The influence of probiotic administration on the phagocytic and oxidative burst activity of neutrophils and monocytes in the peripheral blood of dairy cows during different lactation periods
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Aleri J.W., Hine B.C., Pyman M.F., Mansell P.D., Wales W.J., Mallard B., Fisher A.D.: Periparturient immunosuppression and strategies to improve dairy cow health during the periparturient period. Res Vet Sci 2016, 108, 8–17, doi: 10.1016/j.rvsc.2016.07.007.AleriJ.W.HineB.C.PymanM.F.MansellP.D.WalesW.J.MallardB.FisherA.D.:Periparturient immunosuppression and strategies to improve dairy cow health during the periparturient period.Res Vet Sci2016,108,8–17, doi:10.1016/j.rvsc.2016.07.007.Open DOISearch in Google Scholar
Bomba A., Nemcova R., Mudronova D., Guba P.: The possibilities of potentiating the efficacy of probiotics. Trends Food Sci Tech 2002, 13, 121–126, doi: 10.1016/S0924-2244(02)00129-2.BombaA.NemcovaR.MudronovaD.GubaP.:The possibilities of potentiating the efficacy of probiotics.Trends Food Sci Tech2002,13,121–126, doi:10.1016/S0924-2244(02)00129-2.Open DOISearch in Google Scholar
De Moreno de LeBlanc A., Maldonado-Galdeano C., Chaves S., Perdigón G.: Oral administration of L. casei CRL 431 increases immunity in bronchus and mammary glands. Eur J Inflamm 2005, 3, 23–28, doi: 10.1177/1721727X0500300105.De Moreno de LeBlancA.Maldonado-GaldeanoC.ChavesS.PerdigónG.:Oral administration of L. casei CRL 431 increases immunity in bronchus and mammary glands.Eur J Inflamm2005,3,23–28, doi:10.1177/1721727X0500300105.Open DOISearch in Google Scholar
Deng Q., Odhiambo J.F., Farooq U., Lam T., Dunn S.M., Ametaj B.N.: Intravaginal lactic acid bacteria modulated local and systemic immune responses and lowered the incidence of uterine infections in periparturient dairy cows. PLoS One 2015, 10, e0124167, doi: 10.1371/journal.pone.0124167.DengQ.OdhiamboJ.F.FarooqU.LamT.DunnS.M.AmetajB.N.:Intravaginal lactic acid bacteria modulated local and systemic immune responses and lowered the incidence of uterine infections in periparturient dairy cows.PLoS One2015,10,e0124167, doi:10.1371/journal.pone.0124167.Open DOISearch in Google Scholar
Dogi C.A., Maldonaldo-Galdeano C., Perdigon G.: Gut immune stimulation by non-pathogenic Gram(+) and Gram(–) bacteria. Comparison with a probiotic strain. Cytokine 2008, 41, 223–231, doi: 10.1016/j.cyto.2007.11.014.DogiC.A.Maldonaldo-GaldeanoC.PerdigonG.:Gut immune stimulation by non-pathogenic Gram(+) and Gram(–) bacteria. Comparison with a probiotic strain.Cytokine2008,41,223–231, doi:10.1016/j.cyto.2007.11.014.Open DOISearch in Google Scholar
Fernandez M.F., Boris S., Barbes C.: Probiotic properties of human lactobacilli strains to be used in the gastrointestinal tract. J Appl Microbiol 2003, 94, 449–455, doi: 10.1046/j.1365-2672.2003.01850.x.FernandezM.F.BorisS.BarbesC.:Probiotic properties of human lactobacilli strains to be used in the gastrointestinal tract.J Appl Microbiol2003,94,449–455, doi:10.1046/j.1365-2672.2003.01850.x.Open DOISearch in Google Scholar
