Polymorphism | Genotype | All subjects (N = 940) | No disease (N = 178) | Pleural plaques (N = 416) | Asbestosis (N = 160) | Malignant mesothelioma (N = 154) |
---|---|---|---|---|---|---|
CC | 772 (82.1) | 149 (83.7) | 310 (79.5) | 124 (84.4) | 189 (84) | |
CT | 162 (17.2) | 29 (16.3) | 78 (20) | 23 (15.6) | 32 (14.2) | |
TT | 6 (0.6) | 0 (0) | 2 (0.5) | 0 (0) | 4 (1.8) | |
CC | 581 (61.8) | 114 (64) | 233 (59.7) | 87 (59.2) | 147 (65.3) | |
CT | 306 (32.6) | 54 (30.3) | 135 (34.6) | 51 (34.7) | 66 (29.3) | |
TT | 53 (5.6) | 10 (5.6) | 22 (5.6) | 9 (6.1) | 12 (5.3) | |
present | 384 (40.9) | 74 (41.6) | 159 (40.8) | 64 (43.5) | 87 (38.7) | |
null genotype | 556 (59.1) | 104 (58.4) | 231 (59.2) | 83 (56.5) | 138 (61.3) | |
present | 782 (83.2) | 138 (77.5) | 330 (84.6) | 128 (87.1) | 186 (82.7) | |
null genotype | 158 (16.8) | 40 (22.5) | 60 (15.4) | 19 (12.9) | 39 (17.3) | |
AA | 454 (78.3) | 78 (43.8) | 202 (51.8) | 76 (51.7) | 98 (43.6) | |
AG | 394 (41.9) | 81 (45.5) | 155 (39.7) | 55 (37.4) | 103 (45.8) | |
GG | 92 (9.8) | 19 (10.7) | 33 (8.5) | 16 (10.9) | 24 (10.7) | |
CC | 785 (83.5) | 141 (79.2) | 334 (85.6) | 121 (82.3) | 189 (84) | |
CT | 146 (15.5) | 34 (19.1) | 54 (13.8) | 23 (15.6) | 35 (15.6) | |
TT | 9 (1.0) | 3 (1.7) | 2 (0.5) | 3 (2) | 1 (0.4) |
Asbestos-related disease | Pleural plaques | Asbestosis | MM | MM | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Polymorphism | Genotype | ||||||||||
OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
CC | Reference | Reference | Reference | Reference | Reference | ||||||
rs17883901 | CT+TT | 1.15 (0.74–1.78) | 0.541 | 1.33 (0.83–2.12) | 0.237 | 0.95 (0.52–1.73) | 0.874 | 0.98 (0.57–1.67) | 0.937 | 0.74 (0.48–1.14) | 0.169 |
CC | Reference | Reference | Reference | Reference | Reference | ||||||
CT | 1.14 (0.80–1.63) | 0.476 | 1.22 (0.83–1.80) | 0.308 | 1.24 (0.77–1.99) | 0.378 | 0.95 (0.61–1.46) | 0.809 | 0.77 (0.54–1.11) | 0.164 | |
rs41303970 | TT | 1.05 (0.51–2.15) | 0.895 | 1.08 (0.49–2.35) | 0.853 | 1.18 (0.46–3.03) | 0.732 | 0.93 (0.39–2.23) | 0.872 | 0.86 (0.42–1.80) | 0.697 |
CT+TT | 1.13 (0.80–1.58) | 0.495 | 1.20 (0.83–1.73) | 0.330 | 1.23 (0.78–1.93) | 0.369 | 0.95 (0.63–1.43) | 0.788 | 0.79 (0.56–1.11) | 0.170 | |
present | Reference | Reference | Reference | Reference | Reference | ||||||
null genotype | 1.04 (0.74–1.44) | 0.828 | 1.03 (0.72–1.48) | 0.857 | 0.92 (0.59–1.44) | 0.721 | 1.13 (0.76–1.69) | 0.554 | 1.09 (0.78–1.53) | 0.608 | |
present | Reference | Reference | Reference | Reference | Reference | ||||||
null genotype | 0.63 (0.42–0.95) | 0.63 (0.40–0.98) | 0.51 (0.28–0.93) | 0.72 (0.44–1.18) | 0.198 | 1.15 (0.74–1.79) | 0.527 | ||||
AA | Reference | Reference | Reference | Reference | Reference | ||||||
AG | 0.80 (0.57–1.13) | 0.209 | 0.74 (0.51–1.07) | 0.114 | 0.70 (0.44–1.11) | 0.129 | 1.01 (0.67–1.53) | 0.955 | 1.37 (0.97–1.94) | 0.075 | |
GG | 0.80 (0.45–1.40) | 0.428 | 0.67 (0.36–1.25) | 0.208 | 0.86 (0.41–1.80) | 0.698 | 1.01 (0.51–1.97) | 0.988 | 1.50 (0.84–2.67) | 0.170 | |
AG+GG | 0.80 (0.58–1.11) | 0.185 | 0.73 (0.51–1.04) | 0.078 | 0.73 (0.47–1.13) | 0.157 | 1.01 (0.68–1.5) | 0.958 | 1.39 (1.00–1.94) | ||
CC | Reference | Reference | Reference | Reference | Reference | ||||||
rs1138272 | CT+TT | 0.70 (0.46–1.05) | 0.087 | 0.64 (0.40–1.01) | 0.056 | 0.82 (0.47–1.43) | 0.482 | 0.73 (0.44–1.21) | 0.216 | 1.14 (0.72–1.79) | 0.583 |
