CHR | SNP | Genotype | Genotype number (percentage) | OR (95% CI) | P-value | |
---|---|---|---|---|---|---|
Control | Case | |||||
1 | A/A | 34 (41.5%) | 1 (2.5%) | 24.79 | 1.57 × 10−6 | |
G/A-G/G | 48 (58.5) | 35 (97.2%) | (3.24; 189.80) | |||
G/G | 37 (45.1%) | 2 (5.6%) | 13.98 | 7.08 × 10−6 | ||
A/G-A/A | 45 (54.9%) | 34 (94.4%) | (3.15; 62.08) | |||
2 | A/A | 41 (50.0%) | 3 (8.6%) | 10.67 | 5.15 × 10−6 | |
G/A-G/G | 41 (50.0%) | 32 (91.4%) | (3.03; 37.61) | |||
3 | A/A | 19 (23.2%) | 24 (66.7%) | 0.15 | 7.02 × 10−6 | |
G/A-G/G | 63 (76.8%) | 12 (33.3%) | (0.06; 0.36) | |||
8 | G/G | 49 (59.8%) | 35 (97.2%) | 0.04 | 2.67 × 10−6 | |
A/G-A/A | 33 (40.2%) | 1 (2.8%) | (0.01; 0.33) | |||
12 | G/G | 55 (67.1%) | 8 (22.9%) | 6.87 | 7.92 × 10−6 | |
A/G-A/A | 27 (32.9%) | 27 (77.1%) | (2.76; 17.14) | |||
13 | G/G | 65 (79.3%) | 13 (36.1%) | 6.76 | 6.52 × 10−6 | |
A/G-A/A | 17 (20.7%) | 23 (63.9%) | (2.85; 16.06) | |||
G/G | 38 (46.3%) | 32 (88.9%) | 0.11 | 4.35 × 10−6 | ||
A/G-A/A | 44 (53.7%) | 4 (11.1%) | (0.03; 0.33) | |||
15 | G/G | 37 (45.1%) | 32 (88.9%) | 0.10 | 2.50 × 10−6 | |
A/G-A/A | 45 (54.9%) | 4 (11.1%) | (0.03; 0.32) | |||
A/A | 38 (46.3%) | 32 (88.9%) | 0.11 | 4.35 × 10−6 | ||
G/A-G/G | 44 (53.7%) | 4 (11.1%) | (0.03; 0.33) | |||
16 | G/G | 60 (73.2%) | 8 (23.5%) | 8.86 | 6.14 × 10−7 | |
A/G-A/A | 22 (26.8%) | 26 (76.5%) | (3.49; 22.48) | |||
23 | A/A | 21 (26.2%) | 26 (72.2%) | 0.14 | 2.77 × 10−6 | |
G/A-G/G | 59 (73.8%) | 10 (27.8%) | (0.06; 0.33) | |||
28 | C/C | 51 (62.2%) | 6 (17.1%) | 7.95 | 3.93 × 10−6 | |
A/C-A/A | 31 (37.8%) | 29 (82.9%) | (2.97; 21.31) | |||
32 | G/G | 50 (61.0%) | 35 (97.2%) | 0.04 | 4.52 × 10−6 | |
A/G-A/A | 32 (39.0%) | 1 (2.8%) | (0.01; 0.34) |
SNP | CHR | Location (bp) | Minor allele | MAF (%) | MAFcontrol (%) | MAFcase (%) | HWE P-value | Candidate gene or locus/nearest gene or locus |
---|---|---|---|---|---|---|---|---|
1 | 65,212,166 | G | 46.19 | 37.20 | 66.67 | 0.85 | ||
1 | 65,293,673 | A | 42.37 | 32.93 | 63.89 | 1.00 | ||
1 | 65,819,801 | A | 46.61 | 56.71 | 23.61 | 0.46 | ||
1 | 14,217,295 | G | 47.03 | 52.44 | 34.72 | 0.47 | ||
1 | 67,922,585 | A | 27.97 | 32.32 | 18.06 | 0.25 | ||
