Laser speckle contrast imaging of perfusion in oncological clinical applications: a literature review

1. Li H, Xie X, Du F, Zhu X, Ren H, Ye C, et al. A narrative review of intraoperative use of indocyanine green fluorescence imaging in gastrointestinal cancer: situation and future directions. J Gastrointest Oncol 2023; 14: 1095–113. doi: 10.21037/jgo-23-230 LiH XieX DuF ZhuX RenH YeC A narrative review of intraoperative use of indocyanine green fluorescence imaging in gastrointestinal cancer: situation and future directions J Gastrointest Oncol 2023 14 1095 113 10.21037/jgo-23-230 Open DOISearch in Google Scholar

2. Uppal JS, Meng E, Caycedo-Marulanda A. Current applications of indocyanine green fluorescence in colorectal surgery: a narrative review. Ann Laparosc Endosc Surg 2023; 8: 18–18. doi: 10.21037/ales-22-84 UppalJS MengE Caycedo-MarulandaA Current applications of indocyanine green fluorescence in colorectal surgery: a narrative review Ann Laparosc Endosc Surg 2023 8 18 18 10.21037/ales-22-84 Open DOISearch in Google Scholar

3. Iwamoto M, Ueda K, Kawamura J. A narrative review of the usefulness of indocyanine green fluorescence angiography for perfusion assessment in colorectal surgery. Cancers 2022; 14: 5623. doi: 10.3390/cancers14225623 IwamotoM UedaK KawamuraJ A narrative review of the usefulness of indocyanine green fluorescence angiography for perfusion assessment in colorectal surgery Cancers 2022 14 5623 10.3390/cancers14225623 Open DOISearch in Google Scholar

4. Briers D, Duncan DD, Hirst E, Kirkpatric SJ, Larsson M, Steenberg W, et al. Laser speckle contrast imaging: theoretical and practical limitations. J Biomed Opt 2013; 18: 066018. doi: 10.1117/1.JBO.18.6.066018 BriersD DuncanDD HirstE KirkpatricSJ LarssonM SteenbergW Laser speckle contrast imaging: theoretical and practical limitations J Biomed Opt 2013 18 066018 10.1117/1.JBO.18.6.066018 Open DOISearch in Google Scholar

5. Briers JD, Richards G, He XW. Capillary blood flow monitoring using laser speckle contrast analysis (LASCA). J Biomed Opt 1999; 4: 164. doi: 10.1117/1.429903 BriersJD RichardsG HeXW Capillary blood flow monitoring using laser speckle contrast analysis (LASCA) J Biomed Opt 1999 4 164 10.1117/1.429903 Open DOISearch in Google Scholar

6. Draijer M, Hondebrink E, Van Leeuwen T, Steenbergen W. Review of laser speckle contrast techniques for visualizing tissue perfusion. Lasers Med Sci 2009; 24: 639–51. doi: 10.1007/s10103-008-0626-3 DraijerM HondebrinkE Van LeeuwenT SteenbergenW Review of laser speckle contrast techniques for visualizing tissue perfusion Lasers Med Sci 2009 24 639 51 10.1007/s10103-008-0626-3 Open DOISearch in Google Scholar

7. Hamed AM, El-Ghandoor H, El-Diasty F, Saudy M. Analysis of speckle images to assess surface roughness. Optics & Laser Technology 2004; 36: 249–53. doi: 10.1016/j.optlastec.2003.09.005 HamedAM El-GhandoorH El-DiastyF SaudyM Analysis of speckle images to assess surface roughness Optics & Laser Technology 2004 36 249 53 10.1016/j.optlastec.2003.09.005 Open DOISearch in Google Scholar

8. Heeman W, Steenbergen W, Van Dam GM, Boerma EC. Clinical applications of laser speckle contrast imaging: a review. J Biomed Opt 2019; 24: 1. doi: 10.1117/1.JBO.24.8.080901 HeemanW SteenbergenW Van DamGM BoermaEC Clinical applications of laser speckle contrast imaging: a review J Biomed Opt 2019 24 1 10.1117/1.JBO.24.8.080901 Open DOISearch in Google Scholar

9. Cheng H, Yan Y, Duong TQ. Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging. Opt Express 2008; 16: 10214. doi: 10.1364/OE.16.010214 ChengH YanY DuongTQ Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging Opt Express 2008 16 10214 10.1364/OE.16.010214 Open DOISearch in Google Scholar

10. Hellmann M, Roustit M, Cracowski JL. Skin microvascular endothelial function as a biomarker in cardiovascular diseases? Pharmacol Rep 2015; 67: 803–10. doi: 10.1016/j.pharep.2015.05.008 HellmannM RoustitM CracowskiJL Skin microvascular endothelial function as a biomarker in cardiovascular diseases? Pharmacol Rep 2015 67 803 10 10.1016/j.pharep.2015.05.008 Open DOISearch in Google Scholar

11. Margouta A, Anyfanti P, Lazaridis A, Nikolaidou B, Mastrogiannis K, Malliora A, et al. Blunted microvascular reactivity in psoriasis patients in the absence of cardiovascular disease, as assessed by laser speckle contrast imaging. Life 2022; 12: 1796. doi: 10.3390/life12111796 MargoutaA AnyfantiP LazaridisA NikolaidouB MastrogiannisK MallioraA Blunted microvascular reactivity in psoriasis patients in the absence of cardiovascular disease, as assessed by laser speckle contrast imaging Life 2022 12 1796 10.3390/life12111796 Open DOISearch in Google Scholar

