Otwarty dostęp

The role of polymorphisms in glutathione-related genes in asbestos-related diseases


Zacytuj

Genotype frequencies in all subjects, subjects without asbestos-related disease, subjects with pleural plaques, asbestosis and malignant mesothelioma

PolymorphismGenotypeAll subjects (N = 940)No disease (N = 178)Pleural plaques (N = 416)Asbestosis (N = 160)Malignant mesothelioma (N = 154)
CC772 (82.1)149 (83.7)310 (79.5)124 (84.4)189 (84)
GCLC rs17883901 c.-129C>TCT162 (17.2)29 (16.3)78 (20)23 (15.6)32 (14.2)
TT6 (0.6)0 (0)2 (0.5)0 (0)4 (1.8)
CC581 (61.8)114 (64)233 (59.7)87 (59.2)147 (65.3)
GCLM rs41303970 c.-590C>TCT306 (32.6)54 (30.3)135 (34.6)51 (34.7)66 (29.3)
TT53 (5.6)10 (5.6)22 (5.6)9 (6.1)12 (5.3)
present384 (40.9)74 (41.6)159 (40.8)64 (43.5)87 (38.7)
GSTM1 Gene deletion
null genotype556 (59.1)104 (58.4)231 (59.2)83 (56.5)138 (61.3)
present782 (83.2)138 (77.5)330 (84.6)128 (87.1)186 (82.7)
GSTT1 Gene deletion
null genotype158 (16.8)40 (22.5)60 (15.4)19 (12.9)39 (17.3)
AA454 (78.3)78 (43.8)202 (51.8)76 (51.7)98 (43.6)
GSTP1 rs1695 p.Ile 105ValAG394 (41.9)81 (45.5)155 (39.7)55 (37.4)103 (45.8)
GG92 (9.8)19 (10.7)33 (8.5)16 (10.9)24 (10.7)
CC785 (83.5)141 (79.2)334 (85.6)121 (82.3)189 (84)
GSTP1 rs1138272 p.Ala114ValCT146 (15.5)34 (19.1)54 (13.8)23 (15.6)35 (15.6)
TT9 (1.0)3 (1.7)2 (0.5)3 (2)1 (0.4)

The association between different asbestos-related diseases and genotypes in univariate analysis

Asbestos-related disease vs. no diseasePleural plaques vs. no diseaseAsbestosis vs. no diseaseMM vs. no diseaseMM vs. plaques
PolymorphismGenotype
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
GCLCCCReferenceReferenceReferenceReferenceReference
rs17883901CT+TT1.15 (0.74–1.78)0.5411.33 (0.83–2.12)0.2370.95 (0.52–1.73)0.8740.98 (0.57–1.67)0.9370.74 (0.48–1.14)0.169
CCReferenceReferenceReferenceReferenceReference
GCLMCT1.14 (0.80–1.63)0.4761.22 (0.83–1.80)0.3081.24 (0.77–1.99)0.3780.95 (0.61–1.46)0.8090.77 (0.54–1.11)0.164
rs41303970TT1.05 (0.51–2.15)0.8951.08 (0.49–2.35)0.8531.18 (0.46–3.03)0.7320.93 (0.39–2.23)0.8720.86 (0.42–1.80)0.697
CT+TT1.13 (0.80–1.58)0.4951.20 (0.83–1.73)0.3301.23 (0.78–1.93)0.3690.95 (0.63–1.43)0.7880.79 (0.56–1.11)0.170
presentReferenceReferenceReferenceReferenceReference
GSTM1null genotype1.04 (0.74–1.44)0.8281.03 (0.72–1.48)0.8570.92 (0.59–1.44)0.7211.13 (0.76–1.69)0.5541.09 (0.78–1.53)0.608
presentReferenceReferenceReferenceReferenceReference
GSTT1null genotype0.63 (0.42–0.95)0.0260.63 (0.40–0.98)0.0410.51 (0.28–0.93)0.0280.72 (0.44–1.18)0.1981.15 (0.74–1.79)0.527
AAReferenceReferenceReferenceReferenceReference
AG0.80 (0.57–1.13)0.2090.74 (0.51–1.07)0.1140.70 (0.44–1.11)0.1291.01 (0.67–1.53)0.9551.37 (0.97–1.94)0.075
GSTP1 rs1695
GG0.80 (0.45–1.40)0.4280.67 (0.36–1.25)0.2080.86 (0.41–1.80)0.6981.01 (0.51–1.97)0.9881.50 (0.84–2.67)0.170
AG+GG0.80 (0.58–1.11)0.1850.73 (0.51–1.04)0.0780.73 (0.47–1.13)0.1571.01 (0.68–1.5)0.9581.39 (1.00–1.94)0.049
GSTP1CCReferenceReferenceReferenceReferenceReference
rs1138272CT+TT0.70 (0.46–1.05)0.0870.64 (0.40–1.01)0.0560.82 (0.47–1.43)0.4820.73 (0.44–1.21)0.2161.14 (0.72–1.79)0.583