Foligné B., Parayre S., Cheddani R., Famelart M.H., Madec M.N., Plé C., Breton J., Dewulf J., Jan G., Deutsch S.M.: Immunomodulation properties of multi-species fermented milks. Food Microbiol 2016, 53, 60–69, doi: 10.1016/j.fm.2015.04.002.FolignéB.ParayreS.CheddaniR.FamelartM.H.MadecM.N.PléC.BretonJ.DewulfJ.JanG.DeutschS.M.:Immunomodulation properties of multi-species fermented milks.Food Microbiol2016,53,60–69, doi:10.1016/j.fm.2015.04.002.Open DOISearch in Google Scholar
Gibson G.R., Probert H.M., Van Loo J., Rastall R.A., Robertfroid M.B.: Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 2004, 17, 259–275, doi: 10.1079/NRR200479.GibsonG.R.ProbertH.M.Van LooJ.RastallR.A.RobertfroidM.B.:Dietary modulation of the human colonic microbiota: updating the concept of prebiotics.Nutr Res Rev2004,17,259–275, doi:10.1079/NRR200479.Open DOISearch in Google Scholar
Goff J.P.: Major advances in our understanding of nutritional influences on bovine health. J Dairy Sci 2006, 89, 1292–1301, doi: 10.3168/jds.S0022-0302(06)72197-X.GoffJ.P.:Major advances in our understanding of nutritional influences on bovine health.J Dairy Sci2006,89,1292–1301, doi:10.3168/jds.S0022-0302(06)72197-X.Open DOISearch in Google Scholar
Graugnard D.E., Bionaz M., Trevisi E., Moyes K.M., Salak-Johnson J.L., Wallace R.L., Drackley J.K., Bertoni G., Loor J.J.: Blood immunometabolic indices and polymorphonuclear neutrophil function in peripartum dairy cows are altered by level of dietary energy prepartum. J Dairy Sci 2012, 95, 1749–1758, doi: 10.3168/jds.2011-4579.GraugnardD.E.BionazM.TrevisiE.MoyesK.M.Salak-JohnsonJ.L.WallaceR.L.DrackleyJ.K.BertoniG.LoorJ.J.:Blood immunometabolic indices and polymorphonuclear neutrophil function in peripartum dairy cows are altered by level of dietary energy prepartum.J Dairy Sci2012,95,1749–1758, doi:10.3168/jds.2011-4579.Open DOISearch in Google Scholar
Ingvartsen K.L., Andersen J.B.: Integration of metabolism and intake regulation: a review focusing on periparturient animals. J Dairy Sci 2000, 83, 1573–1597, doi: 10.3168/jds.S0022-0302(00)75029-6.IngvartsenK.L.AndersenJ.B.:Integration of metabolism and intake regulation: a review focusing on periparturient animals.J Dairy Sci2000,83,1573–1597, doi:10.3168/jds.S0022-0302(00)75029-6.Open DOISearch in Google Scholar
Ingvartsen K.L., Moyes K.M.: Factors contributing to immunosuppression in the dairy cow during the periparturient period. Jpn J Vet Res 2015, 63, 15–24.IngvartsenK.L.MoyesK.M.:Factors contributing to immunosuppression in the dairy cow during the periparturient period.Jpn J Vet Res2015,63,15–24.Search in Google Scholar
Jiang K., Cao S., Cui J.Z., Matsubara J.A.: Immuno-modulatory effect of IFN-gamma in AMD and its role as a possible target for therapy. J Clin Exp Ophthalmol 2013, 2, 71–76, doi: 10.4172/2155-9570-S2-007.JiangK.CaoS.CuiJ.Z.MatsubaraJ.A.:Immuno-modulatory effect of IFN-gamma in AMD and its role as a possible target for therapy.J Clin Exp Ophthalmol2013,2,71–76, doi:10.4172/2155-9570-S2-007.Open DOISearch in Google Scholar
Keller D., Farmer S., McCartney A., Gibson G.: Bacillus coagulans as a probiotic. Food Sci Tech Bull Funct Foods 2010, 7, 103–109, doi: 10.1616/1476-2137.16015.KellerD.FarmerS.McCartneyA.GibsonG.:Bacillus coagulans as a probiotic.Food Sci Tech Bull Funct Foods2010,7,103–109, doi:10.1616/1476-2137.16015.Open DOISearch in Google Scholar