12. Gopal JP, Vaz O, Varley R, Spiers H, Goldsworthy MA, Siddagangaiah V, et al. Using laser speckle contrast imaging to quantify perfusion quality in kidney and pancreas grafts on vascular reperfusion: a proof-of-principle study. Transplant Direct 2023; 9: e1472. doi: 10.1097/TXD.0000000000001472 GopalJP VazO VarleyR SpiersH GoldsworthyMA SiddagangaiahV Using laser speckle contrast imaging to quantify perfusion quality in kidney and pancreas grafts on vascular reperfusion: a proof-of-principle study Transplant Direct 2023 9 e1472 10.1097/TXD.0000000000001472 Open DOISearch in Google Scholar

13. Mirdell R, Farnebo S, Sjöberg F, Tesselaar E. Accuracy of laser speckle contrast imaging in the assessment of pediatric scald wounds. Burns 2018; 44: 90–8. doi: 10.1016/j.burns.2017.06.010 MirdellR FarneboS SjöbergF TesselaarE Accuracy of laser speckle contrast imaging in the assessment of pediatric scald wounds Burns 2018 44 90 8 10.1016/j.burns.2017.06.010 Open DOISearch in Google Scholar

14. Mirdell R, Farnebo S, Sjöberg F, Tesselaar E. Interobserver reliability of laser speckle contrast imaging in the assessment of burns. Burns 2019; 45: 1325–35. doi: 10.1016/j.burns.2019.01.011 MirdellR FarneboS SjöbergF TesselaarE Interobserver reliability of laser speckle contrast imaging in the assessment of burns Burns 2019 45 1325 35 10.1016/j.burns.2019.01.011 Open DOISearch in Google Scholar

15. Mirdell R, Farnebo S, Sjöberg F, Tesselaar E. Using blood flow pulsatility to improve the accuracy of laser speckle contrast imaging in the assessment of burns. Burns 2020; 46: 1398–406. doi: 10.1016/j.burns.2020.03.008 MirdellR FarneboS SjöbergF TesselaarE Using blood flow pulsatility to improve the accuracy of laser speckle contrast imaging in the assessment of burns Burns 2020 46 1398 406 10.1016/j.burns.2020.03.008 Open DOISearch in Google Scholar

16. Rege A, Thakor NV, Rhie K, Pathak AP. In vivo laser speckle imaging reveals microvascular remodeling and hemodynamic changes during wound healing angiogenesis. Angiogenesis 2012; 15: 87–98. doi: 10.1007/s10456-011-9245-x RegeA ThakorNV RhieK PathakAP In vivo laser speckle imaging reveals microvascular remodeling and hemodynamic changes during wound healing angiogenesis Angiogenesis 2012 15 87 98 10.1007/s10456-011-9245-x Open DOISearch in Google Scholar

17. Zheng KJ, Middelkoop E, Stoop M, Van Zuijlen PPM, Pijpe A. Validity of laser speckle contrast imaging for the prediction of burn wound healing potential. Burns 2022; 48: 319–27. doi: 10.1016/j.burns.2021.04.028 ZhengKJ MiddelkoopE StoopM Van ZuijlenPPM PijpeA Validity of laser speckle contrast imaging for the prediction of burn wound healing potential Burns 2022 48 319 27 10.1016/j.burns.2021.04.028 Open DOISearch in Google Scholar

18. Mirdell R, Iredahl F, Sjöberg F, Farnebo S, Tesselaar E. Microvascular blood flow in scalds in children and its relation to duration of wound healing: a study using laser speckle contrast imaging. Burns 2016; 42: 648–54. doi: 10.1016/j.burns.2015.12.005 MirdellR IredahlF SjöbergF FarneboS TesselaarE Microvascular blood flow in scalds in children and its relation to duration of wound healing: a study using laser speckle contrast imaging Burns 2016 42 648 54 10.1016/j.burns.2015.12.005 Open DOISearch in Google Scholar

19. Berggren JV, Stridh M, Malmsjö M. Perfusion monitoring during oculoplastic reconstructive surgery: a comprehensive review. Ophthalmic Plast Reconstr Surg 2022; 38: 522–34. doi: 10.1097/IOP.0000000000002114 BerggrenJV StridhM MalmsjöM Perfusion monitoring during oculoplastic reconstructive surgery: a comprehensive review Ophthalmic Plast Reconstr Surg 2022 38 522 34 10.1097/IOP.0000000000002114 Open DOISearch in Google Scholar

20. Hecht N, Woitzik J, König S, Horn P, Vajkoczy P. Laser speckle imaging allows real-time intraoperative blood flow assessment during neurosurgical procedures. J Cereb Blood Flow Metab 2013; 33: 1000–7. doi: 10.1038/jcbfm.2013.42 HechtN WoitzikJ KönigS HornP VajkoczyP Laser speckle imaging allows real-time intraoperative blood flow assessment during neurosurgical procedures J Cereb Blood Flow Metab 2013 33 1000 7 10.1038/jcbfm.2013.42 Open DOISearch in Google Scholar

21. Parthasarathy AB, Weber EL, Richards LM, Fox DJ, Dunn AK. Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery: a pilot clinical study. J Biomed Opt 2010; 15: 066030. doi: 10.1117/1.3526368 ParthasarathyAB WeberEL RichardsLM FoxDJ DunnAK Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery: a pilot clinical study J Biomed Opt 2010 15 066030 10.1117/1.3526368 Open DOISearch in Google Scholar

22. Richards LM, Towle EL, Fox DJ, Dunn AK. Intraoperative laser speckle contrast imaging with retrospective motion correction for quantitative assessment of cerebral blood flow. Neurophoton 2014; 1: 1. doi: 10.1117/1.NPh.1.1.015006 RichardsLM TowleEL FoxDJ DunnAK Intraoperative laser speckle contrast imaging with retrospective motion correction for quantitative assessment of cerebral blood flow Neurophoton 2014 1 1 10.1117/1.NPh.1.1.015006 Open DOISearch in Google Scholar