The association between different asbestos-related diseases and genotypes in multivariate analysis

Asbestos-related disease vs. no diseasePleural plaques vs. no diseaseAsbestosis vs. no diseaseMM vs. no diseaseMM vs. plaques
PolymorphismGenotype
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
GCLCCCReferenceReferenceReferenceReferenceReference
rs17883901CT+TT1.18 (0.75–1.86)0.4661.33 (0.83–2.12)0.2400.96 (0.52–1.78)0.8930.66 (0.28–1.57)0.3440.57 (0.26–1.23)0.154
CCReferenceReferenceReferenceReferenceReference
GCLMCT1.16 (0.8–1.68)0.4311.22 (0.82–1.79)0.3231.10 (0.67–1.81)0.6950.98 (0.51–1.87)0.9450.76 (0.43–1.36)0.360
rs41303970TT1.16 (0.55–2.42)0.6961.06 (0.48–2.32)0.8831.37 (0.52–3.63)0.5241.13 (0.33–3.84)0.8441.05 (0.35–3.09)0.934
CT+TT1.16 (0.82–1.64)0.4061.19 (0.82–1.72)0.3511.14 (0.72–1.83)0.5761.00 (0.55–1.84)0.9940.80 (0.47–1.38)0.429
presentReferenceReferenceReferenceReferenceReference
GSTM1null genotype1.04 (0.74–1.46)0.8371.06 (0.74–1.53)0.7380.84 (0.53–1.34)0.4641.09 (0.60–1.98)0.7741.09 (0.63–1.87)0.756
presentReferenceReferenceReferenceReferenceReference
GSTT1null genotype0.62 (0.41–0.94)0.0250.63 (0.4–0.99)0.0460.51 (0.27–0.95)0.0331.00 (0.48–2.08)0.9961.28 (0.65–2.53)0.479
AAReferenceReferenceReferenceReferenceReference
GSTP1 rs1695AG0.78 (0.54–1.11)0.1620.74 (0.51–1.07)0.1130.65 (0.40–1.06)0.0871.23 (0.66–2.32)0.5131.86 (1.04–3.30)0.036
GG0.8 (0.45–1.43)0.4610.67 (0.36–1.24)0.2030.96 (0.45–2.06)0.9201.65 (0.65–4.16)0.2882.40 (1.04–5.54)0.039
AG+GG0.78 (0.56–1.1)0.1530.72 (0.51–1.04)0.0770.71 (0.45–1.12)0.1401.31 (0.72–2.39)0.3701.97 (1.14–3.39)0.015
GSTP1CCReferenceReferenceReferenceReferenceReference
rs1138272CT+TT0.68 (0.44–1.04)0.0780.64 (0.4–1.02)0.0590.84 (0.47–1.51)0.5650.73 (0.34–1.60)0.4331.02 (0.49–2.13)0.965

Characteristics of subjects without asbestos-related disease, subjects with pleural plaques, asbestosis or malignant mesothelioma

CharacteristicNo disease (N = 178)Pleural plaques (N = 390)Asbestosis (N = 147)Malignant mesothelioma (N = 225)P
Male, N (%)119 (66.9)277 (71.0)110 (74.8)164 (72.9)0.407
GenderChi-square = 2.905,
Female, N (%)59 (33.1)113 (29.0)37 (25.2)61 (27.1)df = 3
Mean ± SD57.6 ± 9.555.8 ± 9.558.7 ± 9.165.0 ± 10.7
Age (years)Median (25%–75%)56.6 (49.6–65.1)55.0 (48.8–62.7)59.1 (51.4–65.3)66 (58–73)Test-statistic < 0.001 = 115.390
Min–max38.2–79.934.4–85.837.2–79.219–95
No, N (%)95 (53.4)193 (49.5)72 (49.0)117 (53.7) [7]1.614
SmokingChi-square = 0.656,
Yes, N (%)83 (46.6)197 (50.5)75 (51.0)101 (46.3)df = 3
Mean ± SD21.0 ± 15.8 [4]18.1 ± 15.6 [22]24.4 ± 18.6 [2]23.2 ± 17.2 [14]
Pack-(smokers years of only) smokingMedian (25%–75%)20 (9–30)15 (5–28)22.8 (10–32.7)20 (8–35)Test-statistic 0.024 = 9.474
Min–max0.1–65.30.05–96.60.15–901–69
Low, N (%)138 (77.5)277 (72.3) [7]75 (51.7) [2]34 (45.9) [151]
< 0.001
Asbestos exposureMiddle, N (%)13 (7.3)38 (9.9)28 (19.3)23 (31.1)Chi-square = 53.864,
High, N (%)27 (15.2)68 (17.8)42 (29.0)17 (23.0)df = 6
eISSN:
1581-3207
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology