Ketoprofen Lysine Salt Has No Gastroprotective Effect in Comparison with Ketoprofen in Female Rats After Ethyl Alcohol Intoxication

Ketoprofen lysine salt - a new non steroidal antiinflammatory drug (NSAID) is an improved formulation of ketoprofen. The former is believed to have gastroprotective properties, the latter to kill acute pain and increase the risk of gastric mucosa damage. In East Europe binge drinking and taking NSAIDs on the day after is common. The aim of the study was to verify the hypothesis about the gastroprotective effect of ketoprofen lysine salt after exposure to 50% alcohol. The experiment was carried out on 36 female Wistar rats divided into 6 groups of 6:

1. 50% ethanol

2. 0.9% NaCl

3. 0.9% NaCl and ketoprofen

4. 50% ethanol and ketoprofen

5. 0.9% NaCl and ketoprofen lysine salt

6. 50% ethanol and ketoprofen lysine salt

On day 7 animals were sacrificed. Their stomachs were dissected for histopathological examination.

Microscopic examination of stomachs from groups 1, 3,4,5,6 revealed non-specific, high-grade lymphocytic-plasmocytic inflammation of the gastric mucosa. Conclusions - Ketoprofen lysine salt and ketoprofen damage gastric mucosa in female rats after and without alcohol intoxication. Ketoprofen lysine salt has no gastroprotective effect