Genotype | ≥ 1000 blasts | 100 ≤ blasts < 1000 | 1 ≤ blasts < 100 | blast negative patients | GC response (cutoff=1000 blasts) Association with prednosine response on day 8 according to Berlin-Frankfurt-Munster (BFM) protocol: prednisone poor responder (PPR) group (≥1000 blasts) vs. prednisone good responder (PGR) group (< 1000 blasts) | GC response (cutoff=1000 blasts) Association with prednosine response on day 8 according to Berlin-Frankfurt-Munster (BFM) protocol: prednisone poor responder (PPR) group (≥1000 blasts) vs. prednisone good responder (PGR) group (< 1000 blasts) Adjusted for age, gender and initial white blood cells (WBC) count using logistic regression | GC response (cutoff=100 blasts) Association with number of blasts on day 8 with cut-off value of 100: higher (≥ 100 blasts) vs lower (< 100 blasts) number of blasts | GC response (cutoff=100 blasts) Association with number of blasts on day 8 with cut-off value of 100: higher (≥ 100 blasts) vs lower (< 100 blasts) number of blasts Adjusted for age, gender and initial white blood cells (WBC) count using logistic regression | GC response (cutoff=0 blasts) Association with blast status on day 8: blast positive vs blast negative patients. | GC response (cutoff=0 blasts) Association with blast status on day 8: blast positive vs blast negative patients. Adjusted for age, gender and initial white blood cells (WBC) count using logistic regression |
---|---|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | OR[95%CI] P value | OR[95%CI] P value | OR[95%CI] P value | OR[95%CI] P value | OR[95%CI] P value | OR[95%CI] P value | |
CC | 10 (76.9) | 21 (67.7) | 33 (86.8) | 32 (80.0) | reference | reference | reference | reference | reference | reference |
CT | 3 (23.1) | 9 (29.0) | 4 (10.5) | 6 (15.0) | 1.12[0.29-4.41] 1 Fisher exact test | 1.10[0.21-5.92] 0.910 | 2.1[0.87-5.05] 0.095 | 1.85[0.73-4.71] 0.195 | 1.12[0.44-2.86] 0.805 | 0.89[0.32-2.44] 0.826 |
TT | 0 (0.0) | 1 (3.2) | 1 (2.6) | 2 (5.0) | ||||||
AA | 4 (30.8) | 11 (35.5) | 7 (18.4) | 9 (22.5) | reference | reference | reference | reference | reference | reference |
AT | 4 (30.8) | 15 (48.4) | 19 (50.0) | 19 (47.5) | 0.74[0.21-2.60] 0.737 Fisher exact test | 0.71[0.16-3.13] 0.658 | 0.5[0.22-1.15] 0.098 | 0.53[0.28-1.26] 0.148 | 0.79[0.32-1.92] 0.606 | 0.83[0.32-2.11] 0.699 |
TT | 5 (38.5) | 5 (16.1) | 12 (31.6) | 12 (30.0) | ||||||
AA | 7 (53.8) | 21 (67.7) | 28 (73.7) | 30 (75.0) | reference | reference | reference | reference | reference | reference |
AG | 4 (30.8) | 10 (32.3) | 9 (23.7) | 10 (25.0) | ||||||
GG | 2 (15.4) | 0 (0.0) | 1 (2.6) | 0 (0.0) | 19.64[1.65-234.32] Recessive model Fisher exact test | 16.76[1.20-234.27] Recessive model | 1.66[0.75-3.68] 0.222 Recessive model | 4.01[0.34-47.4] 0.27 Recessive model | 1.04[0.99-1.08] 0.22 Recessive model | - 1 Recessive model |
AA | 7 (53.8) | 15 (48.4) | 16 (42.1) | 16 (40.0) | reference | reference | reference | reference | reference | reference |
AG | 5 (38.5) | 13 (41.9) | 18 (47.4) | 19 (47.5) | 0.65[0.21-2.06] 0.46 | 0.91[0.26-3.25] 0.885 | 0.70[0.33-1.46] 0.338 | 0.73[0.34-1.58] 0.423 | 0.77[0.36-1.66] 0.508 | 0.84[0.37-1.9] 0.682 |
GG | 1 (7.7) | 3 (9.7) | 4 (10.5) | 5 (12.5) | ||||||
