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An overview of hepatocellular carcinoma with atypical enhancement pattern: spectrum of magnetic resonance imaging findings with pathologic correlation

Jelena Djokic Kovac
Jelena Djokic Kovac
, 
Aleksandar Ivanovic
Aleksandar Ivanovic
, 
Tamara Milovanovic
Tamara Milovanovic
, 
Marjan Micev
Marjan Micev
, 
Francesco Alessandrino
Francesco Alessandrino
 oraz 
Richard M. Gore
Richard M. Gore
   | 29 sty 2021
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Article Category: Review
Data publikacji: 29 sty 2021
Zakres stron: 130 - 143
Otrzymano: 09 paź 2020
Przyjęty: 15 gru 2020
DOI: https://doi.org/10.2478/raon-2021-0004
© 2021 Jelena Djokic Kovac, Aleksandar Ivanovic, Tamara Milovanovic, Marjan Micev, Francesco Alessandrino, Richard M. Gore, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Hypovascular hepatocellular carcinoma (HCC) in 58-year old woman with cirrhosis. On axial T2-weighted image (A), diffusion-weighted image (B) and on in-phase image (C) tumor is isointense with surrounding liver parenchyma. On opposed-phase image there is a partial drop of signal intensity in the lesion (arrow) corresponding to the fatty component (D). The lesion (arrow) is slightly hypointense on arterial phase (E), while it is clearly hypovascular on portal-venous phase (F). On hepatobiliary phase after administration of gadoxetic acid the lesion (arrow) is hypointense (G). Hematoxylin and eosin (H&E) staining showed well-differentiated HCC with fat deposition; original magnification x 200 (H).
Hypovascular hepatocellular carcinoma (HCC) in 58-year old woman with cirrhosis. On axial T2-weighted image (A), diffusion-weighted image (B) and on in-phase image (C) tumor is isointense with surrounding liver parenchyma. On opposed-phase image there is a partial drop of signal intensity in the lesion (arrow) corresponding to the fatty component (D). The lesion (arrow) is slightly hypointense on arterial phase (E), while it is clearly hypovascular on portal-venous phase (F). On hepatobiliary phase after administration of gadoxetic acid the lesion (arrow) is hypointense (G). Hematoxylin and eosin (H&E) staining showed well-differentiated HCC with fat deposition; original magnification x 200 (H).

Figure 2

Isovascular hepatocellular carcinoma (HCC) in 55-year old woman with cirrhosis. On T2-weighted image slightly hyperintense nodule (arrow) is seen in liver segment VII (A). No lesion is seen on arterial (B) and portal venous phase (C). On hepatobiliary phase after administration of gadoxetic acid the lesion (arrow) is hypointense (D). Diffusion-weighted image shows diffusion restriction of the lesion (arrow) (E). Hematoxylin and eosin (H&E) staining showed well-differentiated HCC; original magnification x 200 (F).
Isovascular hepatocellular carcinoma (HCC) in 55-year old woman with cirrhosis. On T2-weighted image slightly hyperintense nodule (arrow) is seen in liver segment VII (A). No lesion is seen on arterial (B) and portal venous phase (C). On hepatobiliary phase after administration of gadoxetic acid the lesion (arrow) is hypointense (D). Diffusion-weighted image shows diffusion restriction of the lesion (arrow) (E). Hematoxylin and eosin (H&E) staining showed well-differentiated HCC; original magnification x 200 (F).

Figure 3

Hypervascular hepatocellular carcinoma (HCC) without washout in 64-year old man with cirrhosis. Axial T2-weighted fat-suppressed image shows hyperintense nodule (arrow) in liver segment VIII (A). On arterial phase the nodule (arrow) is hypervascular (B) without washout on portal-venous phase (C). On hepatobiliary phase the nodule (arrow) is hypointense (D) and on diffusion-weighted image it is hyperintense (E). Hematoxylin and eosin (H&E) staining showed moderately-differentiated HCC; original magnification x 200 (F).
Hypervascular hepatocellular carcinoma (HCC) without washout in 64-year old man with cirrhosis. Axial T2-weighted fat-suppressed image shows hyperintense nodule (arrow) in liver segment VIII (A). On arterial phase the nodule (arrow) is hypervascular (B) without washout on portal-venous phase (C). On hepatobiliary phase the nodule (arrow) is hypointense (D) and on diffusion-weighted image it is hyperintense (E). Hematoxylin and eosin (H&E) staining showed moderately-differentiated HCC; original magnification x 200 (F).

Figure 4

Hypervascular hepatocellular carcinoma (HCC) without washout in 44-year old man with non alcoholic fatty liver disease. Axial T2-weighted fat-suppressed image shows moderately hyperintense lesion (arrow) in segment VI (A). Dual-echo images show that tumor (arrows) is isointense on in-phase image (B) without signal drop on opposed-phase image, while background liver parenchyma shows diffuse signal drop as a consequence of fatty liver disease (C). The lesion (arrows) is hyperintense on diffusion-weighted image (D), hypevascular on arterial phase (E) without washout on portalvenous phase (F). On hepatobiliary phase the tumor (arrow) is hypointense (G). Hematoxylin and eosin (H&E) staining showed moderately-differentiated HCC with very dilatated sinusoidal network; original magnification x 200 (H).
Hypervascular hepatocellular carcinoma (HCC) without washout in 44-year old man with non alcoholic fatty liver disease. Axial T2-weighted fat-suppressed image shows moderately hyperintense lesion (arrow) in segment VI (A). Dual-echo images show that tumor (arrows) is isointense on in-phase image (B) without signal drop on opposed-phase image, while background liver parenchyma shows diffuse signal drop as a consequence of fatty liver disease (C). The lesion (arrows) is hyperintense on diffusion-weighted image (D), hypevascular on arterial phase (E) without washout on portalvenous phase (F). On hepatobiliary phase the tumor (arrow) is hypointense (G). Hematoxylin and eosin (H&E) staining showed moderately-differentiated HCC with very dilatated sinusoidal network; original magnification x 200 (H).

Figure 5

Hepatocellular carcinoma (HCC) in 73-year old man with alcoholic cirrhosis. Axial T2-weighted fat-suppressed image shows slightly hyperintense well-defined nodular lesion (arrow) in segment VII (A). The lesion (arrows) is hypervascular on arterial phase (B) without washout on portal-venous phase (C). On hepatobiliary phase the tumor (arrow) is strongly hyperintense (D) with hyperintensity on diffusion-weighted image (E). Hematoxylin and eosin (H&E) staining showed well-differentiated HCC; original magnification x 200 (F).
Hepatocellular carcinoma (HCC) in 73-year old man with alcoholic cirrhosis. Axial T2-weighted fat-suppressed image shows slightly hyperintense well-defined nodular lesion (arrow) in segment VII (A). The lesion (arrows) is hypervascular on arterial phase (B) without washout on portal-venous phase (C). On hepatobiliary phase the tumor (arrow) is strongly hyperintense (D) with hyperintensity on diffusion-weighted image (E). Hematoxylin and eosin (H&E) staining showed well-differentiated HCC; original magnification x 200 (F).
eISSN:
1581-3207
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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