Epinephrine and Dexamethasone as Adjuvants in Upper Extremity Peripheral Nerve Blocks in Pediatric Patients

1. Eccoffey C, Lacroix F, Gainfre E, Orliaquet G, Courreges P, Association des Anesthesistes Reanimatueurs Pediatriques d’Expression Francaise (ADARPEF). Epidemiology and Morbidity of regional anesthesia in children: a follow up one year prospective survey of the French-Language Society of Paediatric Anesthesiologists (ADARPEF). Pediatr Anesth 2010; 20: 1061–1069.10.1111/j.1460-9592.2010.03448.x21199114Search in Google Scholar

2. Capdevila X, Biboulet PH, Morau D, Mannion S, Choquet O. How and why to use ultrasound for regional blockade Acta Anaesth. Belg., 2008; 59: 147–154.Search in Google Scholar

3. Mikjunovikj Derebanova Lj., Kartalov A., Donev Lj., Leshi A., Tolevska M., Demjanski V.: Epinephrine and dexamethasone as adjuvans in supraclavicular block in pediatric patients: a case series, Macedonian Journal of Anesthesia Vol 5, No 2, 2021, 52– 58, UDC: 616.833.34-089.5-053.2.Search in Google Scholar

4. Orebaugh SL, Williams BA, Vallejo M, Kentor ML. Adverse outcomes associated with stimulator-based peripheral nerve blocks with versus without ultrasound visualization. Reg Anesth Pain Med. 2009; 34: 251–255.10.1097/AAP.0b013e3181a3438e19587625Search in Google Scholar

5. Opperer M, Gerner P, Memtsoudis SG. Additives to local anesthetics for peripheral nerve blocks or local anesthesia: A review of the literature. Pain Manag. 2015; 5: 117–28.10.2217/pmt.15.225806906Search in Google Scholar

6. Swain A, Nag DS, Sahu S, Samaddar DP. Adjuvants to local anesthetics: Current understanding and future trends. World J Clin Cases. 2017; 5: 307.10.12998/wjcc.v5.i8.307556150028868303Search in Google Scholar

7. Suresh S, Ecoffey C, Bosenberg A.et al.The European society of regional anaesthesia and pain therapy/American society of regional anesthesia and pain medicine recommendations on local anesthetics and adjuvants dosage in pediatric regional anesthesia.Reg Anesth Pain Med. 2018; 43: 211–216.10.1097/AAP.000000000000070229319604Search in Google Scholar

8. Dillane D, Finucane BT. Local anesthetic systemic toxicity. Can J Anesth Can D’anesthesie. 2010; 57(4): 368–380.10.1007/s12630-010-9275-720151342Search in Google Scholar

9. Merella F, Canchi Murali N. General principles in regional anesthesia in children. BJA education vol 19. August 2019. DOI:https://doi.org/10.1016/j.bjar.2019.06.003.Search in Google Scholar

10. Fettiplace M.R, Weinberg G. The mechanisms underlying lipid resuscitation therapy. Reg Anesth Pain Med. 2018; 43: 138–149.10.1097/AAP.000000000000071929356774Search in Google Scholar

11. Clinical Guidelines for the Recognition and Assessment of Acute Pain in Children. Royal College of Nursing Institute, 2009. Available at: www.rcn.org.uk/childrenspain guideline.Search in Google Scholar

12. von Baeyer CL, Forsyth SJ, Stanford EA et al. Response biases in preschool children’s ratings of pain in hypothetical situations. Eur J Pain 2009; 13: 209–213.10.1016/j.ejpain.2008.03.01718479952Search in Google Scholar

13. Buttner W, Fincke W. Analysis of behavioural and physiological parameters for the assessment of postoperative analgesic demand in newborns, infants and young children. Paediatr Anaesth 2000; 10: 303–318.10.1046/j.1460-9592.2000.00530.x10792748Search in Google Scholar

14. Gregorio G Di, Neal JM, Rosenquist RW, Weinberg GL. Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009. Reg Anesth Pain Med. 2010; 35: 181–187.10.1097/AAP.0b013e3181d2310bSearch in Google Scholar

15. Weinberg GL. Treatment of local anesthetic systemic toxicity (LAST). Reg Anesth Pain Med. 2010; 35: 188–193.10.1097/AAP.0b013e3181d246c3Search in Google Scholar

16. Barson AJ,Chistwick ML, Doig CM. Fat embolism in infancy after intravenous fat infusions. Arch Dis Child. 1978; 53: 218–223.10.1136/adc.53.3.218Search in Google Scholar

17. Zausig YA, Graf BM, Zink W. Is it “lipid sink,” hemodilution, or both? Critical Care Medicine. 2009; 37(10): p. 2863.10.1097/00003246-200910000-00042Search in Google Scholar

18. Walker BJ, Long J, Madhankumar S. et al. Complications in pediatric regional anesthesia: an analysis of more than 100,000 blocks from the Pediatric Regional Anaesthesia Network.Anesthesiology. 2018; 129: 721–732.10.1097/ALN.0000000000002372Search in Google Scholar

