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MitomiRs: their roles in mitochondria and importance in cancer cell metabolism

Andrej Rencelj
Andrej Rencelj
, 
Nada Gvozdenovic
Nada Gvozdenovic
 oraz 
Maja Cemazar
Maja Cemazar
   | 19 lis 2021
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Article Category: Review
Data publikacji: 19 lis 2021
Zakres stron: 379 - 392
Otrzymano: 10 sie 2021
Przyjęty: 28 wrz 2021
DOI: https://doi.org/10.2478/raon-2021-0042
© 2021 Andrej Rencelj, Nada Gvozdenovic, Maja Cemazar, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Canonical biosynthesis of miRNAs/mitomiRs (adopted from 29, 43, 45). Mature miRNA can be transported into any part of the cell; but miRNA/mitomiR regulation is possible only after incorporation into RISC. (AGO2 = argonaute 2; DGCR8 = DiGeorge critical region 8; EXP5 = exportin 5; GTP = guanosine triphosphate; IMP8 = importin 8; mRISC = RNA induced silencing complex loaded with mature miRNA; POLII = DNA polymerase II; RANGTP = binding nuclear protein RAN; RISC = RNA-induced silencing complex; TRBP2 = RISC-loading complex subunit TRBP2).
Canonical biosynthesis of miRNAs/mitomiRs (adopted from 29, 43, 45). Mature miRNA can be transported into any part of the cell; but miRNA/mitomiR regulation is possible only after incorporation into RISC. (AGO2 = argonaute 2; DGCR8 = DiGeorge critical region 8; EXP5 = exportin 5; GTP = guanosine triphosphate; IMP8 = importin 8; mRISC = RNA induced silencing complex loaded with mature miRNA; POLII = DNA polymerase II; RANGTP = binding nuclear protein RAN; RISC = RNA-induced silencing complex; TRBP2 = RISC-loading complex subunit TRBP2).

Figure 2

The network of the mitomiRs and their target genes (grey rectangle) in primates (data from Table 1). Blue arrows present downregulation, green arrows present upregulation and black T-line present silencing. Purple octagon shape presents monkey miRNA and cyan hexagon presents human miRNAs (figure constructed with Cytoscape Network Data Integration, Analysis, and Visualization in a Box V3.8.2).
The network of the mitomiRs and their target genes (grey rectangle) in primates (data from Table 1). Blue arrows present downregulation, green arrows present upregulation and black T-line present silencing. Purple octagon shape presents monkey miRNA and cyan hexagon presents human miRNAs (figure constructed with Cytoscape Network Data Integration, Analysis, and Visualization in a Box V3.8.2).

Figure 3

The network of the mitomiRs and their target genes (grey rectangle) in rodents (data from Table 1). Blue arrows present downregulation and green arrows present upregulation. Orange diamond shape presents rat miRNAs, yellow rectangle presents mouse miRNAs and cyan hexaon presents human miRNAs. miR-199a and miR-143 show that this two miRNAs regulate (figure constructed with Cytoscape Network Data Integration, Analysis, and Visualization in a Box V3.8.2).
The network of the mitomiRs and their target genes (grey rectangle) in rodents (data from Table 1). Blue arrows present downregulation and green arrows present upregulation. Orange diamond shape presents rat miRNAs, yellow rectangle presents mouse miRNAs and cyan hexaon presents human miRNAs. miR-199a and miR-143 show that this two miRNAs regulate (figure constructed with Cytoscape Network Data Integration, Analysis, and Visualization in a Box V3.8.2).

Figure 4

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Traditional cancer traits.89

