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Sonochemistry studies the physical and molecular level changes induced by ultrasonic energy on solutions. Sonochemical degradation of the chemical warfare agents (CWA) may occur due to three successive phenomena based on the principles of acoustic cavitation phenomena: nucleation, growth, and implosive collapse of microbubbles. The sonolytic degradation of CWA was quantified by GC-MS technique, considering the variation of some parameters such as frequency of ultrasonic waves, power control, temperature, and addition of nanoparticles as catalysts to the solution.