The role of polymorphisms in glutathione-related genes in asbestos-related diseases

Alenka Franko; Katja Goricar; Metoda Dodic Fikfak; Viljem Kovac; Vita Dolzan

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The role of polymorphisms in glutathione-related genes in asbestos-related diseases

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| 26 sty 2021

Radiology and Oncology

Tom 55 (2021): Zeszyt 2 (June 2021)

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Article Category: Research Article

Data publikacji: 26 sty 2021

Zakres stron: 179 - 186

Otrzymano: 09 lis 2020

Przyjęty: 02 gru 2020

DOI: https://doi.org/10.2478/raon-2021-0002

© 2021 Alenka Franko, Katja Goricar, Metoda Dodic Fikfak, Viljem Kovac, Vita Dolzan, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Genotype frequencies in all subjects, subjects without asbestos-related disease, subjects with pleural plaques, asbestosis and malignant mesothelioma

Polymorphism	Genotype	All subjects (N = 940)	No disease (N = 178)	Pleural plaques (N = 416)	Asbestosis (N = 160)	Malignant mesothelioma (N = 154)
	CC	772 (82.1)	149 (83.7)	310 (79.5)	124 (84.4)	189 (84)
GCLC rs17883901 c.-129C>T	CT	162 (17.2)	29 (16.3)	78 (20)	23 (15.6)	32 (14.2)
	TT	6 (0.6)	0 (0)	2 (0.5)	0 (0)	4 (1.8)
	CC	581 (61.8)	114 (64)	233 (59.7)	87 (59.2)	147 (65.3)
GCLM rs41303970 c.-590C>T	CT	306 (32.6)	54 (30.3)	135 (34.6)	51 (34.7)	66 (29.3)
	TT	53 (5.6)	10 (5.6)	22 (5.6)	9 (6.1)	12 (5.3)
	present	384 (40.9)	74 (41.6)	159 (40.8)	64 (43.5)	87 (38.7)
GSTM1 Gene deletion
	null genotype	556 (59.1)	104 (58.4)	231 (59.2)	83 (56.5)	138 (61.3)
	present	782 (83.2)	138 (77.5)	330 (84.6)	128 (87.1)	186 (82.7)
GSTT1 Gene deletion
	null genotype	158 (16.8)	40 (22.5)	60 (15.4)	19 (12.9)	39 (17.3)
	AA	454 (78.3)	78 (43.8)	202 (51.8)	76 (51.7)	98 (43.6)
GSTP1 rs1695 p.Ile 105Val	AG	394 (41.9)	81 (45.5)	155 (39.7)	55 (37.4)	103 (45.8)
	GG	92 (9.8)	19 (10.7)	33 (8.5)	16 (10.9)	24 (10.7)
	CC	785 (83.5)	141 (79.2)	334 (85.6)	121 (82.3)	189 (84)
GSTP1 rs1138272 p.Ala114Val	CT	146 (15.5)	34 (19.1)	54 (13.8)	23 (15.6)	35 (15.6)
	TT	9 (1.0)	3 (1.7)	2 (0.5)	3 (2)	1 (0.4)

The association between different asbestos-related diseases and genotypes in univariate analysis

