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Decreased plasma epidermal growth factor (EGF) levels in patients with severe chronic obstructive pulmonary disease

Retno AS Soemarwoto

Retno AS Soemarwoto

Biomedical Sciences Post-Graduate Programme, Faculty of Medicine, Universitas AndalasPadang, Indonesia
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Soemarwoto, Retno AS
, 
Jamsari,

Jamsari,

Faculty of Agriculture, Universitas AndalasPadang, Indonesia
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Jamsari,
, 
Yanwirasti,

Yanwirasti,

Department of Anatomy, Faculty of Medicine, Universitas AndalasPadang, Indonesia
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Yanwirasti,
, 
Andika Chandra Putra

Andika Chandra Putra

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Persahabatan Hospital, Universitas IndonesiaJakarta, Indonesia
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Putra, Andika Chandra
 oraz 
Syazili Mustofa

Syazili Mustofa

Department of Biochemistry, Molecular Biology, and Physiology, Faculty of Medicine, Universitas LampungBandar Lampung, Indonesia
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Mustofa, Syazili
  
02 lip 2019
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Kategoria artykułu: Original Papers
Data publikacji: 02 lip 2019
Zakres stron: 21 - 26
DOI: https://doi.org/10.2478/pneum-2019-0004
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© 2019 Soemarwoto et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Distribution of EGF values in subgroups of patients EGF, epidermal growth factor.
Distribution of EGF values in subgroups of patients EGF, epidermal growth factor.

Clinical and physiological characteristics of smokers with COPD vs healthy smokers

Male smokers with COPDMale healthy smokersp
Age (SD) (years)64.5 (8.6)61.6 (9.5)0.79
Brinkman Index (SD)409.6 (199.22)426.14 (243.14)0.632
FEV1* (SD)55.40 (20.47)103.81 (20.07)0.000
FVC* (SD)74.50 (19.49)94.64 (16.18)0.000
FEV1/FVC (SD)73.24 (14.51)110.64 (18.64)0.000

Plasma EGF levels in COPD smokers vs_ healthy smokers_

GroupNMean (pg/mL)SDp
COPD smokers8269.30561.4520.046
Healthy smokers8683.82263.927

Diagnosis of airflow obstruction according to Pneumobile Project, Indonesia_

FEV1 predicted (%)FEV1/FVC (%)
Normal airflow≥80≥76
Airflow obstruction<80>76

Univariate analysis for plasma EGF levels and potential confounding variables_

VariablesNMean plasma level of EGF (SD)p
Airflow limitation severity
GOLD 1 (mild)10120.43 (76.59)0.004
GOLD 2–4 (moderate–very severe)7262.204 (56.08)
Sputum production
Nonspontaneous3581.50 (64.56)0.122
Spontaneous4260.22(58.06)
COPD exacerbation in previous year
No exacerbation5076.35(63.02)0.138
Exacerbation3258.29 (58.17)
Język:
Angielski
Częstotliwość wydawania:
Volume Open
Dziedziny czasopisma:
Medycyna, Medycyna kliniczna, Medycyna wewnętrzna, Pulmonologia, Medycyna kliniczna, inne
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