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Advances in the management of craniopharyngioma in children and adults

Mojca Jensterle

Mojca Jensterle

  • Department of Endocrinology, Diabetes and Metabolism, University Medical Centre LjubljanaLjubljana, Slovenia
  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Jensterle, Mojca
, 
Soncka Jazbinsek

Soncka Jazbinsek

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Department of Endocrinology, Diabetes and Metabolism, University Children’s Hospital, University Medical Centre LjubljanaLjubljana, Slovenia
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Jazbinsek, Soncka
, 
Roman Bosnjak

Roman Bosnjak

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Department of Neurosurgery, University Medical Centre LjubljanaLjubljana, Slovenia
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Bosnjak, Roman
, 
Mara Popovic

Mara Popovic

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Institute of Pathology, Medical Faculty, University of LjubljanaLjubljana, Slovenia
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Popovic, Mara
, 
Lorna Zadravec Zaletel

Lorna Zadravec Zaletel

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Department of Radiotherapy, Institute of Oncology LjubljanaLjubljana, Slovenia
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Zaletel, Lorna Zadravec
, 
Tina Vipotnik Vesnaver

Tina Vipotnik Vesnaver

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Clinical Institute of Radiology, University Medical Centre LjubljanaLjubljana, Slovenia
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Vesnaver, Tina Vipotnik
, 
Barbara Faganel Kotnik

Barbara Faganel Kotnik

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Department of Hematology and Oncology, University Children’s Hospital, University Medical Centre LjubljanaLjubljana, Slovenia
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Kotnik, Barbara Faganel
 oraz 
Primoz Kotnik

Primoz Kotnik

  • Medical Faculty, University of LjubljanaLjubljana, Slovenia
  • Department of Endocrinology, Diabetes and Metabolism, University Children’s Hospital, University Medical Centre LjubljanaLjubljana, Slovenia
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Kotnik, Primoz
  
25 paź 2019
Advances in the management of craniopharyngioma in children and adults's Cover Image
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Kategoria artykułu: Review
Data publikacji: 25 paź 2019
Zakres stron: 388 - 396
Otrzymano: 21 cze 2019
Przyjęty: 11 lip 2019
DOI: https://doi.org/10.2478/raon-2019-0036
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© 2019 Mojca Jensterle, Soncka Jazbinsek, Roman Bosnjak, Mara Popovic, Lorna Zadravec Zaletel, Tina Vipotnik Vesnaver, Barbara Faganel Kotnik, Primoz Kotnik, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Large, partially solid, partially multicystic adamantinomatous craniopharyngioma in a 5-year old boy. (A) Coronal T2 sequence through sellar region; solid part of the tumor (white arrow) involves enlarged sella turcica, parasellar regions, occupies the suprasellar cistern and the third ventricle. The cystic portion of the tumor (black arrow) extends into the lateral ventricles and on the right side it infiltrates the adjacent brain parenchym (small arrow). Lateral ventricles are enlarged with a band of periventricular transependimal edema as a sign of acute hydrocephalus. (B) Sagital T2 sequence through the sellar region; Hypothalamus and mammillary bodies are not visible (arrow). (C) SWI sequence through the multicystic portion of the tumor shows multiple calcifications in the cyst walls (arrow).
Large, partially solid, partially multicystic adamantinomatous craniopharyngioma in a 5-year old boy. (A) Coronal T2 sequence through sellar region; solid part of the tumor (white arrow) involves enlarged sella turcica, parasellar regions, occupies the suprasellar cistern and the third ventricle. The cystic portion of the tumor (black arrow) extends into the lateral ventricles and on the right side it infiltrates the adjacent brain parenchym (small arrow). Lateral ventricles are enlarged with a band of periventricular transependimal edema as a sign of acute hydrocephalus. (B) Sagital T2 sequence through the sellar region; Hypothalamus and mammillary bodies are not visible (arrow). (C) SWI sequence through the multicystic portion of the tumor shows multiple calcifications in the cyst walls (arrow).

Comparison of pediatric and adult-onset craniopharyngioma characteristics

Pediatric-onsetAdult-onset
30–50 % of all CPs
Age at presentationPeak at 5–14 years1Peak at 40–44 years2
Gender distribution (m/f)Equal8,21Equal8,27
Most frequent presentationHeadache (68–85%)Visual impairment (40–84%)
Visual impairment (36– 55%)Menstrual irregularities (57%)
Growth failure (7–36%)9,35,66Headache (42–56%)13,26,27
Pathohistological typeAdamantinomatous 99%33
Papillary extremely rare*Papillary 14–50%
Initial hypothalamic involvement42–66%8,9,3542%18
Endocrine deficits at diagnosis
Any40–87%8,13,21,35,65,6641–73%8
GH41–75%8,13,21,35,65,6618–86%8,13
FSH/LH20–56%8,13,21,35,65,6629–74%8,13
ACTH8–68%8,13,21,35,65,6635–58%8,13
TSH15–32%8,13,21,35,65,6635–56%8,13
ADH7–17%8,13,21,35,65,666–17%8,13
Pituitary hormone deficiencies after treatment
Any64–100%8,6448–97%8,64
GH93–96%8,18,2152–68%8,18
FSH/LH59–95%8,18,2170–94%8,18
ACTH78–100%8,18,2174–88%8,18
TSH86–100%8,18,2181–92%8,18
ADH65–96%8,18,2143–70%8,18
Panhypopituitarism***43–100%8,18,6459–74%8,18,64
Obesity**44–64%8,9,19,6441–47%8,19,64
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Medycyna, Medycyna kliniczna, Medycyna wewnętrzna, Hematologia, onkologia, Radiologia
Kanał RSS czasopisma