		Asbestos-related disease vs. no disease		Pleural plaques vs. no disease		Asbestosis vs. no disease		MM vs. no disease		MM vs. plaques
Polymorphism	Genotype
		OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
GCLC	CC	Reference		Reference		Reference		Reference		Reference
rs17883901	CT+TT	1.15 (0.74–1.78)	0.541	1.33 (0.83–2.12)	0.237	0.95 (0.52–1.73)	0.874	0.98 (0.57–1.67)	0.937	0.74 (0.48–1.14)	0.169
	CC	Reference		Reference		Reference		Reference		Reference
GCLM	CT	1.14 (0.80–1.63)	0.476	1.22 (0.83–1.80)	0.308	1.24 (0.77–1.99)	0.378	0.95 (0.61–1.46)	0.809	0.77 (0.54–1.11)	0.164
rs41303970	TT	1.05 (0.51–2.15)	0.895	1.08 (0.49–2.35)	0.853	1.18 (0.46–3.03)	0.732	0.93 (0.39–2.23)	0.872	0.86 (0.42–1.80)	0.697
	CT+TT	1.13 (0.80–1.58)	0.495	1.20 (0.83–1.73)	0.330	1.23 (0.78–1.93)	0.369	0.95 (0.63–1.43)	0.788	0.79 (0.56–1.11)	0.170
	present	Reference		Reference		Reference		Reference		Reference
GSTM1	null genotype	1.04 (0.74–1.44)	0.828	1.03 (0.72–1.48)	0.857	0.92 (0.59–1.44)	0.721	1.13 (0.76–1.69)	0.554	1.09 (0.78–1.53)	0.608
	present	Reference		Reference		Reference		Reference		Reference
GSTT1	null genotype	0.63 (0.42–0.95)	0.026	0.63 (0.40–0.98)	0.041	0.51 (0.28–0.93)	0.028	0.72 (0.44–1.18)	0.198	1.15 (0.74–1.79)	0.527
	AA	Reference		Reference		Reference		Reference		Reference
	AG	0.80 (0.57–1.13)	0.209	0.74 (0.51–1.07)	0.114	0.70 (0.44–1.11)	0.129	1.01 (0.67–1.53)	0.955	1.37 (0.97–1.94)	0.075
GSTP1 rs1695
	GG	0.80 (0.45–1.40)	0.428	0.67 (0.36–1.25)	0.208	0.86 (0.41–1.80)	0.698	1.01 (0.51–1.97)	0.988	1.50 (0.84–2.67)	0.170
	AG+GG	0.80 (0.58–1.11)	0.185	0.73 (0.51–1.04)	0.078	0.73 (0.47–1.13)	0.157	1.01 (0.68–1.5)	0.958	1.39 (1.00–1.94)	0.049
GSTP1	CC	Reference		Reference		Reference		Reference		Reference
rs1138272	CT+TT	0.70 (0.46–1.05)	0.087	0.64 (0.40–1.01)	0.056	0.82 (0.47–1.43)	0.482	0.73 (0.44–1.21)	0.216	1.14 (0.72–1.79)	0.583

The association between different asbestos-related diseases and genotypes in multivariate analysis

