Target volume/ Organ at risk | The whole group | Small CTV | Medium CTV | Large CTV | p value |
---|---|---|---|---|---|
CTV [cm3] | 800.6 (124.8–2970.9) | 425.7 (124.8–545.5) | 867.0 (652.1–1295.1) | 1586.8 (1348.9–2970.9) | 0.021 |
PTVeval [cm3] | 990.7 (233.5–3336.1) | 583.0 (233.5–711.1) | 1035.9 (834.3–1576.5) | 1874.3 (1605.8–3336.1) | < 0.005 |
PTV [cm3] | 1163.3 (340.1–3792.2) | 730.7 (340.1–856.6) | 1212.3 (985.1–1805) | 2134.8 (1826.4–3792.2) | < 0.005 |
CWS [cm] | 23.1 (17.9–33.2) | 19.5 (17.9–23.2) | 24.0 (19.9–28.5) | 27.5 (22.9–33.2) | < 0.005 |
4th arch metrics [cm] | 4.4 (0–11.6) | 1.6 (0–9.6) | 5.5 (0–11.6) | 7.1 (0–10.7) | 0.008 |
Heart [cm3] | 677.7 (432.9–1192.7) | 625.2 (432.9–912.8) | 671.1 (563.5–872.4) | 817.9 (620.1–1192.7) | < 0.005 |
Left Ventricle [cm3] | 173.8 (116–277.4) | 161.3 (116–251.7) | 173.8 (120.8–229.8) | 188.7 (147.4–277.4) | 0.018 |
Left Lung [cm3] | 1245.1 (809.3–2127.9) | 1458.9 (824.5–2127.9) | 1123.8 (944.2–1619.2) | 1230.6 (809.3–1541.7) | 0.003 |
Right Lung [cm3] | 1563.4 (855–2560.1) | 1721.9 (992.9–2560.1) | 1466.4 (855.1–1838.2) | 1493.2 (1089.6–1925.6) | 0.002 |
Lungs [cm3] | 2879.7 (1504.6–4789.2) | 3241.3 (1877.5–4789.2) | 2634.4 (1504.6–3513.6) | 2799.8 (1960.2–3479.2) | 0.001 |
Parameter | 3D-CRT | t-IMRT | p value* |
---|---|---|---|
MWHD [Gy] | 1.90 (0.61–4.14) | 2.13 (1.06–4.4) | < 0.005 |
LV-Dmean [Gy] | 2.98 (0.78–8.03) | 3.22 (1.31–7.25) | < 0.005 |
LV-V5 Gy [%] | 8.67 (0–26.3) | 9.21 (0–26.02) | 0.455 |
LV-V23 Gy [%] | 2.46 (0–14.32) | 1.86 (0–10.58) | 0.003 |
LV anterior-Dmean [Gy] | 5.00 (1.27–20.17) | 5.42 (1.94–19.18) | < 0.005 |
LV apical-Dmean [Gy] | 8.97 (1.22–24.89) | 8.47 (1.64–22.16) | < 0.005 |
LADCA-Dmean [Gy] | 8.20 (1.23–27.92) | 8.39 (1.8–27.62) | < 0.005 |
LADCA-V30 Gy [%] | 5.39 (0–66.34) | 2.01 (0–84.20) | < 0.005 |
LADCA-V40 Gy [%] | 0 (0–37.8) | 0 (0–43.09) | < 0.005 |
LADCA-prox-Dmean [Gy] | 2.17 (0.62–8.68) | 2.66 (1.22–12.43) | < 0.005 |
LADCA-mid-Dmean [Gy] | 9.63 (1.67–40.07) | 11.05 (2.26–39.63) | 0.956 |
LADCA-dist-Dmean [Gy] | 13.73 (1.44–41.11) | 15.93 (2.03–3.89) | 0.132 |
Small CTV | Medium CTV | Large CTV | |||||
---|---|---|---|---|---|---|---|