Kimura K., Reinhardt T.A., Goff J.P.: Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. J Dairy Sci 2006, 89, 2588–2595, doi: 10.3168/jds.S0022-0302(06)72335-9.KimuraK.ReinhardtT.A.GoffJ.P.:Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle.J Dairy Sci2006,89,2588–2595, doi:10.3168/jds.S0022-0302(06)72335-9.Open DOISearch in Google Scholar
Lemme-Dumit J.M., Polti M.A., Perdigón G., Maldonaldo-Galdeano C.: Probiotic bacteria cell walls stimulate the activity of the intestinal epithelial cells and macrophage functionality. Benef Microbes 2018, 9, 153–164, doi: 10.3920/BM2016.0220.Lemme-DumitJ.M.PoltiM.A.PerdigónG.Maldonaldo-GaldeanoC.:Probiotic bacteria cell walls stimulate the activity of the intestinal epithelial cells and macrophage functionality.Benef Microbes2018,9,153–164, doi:10.3920/BM2016.0220.Open DOISearch in Google Scholar
Luan S., Duersteler M., Galbraith E.A., Cardoso F.C.: Effects of direct-fed Bacillus pumilus 8G-134 on feed intake, milk yield, milk composition, feed conversion, and health condition of pre- and postpartum Holstein cows. J Dairy Sci 2015, 98, 6423–6432, doi: 10.3168/jds.2015-9512.LuanS.DuerstelerM.GalbraithE.A.CardosoF.C.:Effects of direct-fed Bacillus pumilus 8G-134 on feed intake, milk yield, milk composition, feed conversion, and health condition of pre- and postpartum Holstein cows.J Dairy Sci2015,98,6423–6432, doi:10.3168/jds.2015-9512.Open DOISearch in Google Scholar
Maldonado-Galdeano C., Cazorla S.I., Lemme-Dumit J.M., Vélez E., Perdigón G.: Beneficial effects of probiotic consumption on the immune system. Ann Nutr Metab 2019, 74, 115–124, doi: 10.1159/000496426.Maldonado-GaldeanoC.CazorlaS.I.Lemme-DumitJ.M.VélezE.PerdigónG.:Beneficial effects of probiotic consumption on the immune system.Ann Nutr Metab2019,74,115–124, doi:10.1159/000496426.Open DOISearch in Google Scholar
Maldonado-Galdeano C., Novotny-Núñez I., de Moreno de LeBlanc A., Carmuega E., Weill R., Perdigón G.: Impact of a probiotic fermented milk in the gut ecosystem and in the systemic immunity using a non-severe protein-energy-malnutrition model in mice. BMC Gastroenterology 2011, 11, 64, doi: 10.1186/1471-230X-11-64.Maldonado-GaldeanoC.Novotny-NúñezI.de Moreno de LeBlancA.CarmuegaE.WeillR.PerdigónG.:Impact of a probiotic fermented milk in the gut ecosystem and in the systemic immunity using a non-severe protein-energy-malnutrition model in mice.BMC Gastroenterology2011,11,64, doi:10.1186/1471-230X-11-64.Open DOISearch in Google Scholar
Martinez N., Sinedino L.D.P., Bisinotto R.S., Ribeiro E.S., Gomes G.C., Lima F.S., Greco L.F., Risco C.A., Galvão K.N., Taylor-Rodriguez D., Driver J.P., Thatcher W.W., Santos J.E.P.: Effect of induced subclinical hypocalcemia on physiological responses and neutrophil function in dairy cows. J Dairy Sci 2014, 97, 874–887, doi: 10.3168/jds.2013-7408.MartinezN.SinedinoL.D.P.BisinottoR.S.RibeiroE.S.GomesG.C.LimaF.S.GrecoL.F.RiscoC.A.GalvãoK.N.Taylor-RodriguezD.DriverJ.P.ThatcherW.W.SantosJ.E.P.:Effect of induced subclinical hypocalcemia on physiological responses and neutrophil function in dairy cows.J Dairy Sci2014,97,874–887, doi:10.3168/jds.2013-7408.Open DOISearch in Google Scholar
McArt J.A.A., Nydam D.V., Oetzel G.R.: Epidemiology of subclinical ketosis in early lactation dairy cattle. J Dairy Sci 2012, 95, 5056–5066, doi: 10.3168/jds.2012-5443.McArtJ.A.A.NydamD.V.OetzelG.R.:Epidemiology of subclinical ketosis in early lactation dairy cattle.J Dairy Sci2012,95,5056–5066, doi:10.3168/jds.2012-5443.Open DOISearch in Google Scholar