23. Woitzik J, Hecht N, Pinczolits A, Sandow N, Major S, Winkler MKL, et al. Propagation of cortical spreading depolarization in the human cortex after malignant stroke. Neurology 2013; 80: 1095–102. doi: 10.1212/WNL.0b013e3182886932 WoitzikJ HechtN PinczolitsA SandowN MajorS WinklerMKL Propagation of cortical spreading depolarization in the human cortex after malignant stroke Neurology 2013 80 1095 102 10.1212/WNL.0b013e3182886932 Open DOISearch in Google Scholar

24. Hecht N, Müller MM, Sandow N, Pinczolits A, Vajkoczy P, Woitzik J. Infarct prediction by intraoperative laser speckle imaging in patients with malignant hemispheric stroke. J Cereb Blood Flow Metab 2016; 36: 1022–32. doi: 10.1177/0271678X15612487 HechtN MüllerMM SandowN PinczolitsA VajkoczyP WoitzikJ Infarct prediction by intraoperative laser speckle imaging in patients with malignant hemispheric stroke J Cereb Blood Flow Metab 2016 36 1022 32 10.1177/0271678X15612487 Open DOISearch in Google Scholar

25. Klijn E, Hulscher HC, Balvers RK, Holland WPJ, Bakker J, Vincent ALPE, et al. Laser speckle imaging identification of increases in cortical microcirculatory blood flow induced by motor activity during awake craniotomy: clinical article. J Neurosurg 2013; 118: 280–86. doi: 10.3171/2012.10.JNS1219 KlijnE HulscherHC BalversRK HollandWPJ BakkerJ VincentALPE Laser speckle imaging identification of increases in cortical microcirculatory blood flow induced by motor activity during awake craniotomy: clinical article J Neurosurg 2013 118 280 86 10.3171/2012.10.JNS1219 Open DOISearch in Google Scholar

26. Konovalov A, Gadzhiagaev V, Grebenev F, Stavtsev D, Piavchenko G, Gerasimenko A, et al. Laser speckle contrast imaging in neurosurgery: a systematic review. World Neurosurg 2023; 171: 35–40. doi: 10.1016/j.wneu.2022.12.048 KonovalovA GadzhiagaevV GrebenevF StavtsevD PiavchenkoG GerasimenkoA Laser speckle contrast imaging in neurosurgery: a systematic review World Neurosurg 2023 171 35 40 10.1016/j.wneu.2022.12.048 Open DOISearch in Google Scholar

27. Richards LM, Kazmi SS, Olin KE, Waldron JS, Fox DJ, Dunn AK. Intraoperative multi-exposure speckle imaging of cerebral blood flow. J Cereb Blood Flow Metab 2017; 37: 3097–109. doi: 10.1177/0271678X16686987 RichardsLM KazmiSS OlinKE WaldronJS FoxDJ DunnAK Intraoperative multi-exposure speckle imaging of cerebral blood flow J Cereb Blood Flow Metab 2017 37 3097 109 10.1177/0271678X16686987 Open DOISearch in Google Scholar

28. Ideguchi M, Kajiwara K, Yoshikawa K, Goto H, Sugimoto K, Inoue T, et al. Avoidance of ischemic complications after resection of a brain lesion based on intraoperative real-time recognition of the vasculature using laser speckle flow imaging. J Neurosurg 2017; 126: 274–80. doi: 10.3171/2016.1.JNS152067 IdeguchiM KajiwaraK YoshikawaK GotoH SugimotoK InoueT Avoidance of ischemic complications after resection of a brain lesion based on intraoperative real-time recognition of the vasculature using laser speckle flow imaging J Neurosurg 2017 126 274 80 10.3171/2016.1.JNS152067 Open DOISearch in Google Scholar

29. Tesselaar E, Flejmer AM, Farnebo S, Dasu A. Changes in skin microcirculation during radiation therapy for breast cancer. Acta Oncol 2017; 56: 1072–80. doi: 10.1080/0284186X.2017.1299220 TesselaarE FlejmerAM FarneboS DasuA Changes in skin microcirculation during radiation therapy for breast cancer Acta Oncol 2017 56 1072 80 10.1080/0284186X.2017.1299220 Open DOISearch in Google Scholar

30. Zötterman J, Opsomer D, Farnebo S, Blondeel P, Monstrey S, Tesselaar E. Intraoperative laser speckle contrast imaging in DIEP breast reconstruction: a prospective case series study. Plast Reconstr Surg Glob Open 2020; 8: e2529. doi: 10.1097/GOX.0000000000002529 ZöttermanJ OpsomerD FarneboS BlondeelP MonstreyS TesselaarE Intraoperative laser speckle contrast imaging in DIEP breast reconstruction: a prospective case series study Plast Reconstr Surg Glob Open 2020 8 e2529 10.1097/GOX.0000000000002529 Open DOISearch in Google Scholar

31. De Paula MP, Moraes AB, De Souza MDGC, Cavalari EMR, Campbell RC, da Silva Fernandes G, et al. Cortisol level after dexamethasone suppression test in patients with non-functioning adrenal incidentaloma is positively associated with the duration of reactive hyperemia response on microvascular bed. J Endocrinol Invest 2021; 44: 609–19. doi: 10.1007/s40618-020-01360-z De PaulaMP MoraesAB De SouzaMDGC CavalariEMR CampbellRC da Silva FernandesG Cortisol level after dexamethasone suppression test in patients with non-functioning adrenal incidentaloma is positively associated with the duration of reactive hyperemia response on microvascular bed J Endocrinol Invest 2021 44 609 19 10.1007/s40618-020-01360-z Open DOISearch in Google Scholar

32. Mannoh EA, Thomas G, Solórzano CC, Mahadevan-Jansen A. Intraoperative assessment of parathyroid viability using laser speckle contrast imaging. Sci Rep 2017; 7: 14798. doi: 10.1038/s41598-017-14941-5 MannohEA ThomasG SolórzanoCC Mahadevan-JansenA Intraoperative assessment of parathyroid viability using laser speckle contrast imaging Sci Rep 2017 7 14798 10.1038/s41598-017-14941-5 Open DOISearch in Google Scholar

