<abstract xmlns="http://www.w3.org/1999/xhtml">A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound <bold>4b</bold> was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound <bold>4b</bold> evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound <bold>4b</bold> increased the concentration of caspase 3 by 4 fold more than untreated control.</abstract>

A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound 4b was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound 4b evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound 4b increased the concentration of caspase 3 by 4 fold more than untreated control.

Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were...

Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives

Data publikacji: 26 wrz 2019

Zakres stron: 19 - 25

DOI: https://doi.org/10.2478/pjct-2019-0025

Słowa kluczowe
Thiazole, Anticancer, Cell Cycle Analysis, Annexin V, FITC, Doxorubicin

© 2019 Safyah B. Bakare, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives

Data publikacji: 26 wrz 2019

Zakres stron: 19 - 25

DOI: https://doi.org/10.2478/pjct-2019-0025

Słowa kluczoweThiazole, Anticancer, Cell Cycle Analysis, Annexin V, FITC, Doxorubicin

© 2019 Safyah B. Bakare, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
Thiazole, Anticancer, Cell Cycle Analysis, Annexin V, FITC, Doxorubicin