The Role of Protein Restriction in the Progression of Chronic Kidney Disease

1 Bellizzi V. Low-protein diet or nutritional therapy in chronic kidney disease? Blood Purif. 2013;36(1):41-6 Search in Google Scholar

2 Thilly N. Low-protein diet in chronic kidney disease: from questions of effectiveness to those of feasibility. Nephrol Dial Transplant. 2013;28(9):2203-5. Search in Google Scholar

3 Sällström J, Carlström M, Olerud J, et al. High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases. Am J Physiol Regul Integr Comp Physiol. 2010; 299: R1263- R1268. Search in Google Scholar

4 Cirillo M, Lombardi C, Chiricone D, De Santo NG, Zanchetti A, Bilancio G. Protein intake and kidney function in the middle-age population: contrast between cross-sectional and longitudinal data. Nephrol Dial Transplant. 2014; 29:1733-40. Search in Google Scholar

5 Hostetter TH, Meyer TW, Rennke HG, Brenner BM. Chronic effects of dietary protein in the rat with intact and reduced renal mass. Kidney International.1986;30(4):509‐17 Search in Google Scholar

6 Kalantar-Zadeh K, Fouque D. Nutritional Management of Chronic Kidney Disease. N Engl J Med. 2017;377(18):1765-1776. doi:10.1056/NEJMra1700312 Search in Google Scholar

7 Correa-Rotter R, Hostetter TH, Rosenberg ME. Effect of dietary protein on renin and angiotensinogen gene expression after renal ablation. Am J Physiol. 1992;262(4 Pt 2):F631-F638. doi:10.1152/ajprenal.1992.262.4.F631 Search in Google Scholar

8 Rosenberg ME, Kren SM, Hostetter TH. Effect of dietary protein on the renin-angiotensin system in subtotally nephrectomized rats. Kidney Int. 1990;38(2):240-248. doi:10.1038/ki.1990.192 Search in Google Scholar

9 Kasiske BL, Lakatua JD, Ma JZ, Louis TA. A meta‐analysis of the effects of dietary protein restriction on the rate of decline in renal function. American Journal of Kidney Diseases.1998;31(6):954‐61 Search in Google Scholar

10 Kalantar-Zadeh K, Moore LW, Tortorici AR, et al. North American experience with Low protein diet for Non-dialysis-dependent chronic kidney disease. BMC Nephrol. 2016;17(1):90. Search in Google Scholar

11 Blatt AD, Roe LS, Rolls BJ. Increasing the protein content of meals and its effect on daily energy intake. J Am Diet Assoc. 2011;111(2):290-4. Search in Google Scholar

12 Kopple JD, Monteon FJ, Shaib JK. Effect of energy intake on nitrogen metabolism in nondialyzed patients with chronic renal failure. Kidney Int. 1986;29(3):734-42 Search in Google Scholar

13 Ikizler TA, Burrowes JD, Byham-Gray LD, et al; KDOQI Nutrition in CKD Guideline Work Group. KDOQI clinical practice guideline for nutrition in CKD: 2020 update. Am J Kidney Dis. 2020;76(3)(suppl 1):S1-S107 Search in Google Scholar

14 Garneata L, Mircescu G. Effect of low‐protein diet supplemented with keto acids on progression of chronic kidney disease. Journal of Renal Nutrition 2013;23(3):210‐3 Search in Google Scholar

15 Maroni BJ, Steinman TI, Mitch WE. A method for estimating nitrogen intake of patients with chronic renal failure. Kidney International 1985;27(1):58‐65 Search in Google Scholar

16 Klahr S, Levey AS, Beck GJ, Caggiula AW, Hunsicker L, Kusek JW, Striker G. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. N Engl J Med. 1994;330(13):877-84. Search in Google Scholar

17 Garneata L, Stancu A, Dragomir D, Stefan G, Mircescu G. Ketoanalogue-Supplemented Vegetarian Very Low-Protein Diet and CKD Progression. J Am Soc Nephrol.2016; 27(7):2164-76. Search in Google Scholar

18 Duenhas M, Gonçalves E, Dias M, Leme G, Laranja S. Reduction of morbidity related to emergency access to dialysis with very low protein diet supplemented with ketoacids (VLPD+KA). Clin Nephrol. 2013;79(5):387-93. Search in Google Scholar

19 Brunori G, Viola BF, Parrinello G, De Biase V, Como G, Franco V, Garibotto G, Zubani R, Cancarini GC. Efficacy and safety of a very-low-protein diet when postponing dialysis in the elderly: a prospective randomized multicenter controlled study. Am J Kidney Dis. 2007;49(5):569-80. Search in Google Scholar