33. Mannoh EA, Thomas G, Baregamian N, Rohde SL, Solórzano CC, Mahadevan-Jansen A. Assessing intraoperative laser speckle contrast imaging of parathyroid glands in relation to total thyroidectomy patient outcomes. Thyroid 2021: 31: 1558–65. doi: 10.1089/thy.2021.0093 MannohEA ThomasG BaregamianN RohdeSL SolórzanoCC Mahadevan-JansenA Assessing intraoperative laser speckle contrast imaging of parathyroid glands in relation to total thyroidectomy patient outcomes Thyroid 2021 31 1558 65 10.1089/thy.2021.0093 Open DOISearch in Google Scholar

34. Mannoh EA, Baregamian N, Thomas G, Solórzano CC, Mahadevan-Jansen A. Comparing laser speckle contrast imaging and indocyanine green angiography for assessment of parathyroid perfusion. Sci Rep 2023; 13: 17270. doi: 10.1038/s41598-023-42649-2 MannohEA BaregamianN ThomasG SolórzanoCC Mahadevan-JansenA Comparing laser speckle contrast imaging and indocyanine green angiography for assessment of parathyroid perfusion Sci Rep 2023 13 17270 10.1038/s41598-023-42649-2 Open DOISearch in Google Scholar

35. Tchvialeva L, Dhadwal G, Lui H, Kalia S, Zeng H, McLean DI, et al. Polarization speckle imaging as a potential technique for in vivo skin cancer detection. J Biomed Opt 2012; 18: 061211. doi: 10.1117/1.JBO.18.6.061211 TchvialevaL DhadwalG LuiH KaliaS ZengH McLeanDI Polarization speckle imaging as a potential technique for in vivo skin cancer detection J Biomed Opt 2012 18 061211 10.1117/1.JBO.18.6.061211 Open DOISearch in Google Scholar

36. Reyal J, Lebas N, Fourme E, Guihard T, Vilmer C, Masurier PL. Post-occlusive reactive hyperemia in basal cell carcinoma and its potential application to improve the efficacy of solid tumor therapies. Tohoku J Exp Med 2012; 227: 139–47. doi: 10.1620/tjem.227.139 ReyalJ LebasN FourmeE GuihardT VilmerC MasurierPL Post-occlusive reactive hyperemia in basal cell carcinoma and its potential application to improve the efficacy of solid tumor therapies Tohoku J Exp Med 2012 227 139 47 10.1620/tjem.227.139 Open DOISearch in Google Scholar

37. Zhang Y, Zhao L, Li J, Wang J, Yu H. Microcirculation evaluation of facial nerve palsy using laser speckle contrast imaging: a prospective study. Eur Arch Otorhinolaryngol 2019; 276: 685–92. doi: 10.1007/s00405-019-05281-3 ZhangY ZhaoL LiJ WangJ YuH Microcirculation evaluation of facial nerve palsy using laser speckle contrast imaging: a prospective study Eur Arch Otorhinolaryngol 2019 276 685 92 10.1007/s00405-019-05281-3 Open DOISearch in Google Scholar

38. Zieger M, Kaatz M, Springer S, Riesenberg R, Wuttig A, Kanka M, et al. Multi-wavelength, handheld laser speckle imaging for skin evaluation. Skin Res Technol 2021; 27: 486–93. doi: 10.1111/srt.12959 ZiegerM KaatzM SpringerS RiesenbergR WuttigA KankaM Multi-wavelength, handheld laser speckle imaging for skin evaluation Skin Res Technol 2021 27 486 93 10.1111/srt.12959 Open DOISearch in Google Scholar

39. Tenland K, Memarzadeh K, Berggren J, Nguyen CD, Dahlstrand U, Hult J, et al. Perfusion monitoring shows minimal blood flow from the flap pedicle to the tarsoconjunctival flap. Ophthalmic Plast Reconstr Surg 2019; 35: 346–9. doi: 10.1097/IOP.0000000000001250 TenlandK MemarzadehK BerggrenJ NguyenCD DahlstrandU HultJ Perfusion monitoring shows minimal blood flow from the flap pedicle to the tarsoconjunctival flap Ophthalmic Plast Reconstr Surg 2019 35 346 9 10.1097/IOP.0000000000001250 Open DOISearch in Google Scholar

40. Berggren J, Tenland K, Ansson CD, Dahlstrand U, Sheikh R, Hult J, et al. Revascularization of free skin grafts overlying modified hughes tarsoconjunctival flaps monitored using laser-based techniques. Ophthalmic Plast Reconstr Surg 2019; 35: 378–82. doi: 10.1097/IOP.0000000000001286 BerggrenJ TenlandK AnssonCD DahlstrandU SheikhR HultJ Revascularization of free skin grafts overlying modified hughes tarsoconjunctival flaps monitored using laser-based techniques Ophthalmic Plast Reconstr Surg 2019 35 378 82 10.1097/IOP.0000000000001286 Open DOISearch in Google Scholar

41. Tenland K, Berggren J, Engelsberg K, Bohman E, Dahlstrand U, Castelo N, et al. Successful free bilamellar eyelid grafts for the repair of upper and lower eyelid defects in patients and laser speckle contrast imaging of revascularization. Ophthalmic Plast Reconstr Surg 2021; 37: 168–72. doi: 10.1097/IOP.0000000000001724 TenlandK BerggrenJ EngelsbergK BohmanE DahlstrandU CasteloN Successful free bilamellar eyelid grafts for the repair of upper and lower eyelid defects in patients and laser speckle contrast imaging of revascularization Ophthalmic Plast Reconstr Surg 2021 37 168 72 10.1097/IOP.0000000000001724 Open DOISearch in Google Scholar