Parameter | p value | ||||||
3D-CRT | t-IMRT | 3D-CRT | t-IMRT | 3D-CRT | t-IMRT | ||
MWHD [Gy] | 1.29 (0.61–3.75) | 1.99 (1.06–3.98) | 2.05 (1.06–3.84) | 2.11 (1.62–3.54) | 2.26 (1.04–4.14) | 2.72 (1.46–4.4) | < 0.005*; 0.047† |
Heart-V5 Gy [%] | 2.56 (0.02–10.84) | 3.77 (0.1–11.01) | 4.99 (0.59–10.87) | 4.34 (1.19–9.58) | 5.29 (0–12.81) | 6.19 (0.04–12.83) | 0.043* |
Heart-V10 Gy [%] | 1.28 (0–7.91) | 2.01 (0–7.59) | 2.71 (0.01–7.73) | 2.24 (0.12–68.14) | 3.09 (0–8.24) | 3.17 (0–8.54) | NS |
Heart-V17 Gy [%] | 0.76 (0–6.61) | 1.22 (0–6.08) | 2.03 (0–6.52) | 1.36 (0–4.79) | 2.37 (0–6.92) | 3.36 (0–6.42) | NS |
Heart-V20 Gy [%] | 0.62 (0–6.22) | 1 (0–5.63) | 1.83 (0–6.16) | 1.17 (0–4.38) | 2.15 (0–6.51) | 2.01 (0–5.81) | NS |
Heart-V35 Gy [%] | 0.15 (0–4.12) | 0.2 (0–3.4) | 0.93 (0–4.15) | 0.31 (0–2.3) | 1.06 (0–4.32) | 0.63 (0–2.91) | NS |
Heart-V40 Gy [%] | 0.02 (0–1.41) | 0.01 (0–1.65) | 0.24 (0–1.45) | 0.03 (0–0.42) | 0.03 (0–1.93) | 0.04 (0–1.69) | NS |
LV-Dmean [Gy] | 2.3 (0.7–5.7) | 2.9 (1.31–5.84) | 3.2 (1.1–6.9) | 3.15 (1.78–5.97) | 3.5 (1.3–8.0) | 3.92 (1.83–7.25) | 0.019* |
LV-V5 Gy [%] | 6.8 (0–17.4) | 8.27 (0–17.39) | 9.7 (0–22.0) | 8.47 (0.46–19.87) | 10.8 (0–26.3) | 12 (0–26.02) | 0.052* |
LV-V23 Gy [%] | 1.4 (0–9.5) | 1.73 (0–8.47) | 2.8 (0–12.0) | 1.81 (0–8.18) | 3.3 (0–14.3) | 3.1 (0–10.58) | NS |
LV anterior-Dmean [Gy] | 3.6 (1.2–12.8) | 4.86 (1.94–12.35) | 6.8 (2.0–15.9) | 5.71 (2.69–14.48) | 6.8 (1.9–20.1) | 6.94 (2.58–19.18) | 0.017* |
LV lateral-Dmean [Gy] | 1.6 (0.7–2.8) | 2.16 (1.18–3.38) | 1.8 (0.9–6.3) | 2.24 (1.55–5.12) | 2.5 (1.2–8.7) | 2.98 (1.73–7.59) | < < 0.0010.001*, |
LV inferior-Dmean [Gy] | 0.5 (0.3–3.3) | 0.96 (0.77–1.17) | 0.6 (0.5–0.9) | 1.07 (0.9–1.32) | 0.8 (0.6–2.0) | 1.33 (0.96–1.98) | < < 0.0050.005*, |
LV septal-Dmean [Gy] | 1.2 (0.4–3.4) | 1.8 (1.01–3.71) | 1.6 (1.1–3.4) | 2.19 (1.77–3.74) | 1.9 (1.2–3.9) | 2.56 (1.72–4.46) | < < 0.0050.005*, |
LV apical-Dmean [Gy] | 6.9 (1.2–19.6) | 8.54 (1.64–19.79) | 9.0 (1.7–21.9) | 8.42 (2.46–19.68) | 9.5 (1.2–24.8) | 8.91 (1.76–22.16) | NS |
LADCA-Dmean [Gy] | 5.2 (1.2–27.9) | 6.84 (1.8–27.62) | 13.8 (2.6–25.2) | 10.76 (3.01–20.73) | 11.1 (2.2–21.2) | 8.24 (2.84–21.22) | NS |