20 Fouque D, Laville M, Boissel JP. Low protein diets for chronic kidney disease in non diabetic adults. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD001892. doi: 10.1002/14651858. CD001892.pub2. Update in: Cochrane Database Syst Rev. 2009;(3):CD001892. Search in Google Scholar

21 Hahn D, Hodson EM, Fouque D. Low protein diets for non-diabetic adults with chronic kidney disease. Cochrane Database Syst Rev. 2018 Oct 4;10(10):CD001892. Update in: Cochrane Database Syst Rev. 2020;10:CD001892. Search in Google Scholar

22 Mitch WE, Remuzzi G. Diets for patients with chronic kidney disease, should we reconsider? BMC Nephrology 2016;17(1):80. Search in Google Scholar

23 Hansen HP, Tauber-Lassen E, Jensen BR, Parving HH. Effect of dietary protein restriction on prognosis in patients with diabetic nephropathy. Kidney Int. 2002;62(1):220-8. Search in Google Scholar

24 Nezu U, Kamiyama H, Kondo Y, Sakuma M, Morimoto T, Ueda S. Effect of low-protein diet on kidney function in diabetic nephropathy: meta-analysis of randomised controlled trials. BMJ Open. 2013;3(5):e002934. Search in Google Scholar

25 Rughooputh MS, Zeng R, Yao Y. Protein Diet Restriction Slows Chronic Kidney Disease Progression in Non-Diabetic and in Type 1 Diabetic Patients, but Not in Type 2 Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials Using Glomerular Filtration Rate as a Surrogate. PLoS One. 2015;10(12):e0145505. Search in Google Scholar

26 Robertson L et al. Protein restriction for diabetic renal disease. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD002181. Search in Google Scholar

27 Pan Y, Guo LL, Jin HM. Low-protein diet for diabetic nephropathy: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2008;88(3):660-6. Search in Google Scholar

28 Pedrini MT, Levey AS, Lau J, Chalmers TC, Wang PH. The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis. Ann Intern Med. 1996;124(7):627-32. Search in Google Scholar

29 Otoda T, Kanasaki K, Koya D. Low-protein diet for diabetic nephropathy. Curr Diab Rep. 2014;14(9):523. Search in Google Scholar

30 Levey AS et al. Dietary protein restriction and the progression of chronic renal disease: what have all of the results of the MDRD study shown? Modification of Diet in Renal Disease Study group. J Am Soc Nephrol. 1999;10(11):2426-39. Search in Google Scholar

31 Chauveau P, Combe C, Rigalleau V, Vendrely B, Aparicio M. Restricted protein diet is associated with decrease in proteinuria: consequences on the progression of renal failure. J Ren Nutr. 2007;17(4):250-7. Search in Google Scholar

32 Kaysen GA, Gambertoglio J, Jimenez I, Jones H, Hutchison FN. Effect of dietary protein intake on albumin homeostasis in nephrotic patients. Kidney Int. 1986;29(2):572-7. Search in Google Scholar

33 Aparicio M, Chauveau P, Précigout V, Bouchet JL, Lasseur C, Combe C. Nutrition and outcome on renal replacement therapy of patients with chronic renal failure treated by a supplemented very low protein diet. J Am Soc Nephrol. 2000;11(4):708-716. Search in Google Scholar

34 Giordano M, Ciarambino T, Castellino P, Cataliotti A, Malatino L, Ferrara N, Politi C, Paolisso G. Long-term effects of moderate protein diet on renal function and low-grade inflammation in older adults with type 2 diabetes and chronic kidney disease. Nutrition. 2014;30(9):1045-9. Search in Google Scholar

35 Koya D et al. Low-Protein Diet Study Group. Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial. Diabetologia. 2009;52(10):2037-45. Search in Google Scholar

36 Cianciaruso B, Pota A, Bellizzi V, Di Giuseppe D, Di Micco L, Minutolo R, Pisani A, Sabbatini M, Ravani P. Effect of a low- versus moderate-protein diet on progression of CKD: follow-up of a randomized controlled trial. Am J Kidney Dis. 2009;54(6):1052-61. Search in Google Scholar

37 Zhang J, Xie H, Fang M, Wang K, Chen J, Sun W, Yang L, Lin H. Keto-supplemented Low Protein Diet: A Valid Therapeutic Approach for Patients with Steroid-resistant Proteinuria during Early-stage Chronic Kidney Disease. J Nutr Health Aging. 2016;20(4):420-7. Search in Google Scholar

