<abstract xmlns="http://www.w3.org/1999/xhtml">

The article is devoted to the study of the biological properties of nanocomposites obtained by immobilisation of precious metals (Au2+, Ag2+) in the structures of extracts of plant hepatoprotectors (milk thistle, saffron), in experiments on small sexually mature laboratory animals. Aqueous solutions of nanocomposites were administered to animals intraperitoneally 30 minutes prior to exposure to ionising radiation. Quantitative changes in lipid peroxidation were determined on the basis of the analysis of the concentration of malonic dealdehyde and hydroperoxide in liver tissue of control and experimental animals. It was revealed that nanocomposites introduced to animals before irradiation partially protect them from its destructive effect. More pronounced hepatoprotective effects in comparison with Ag2+ ions are manifested by Au2+ ions. Animals were also tested for behavioural responses in an open field model against the background of the introduction of a corresponding dose of the nanocomposite solution before irradiation. There were also changes in behavioural responses.
</abstract>

The article is devoted to the study of the biological properties of nanocomposites obtained by immobilisation of precious metals (Au2+, Ag2+) in the structures of extracts of plant hepatoprotectors (milk thistle, saffron), in experiments on small sexually mature laboratory animals. Aqueous solutions of nanocomposites were administered to animals intraperitoneally 30 minutes prior to exposure to ionising radiation. Quantitative changes in lipid peroxidation were determined on the basis of the analysis of the concentration of malonic dealdehyde and hydroperoxide in liver tissue of control and experimental animals. It was revealed that nanocomposites introduced to animals before irradiation partially protect them from its destructive effect. More pronounced hepatoprotective effects in comparison with Ag2+ ions are manifested by Au2+ ions. Animals were also tested for behavioural responses in an open field model against the background of the introduction of a corresponding dose of the nanocomposite solution before irradiation. There were also changes in behavioural responses.

New Nanometal-Containing Hepatoprotectors: Obtaining and Studying Biological Properties

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution 4.0 International License.

The article is devoted to the study of the biological properties of nanocomposites obtained by immobilisation of precious metals (Au2+, Ag2+) in the structures...

New Nanometal-Containing Hepatoprotectors: Obtaining and Studying Biological Properties

Data publikacji: 09 mar 2023

Zakres stron: 66 - 72

Otrzymano: 07 sty 2021

Przyjęty: 29 mar 2022

DOI: https://doi.org/10.2478/prolas-2023-0009

Słowa kluczowe
nanocomposites, radiation damage, malonic dealdehyde, lipid peroxidation, animal behaviour

© 2023 Afig Gurbanali Gaziev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

New Nanometal-Containing Hepatoprotectors: Obtaining and Studying Biological Properties

Data publikacji: 09 mar 2023

Zakres stron: 66 - 72

Otrzymano: 07 sty 2021

Przyjęty: 29 mar 2022

DOI: https://doi.org/10.2478/prolas-2023-0009

Słowa kluczowenanocomposites, radiation damage, malonic dealdehyde, lipid peroxidation, animal behaviour

© 2023 Afig Gurbanali Gaziev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Słowa kluczowe
nanocomposites, radiation damage, malonic dealdehyde, lipid peroxidation, animal behaviour