Characteristic | All patients median (range) | Responders (OS > 14.9 months) median (range) | Non-responders (OS < 14.9 months) median (range) | p-value |
---|---|---|---|---|
Number of patients | 30 | 16 | 14 | |
Age [years] | 65 (46–77) | 67 (48–76) | 61 (46–77) | 0.298 |
PD-L1 TPS [%] | 75 (3–100) | 77.5 (3–100) | 75 (10–100) | 0.933 |
Female | 15 | 9 | 6 | |
Male | 15 | 7 | 8 | |
Adenocarcinoma | 17 | 8 | 9 | |
Squamous cell carcinoma | 8 | 4 | 4 | |
Other | 5 | 4 | 1 | |
Never | 1 | 0 | 1 | |
Former > 3 years ago | 12 | 7 | 5 | |
Former < 3 years ago | 5 | 3 | 2 | |
Until current disease | 8 | 3 | 5 | |
Current smoker | 4 | 3 | 1 | |
0 | 8 | 2 | 6 | |
1 | 18 | 12 | 6 | |
2 | 4 | 2 | 2 | |
1st | 15 | 10 | 5 | |
2nd | 13 | 4 | 9 | |
3rd | 2 | 2 | 0 | |
No | 24 | 12 | 12 | |
Yes | 6 | 4 | 2 |
Feature | Responders (OS > 14.9 months) median (range) | Non-responders (OS < 14.9 months) median (range) | p-value | AUC (95% CI) |
---|---|---|---|---|
Volume [cm3] | 27.9 (2.64–351) | 44.4 (7.81–792) | 0.098 | 0.69 (0.49–0.89) |
SUVmax [g/ml] | 20.6 (5.21–32.1) | 15.6 (9.54–37.0) | 0.185 | 0.65 (0.43–0.87) |
Sum entropy | 3.69 (3.53–3.77) | 3.7 (3.54–3.76) | 0.387 | 0.60 (0.38–0.82) |
Difference entropy | 2.98 (2.74–3.07) | 2.89 (2.74–3.06) | 0.080 | 0.70 (0.49–0.90) |
Feature | Univariate HR (95% CI) | Univariate p-value | Multivariate HR (95% CI) | Multivariate p-value |
---|---|---|---|---|
SUVmax | 0.77 (0.46–1.3) | 0.320 | ||
Sum Entropy | 0.96 (0.60–1.5) | 0.860 | ||
Entropy-GLCM | 1.4 (0.82–2.3) | 0.230 | ||