42. Berggren J, Castelo N, Tenland K, Engelsberg K, Dahlstand U, Albinsson J, et al. Revascularization after H-plasty reconstructive surgery in the periorbital region monitored with laser speckle contrast imaging. Ophthalmic Plast Reconstr Surg 2021; 37: 269–73. doi: 10.1097/IOP.0000000000001799 BerggrenJ CasteloN TenlandK EngelsbergK DahlstandU AlbinssonJ Revascularization after H-plasty reconstructive surgery in the periorbital region monitored with laser speckle contrast imaging Ophthalmic Plast Reconstr Surg 2021 37 269 73 10.1097/IOP.0000000000001799 Open DOISearch in Google Scholar

43. Berggren J, Castelo N, Tenland K, Dahlstrand, Engelsberg K, Lindstedt S, et al. Reperfusion of free full-thickness skin grafts in periocular reconstructive surgery monitored using laser speckle contrast imaging. Ophthalmic Plast Reconstr Surg 2021; 37: 324–8. doi: 10.1097/IOP.0000000000001851 BerggrenJ CasteloN TenlandK Dahlstrand EngelsbergK LindstedtS Reperfusion of free full-thickness skin grafts in periocular reconstructive surgery monitored using laser speckle contrast imaging Ophthalmic Plast Reconstr Surg 2021 37 324 8 10.1097/IOP.0000000000001851 Open DOISearch in Google Scholar

44. Berggren JV, Sheikh R, Hult J, Engelsberg K, Malmsjö M. Laser speckle contrast imaging of a rotational full-thickness lower eyelid flap shows satisfactory blood perfusion. Ophthalmic Plast Reconstr Surg 2021; 37: e139–e141. doi: 10.1097/IOP.0000000000001921 BerggrenJV SheikhR HultJ EngelsbergK MalmsjöM Laser speckle contrast imaging of a rotational full-thickness lower eyelid flap shows satisfactory blood perfusion Ophthalmic Plast Reconstr Surg 2021 37 e139 e141 10.1097/IOP.0000000000001921 Open DOISearch in Google Scholar

45. Berggren JV, Tenland K, Sheikh R, Hult J, Engelsberg K, Lindstedt S, et al. Laser speckle contrast imaging of the blood perfusion in glabellar flaps used to repair medial canthal defects. Ophthalmic Plast Reconstr Surg 2022; 38: 274–9. doi: 10.1097/IOP.0000000000002082 BerggrenJV TenlandK SheikhR HultJ EngelsbergK LindstedtS Laser speckle contrast imaging of the blood perfusion in glabellar flaps used to repair medial canthal defects Ophthalmic Plast Reconstr Surg 2022 38 274 9 10.1097/IOP.0000000000002082 Open DOISearch in Google Scholar

46. Stridh M, Dahlstrand U, Naumovska M, Engelsberg K, Gesslein B, Sheikh R, et al. Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging. Orbit 2024; 9: 1–11. doi: 10.1080/01676830.2024.2331718 StridhM DahlstrandU NaumovskaM EngelsbergK GessleinB SheikhR Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging Orbit 2024 9 1 11 10.1080/01676830.2024.2331718 Open DOISearch in Google Scholar

47. Eriksson S, Jan N, Gert L, Sturesson C. Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study. Med Devices 2014; 25: 257–61. doi: 10.2147/MDER.S63393 ErikssonS JanN GertL SturessonC Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study Med Devices 2014 25 257 61 10.2147/MDER.S63393 Open DOISearch in Google Scholar

48. Milstein DMJ, Ince C, Gisbertz SS, Boateng KB, Geerts BF, Hollmann MW, et al. Laser speckle contrast imaging identifies ischemic areas on gastric tube reconstructions following esophagectomy. Medicine 2016; 95: e3875. doi: 10.1097/MD.0000000000003875 MilsteinDMJ InceC GisbertzSS BoatengKB GeertsBF HollmannMW Laser speckle contrast imaging identifies ischemic areas on gastric tube reconstructions following esophagectomy Medicine 2016 95 e3875 10.1097/MD.0000000000003875 Open DOISearch in Google Scholar

49. Ambrus R, Achiam MP, Secher NH, Svendsen MB, Runitz K, Siemsen M, et al. Evaluation of gastric microcirculation by laser speckle contrast imaging during esophagectomy. J Am Col Surg 2017; 225: 395–402. doi: 10.1016/j.jamcollsurg.2017.06.003 AmbrusR AchiamMP SecherNH SvendsenMB RunitzK SiemsenM Evaluation of gastric microcirculation by laser speckle contrast imaging during esophagectomy J Am Col Surg 2017 225 395 402 10.1016/j.jamcollsurg.2017.06.003 Open DOISearch in Google Scholar

50. Ambrus R, Svendsen LB, Secher NH, Runitz K, Frediriksen HJ, Svendsen MBS, et al. A reduced gastric corpus microvascular blood flow during Ivor-Lewis esophagectomy detected by laser speckle contrast imaging technique. Scand J Gastroenterol 2017; 52: 455–61. doi: 10.1080/00365521.2016.1265664 AmbrusR SvendsenLB SecherNH RunitzK FrediriksenHJ SvendsenMBS A reduced gastric corpus microvascular blood flow during Ivor-Lewis esophagectomy detected by laser speckle contrast imaging technique Scand J Gastroenterol 2017 52 455 61 10.1080/00365521.2016.1265664 Open DOISearch in Google Scholar