Asbestos-related disease | Pleural plaques | Asbestosis | MM | MM | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Polymorphism | Genotype | ||||||||||
OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
CC | Reference | Reference | Reference | Reference | Reference | ||||||
rs17883901 | CT+TT | 1.18 (0.75–1.86) | 0.466 | 1.33 (0.83–2.12) | 0.240 | 0.96 (0.52–1.78) | 0.893 | 0.66 (0.28–1.57) | 0.344 | 0.57 (0.26–1.23) | 0.154 |
CC | Reference | Reference | Reference | Reference | Reference | ||||||
CT | 1.16 (0.8–1.68) | 0.431 | 1.22 (0.82–1.79) | 0.323 | 1.10 (0.67–1.81) | 0.695 | 0.98 (0.51–1.87) | 0.945 | 0.76 (0.43–1.36) | 0.360 | |
rs41303970 | TT | 1.16 (0.55–2.42) | 0.696 | 1.06 (0.48–2.32) | 0.883 | 1.37 (0.52–3.63) | 0.524 | 1.13 (0.33–3.84) | 0.844 | 1.05 (0.35–3.09) | 0.934 |
CT+TT | 1.16 (0.82–1.64) | 0.406 | 1.19 (0.82–1.72) | 0.351 | 1.14 (0.72–1.83) | 0.576 | 1.00 (0.55–1.84) | 0.994 | 0.80 (0.47–1.38) | 0.429 | |
present | Reference | Reference | Reference | Reference | Reference | ||||||
null genotype | 1.04 (0.74–1.46) | 0.837 | 1.06 (0.74–1.53) | 0.738 | 0.84 (0.53–1.34) | 0.464 | 1.09 (0.60–1.98) | 0.774 | 1.09 (0.63–1.87) | 0.756 | |
present | Reference | Reference | Reference | Reference | Reference | ||||||
null genotype | 0.62 (0.41–0.94) | 0.63 (0.4–0.99) | 0.51 (0.27–0.95) | 1.00 (0.48–2.08) | 0.996 | 1.28 (0.65–2.53) | 0.479 | ||||
AA | Reference | Reference | Reference | Reference | Reference | ||||||
AG | 0.78 (0.54–1.11) | 0.162 | 0.74 (0.51–1.07) | 0.113 | 0.65 (0.40–1.06) | 0.087 | 1.23 (0.66–2.32) | 0.513 | 1.86 (1.04–3.30) | ||
GG | 0.8 (0.45–1.43) | 0.461 | 0.67 (0.36–1.24) | 0.203 | 0.96 (0.45–2.06) | 0.920 | 1.65 (0.65–4.16) | 0.288 | 2.40 (1.04–5.54) | ||
AG+GG | 0.78 (0.56–1.1) | 0.153 | 0.72 (0.51–1.04) | 0.077 | 0.71 (0.45–1.12) | 0.140 | 1.31 (0.72–2.39) | 0.370 | 1.97 (1.14–3.39) | ||
CC | Reference | Reference | Reference | Reference | Reference | ||||||
rs1138272 | CT+TT | 0.68 (0.44–1.04) | 0.078 | 0.64 (0.4–1.02) | 0.059 | 0.84 (0.47–1.51) | 0.565 | 0.73 (0.34–1.60) | 0.433 | 1.02 (0.49–2.13) | 0.965 |
Characteristic | No disease (N = 178) | Pleural plaques (N = 390) | Asbestosis (N = 147) | Malignant mesothelioma (N = 225) | P | |
---|---|---|---|---|---|---|
Male, N (%) | 119 (66.9) | 277 (71.0) | 110 (74.8) | 164 (72.9) | 0.407 | |
Gender | Chi-square = 2.905, | |||||
Female, N (%) | 59 (33.1) | 113 (29.0) | 37 (25.2) | 61 (27.1) | df = 3 | |
Mean ± SD | 57.6 ± 9.5 | 55.8 ± 9.5 | 58.7 ± 9.1 | 65.0 ± 10.7 | ||
Age (years) | Median (25%–75%) | 56.6 (49.6–65.1) | 55.0 (48.8–62.7) | 59.1 (51.4–65.3) | 66 (58–73) | Test-statistic < 0.001 = 115.390 |
Min–max | 38.2–79.9 | 34.4–85.8 | 37.2–79.2 | 19–95 | ||
No, N (%) | 95 (53.4) | 193 (49.5) | 72 (49.0) | 117 (53.7) [7] | 1.614 | |
Smoking | Chi-square = 0.656, | |||||
Yes, N (%) | 83 (46.6) | 197 (50.5) | 75 (51.0) | 101 (46.3) | df = 3 | |
Mean ± SD | 21.0 ± 15.8 [4] | 18.1 ± 15.6 [22] | 24.4 ± 18.6 [2] | 23.2 ± 17.2 [14] | ||
Pack-(smokers years of only) smoking | Median (25%–75%) | 20 (9–30) | 15 (5–28) | 22.8 (10–32.7) | 20 (8–35) | Test-statistic 0.024 = 9.474 |
Min–max | 0.1–65.3 | 0.05–96.6 | 0.15–90 | 1–69 | ||
Low, N (%) | 138 (77.5) | 277 (72.3) [7] | 75 (51.7) [2] | 34 (45.9) [151] | ||
< 0.001 | ||||||
Asbestos exposure | Middle, N (%) | 13 (7.3) | 38 (9.9) | 28 (19.3) | 23 (31.1) | Chi-square = 53.864, |
High, N (%) | 27 (15.2) | 68 (17.8) | 42 (29.0) | 17 (23.0) | df = 6 |