Age (mean ± SD) (years) | 54.00 ± 7.91 |
Maximum diameter (mean ± SD) (mm) | 25.10 (13.76, 42.58) |
FIGO stage n (%) | |
IA | 44 (59.46) |
IB | 30 (40.54) |
Histologic subtype n (%) | |
Adenocarcinoma | 67 (90.54) |
Non-adenocarcinoma | 7 (9.46) |
Clear-cell | 3 (4.06) |
Undifferentiated carcinoma | 2 (2.70) |
Carcinosarcoma | 2 (2.70) |
Lymphovascular space invasion n (%) | |
Positive | 10 (6.76) |
Negative | 64 (93.24) |
Histologic grade n (%) | |
Grade 1 | 54 (72.98) |
Grade 2 | 10 (13.51) |
Grade 3 | 10 (13.51) |
Risk stratification n (%) | |
Low | 44 (59.46) |
Intermediate | 20 (27.03) |
High-intermediate | 0 (0.00) |
High | 10 (13.51) |
TP53 expression | |
Mutant | 21 (28.38) |
Wild | 25 (33.78) |
No result | 28 (37.84) |
Risk stratification | ||||||
High-risk (n = 10) | 0.63 (0.40, 0.73) | 58.40 (40.10, 88.73) | 1.64 ± 0.60 | 0.35 (0.15, 0.43) | 0.30 ± 0.07 | 1.23 (0.48, 1.54) |
High-intermediate-risk (n = 0) | / | / | / | / | / | / |
Intermediate-risk (n = 20) | 0.55 (0.40, 0.81) | 52.00 (26.88, 74.33) | 1.74 ± 0.96 | 0.37 (0.29, 0.47) | 0.33 ± 0.14 | 1.24 (0.82, 1.98) |
Low-risk (n = 44) | 0.86 (0.64, 1.16) | 44.35 (21.93, 95.33) | 2.43 ± 1.08 | 0.61 (0.43, 1.14) | 0.58 ± 0.25 | 1.53 (0.79, 2.21) |
P-value | 0.464 |
0.191 |
||||
P-value (High |
0.880 |
0.248 |
0.735 |
0.397 |
0.532 |
0.307 |
P-value (High |
0.238 |
0.099 |
||||
P-value (Intermediate vs Low) | 0.937 |
0.582 | ||||
Low-risk (n = 44) | 0.86 (0.64, 1.16) | 44.35 (21.93, 95.33) | 2.43 ± 1.08 | 0.61 (0.43, 1.14) | 0.58 ± 0.25 | 1.53 (0.79, 2.21) |
Non-low-risk (High + Intermediate, n = 30) | 0.58 (0.40, 0.77) | 55.25 (34.63, 72.78) | 1.71 ± 0.84 | 0.37 (0.28, 0.45) | 0.32 ± 0.12 | 1.23 (0.82, 1.87) |
z/t value | − 3.793 | −0.523 | 3.234 | −5.109 | 5.304 | −1.233 |
P-value | 0.601 |
0.218 |
||||
TP53 expression | ||||||
Mutant (n = 21) | 0.72 ± 0.31 | 43.70 (16.30, 90.75) | 2.30 ± 1.09 | 0.67 (0.41, 1.14) | 0.32 (0.25, 0.91) | 1.67 (1.17, 2.09) |
Wild (n = 25) | 0.91 ± 0.29 | 50.60 (26.90, 82.75) | 2.20 ± 1.02 | 0.43 (0.37, 0.49) | 0.49 (0.36, 0.76) | 0.90 (0.58, 1.55) |
Z/t value | −2.155 | −0.518 | 0.321 | −2.073 | −0.783 | −3.165 |
P-value | 0.604 |
0.750 |
0.434 |
Low vs non-low risk | ||||
Age (year) | 1.462 (0.894–2.388) | 0.130 | / | / |
Tumor size (mm) | 1.055 (1.003–1.110) | 1.083 (0.979–1.197) | 0.123 | |
TP53 mutant | 1.506 (0.407–5.578) | 0.540 | / | / |
D (×10−3mm2/s) | 0.089 (0.021–0.373) | 0.144 (0.015–1.334) | 0.088 | |
D* (×10−3mm2/s) | 0.867 (0.533–1.412) | 0.567 | / | / |
f (%) | 0.419 (0.226–0.776) | 0.292 (0.093–0.921) | ||
Ktrans (min−1) | 0.009 (0.001–0.153) | 0.001 (0.000–0.089) | ||
Ve | 0.173 (0.069–0.432) | 0.130 (0.022–0.766) | ||
Kep (min−1) | 0.642 (0.367–1.126) | 0.122 | / | / |