51. Di Maria C, Hainsworth PJ, Allen J. Intraoperative thermal and laser speckle contrast imaging assessment of bowel perfusion in two cases of colorectal resection surgery. In: Ng EY, Etehadtavakol M, editors. Application of infrared to biomedical sciences. Series in BioEngineering. Singapore: Springer; 2017. p. 437–49. doi: 10.1007/978-981-10-3147-2_25 Di MariaC HainsworthPJ AllenJ Intraoperative thermal and laser speckle contrast imaging assessment of bowel perfusion in two cases of colorectal resection surgery In: NgEY EtehadtavakolM editors. Application of infrared to biomedical sciences Series in BioEngineering. Singapore Springer 2017 437 49 10.1007/978-981-10-3147-2_25 Open DOISearch in Google Scholar

52. Jansen SM, De Bruin DM, Van Berge Henegouwen MI, Bloemen PR, Strackee SD, Veelo DP, et al. Effect of ephedrine on gastric conduit perfusion measured by laser speckle contrast imaging after esophagectomy: a prospective in vivo cohort study. Dis Esophagus 2018; 1: 31. doi: 10.1093/dote/doy031 JansenSM De BruinDM Van Berge HenegouwenMI BloemenPR StrackeeSD VeeloDP Effect of ephedrine on gastric conduit perfusion measured by laser speckle contrast imaging after esophagectomy: a prospective in vivo cohort study Dis Esophagus 2018 1 31 10.1093/dote/doy031 Open DOISearch in Google Scholar

53. Kojima S, Sakamoto T, Nagai Y, Matsui Y, Nambu K, Masamune K. Laser speckle contrast imaging for intraoperative quantitative assessment of intestinal blood perfusion during colorectal surgery: a prospective pilot study. Surg Innov 2019; 26: 293–301. doi: 10.1177/1553350618823426 KojimaS SakamotoT NagaiY MatsuiY NambuK MasamuneK Laser speckle contrast imaging for intraoperative quantitative assessment of intestinal blood perfusion during colorectal surgery: a prospective pilot study Surg Innov 2019 26 293 301 10.1177/1553350618823426 Open DOISearch in Google Scholar

54. Kaneko T, Funahashi K, Ushigome M, Kagami S, Yoshida K, Koda T, et al. Noninvasive assessment of bowel blood perfusion using intraoperative laser speckle flowgraphy. Langenbecks Arch Surg 2020; 405: 817–26. doi: 10.1007/s00423-020-01933-9 KanekoT FunahashiK UshigomeM KagamiS YoshidaK KodaT Noninvasive assessment of bowel blood perfusion using intraoperative laser speckle flowgraphy Langenbecks Arch Surg 2020 405 817 26 10.1007/s00423-020-01933-9 Open DOISearch in Google Scholar

55. Heeman W, Dijkstra K, Hoff C, Koopal S, Pierie JP, Bouma H, et al. Application of laser speckle contrast imaging in laparoscopic surgery. Biomed Opt Express 2019; 10: 2010–9. doi: 10.1364/BOE.10.002010 HeemanW DijkstraK HoffC KoopalS PierieJP BoumaH Application of laser speckle contrast imaging in laparoscopic surgery Biomed Opt Express 2019 10 2010 9 10.1364/BOE.10.002010 Open DOISearch in Google Scholar

56. Kojima S, Sakamoto T, Matsui Y, Nambu K, Masamune K. Clinical efficacy of bowel perfusion assessment during laparoscopic colorectal resection using laser speckle contrast imaging: a matched case-control study. Asian J Endoscop Surgery 2020; 13: 329–35. doi: 10.1111/ases.12759 KojimaS SakamotoT MatsuiY NambuK MasamuneK Clinical efficacy of bowel perfusion assessment during laparoscopic colorectal resection using laser speckle contrast imaging: a matched case-control study Asian J Endoscop Surgery 2020 13 329 35 10.1111/ases.12759 Open DOISearch in Google Scholar

57. Slooter MD, Jansen SMA, Bloemen PR, van den Elzen RM, Wilk LS, van Leeuwen TG, et al. Comparison of optical imaging techniques to quantitatively assess the perfusion of the gastric conduit during oesophagectomy. Applied Sciences 2020; 10: 5522. doi: 10.3390/app10165522 SlooterMD JansenSMA BloemenPR van den ElzenRM WilkLS van LeeuwenTG Comparison of optical imaging techniques to quantitatively assess the perfusion of the gastric conduit during oesophagectomy Applied Sciences 2020 10 5522 10.3390/app10165522 Open DOISearch in Google Scholar

58. Heeman W, Calon J, Van Der Bilt A, Pierie JPEN, Pereboom I, van Dam GM, et al. Dye-free visualisation of intestinal perfusion using laser speckle contrast imaging in laparoscopic surgery: a prospective, observational multi-centre study. Surg Endosc 2023; 37: 9139–46. doi: 10.1007/s00464-023-10493-0 HeemanW CalonJ Van Der BiltA PierieJPEN PereboomI van DamGM Dye-free visualisation of intestinal perfusion using laser speckle contrast imaging in laparoscopic surgery: a prospective, observational multi-centre study Surg Endosc 2023 37 9139 46 10.1007/s00464-023-10493-0 Open DOISearch in Google Scholar

59. Nwaiwu CA, McCulloh CJ, Skinner G, Shah SK, Kim PC, Schwaitzberg SD, et al. Real-time first-in-human comparison of laser speckle contrast imaging and ICG in minimally invasive colorectal & bariatric surgery. J Gastrointest Surgery 2023; 27: 3083–5. doi: 10.1007/s11605-023-05855-x NwaiwuCA McCullohCJ SkinnerG ShahSK KimPC SchwaitzbergSD Real-time first-in-human comparison of laser speckle contrast imaging and ICG in minimally invasive colorectal & bariatric surgery J Gastrointest Surgery 2023 27 3083 5 10.1007/s11605-023-05855-x Open DOISearch in Google Scholar