Mulligan F.J., Doherty M.L.: Production diseases of the transition cow. Vet J 2008, 176, 3–9, doi: 10.1016/j.tvjl.2007.12.018.MulliganF.J.DohertyM.L.:Production diseases of the transition cow.Vet J2008,176,3–9, doi:10.1016/j.tvjl.2007.12.018.Open DOISearch in Google Scholar
Nocek J.E., Kautz W.P.: Direct-fed microbial supplementation on ruminal digestion, health, and performance of pre- and postpartum dairy cattle. J Dairy Sci 2006, 89, 260–266, doi: 10.3168/jds.S0022-0302(06)72090-2.NocekJ.E.KautzW.P.:Direct-fed microbial supplementation on ruminal digestion, health, and performance of pre- and postpartum dairy cattle.J Dairy Sci2006,89,260–266, doi:10.3168/jds.S0022-0302(06)72090-2.Open DOISearch in Google Scholar
Nocek J.E., Kautz W.P., Leedle J.A.Z., Block E.: Direct-fed microbial supplementation on the performance of dairy cattle during the transition period. J Dairy Sci 2003, 86, 331–335, doi: 10.3168/jds.S0022-0302(03)73610-8.NocekJ.E.KautzW.P.LeedleJ.A.Z.BlockE.:Direct-fed microbial supplementation on the performance of dairy cattle during the transition period.J Dairy Sci2003,86,331–335, doi:10.3168/jds.S0022-0302(03)73610-8.Open DOISearch in Google Scholar
Oelschlaeger T.A.: Mechanisms of probiotic actions – a review. Int J Med Microbiol 2010, 300, 57–62, doi: 10.1016/j.ijmm.2009.08.005.OelschlaegerT.A.:Mechanisms of probiotic actions – a review.Int J Med Microbiol2010,300,57–62, doi:10.1016/j.ijmm.2009.08.005.Open DOISearch in Google Scholar
Panasiuk A., Wysocka J., Maciorkowska E., Panasiuk B., Prokopowicz D., Zak J., Radomski K.: Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis. World J Gastroenterol 2005, 11, 7661–7665, doi: 10.3748/wjg.v11.i48.7661.PanasiukA.WysockaJ.MaciorkowskaE.PanasiukB.ProkopowiczD.ZakJ.RadomskiK.:Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis.World J Gastroenterol2005,11,7661–7665, doi:10.3748/wjg.v11.i48.7661.Open DOISearch in Google Scholar
Peng H., Wang J.Q., Kang H.Y., Dong S.H., Sun P., Bu D.P., Zhou L.Y.: Effect of feeding Bacillus subtilis natto fermentation product on milk production and composition, blood metabolites and rumen fermentation in early lactation dairy cows. J Anim Physiol Anim Nutr 2012, 96, 506–512, doi: 10.1111/j.1439-0396.2011.01173.x.PengH.WangJ.Q.KangH.Y.DongS.H.SunP.BuD.P.ZhouL.Y.:Effect of feeding Bacillus subtilis natto fermentation product on milk production and composition, blood metabolites and rumen fermentation in early lactation dairy cows.J Anim Physiol Anim Nutr2012,96,506–512, doi:10.1111/j.1439-0396.2011.01173.x.Open DOISearch in Google Scholar
Petrof E.O., Kojima K., Ropeleski M.J., Musch M.W., Tao Y., De Simone C., Chang E.B.: Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology 2004, 127, 1474–1487, doi: 10.1053/j.gastro.2004.09.001.PetrofE.O.KojimaK.RopeleskiM.J.MuschM.W.TaoY.De SimoneC.ChangE.B.:Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.Gastroenterology2004,127,1474–1487, doi:10.1053/j.gastro.2004.09.001.Open DOISearch in Google Scholar