CC | 9 (69.2) | 25 (80.6) | 31 (81.6) | 38 (95.0) | reference | reference | reference | reference | reference | reference |
CT | 3 (23.1) | 6 (19.4) | 7 (18.4) | 2 (5.0) | 2.79[0.76-10.20] 0.119 Fisher exact test | 3.17[0.76-13.28] 0.115 | 2.26[0.84-6.07] 0.122 | 2.23[0.81-6.15] 0.121 | 4.97[1.09-22.69] | 4.44[0.9-21.08] 0.060 |
TT | 1 (7.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||||
WT | 6 (46.2) | 13 (41.9) | 18 (47.4) | 19 (47.5) | reference | reference | reference | reference | reference | reference |
DEL | 7 (53.8) | 18 (58.1) | 20 (52.6) | 21 (52.5) | 0.99[0.31-3.13] 0.99 | 0.96[0.25-3.70] 0.953 | 1.19[0.56-2.50] 0.707 | 1.03[0.47-2.27] 0.941 | 1.0[0.51-2.38] 0.805 | 0.96[0.43-2.18] 0.935 |
WT | 8 (61.5) | 23 (74.2) | 31 (81.6) | 35 (87.5) | reference | reference | reference | reference | reference | reference |
DEL | 5 (38.5) | 8 (25.8) | 7 (18.4) | 5 (12.5) | 2.78[0.82-9.09] 0.138 Fisher exact test | 3.70[0.95-14.08] 0.058 | 2.33[0.94-5.56] 0.063 | 2.39[1.03-6.25] | 2.27[0.78-6.67] 0.127 | 2.06[0.67-6.29] 0.202 |
CC | 5 (38.5) | 10 (32.3) | 13 (34.2) | 13 (32.5) | reference | reference | reference | reference | reference | reference |
CT | 6 (46.2) | 16 (51.6) | 21 (55.3) | 17 (42.5) | 0.79[0.24-2.59] 0.759 Fisher exact test | 0.74[0.20-2.76] 0.651 | 0.97[0.44-2.11] 0.932 | 0.89[0.40-1.99] 0.773 | 0.92[0.41-2.07] 0.857 | 0.84[0.36-1.97] 0.691 |
TT | 2 (15.4) | 5 (16.1) | 4 (10.5) | 10 (25.0) | ||||||
GG | 5 (31.3) | 9 (24.3) | 15 (30.6) | 14 (27.5) | reference | reference | reference | reference | reference | reference |
GT | 4 (25.0) | 16 (43.2) | 17 (34.7) | 16 (31.4) | 0.86[0.26-2.80] 0.769 Fisher exact test | 1.08[0.29-4.05] 0.908 | 1.27[0.58-2.78] 0.693 | 1.27[0.56-2.88] 0.57 | 0.98[0.44-2.17] 0.968 | 0.9[0.39-2.1] 0.813 |
TT | 3 (18.8) | 5 (13.5) | 6 (12.2) | 9 (17.6) | ||||||
GA | 1 (6.3) | 1 (2.7) | 0 (0.0) | 1 (2.0) | ||||||
CC | 3 (23.1) | 6 (19.4) | 11 (28.9) | 11 (27.5) | reference | reference | reference | reference | reference | reference |
CT | 7 (53.8) | 16 (51.6) | 19 (50.0) | 18 (45.0) | 1.15[0.30-4.49] 1 Fisher exact test | 1.47[0.31-6.35] 0.657 | 1.53[0.63-3.70] 0.393 | 1.92[0.74-4.98] 0.18 | 1.17[0.5-2.77] 0.711 | 1.31[0.52-3.28] 0.559 |
TT | 3 (23.1) | 9 (29.0) | 8 (21.1) | 11 (27.5) |
Haplotype (estimated frequency) | Carrier status∗ | ≥ 1000 blasts | 100 ≤ blasts < 1000 | 1 ≤ blasts < 100 | blast negative patients | GC response (cutoff=1000 blasts) Association with blast status on day 8: blast positive vs blast negative patients. | GC response (cutoff=1000 blasts) Association with blast status on day 8: blast positive vs blast negative patients. Adjusted for age, gender and initial white blood cells (WBC) count using logistic regression | GC response (cutoff=100 blasts) Association with number of blasts on day 8 with cut-off value of 100: higher (≥ 100 blasts) vs lower (< 100 blasts) number of blasts | GC response (cutoff=100 blasts) Association with number of blasts on day 8 with cut-off value of 100: higher (≥ 100 blasts) vs lower (< 100 blasts) number of blasts Adjusted for age, gender and initial white blood cells (WBC) count using logistic regression | GC response (cutoff=0 blasts) Association with prednosine response on day 8 according to Berlin-Frankfurt-Munster (BFM) protocol: prednisone poor responder (PPR) group (≥ 1000 blasts) vs. prednisone good responder (PGR) group (< 1000 blasts) | GC response (cutoff=0 blasts) Association with prednosine response on day 8 according to Berlin-Frankfurt-Munster (BFM) protocol: prednisone poor responder (PPR) group (≥ 1000 blasts) vs. prednisone good responder (PGR) group (< 1000 blasts) Adjusted for age, gender and initial white blood cells (WBC) count using logistic regression |