60. Yataco AR, Corretti MC, Gardner AW, Womack CJ, Katzel LI. Endothelial reactivity and cardiac risk factors in older patients with peripheral arterial disease. Am J Cardiol 1999; 83: 754–8. doi: 10.1016/S0002-9149(98)00984-9 YatacoAR CorrettiMC GardnerAW WomackCJ KatzelLI Endothelial reactivity and cardiac risk factors in older patients with peripheral arterial disease Am J Cardiol 1999 83 754 8 10.1016/S0002-9149(98)00984-9 Open DOISearch in Google Scholar

61. Souza EG, De Lorenzo A, Huguenin G, Oliveira GMM, Tibiriçá E. Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging. Coron Artery Dis 2014; 25: 23–28. doi: 10.1097/MCA.0000000000000055 SouzaEG De LorenzoA HugueninG OliveiraGMM TibiriçáE Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging Coron Artery Dis 2014 25 23 28 10.1097/MCA.0000000000000055 Open DOISearch in Google Scholar

62. Paras C, Keller M, White L, Phay J, Mahadevan-Jansen A. Near-infrared autofluorescence for the detection of parathyroid glands. J Biomed Opt 2011; 16: 067012. doi: 10.1117/1.3583571 ParasC KellerM WhiteL PhayJ Mahadevan-JansenA Near-infrared autofluorescence for the detection of parathyroid glands J Biomed Opt 2011 16 067012 10.1117/1.3583571 Open DOISearch in Google Scholar

63. Benmiloud F, Godiris-Petit G, Gras R, Gillot JC, Turrin N, Penarada G, et al. Association of autofluorescence-based detection of the parathyroid glands during total thyroidectomy with postoperative hypocalcemia risk: results of the PARAFLUO multicenter randomized clinical trial. JAMA Surg 2020; 155: 106. doi: 10.1001/jamasurg.2019.4613 BenmiloudF Godiris-PetitG GrasR GillotJC TurrinN PenaradaG Association of autofluorescence-based detection of the parathyroid glands during total thyroidectomy with postoperative hypocalcemia risk: results of the PARAFLUO multicenter randomized clinical trial JAMA Surg 2020 155 106 10.1001/jamasurg.2019.4613 Open DOISearch in Google Scholar

64. Dip F, Falco J, Verna S, Prunello M, Loccisano M, Quadri P, et al. Randomized controlled trial comparing white light with near-infrared autofluorescence for parathyroid gland identification during total thyroidectomy. J Am Coll Surg 2019; 228: 744–51. doi: 10.1016/j.jamcollsurg.2018.12.044 DipF FalcoJ VernaS PrunelloM LoccisanoM QuadriP Randomized controlled trial comparing white light with near-infrared autofluorescence for parathyroid gland identification during total thyroidectomy J Am Coll Surg 2019 228 744 51 10.1016/j.jamcollsurg.2018.12.044 Open DOISearch in Google Scholar

65. Stergar J, Hren R, Milanič M. Design and validation of a custom-made laboratory hyperspectral imaging system for biomedical applications using a broadband LED light source. Sensors 2022; 22: 6274. doi: 10.3390/s22166274 StergarJ HrenR MilaničM Design and validation of a custom-made laboratory hyperspectral imaging system for biomedical applications using a broadband LED light source Sensors 2022 22 6274 10.3390/s22166274 Open DOISearch in Google Scholar

66. Hren R, Sersa G, Simoncic U, Milanic M. Imaging perfusion changes in oncological clinical applications by hyperspectral imaging: a literature review. Radiol Oncol 2022; 56: 420–9. doi: 10.2478/raon-2022-0051 HrenR SersaG SimoncicU MilanicM Imaging perfusion changes in oncological clinical applications by hyperspectral imaging: a literature review Radiol Oncol 2022 56 420 9 10.2478/raon-2022-0051 Open DOISearch in Google Scholar

67. Hren R, Stergar J, Simončič U, Serša G, Milanič M. Assessing perfusion changes in clinical oncology applications using hyperspectral imaging. In: Jarm T, Šmerc R, Mahnič-Kalamiza S, editors. 9th European Medical and Biological Engineering Conference. Portorož, Slovenia; 2024 Jun 9–13. Vol 112. IFMBE Proceedings. Switzerland: Springer Nature; 2024. p. 122–9. doi: 10.1007/978-3-031-61625-9_14 HrenR StergarJ SimončičU SeršaG MilaničM Assessing perfusion changes in clinical oncology applications using hyperspectral imaging In: JarmT ŠmercR Mahnič-KalamizaS editors. 9th European Medical and Biological Engineering Conference Portorož, Slovenia 2024 Jun 9–13 Vol 112. IFMBE Proceedings. Switzerland: Springer Nature; 2024. 122 9 10.1007/978-3-031-61625-9_14 Open DOISearch in Google Scholar

68. Lin L, Wang LV. The emerging role of photoacoustic imaging in clinical oncology. Nat Rev Clin Oncol 2022; 19: 365–84. doi: 10.1038/s41571-022-00615-3 LinL WangLV The emerging role of photoacoustic imaging in clinical oncology Nat Rev Clin Oncol 2022 19 365 84 10.1038/s41571-022-00615-3 Open DOISearch in Google Scholar

69. Xia Q, Li D, Yu T, Zhu J, Zhu D. In vivo skin optical clearing for improving imaging and light-induced therapy: a review. J Biomed Opt 2023; 28: 060901. doi: 10.1117/1.JBO.28.6.060901 XiaQ LiD YuT ZhuJ ZhuD In vivo skin optical clearing for improving imaging and light-induced therapy: a review J Biomed Opt 2023 28 060901 10.1117/1.JBO.28.6.060901 Open DOISearch in Google Scholar

