) image (A), contrast enhanced (CE) T1W image (B), and CE T1W VIBE-PET fused image (C). The AC PET axial image (D) does not show FDG uptake. CT yielded false-negative results (E).AC PET = attenuation-corrected raw data positron-emission tomography; FDG = fluorodeoxyglucose; VIBE = volume-interpolated breath-hold examination

Diagnostic performance of sequences

Sequences Sensitivity (%) Specificity (%) 95%CI AUC P PPV (%) NPV (%)
Precontrast T1W 78 50 63.2–78.3 0.587 ± 0.064 0.191 75 54
CE T1W VIBE 82 58 67.3–88.9 0.751 ± 0.065 0.024 79 63
AC PET 80 54 67.9–79.4 0.667 ± 0.065 0.013 78 58
T1W-PET 84 61.5 72.2–91.9 0.796 ± 0.063 0.003 81 67
CE T1W-PET 100 92 74.0–99.8 0.952 ± 0.067 0.001 96 100

Inter-observer variability for the detection of bone metastases on all sequences

Sequences kappa 95 %CI
Precontrast T1W 0.86 0.69–0.92
CE T1W VIBE 0.87 0.77–0.94
AC PET 0.83 0.76–0.90
T1W-PET 0.86 0.78–0.91
CE T1W-PET 0.88 0.82–0.94

Tumor histopathologic features

Primary malignant tumors n
Hepatobiliary 12
Gastrointestinal 7
Genitourinary 8
Breast 23
Lung 26
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medycyna, Medycyna kliniczna, Medycyna wewnętrzna, Hematologia, onkologia, Radiologia
Kanał RSS czasopisma