---|---|---|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | OR [95%CI] p value | OR [95%CI] p value | OR [95%CI] p value | OR [95%CI] p value | OR [95%CI] p value | OR [95%CI] p value | ||
CTA (51.2%) | absent | 4 (30.8) | 11 (35.5) | 7 (18.4) | 9 (22.5) | reference | reference | reference | reference | reference | reference |
present | 9 (69.2) | 20 (64.5) | 31 (81.6) | 31 (77.5) | 0.71[0.21-2.60] 0.737 Fisher exact test | 0.72[0.16-3.13] 0.658 | 0.50[0.22-1.15] 0.098 | 0.53[0.22-1.26] 0.148 | 0.79[0.32-1.92] 0.606 | 0.83[0.32-2.11] 0.699 | |
CAA (20.5%) | absent | 12 (92.3) | 15 (48.4) | 25 (65.8) | 25 (62.5) | reference | reference | reference | reference | reference | reference |
present | 1 (7.7) | 16 (51.6) | 13 (34.2) | 15 (37.5) | 0.12[0.015-0.98] Fisher exact test | 0.12[0.013-1.02] 0.052 | 1.12[0.52-2.41] 0.763 | 1.27[0.57-2.80] 0.561 | 0.96[0.44-2.1] 0.922 | 1.22[0.53-2.80] 0.643 | |
CAG (16.0%) | absent | 7 (53.8) | 20 (64.5) | 28 (73.7) | 29 (72.5) | reference | reference | reference | reference | reference | reference |
present | 6 (46.2) | 11 (35.5) | 10 (26.3) | 11 (27.5) | 2.06[0.64-6.62] 0.222 Fisher exact test | 1.82[0.49-6.74] 0.372 | 1.71[0.78-3.75] 0.18 | 1.60[0.70-3.65] 0.262 | 1.29[0.56-2.97] 0.543 | 1.28[0.53-3.1],0.576 | |
TAA (12.3%) | absent | 10 (76.9) | 21 (67.7) | 33 (86.8) | 32 (80.0) | reference | reference | reference | reference | reference | reference |
present | 3 (23.1) | 10 (32.3) | 5 (13.2) | 8 (20.0) | 1.12[0.29-4.41] 1.000 Fisher exact test | 1.10[0.21-5.92] 0.91 | 2.10[0.87-5.05] 0.095 | 1.85[0.73-4.71] 0.195 | 1.12[0.44-2.86] 0.805 | 0.89[0.32-2.44] 0.826 | |
AC (66.4%) | absent | 1 (7.7) | 3 (9.7) | 4 (10.5) | 5 (12.5) | reference | reference | reference | reference | reference | reference |
present | 12 (92.3) | 28 (90.3) | 34 (89.5) | 35 (87.5) | 1.49[0.18-12.45] 1.000 Fisher exact test | 0.99[0.11-9.21] 0.993 | 1.30[0.38-4.51] 0.768F | 1.18[0.33-4.19] 0.797 | 1.32[0.4-4.33] 0.756 | 1.15[0.33-3.93] 0.825 | |
GC (25.4%) | absent | 11 (84.6) | 20 (64.5) | 21 (55.3) | 18 (45.0) | reference | reference | reference | reference | reference | reference |
present | 2 (15.4) | 11 (35.5) | 17 (44.7) | 22 (55.0) | 0.22[0.045-1.01] | 0.27[0.054-1.38] 0.117 | 0.42[0.19-9.20] | 0.42[0.19-0.96] | 0.47[0.22-1.02] 0.054 | 0.55[0.24-1.23] 0.149 | |
GT (7.8%) | absent | 9 (69.2) | 25 (80.6) | 32 (84.2) | 38 (95.0) | reference | reference | reference | reference | reference | reference |
present | 4 (30.8) | 6 (19.4) | 6 (15.8) | 2 (5.0) | 3.02[0.82-11.12] 0.101 Fisher exact test | 3.41[0.81-14.34] 0.094 | 2.57[0.93-7.11] 0.062 | 2.61[0.93-7.37] 0.069 | 4.6[1.00-21.12] | 4.33[0.91-20.62] 0.065 | |
CGC (45.9%) | absent | 4 (30.8) | 10 (32.3) | 8 (21.1) | 12 (30.0) | reference | reference | reference | reference | reference | reference |