70. Heeman W, Maassen H, Dijkstra K, Calon J, van Goor H, Leuvenik H, et al. Real-time, multi-spectral motion artefact correction and compensation for laser speckle contrast imaging. Sci Rep 2022; 12: 21718. doi: 10.1038/s41598-022-26154-6 HeemanW MaassenH DijkstraK CalonJ van GoorH LeuvenikH Real-time, multi-spectral motion artefact correction and compensation for laser speckle contrast imaging Sci Rep 2022 12 21718 10.1038/s41598-022-26154-6 Open DOISearch in Google Scholar

71. Gnyawali SC, Blum K, Pal D, Ghatak S, Khanna S, Roy S, et al. Retooling laser speckle contrast analysis algorithm to enhance non-invasive high resolution laser speckle functional imaging of cutaneous microcirculation. Sci Rep 2017; 7: 41048. doi: 10.1038/srep41048 GnyawaliSC BlumK PalD GhatakS KhannaS RoyS Retooling laser speckle contrast analysis algorithm to enhance non-invasive high resolution laser speckle functional imaging of cutaneous microcirculation Sci Rep 2017 7 41048 10.1038/srep41048 Open DOISearch in Google Scholar

72. Han G, Li D, Wang J, Guo Q, Yuan J, Chen R, et al. Adaptive window space direction laser speckle contrast imaging to improve vascular visualization. Biomed Opt Express 2023; 14: 3086. doi: 10.1364/BOE.488054 HanG LiD WangJ GuoQ YuanJ ChenR Adaptive window space direction laser speckle contrast imaging to improve vascular visualization Biomed Opt Express 2023 14 3086 10.1364/BOE.488054 Open DOISearch in Google Scholar

73. Hren R, Sersa G, Simoncic U, Milanic M. Imaging microvascular changes in nonocular oncological clinical applications by optical coherence tomography angiography: a literature review. Radiol Oncol 2023; 57: 411–8. doi: 10.2478/raon-2023-0057 HrenR SersaG SimoncicU MilanicM Imaging microvascular changes in nonocular oncological clinical applications by optical coherence tomography angiography: a literature review Radiol Oncol 2023 57 411 8 10.2478/raon-2023-0057 Open DOISearch in Google Scholar

74. Stergar J, Hren R, Milanič M. Design and validation of a custom-made hyperspectral microscope imaging system for biomedical applications. Sensors 2023; 23: 2374. doi: 10.3390/s23052374 StergarJ HrenR MilaničM Design and validation of a custom-made hyperspectral microscope imaging system for biomedical applications Sensors 2023 23 2374 10.3390/s23052374 Open DOISearch in Google Scholar

75. Marin A, Hren R, Milanič M. Pulsed photothermal radiometric depth profiling of bruises by 532 nm and 1064 nm lasers. Sensors 2023; 23: 2196. doi: 10.3390/s23042196 MarinA HrenR MilaničM Pulsed photothermal radiometric depth profiling of bruises by 532 nm and 1064 nm lasers Sensors 2023 23 2196 10.3390/s23042196 Open DOISearch in Google Scholar

76. Rogelj L, Dolenec R, Tomšič MV, Laister E, Simončič U, Milanič M, et al. Anatomically accurate, high-resolution modeling of the human index finger using in vivo magnetic resonance imaging. Tomography 2022; 8: 2347–59. doi: 10.3390/tomography8050196 RogeljL DolenecR TomšičMV LaisterE SimončičU MilaničM Anatomically accurate, high-resolution modeling of the human index finger using in vivo magnetic resonance imaging Tomography 2022 8 2347 59 10.3390/tomography8050196 Open DOISearch in Google Scholar

77. Milanic M, Hren R, Stergar J, Simoncic U. Monitoring of caffeine consumption effect on skin blood properties by diffuse reflectance spectroscopy. Physiol Res 2024; 73: 47–56. doi: 10.33549/physiolres.935138 MilanicM HrenR StergarJ SimoncicU Monitoring of caffeine consumption effect on skin blood properties by diffuse reflectance spectroscopy Physiol Res 2024 73 47 56 10.33549/physiolres.935138 Open DOISearch in Google Scholar

78. Marin A, Verdel N, Milanič M, Majaron B. Noninvasive monitoring of dynamical processes in bruised human skin using diffuse reflectance spectroscopy and pulsed photothermal radiometry. Sensors 2021; 21: 302. doi: 10.3390/s21010302 MarinA VerdelN MilaničM MajaronB Noninvasive monitoring of dynamical processes in bruised human skin using diffuse reflectance spectroscopy and pulsed photothermal radiometry Sensors 2021 21 302 10.3390/s21010302 Open DOISearch in Google Scholar

79. Milanic M, Marin A, Stergar J, Verdel N, Majaron B. Monitoring of caffeine consumption effect on skin blood properties by diffuse reflectance spectroscopy. In: Dehghani H, Wabnitz H, editors. Diffuse optical spectroscopy and imaging VI. SPIE Proceedings; European Conference on Biomedical Optics 2017. Munich Germany; 25–29 Jun 2017. Paper 1041215. doi: 10.1117/12.2286140 MilanicM MarinA StergarJ VerdelN MajaronB Monitoring of caffeine consumption effect on skin blood properties by diffuse reflectance spectroscopy In: DehghaniH WabnitzH editors. Diffuse optical spectroscopy and imaging VI SPIE Proceedings; European Conference on Biomedical Optics 2017 Munich Germany 25–29 Jun 2017 Paper 1041215. 10.1117/12.2286140 Open DOISearch in Google Scholar

80. Verdel N, Marin A, Milanič M, Majaron B. Physiological and structural characterization of human skin in vivo using combined photothermal radiometry and diffuse reflectance spectroscopy. Biomed Opt Express 2019; 10: 944. doi: 10.1364/BOE.10.000944 VerdelN MarinA MilaničM MajaronB Physiological and structural characterization of human skin in vivo using combined photothermal radiometry and diffuse reflectance spectroscopy Biomed Opt Express 2019 10 944 10.1364/BOE.10.000944 Open DOISearch in Google Scholar