Punetha M., Roy A.K., Ajithakumar H.M., Para I.A., Gupta D., Singh M., Bharati J.: Immunomodulatory effects of probiotics and prilled fat supplementation on immune genes expression and lymphocyte proliferation of transition stage Karan Fries cows. Vet World 2018, 11, 209–214, doi: 10.14202/vetworld.2018.209-214.PunethaM.RoyA.K.AjithakumarH.M.ParaI.A.GuptaD.SinghM.BharatiJ.:Immunomodulatory effects of probiotics and prilled fat supplementation on immune genes expression and lymphocyte proliferation of transition stage Karan Fries cows.Vet World2018,11,209–214, doi:10.14202/vetworld.2018.209-214.Open DOISearch in Google Scholar
Ribeiro E.S., Lima F.S., Greco L.F., Bisinotto R.S., Monteiro A.P.A., Favoreto M., Ayres H., Marsola R.S., Martinez N., Thatcher W.W., Santos J.E.P.: Prevalence of periparturient diseases and effects on fertility of seasonally calving grazing dairy cows supplemented with concentrates. J Dairy Sci 2013, 96, 5682–5697, doi: 10.3168/jds.2012-6335.RibeiroE.S.LimaF.S.GrecoL.F.BisinottoR.S.MonteiroA.P.A.FavoretoM.AyresH.MarsolaR.S.MartinezN.ThatcherW.W.SantosJ.E.P.:Prevalence of periparturient diseases and effects on fertility of seasonally calving grazing dairy cows supplemented with concentrates.J Dairy Sci2013,96,5682–5697, doi:10.3168/jds.2012-6335.Open DOISearch in Google Scholar
Saulnier D.M.A., Spinler J.K., Gibson G.R., Versalovic J.: Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol 2009, 20, 135–141, doi: 10.1016/j.copbio.2009.01.002.SaulnierD.M.A.SpinlerJ.K.GibsonG.R.VersalovicJ.:Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods.Curr Opin Biotechnol2009,20,135–141, doi:10.1016/j.copbio.2009.01.002.Open DOISearch in Google Scholar
Scalia D., Lacetera N., Bernabucci U., Demeyere K., Duchateau L., Burvenich C.: In vitro effects of nonesterified fatty acids on bovine neutrophils oxidative burst and viability. J Dairy Sci 2006, 89, 147–154, doi: 10.3168/jds.S0022-0302(06)72078-1.ScaliaD.LaceteraN.BernabucciU.DemeyereK.DuchateauL.BurvenichC.:In vitro effects of nonesterified fatty acids on bovine neutrophils oxidative burst and viability.J Dairy Sci2006,89,147–154, doi:10.3168/jds.S0022-0302(06)72078-1.Open DOISearch in Google Scholar
Schrezenmeir J., de Vrese M.: Probiotics, prebiotics and synbiotics—approaching a definition. Am J Clin Nutr 2001, 73, 361–364, doi: 10.1093/ajcn/73.2.361s.SchrezenmeirJ.de VreseM.:Probiotics, prebiotics and synbiotics—approaching a definition.Am J Clin Nutr2001,73,361–364, doi:10.1093/ajcn/73.2.361s.Open DOISearch in Google Scholar
Sheikhi A., Giti H., Heibor M.R., Jafarzadeh A., Shakerian M., Baharifar N., Niruzad F., Moghaddam A.S., Kokhaei P., Baghaeifar M.: Lactobacilus delbrueckii subsp. bulgaricus modulates the secretion of Th1/Th2 and Treg cell-related cytokines by PBMCs from patients with atopic dermatitis. Drug Res 2017, 67, 724–729, doi: 10.1055/s-0043-117612.SheikhiA.GitiH.HeiborM.R.JafarzadehA.ShakerianM.BaharifarN.NiruzadF.MoghaddamA.S.KokhaeiP.BaghaeifarM.:Lactobacilus delbrueckii subsp. bulgaricus modulates the secretion of Th1/Th2 and Treg cell-related cytokines by PBMCs from patients with atopic dermatitis.Drug Res2017,67,724–729, doi:10.1055/s-0043-117612.Open DOISearch in Google Scholar
