Limited proteolysis and oxidative modification of proteins in the hepatocytes of patients with resistant forms of tuberculosis

R/B ratio with specific staining of acid and basic proteins by Michel-Calvo in the hepatocytes of patients with pulmonary tuberculosis and in the comparison group (X ± Sx)_ Computed microspectrometry_

Acinus zone (by Rappoport)	Study groups
	Comparison group (n = 20)	Main group
		Subgroup I (n = 19)	Subgroup II (n = 21)	Subgroup III (n = 20)
Zone I	1.09 ± 0.008	1.27 ± 0.014*	1.73 ± 0.041**	2.05 ± 0.072#
Zone II	1.11 ± 0.004	1.39 ± 0.009*	1.81 ± 0.032**	2.34 ± 0.094#
Zone III	1.13 ± 0.012	1.48 ± 0.041*	1.95 ± 0.063**	2.68 ± 0.108#

Quantitative parameters of optical density of a specific colouration on the free amino group of proteins by A_ Yasuma and T_ Ichikava (X ± Sx) in the hepatocytes of patients with pulmonary tuberculosis and in the comparison group, relative units of optical density_ Computed microdensitometry_

Acinus zone (by Rappoport)	Study groups
	Comparison group (n = 20)	Main group
		Subgroup I (n = 19)	Subgroup II (n = 21)	Subgroup III (n = 20)
Zone I	0.195 ± 0.0012	0.221 ± 0.0016*	0.249 ± 0.0012**	0.302 ± 0.021#
Zone II	0.196 ± 0.0031	0.245 ± 0.0009*	0.262 ± 0.0021**	0.318 ± 0.008#
Zone III	0.198 ± 0.0012	0.251 ± 0.0012*	0.274 ± 0.0013**	0.327 ± 0.014#