LADCA-V30 Gy [%] | 0.2 (0–66.3) | 0.36 (0–63.48) | 17.8 (0–59.0) | 7.39 (0–84.2) | 8.9 (0–43.3) | 2.13 (0–46.34) | NS |
LADCA-V40 Gy [%] | 0 (0–37.8) | 0 (0–43.09) | 0.5 (0–32.9) | 0 (0–3.22) | 0 (0–19.2) | 0 (0–7.26) | NS |
LADCA-prox-Dmean [Gy] | 1.6 (0.6–8.6) | 2.22 (1.22–7.95) | 2.9 (0.6–7.2) | 2.96 (1.96–5.19) | 2.5 (1.4–7.2) | 2.84 (2.07–12.43) | < 0.001*, 0.002† |
LADCA-mid-Dmean [Gy] | 7.9 (1.6–40.0) | 9.12 (2.26–39.63) | 17.9 (2.0–38.7) | 13.81 (4.22–30.95) | 10.4 (2.5–29.8) | 11.14 (3.23–36.01) | NS |
LADCA-dist-Dmean [Gy] | 5.5 (1.4–41.1) | 8.58 (2.03–40.65) | 26.9 (3.5–39.4) | 17.46 (3.98–35.39) | 14.0 (2.4–39.7) | 16.32 (2.87–34.95) | NS |
Structure | Target goals |
---|---|
PTV | D2%< 108% |
PTVeval | V95%> 95% |
Whole Body Contour | Global Dmax < V110% |
Dmean < 3.2 Gy | |
Heart | V17 Gy < 10% |
V35 Gy < 5% | |
Dmean < 10 Gy | |
Ipsilateral Lung | V17 Gy < 25% |
V26 Gy < 20% | |
Bilateral lung | Dmean < 3.2 Gy |
Target volume | 3D-CRT | t-IMRT | p value |
---|---|---|---|
PTVeval D98% [Gy] | 40.6 (39.8–41.4) | 40.3 (38.7–41.6) | 0.002 |
PTVeval D2% [Gy] | 44.7 (44.4–45.5) | 43.8 (43.8–47.1) | NS |
PTVeval D50% [Gy] | 43.3 (42.7–43.7) | 42.9 (42.2–43.9) | < 0.005 |
PTVeval V95% [%] | 98.1 (95.3–99.6) | 96.8 (79.9–99.9) | 0.001 |
PTVeval V105% [%] | 1.3 (0.1–10.3) | 4.3 (0.01–85.9) | < 0.005 |
PTVeval V105% [cm3] | 11.7 (0.08–656.7) | 5.4 (0.06–68.0) | 0.014 |
PTVeval V107% [%] | 0 (0–1.4) | 0.1 (0–9.6) | < 0.005 |
PTVeval V107% [cm3] | 0 (0–321.4) | 0 (0–7.2) | NS |
PTVeval V110% [%] | 0 (0–0) | 0 (0–0) | NS |
Dmax [Gy] | 45.7 (45.1–46.9) | 46.9 (45.3–51) | < 0.005 |
Target volume | Small CTV | Medium CTV | Large CTV | p value (S vs. M vs. L) |
---|---|---|---|---|
3D-CRT PTVeval V95% [%] | 97.7 (95.3–99.6) | 98.3 (96.2–99.5) | 98.8 (97.5–99.4) | 0.022 (S |
t-IMRT PTVeval V95% [%] | 97.9 (96.3–99.2) | 97.3 (95.3–99.0) | 96.8 (79.9–99.9) | NS |
NS | p = 0.003 | p = 0.013 | ||
3D-CRT PTVeval V105% [cm3] | 8.1 (0.5–17.5) | 12.5 (0.08–91.3) | 87.3 (9.5–656.6) | < 0.005 (S |
t-IMRT PTVeval V105% [cm3] | 7.4 (0.1–61.5) | 5.9 (0.09–54) | 4.2 (0.06–68.2) | NS |
NS | NS | p = 0.012 |