Sichetti M., De Marco S., Pagiotti R., Traina G., Pietrella D.: Anti-inflammatory effect of multistrain probiotic formulation (L. rhamnosus, B. lactis, and B. longum). Nutrition 2018, 53, 95–102, doi: 10.1016/j.nut.2018.02.005.SichettiM.De MarcoS.PagiottiR.TrainaG.PietrellaD.:Anti-inflammatory effect of multistrain probiotic formulation (L. rhamnosus, B. lactis, and B. longum).Nutrition2018,53,95–102, doi:10.1016/j.nut.2018.02.005.Open DOISearch in Google Scholar
Sordillo L.M., Mavangira V.: The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows. Anim Prod Sci 2014, 54, 1204–1214, doi: 10.1071/AN14503.SordilloL.M.MavangiraV.:The nexus between nutrient metabolism, oxidative stress and inflammation in transition cows.Anim Prod Sci2014,54,1204–1214, doi:10.1071/AN14503.Open DOISearch in Google Scholar
Takeda S., Kawahara S., Hidaka M., Yoshida H., Watanabe W., Takeshita M., Kikuchi Y., Bumbein D., Muguruma M., Kurokawa M.: Effects of oral administration of probiotics from Mongolian dairy products on the Th1 immune response in mice. Biosci Biotechnol Biochem 2013, 77, 1372–1378, doi: 10.1271/bbb.120624.TakedaS.KawaharaS.HidakaM.YoshidaH.WatanabeW.TakeshitaM.KikuchiY.BumbeinD.MugurumaM.KurokawaM.:Effects of oral administration of probiotics from Mongolian dairy products on the Th1 immune response in mice.Biosci Biotechnol Biochem2013,77,1372–1378, doi:10.1271/bbb.120624.Open DOISearch in Google Scholar
Uyeno Y., Shigemori S., Shimosato T.: Effect of Probiotics/ Prebiotics on Cattle Health and Productivity. Microbes Environ 2015, 30, 126–132, doi: 10.1264/jsme2.ME14176.UyenoY.ShigemoriS.ShimosatoT.:Effect of Probiotics/ Prebiotics on Cattle Health and Productivity.Microbes Environ2015,30,126–132, doi:10.1264/jsme2.ME14176.Open DOISearch in Google Scholar
van Knegsel A.T.M., de Vries Reilingh G., Meulenberg S., van den Brand H., Dijkstra J., Kemp B., Parmentier H.K.: Natural antibodies related to energy balance in early lactation dairy cows. J Dairy Sci 2007, 90, 5490–5498, doi: 10.3168/jds.2007-0289.van KnegselA.T.M.de Vries ReilinghG.MeulenbergS.van den BrandH.DijkstraJ.KempB.ParmentierH.K.:Natural antibodies related to energy balance in early lactation dairy cows.J Dairy Sci2007,90,5490–5498, doi:10.3168/jds.2007-0289.Open DOISearch in Google Scholar
Wan M.L.Y., Forsythe S.J., El-Nezami H.: Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges. Crit Rev Food Sci Nutr 2019, 59, 3320–3333, doi: 10.1080/10408398.2018.1490885.WanM.L.Y.ForsytheS.J.El-NezamiH.:Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges.Crit Rev Food Sci Nutr2019,59,3320–3333, doi:10.1080/10408398.2018.1490885.Open DOISearch in Google Scholar
Wankhade P.R., Manimaran A., Kumaresan A., Jeyakumar S., Ramesha K.P., Sejian V., Rajendran D., Varghese M.R.: Metabolic and immunological changes in transition dairy cows: A review. Vet World 2017, 10, 1367–1377, doi: 10.14202/vetworld.2017. 1367-1377.WankhadeP.R.ManimaranA.KumaresanA.JeyakumarS.RameshaK.P.SejianV.RajendranD.VargheseM.R.:Metabolic and immunological changes in transition dairy cows: A review.Vet World2017,10,1367–1377, doi:10.14202/vetworld.2017.1367-1377.Open DOISearch in Google Scholar
Yoo J.Y., Kim S.S.: Probiotics and prebiotics: present status and future perspective on metabolic disorders. Nutrients 2016, 8, 173, doi: 10.3390/nu8030173.YooJ.Y.KimS.S.:Probiotics and prebiotics: present status and future perspective on metabolic disorders.Nutrients2016,8,173, doi:10.3390/nu8030173.Open DOISearch in Google Scholar