present | 9 (69.2) | 21 (67.7) | 30 (78.9) | 28 (70.0) | 0.85[0.25-2.98] 0.754 Fisher exact test | 0.74[0.19-2.81] 0.654 | 0.74[0.33-1.67] 0.465 | 0.73[0.32-1.69] 0.461 | 1.17[0.5-2.7] 0.714 | 1.43[0.58-3.53] 0.432 | |
TTT (36.9%) | absent | 6 (46.2) | 12 (38.7) | 17 (44.7) | 16 (40.0) | reference | reference | reference | reference | reference | reference |
present | 7 (53.8) | 19 (61.3) | 21 (55.3) | 24 (60.0) | 0.82[0.26-2.60] 0.772 | 0.85[0.24-3.08] 0.805 | 1.06[0.50-2.24] 0.88 | 1.13[0.52-2.47] 0.76 | 0.89[0.41-1.93] 0.778 | 0.91[0.4-2.05] 0.821 | |
CGT (8.6%) | absent | 10 (76.9) | 24 (77.4) | 30 (78.9) | 38 (95.0) | reference | reference | reference | reference | reference | reference |
present | 3 (23.1) | 7 (22.6) | 8 (21.1) | 2 (5.0) | 1.62[0.40-6.52] 0.446 Fisher exact test | 2.29[0.50-10.59] 0.289 | 2.00[0.76-5.27] 0.156 | 2.34[0.86-6.33] 0.095 | 5.34[1.17-24.31] | 7.56[1.6-35.82] |
Patients characteristics | Group | Entire group | ≥1000 blasts | 100≤ blasts <1000 | 1≤ blasts <100 | blast negative patients | GC response (cutoff=1000 blasts) Association with prednosine response on day 8 according to Berlin-Frankfurt-Munster (BFM) protocol: prednisone poor responder (PPR) group (≥1000 blasts) vs. prednisone good responder (PGR) group (<1000 blasts) | GC response (cutoff=100 blasts) Association with number of blasts on day 8 with cut-off value of 100: higher (≥ 100 blasts) vs lower (< 100 blasts) number of blasts | GC response (cutoff=0 blasts) Association with blast status on day 8: blast positive vs blast negative patients. |
---|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | n (%) | OR [95%CI], p Association with prednosine response on day 8 according to Berlin-Frankfurt-Munster (BFM) protocol: prednisone poor responder (PPR) group (≥1000 blasts) vs. prednisone good responder (PGR) group (<1000 blasts) | OR [95%CI], p Association with number of blasts on day 8 with cut-off value of 100: higher (≥ 100 blasts) vs lower (< 100 blasts) number of blasts | OR [95%CI], p Association with blast status on day 8: blast positive vs blast negative patients. | ||
Age | ≥1 and <6 (non-risk) | 65 (53.3) | 4 (30.8) | 17 (54.8) | 21 (55.3) | 23 (57.5) | reference | reference | reference |
<1 or ≥6 (risk) | 57 (46.7) | 9 (69.2) | 14 (45.2) | 17 (44.7) | 17 (42.5) | 2.86 [0.83-9.85], 0.085 | 1.42 [0.68-2.98], 0.356 | 1.29 [0.60-2.76], 0.514 | |
Gender | male | 66 (54.1) | 10 (76.9) | 13 (41.9) | 20 (52.6) | 23 (57.5) | reference | reference | reference |
female | 56 (45.9) | 3 (23.1) | 18 (58.1) | 18 (47.4) | 17 (42.5) | 0.32 [0.083-1.26], 0.081 | 1.12 [0.54-2.35], 0.761 | 1.28 [0.57-2.63], 0.598 | |
Initial WBC count∗ | <20,000/microL | 64 (53.3) | 1 (8.3) | 13 (43.3) | 21 (55.3) | 29 (72.5) | reference | reference | reference |
≥20,000/microL | 56 (46.7) | 11 (91.7) | 17 (56.7) | 17 (44.7) | 11 (27.5) | 15.40 [1.92-123.6], | 3.57 [1.62-7.88], | 3.39 [1.49-7.72], | |
Immunophenotype | B | 108 (88.5) | 9 (69.2) | 27 (87.1) | 35 (92.1) | 37 (92.5) | reference | reference | reference |
T | 14 (11.5) | 4 (30.8) | 4 (12.9) | 3 (7.9) | 3 (7.5) | 4.40 [1.15-16.90], Fisher exact test | 2.67 [0.86-8.27], 0.081 | 1.91 [0.50-7.28], 0.546 |