		Asbestos-related disease vs. no disease		Pleural plaques vs. no disease		Asbestosis vs. no disease		MM vs. no disease		MM vs. plaques
Polymorphism	Genotype
		OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
GCLC	CC	Reference		Reference		Reference		Reference		Reference
rs17883901	CT+TT	1.18 (0.75–1.86)	0.466	1.33 (0.83–2.12)	0.240	0.96 (0.52–1.78)	0.893	0.66 (0.28–1.57)	0.344	0.57 (0.26–1.23)	0.154
	CC	Reference		Reference		Reference		Reference		Reference
GCLM	CT	1.16 (0.8–1.68)	0.431	1.22 (0.82–1.79)	0.323	1.10 (0.67–1.81)	0.695	0.98 (0.51–1.87)	0.945	0.76 (0.43–1.36)	0.360
rs41303970	TT	1.16 (0.55–2.42)	0.696	1.06 (0.48–2.32)	0.883	1.37 (0.52–3.63)	0.524	1.13 (0.33–3.84)	0.844	1.05 (0.35–3.09)	0.934
	CT+TT	1.16 (0.82–1.64)	0.406	1.19 (0.82–1.72)	0.351	1.14 (0.72–1.83)	0.576	1.00 (0.55–1.84)	0.994	0.80 (0.47–1.38)	0.429
	present	Reference		Reference		Reference		Reference		Reference
GSTM1	null genotype	1.04 (0.74–1.46)	0.837	1.06 (0.74–1.53)	0.738	0.84 (0.53–1.34)	0.464	1.09 (0.60–1.98)	0.774	1.09 (0.63–1.87)	0.756
	present	Reference		Reference		Reference		Reference		Reference
GSTT1	null genotype	0.62 (0.41–0.94)	0.025	0.63 (0.4–0.99)	0.046	0.51 (0.27–0.95)	0.033	1.00 (0.48–2.08)	0.996	1.28 (0.65–2.53)	0.479
	AA	Reference		Reference		Reference		Reference		Reference
GSTP1 rs1695	AG	0.78 (0.54–1.11)	0.162	0.74 (0.51–1.07)	0.113	0.65 (0.40–1.06)	0.087	1.23 (0.66–2.32)	0.513	1.86 (1.04–3.30)	0.036
	GG	0.8 (0.45–1.43)	0.461	0.67 (0.36–1.24)	0.203	0.96 (0.45–2.06)	0.920	1.65 (0.65–4.16)	0.288	2.40 (1.04–5.54)	0.039
	AG+GG	0.78 (0.56–1.1)	0.153	0.72 (0.51–1.04)	0.077	0.71 (0.45–1.12)	0.140	1.31 (0.72–2.39)	0.370	1.97 (1.14–3.39)	0.015
GSTP1	CC	Reference		Reference		Reference		Reference		Reference
rs1138272	CT+TT	0.68 (0.44–1.04)	0.078	0.64 (0.4–1.02)	0.059	0.84 (0.47–1.51)	0.565	0.73 (0.34–1.60)	0.433	1.02 (0.49–2.13)	0.965

Characteristics of subjects without asbestos-related disease, subjects with pleural plaques, asbestosis or malignant mesothelioma

Characteristic		No disease (N = 178)	Pleural plaques (N = 390)	Asbestosis (N = 147)	Malignant mesothelioma (N = 225)	P
	Male, N (%)	119 (66.9)	277 (71.0)	110 (74.8)	164 (72.9)	0.407
Gender						Chi-square = 2.905,
	Female, N (%)	59 (33.1)	113 (29.0)	37 (25.2)	61 (27.1)	df = 3
	Mean ± SD	57.6 ± 9.5	55.8 ± 9.5	58.7 ± 9.1	65.0 ± 10.7
Age (years)	Median (25%–75%)	56.6 (49.6–65.1)	55.0 (48.8–62.7)	59.1 (51.4–65.3)	66 (58–73)	Test-statistic < 0.001 = 115.390
	Min–max	38.2–79.9	34.4–85.8	37.2–79.2	19–95
	No, N (%)	95 (53.4)	193 (49.5)	72 (49.0)	117 (53.7) [7]	1.614
Smoking						Chi-square = 0.656,
	Yes, N (%)	83 (46.6)	197 (50.5)	75 (51.0)	101 (46.3)	df = 3
	Mean ± SD	21.0 ± 15.8 [4]	18.1 ± 15.6 [22]	24.4 ± 18.6 [2]	23.2 ± 17.2 [14]
Pack-(smokers years of only) smoking	Median (25%–75%)	20 (9–30)	15 (5–28)	22.8 (10–32.7)	20 (8–35)	Test-statistic 0.024 = 9.474
	Min–max	0.1–65.3	0.05–96.6	0.15–90	1–69
	Low, N (%)	138 (77.5)	277 (72.3) [7]	75 (51.7) [2]	34 (45.9) [151]
						< 0.001
Asbestos exposure	Middle, N (%)	13 (7.3)	38 (9.9)	28 (19.3)	23 (31.1)	Chi-square = 53.864,
	High, N (%)	27 (15.2)	68 (17.8)	42 (29.0)	17 (23.0)	df = 6

eISSN:: 1581-3207
Język:: Angielski

Częstotliwość wydawania:: 4 razy w roku
Dziedziny czasopisma:: Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology

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