TP53 mutant vs wild | ||||
Age (year) | 0.855 (0.465–1.548) | 0.605 | / | / |
Tumor size (mm) | 1.175 (0.649–2.127) | 0.594 | / | / |
Subtype | 77.708 (0.001–100.5) | 0.999 | / | / |
Grade | 2.099 (0.957–4.602) | 1.961 (0.816–4.717) | 0.132 | |
Risk stratification | 1.506 (0.407–5.578) | 0.540 | / | / |
FIGO stage | 1.360 (0.739–2.505) | 0.323 | / | / |
LVSI | 802.578 (0.001–1150.5) | 0.999 | / | / |
D (×10−3mm2/s) | 2.063 (1.016–4.191) | 8.274 (2.066–33.136) | ||
D* (×10−3mm2/s) | 1.020 (0.567–1.835) | 0.948 | / | / |
f (%) | 0.906 (0.504–1.629) | 0.742 | / | / |
Ktrans (min−1) | 0.487 (0.236–1.003) | 0.155 (0.034–0.710) | ||
Ve | 1.008 (0.560–1.812) | 0.979 | / | / |
Kep (min−1) | 0.501 (0.244–1.032) | 1.172 (0.425–3.234) | 0.759 |
Sequence | 2D-FSE | 2D-FSE | 2D-SS-EPI | 2D-SS-EPI | 3D-LAVA |
Orientation | Oblique Axial | Oblique Axial | Oblique Axial | Oblique Axial | Oblique Axial |
TR/TE (ms) | 659/12.3 | 6000/95 | 3708/74.3 | 2000/80.7 | 3.5/1.7 |
FOV (cm2) | 40 × 40 | 40 × 40 | 40 × 40 | 40 × 40 | 36 × 36 |
Matrix | 288 × 192 | 320 × 320 | 96 × 128 | 128 × 192 | 288 × 192 |
Flip angle (°) | 160 | 160 | 90 | 90 | 15 |
Slice thickness (mm) | 6 | 6 | 6 | 6 | 6 |
No. of sections | 20 | 20 | 20 | Based on lesion's size | 26 |
NEX | 1 | 1 | 1, 4 | 1, 1, 1, 1, 1, 1, 2, 4, 4, 6 | 0.73 |
Fat suppression | / | STIR | STIR | STIR | FLEX |
b-values (s/mm2) | / | / | 0, 800 | 0, 20, 40, 80, 160, 200, 400, 600, 800, 1000 | / |
Respiratory compensation | Free | Free | Free | Free | Free |
Scan time | 1 min 56 s | 48 s | 1 min 04 s | 3~6min | 6 min 08 s (40 phases) |
Low vs non-low risk | ||||||
D (×10−3mm2/s) | 0.761 (0.648–0.853) | < 0.001 | 0.691 | 73.33% | 72.73% | Z = 3.113, P = 0.002 |
D* (×10−3mm2/s) | 0.536 (0.416–0.653) | 0.598 | / | / | / | / |
f (%) | 0.688 (0.569–0.790) | 0.003 | 1.240 | 36.67% | 93.18% | Z = 4.317, P < 0.001 |
Ktrans (min−1) | 0.852 (0.750–0.924) | < 0.001 | 0.487 | 90.00% | 68.18% | Z = 2.713, P = 0.007 |
Ve | 0.808 (0.700–0.890) | < 0.001 | 0.401 | 83.33% | 70.45% | Z = 3.175, P = 0.002 |
Kep (min−1) | 0.585 (0.652–0.849) | 0.204 | / | / | / | / |
Combined diagnosis 1 | 0.947 (0.869–0.986) | < 0.001 | / | 83.33% | 93.18% | / |
TP53 mutant vs wild | ||||||
D (×10−3mm2/s) | 0.694 (0.541–0.821) | 0.019 | 0.605 | 92.00% | 47.62% | Z = 2.169, P = 0.030 |
D* (×10−3mm2/s) | 0.545 (0.391–0.692) | 0.498 | / | / | / | / |
f (%) | 0.535 (0.382–0.648) | 0.388 | / | / | / | / |
Ktrans (min−1) | 0.679 (0.525–0.809) | 0.036 | 0.499 | 80.00% | 61.90% | Z = 2.572, P = 0.010 |
Ve | 0.568 (0.413–0.713) | 0.675 | / | / | / | / |
Kep (min−1) | 0.773 (0.626–0.884) | < 0.001 | 1.557 | 80.00% | 66.67% | Z = 1.272, P = 0.203 |
Combined diagnosis 2 | 0.867 (0.734–0.949) | < 0.001 | / | 92.00% | 80.95% | / |