Summary of microRNAs and their roles in mitochondria

miR miR accession number Target genes Gene accession number Function Functional pathway Location Species References
miR-378 MI0000795 Crat ENSMUSG00000026853 Downregulation Mitochondrial oxidative metabolism Mitochondria in liver cells Mouse Carrer et al., 201259
miR-24 MI0000080 H2ax ENSMUSG00000049932 Downregulation Insulin pathway signaling Mitochondria liver cells in Human Jeong et al., 201761
miR-23b MI0000439 GLS ENSG00000115419 Downregulation Glutamine metabolism LMitochondria liver cells in Human Gao et al., 200960
SLC2A1 ENSG00000117394 Downregulation
miR-1291 MI0006353 CPT1C ESRRA ENSG00000169169 ENSG00000173153 Downregulation Downregulation Mitochondrial Mitochondria in Human Yamasaki et al., 2013; Chen et al.,
ASS1 ENSG00000130707 Downregulation metabolism renal cells 2020, Tu et al., 202063, 64, 65
GLUT1 ENSG00000117394 Downregulation
miR-138 MI0000455 PDK1 ENSG00000152256 Downregulation Glucose metabolism Mitochondria in cardiac cells Human Zhu et al., 201766
miR-150 MI0000920 MI0000479 Slc2a4 SLC2A1 ENSRNOG00000017226 ENSG00000117394 Downregulation Downregulation Metabolism Mitochondria in cardiac cells Rat Human Ju et al., 202067 Li et al., 201768
Slc2a4 ENSRNOG00000017226 Upregulation Mitochondria in
miR-199a MI0000941 Hk2 ENSRNOG00000006116 Upregulation Expression of muscle cells Rat Esteves et al., 2018, Yan et al., 2014, Guo
MI0000242 HK2 ENSG00000159399 Upregulation glucose transporters Mitochondria in liver cells Human et al., 20154, 69, 70
miR-532-5p MI0006154 SlcHk22 a4 ENSRNOGENSRNOG00000017226 00000006116 Upregulation Upregulation Expression glucose transporters of Mitochondria muscle cells in Rat Esteves et al., 201870
Mitochondrial Mitochondria in
miR-29a MI0000576 Slc16a1 ENSMUSG00000032902 Downregulation oxidative metabolism pancreatic betacells Mouse Pullen et al., 201171
miR-29b MI0000143 Slc16a1 ENSMUSG00000032902 Downregulation Mitochondrial oxidative metabolism Mitochondria in pancreatic betacells Mouse Pullen et al., 201171
Mitochondrial Mitochondria in
miR-124 MI0000716 Slc16a1 ENSMUSG00000032902 Downregulation oxidative pancreatic beta- Mouse Pullen et al., 201171
metabolism cells
CROT ENSANAG00000028065 Downregulation
CPT1A ENSANAG00000017356 Downregulation
HADHB ENSANAG00000027802 Downregulation
PRKAA1 ENSANAG00000032687 Downregulation
miR-33a/b a-MI0002684, b-MI0007603 ABCA1 ENSANAG00000033387 Downregulation Lipid metabolism Mitochondria in liver cells Monkey Rayner et al., 201172
SREBF1 ENSANAG00000021477 Upregulation
FASN ENSANAG00000032055 Upregulation
ACLY ENSANAG00000036009 Upregulation
ACACA ENSANAG00000035253 Upregulation
miR-143 MI0000916 Map2k5 ENSRNOG00000007926 Downregulation Adipogenesis Mitochondria in adipose cells Rat Chen et al., 201473
MI0000459 APOL6 ENSG00000221963 Downregulation Adpiogenesis Mitochondria in adipose cells Human Ye et al., 201374
miR-204 MI0000284 ACACB ENSG00000076555 Downregulation Lipid metabolism Mitochondria adipose cells in Human Civelek et al., 201375
miR-200 MI0000737 ZEBZEB1 2 ENSGENSG00000148516 00000169554 Upregulation Upregulation Lipid metabolism Mitochondria breast cells in Human Ahmad et al., 201176
miR-338 MI0000618 COXIV ENSRNOG00000007827 Downregulation Mitochondria oxidative metabolism Mitochondria in neural cells Rat Aschrafi et al., 200877
miR-181c MI0000924 COX1 ENSRNOG00000034234 Downregulation Mitochondria oxidative metabolism Mitochondria in cardiac cells Rat Das et al., 201288
miR-210 MI0000268 ISCU ENSG00000136003 Downregulation Mitochondria oxidative metabolism Mitochondria in placenta cells Human Colleoni et al., 2013; Qiao et al., 201381, 85
miR-15b MI0000843 Arl2 ENSRNOG00000021010 Downregulation ATP production Mitochondria in cardiac cells Rat Nishi et al., 201082
Bcl2 ENSRNOG00000002791 Downregulation
miR-16 MI0000844 Bcl2 ENSRNOG00000002791 Downregulation ATP production Mitochondria in cardiac cells Rat Nishi et al., 201082
Arl2 ENSRNOG00000021010 Downregulation
miR-195 MI0000939 Arl2 ENSRNOG00000021010 Downregulation ATP production Mitochondria in cardiac cells Rat Nishi et al., 201082
miR-29a-3p MI0000576 Foxa2 ENSMUSG00000037025 Upregulation Lipid metabolism Mitochondria liver cells in Mouse Kurtz et al., 201486
miR-19b MI0000074 MFN1 ENSG00000171109 Downregulation Apoptosis Mitochondria in bone cells Human Li et al., 201487
miR-101-3p MI0000103 ATP5B ENSG00000110955 Silencing Mitochondria metabolism Mitochondria heLa cells in Human Zheng et al., 201184