38 Gansevoort RT, de Zeeuw D, de Jong PE. Additive antiproteinuric effect of ACE inhibition and a low-protein diet in human renal disease. Nephrol Dial Transplant. 1995;10(4):497-504. Search in Google Scholar

39 Mitch WE, Abras E, Walser M. Long-term effects of a new ketoacid-amino acid supplement in patients with chronic renal failure. Kidney Int. 1982;22(1):48-53. Search in Google Scholar

40 Walser M. Does prolonged protein restriction preceding dialysis lead to protein malnutrition at the onset of dialysis?. Kidney Int. 1993;44(5):1139-1144. Search in Google Scholar

41 Goodship TH, Mitch WE, Hoerr RA, Wagner DA, Steinman TI, Young VR. Adaptation to low-protein diets in renal failure: leucine turnover and nitrogen balance. J Am Soc Nephrol. 1990;1(1):66-75. Search in Google Scholar

42 Tom K, Young VR, Chapman T, Masud T, Akpele L, Maroni BJ. Long-term adaptive responses to dietary protein restriction in chronic renal failure. Am J Physiol. 1995;268(4 Pt 1):E668-E677. Search in Google Scholar

43 Maroni BJ, Staffeld C, Young VR, Manatunga A, Tom K. Mechanisms permitting nephrotic patients to achieve nitrogen equilibrium with a protein-restricted diet. J Clin Invest. 1997;99(10):2479-87. Search in Google Scholar

44 Masud T et al. Adaptive responses to very low protein diets: the first comparison of ketoacids to essential aminoacids. Kidney International 1994; 45: 1182-92 Search in Google Scholar

45 Pacy PJ, Price GM, Halliday D, Quevedo MR, Millward DJ. Nitrogen homeostasis in man: the diurnal responses of protein synthesis and degradation and amino acid oxidation to diets with increasing protein intakes. Clin Sci (Lond). 1994;86(1):103-16. Search in Google Scholar

46 Reaich D, Channon SM, Scrimgeour CM, Daley SE, Wilkinson R, Goodship TH. Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol. 1993;265(2 Pt 1):E230-E235. Search in Google Scholar

47 Williams B, Hattersley J, Layward E, Walls J. Metabolic acidosis and skeletal muscle adaptation to low protein diets in chronic uremia. Kidney Int. 1991;40(4):779-86. Search in Google Scholar

48 Bellizzi V et al; “Conservative Treatment of CKD” study group of the Italian Society of Nephrology. Low-protein diets for chronic kidney disease patients: the Italian experience. BMC Nephrol. 2016;17(1):77. doi.org/10.1186/s12882-016-0280-0 Search in Google Scholar

49 Bellizzi V, Calella P, Hernández JN, et al. Safety and effectiveness of low-protein diet supplemented with ketoacids in diabetic patients with chronic kidney disease. BMC Nephrol. 2018;19(1):110. Search in Google Scholar

50 Baragetti I, De Simone I, Biazzi C, et al. The low-protein diet for chronic kidney disease: 8 years of clinical experience in a nephrology ward. Clin Kidney J. 2019;13(2):253-260. Search in Google Scholar

51 Yue H, Zhou P, Xu Z, et al. Effect of low-protein diet on kidney function and nutrition in nephropathy: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2020;39(9):2675-2685. Search in Google Scholar

52 Ko GJ, Obi Y, Tortorici AR, Kalantar- Zadeh K. Dietary protein intake and chronic kidney disease. Curr Opin Clin Nutr Metab Care 2017; 20:77-85. Search in Google Scholar

53 Lameire N, Van Biesen W. Epidemiology of peritoneal dialysis: a story of believers and non-believers. Nat Rev Nephrol. 2010;6(2):75-82. doi:10.1038/nrneph.2009.210 Search in Google Scholar

54 Torreggiani M, Fois A, Moio MR, et al. Spontaneously Low Protein Intake in Elderly CKD Patients: Myth or Reality? Analysis of Baseline Protein Intake in a Large Cohort of Patients with Advanced CKD. Nutrients. 2021;13(12):4371. Search in Google Scholar

55 Apetrii M, Timofte D, Voroneanu L, Covic A. Nutrition in Chronic Kidney Disease-The Role of Proteins and Specific Diets. Nutrients. 2021;13(3):956. Search in Google Scholar