The aim of the paper is to describe spatial differences in the uncertainty of features of the flow regimes of rivers in Europe on the basis of measures whose methodological assumptions derive from Shannon’s information entropy theory (1948). They included: the entropy of monthly flow volumes, the entropy of the flow distribution over time, and the entropy of maximum and minimum monthly flows. An analysis was made of monthly flow series for the years 1951-1990 from 510 gauging stations located on 369 rivers in Europe. It allowed a quantitative determination of the degree of uncertainty of the four regime characteristics, indirectly establishing the predictability, regularity and stability of their appearance and their spatial variability. In the procedure of identification of spatial differences among rivers concerning the uncertainty of their flow regime features, use was made of local indices of spatial dependence. On application of LISA (Local Indicators of Spatial Association) based on Moran’s local