Summary of mitomiRs with roles in cancer

miR miR accession number Target genes Gene accession number Function Functional pathway Type of cancer Species References
HIF-1 ENSG00000258777 Upregulation
ISCU ENSG00000136003 Upregulation
miR-210 MI0000286 COX10 ENSG00000006695 Upregulation Hypoxia Breast cancer, neck and head cancer, lung cancer Human Qin et al., 2014; Gee et al., 2010; Puissegur et al., 2011109, 110, 111
SDHD ENSG00000204370 Upregulation
NDUFA4 ENSG00000189043 Upregulation
miR-200a MI0000342 TFAM ENSG00000108064 Downregulation Mitochondrial biogenesis, cancer metabolism Breast cancer Human Yao et al., 2014112
miR-155 MI0000681 HK2 ENSG00000159399 Upregulation phosphorylation Glucose Breast cancer Human Jiang Fang et et al.al., , 20122012; 104
miR-124 MI0000443 PKM ENSG00000067225 Upregulation metabolism Glucose Colorectal cancer Human Sun et al., 2012105
miR-137 MI0000454 PKM ENSG00000067225 Upregulation metabolism Glucose Colorectal cancer Human Sun et al., 2012105
miR-340 MI0000802 PKM ENSG00000067225 Upregulation metabolism Glucose Colorectal cancer Human Sun et al., 2012105
miR-326 MI0000808 PKM2 ENSG00000067225 Downregulation metabolism Glucose Glioblastoma Human Kefas et al., 2010106
miR-181-5p MIMAT0000256 RASSF6INPP5A ENSG00000169435ENSG00000068383 DownregulationDownregulation Mitogen-activated protein kinase (MAPK) signaling pathway Gastric cancer, cervical cancer Human Mi et al., 2017; Zhuang et al., 2017108, 113
miR-92a-1 MI0000093 BCL2L11 ENSG00000153094 Downregulation Apoptosis Lymphoma Human Mogilyansky Rigoutsos, 2013 and 94
PIK3R2 ENSG00000105647 Downregulation Breast cancer cells Zhu et al., 2011114
PLK2 ENSG00000260410 Downregulation Acute leukaemia cells Li et al., 2008115
EGFL7 ENSG00000172889 Downregulation Oral squamous cells Sasahira et al., 2012116
CRK ENSG00000167193 Downregulation Lung cancer cells Crawford 2008117 et al.,
ADAM9 ENSG00000168615 Downregulation Melanoma cells cancer Felli et al., 2013118
miR-126 MI0000471 HOXA9 ENSG00000078399 Downregulation Inflammation, angiogenesis Acute leukaemia cells Human Shen et al., 2008119
IRS1 ENSG00000169047 Downregulation Breast cancer cells Zhang et al., 2008120
SOX-2 ENSG00000242808 Downregulation Gastric cells cancer Otsubo et al., 2011121
SLC7A5 ENSG00000103257 Downregulation Lung cancer cells Miko et al., 2011122
VEGFA ENSG00000150630 Downregulation Oral squamous cells Sasahira et al., 2012116
MMP7 ENSG00000137673 Downregulation Melanoma cells cancer Felli et al., 2013118
BCL-2 ENSG00000171791 Downregulation
Gao et al., 2010101
MCL-1 ENSG00000143384 Downregulation
COX4I2 ENSG00000131055 Downregulation
miR-15a MI0000069 COX6A2 ENSG00000156885 Downregulation Apoptosis, ATP production B-cell chronic lymphocytic leukemia Human Siengdee et al.,
NDUFB7 ENSG00000099795 Downregulation 2010102
NDUFV1 ENSG00000167792 Downregulation
NDUFS4 ENSG00000164258 Downregulation
COX4I2 ENSG00000131055 Downregulation
COX6A2 ENSG00000156885 Downregulation
miR-16a MI0000070 NDUFB7 ENSG00000099795 Downregulation Apoptosis, ATP production B-lymphocytic cell chronic leukemia Human Siengdee et al., 2010102
NDUFV1 ENSG00000167792 Downregulation
NDUFS4 ENSG00000164258 Downregulation
eISSN:
1581-3207
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
Kanał RSS czasopisma