19. Berde CB: Toxicity of local anesthetics in infants and children. J Pediatr 1993; 122(Pt 2): S14-S20.10.1016/S0022-3476(11)80004-1Search in Google Scholar

20. Tschopp C, Tramèr MR, Schneider A, Zaarour M, Elia N. Benefit and harm of adding epinephrine to a local anesthetic for neuraxial and locoregional anesthesia: a meta-analysis of randomized controlled trials with trial sequential analyses. Anesth Analg 2018; 127: 228–239. doi: 10.1213/ANE.0000000000003417.10.1213/ANE.000000000000341729782398Search in Google Scholar

21. Pietraszek P. Regional anaesthesia induced peripheral nerve injury. Anaesthesiol Intensive Ther 2018; 50: 367–377. doi: 10.5603/AIT.2018.0049.10.5603/AIT.2018.004930615796Search in Google Scholar

22. Komatsu T, Takenami T, Nara Y, et al. Epinephrine administered with lidocaine solution does not worsen intrathecal lidocaine neurotoxicity in rats. Reg Anesth Pain Med 2013; 38: 140–144. doi: 10.1097/AAP. 0b013e318279499d.Search in Google Scholar

23. Brummett CM, Williams BA. Additives to local anesthetics for peripheral nerve blockade. Int Anesthesiol Clin. 2011; 49: v104–116.10.1097/AIA.0b013e31820e4a49342765121956081Search in Google Scholar

24. Myers RR, Heckman HM. Effects of local anesthesia on nerve blood flow: studies using lidocaine with and without epinephrine. Anesthesiology. 1989; 71: 757–762.10.1097/00000542-198911000-000212817471Search in Google Scholar

25. Kapral S, Krafft P, Eibenberger K, Fitzgerald R, Gosch M, Weinstabl C. Ultrasound-guided supraclavicular approach for regional anesthesia of the brachial plexus. Anesth Analg. 1994; 78: 507Y513.10.1213/00000539-199403000-000168109769Search in Google Scholar

26. Neal JM. Effects of epinephrine in local anesthetics on the central and peripheral nervous systems: neurotoxicity and neural blood flow. Reg Anesth Pain Med. 2003; 28(2): 124–134.10.1097/00115550-200303000-00010Search in Google Scholar

27. Neal JM, Barrington MJ, Fettiplace MR, et al. The third American Society of Regional Anesthesia and Pain Medicine practice advisory on local anesthetic systemic toxicity: executive summary 2017. Reg Anesth Pain Med 2018; 43: 113-123. doi: 10.1097/AAP. 0000000000000720.16Search in Google Scholar

28. Choi S, Rodseth R, McCartney CJ. Effects of dexamethasone as a local anaesthetic adjuvant for brachial plexus block: a systematic review and meta-analysis of randomized trials. Br J Anaesth. 2014; 112(3): 427–39.10.1093/bja/aet41724413428Search in Google Scholar

29. Kirkham KR, Jacot-Guillarmod A, Albrecht E. Optimal dose of perineural dexamethasone to prolong analgesia after brachial plexus blockade: a systematic review and meta-analysis. Anesth Analg 2018; 126: 270e9.10.1213/ANE.000000000000248828922230Search in Google Scholar

30. Ma R, Wang X, Lu C, et al. Dexamethasone attenuated bupivacaine-induced neuron injury in vitro through a threonine-serine protein kinase B-dependent mechanism. Neuroscience 2010; 5: 67: 329–342. doi: 10.1016/j.neuroscience.2009.12.049.10.1016/j.neuroscience.2009.12.04920038443Search in Google Scholar

31. Polderman JAW, Farhang-Razi V, van Dieren S et al. Adverse side-effects of dexamethasone in surgical patients - an abridged Cochrane systematic review. Anaesthesia 2019.10.1002/14651858.CD011940.pub2651349530152137Search in Google Scholar

32. Biradar PA, Kaimar P, Gopalakrishna K. Effect of dexamethasone added to lidocaine in supraclavicular brachial plexus block: A prospective, randomised, double-blind study. Indian J Anaesth. 2013; 57: 180–184.10.4103/0019-5049.111850369626723825819Search in Google Scholar

33. Liu J, Richman KA, Grodofsky SR, Bhatt S. Huffman GR, Kelly JD 4th, Glaser DL, Elkassabany N. Is there a dose response of dexamethasone as adjuvant for supraclavicular brachial plexus nerve block? A prospective randomized double-blinded clinical study. J Clin Anesth. 2015; 27: 237–242.10.1016/j.jclinane.2014.12.00425637938Search in Google Scholar

34. Rahangdale R, Kendall MC, McCarthy RJ, Tureanu L, Doty R Jr, Weingart A, De Oliveira GS Jr. The effects of perineural versus intravenous dexamethasone on sciatic nerve blockade outcomes: a randomized, double-blind, placebo-controlled study. Anesth Analg. 2014; 118: 1113–1119.10.1213/ANE.000000000000013724686045Search in Google Scholar