1 | 41,988,950 | A | 14.83 | 6.71 | 33.33 | 0.00 | ||
1 | 66,185,882 | A | 36.86 | 26.22 | 61.11 | 0.00 | ||
2 | 82,135,437 | G | 39.32 | 32.93 | 54.29 | 0.70 | ||
3 | 27,421,551 | G | 41.53 | 51.22 | 19.44 | 0.34 | ||
3 | 36,857,983 | A | 49.57 | 57.93 | 30.00 | 0.06 | ||
3 | 27,777,144 | A | 49.57 | 59.76 | 26.39 | 0.03 | ||
8 | 12664933 | A | 36.75 | 24.07 | 65.28 | 0.05 | ||
8 | 49,696,532 | A | 19.07 | 26.83 | 1.39 | 0.00 | ||
8 | 34,943,508 | A | 17.37 | 11.59 | 30.56 | 0.34 | ||
8 | 56,964,583 | A | 39.57 | 37.80 | 43.94 | 0.02 | ||
10 | 47,442,988 | A | 36.44 | 33.53 | 43.06 | 0.00 | ||
11 | 61,345,663 | G | 47.88 | 56.71 | 27.78 | 0.01 | ||
11 | 52,671,467 | A | 23.73 | 26.22 | 18.06 | 0.01 | ||
12 | 19,343,255 | A | 26.50 | 19.51 | 42.86 | 1.00 | ||
13 | 39,050,399 | A | 19.49 | 10.98 | 38.89 | 0.38 | ||
14 | 45,742,638 | A | 42.80 | 53.05 | 19.44 | 0.19 | ||
14 | 45,744,668 | G | 42.37 | 52.44 | 19.44 | 0.19 | ||
15 | 42,346,461 | A | 27.12 | 35.37 | 8.33 | 0.00 | ||
15 | 42,358,113 | G | 27.12 | 35.37 | 8.33 | 0.00 | ||
15 | 42,352,911 | A | 27.54 | 35.98 | 8.33 | 0.00 | ||
16 | 35,869,183 | A | 23.28 | 14.63 | 44.12 | 1.00 | ||
19 | 46,961,958 | A | 27.35 | 22.56 | 38.57 | 0.06 | ||
22 | 7,706,835 | A | 49.15 | 56.10 | 32.86 | 0.10 | ||
23 | 51,871,689 | G | 43.53 | 55.63 | 16.67 | 0.00 | ||
24 | 29,281,559 | T | 25.42 | 17.07 | 44.44 | 1.00 | ||
28 | 20,841,387 | A | 29.91 | 21.95 | 48.57 | 1.00 | ||
30 | 35,183,072 | A | 42.37 | 31.71 | 66.67 | 0.00 | ||
32 | 29,141,932 | A | 16.53 | 23.17 | 1.39 | 0.09 | ||
34 | 30,205,708 | G | 49.58 | 39.02 | 73.61 | 0.07 | ||
35 | 20,654,940 | A | 22.03 | 14.63 | 38.89 | 0.01 | ||
35 | 15,603,710 | A | 36.44 | 46.34 | 13.89 | 0.05 | ||
37 | 30,735,796 | A | 38.46 | 34.76 | 47.14 | 0.56 | ||
37 | 24,240,716 | G | 38.98 | 35.98 | 45.83 | 0.44 | ||
37 | 9,335,944 | G | 40.25 | 50.00 | 18.06 | 0.03 | ||
X | 32,408,330 | A | 31.62 | 25.61 | 45.71 | 0.20 |
CHR | SNP | Genotype | Genotype number (percentage) | OR | 95% CI | P-value | |
---|---|---|---|---|---|---|---|
Control | Case | ||||||
1 | A/A | 34 (41.5%) | 1 (2.8%) | 1.00 | |||
G/A | 35 (42.7%) | 22 (61.1%) | 2.73 | (2.73; 167.5) | 6.1 × 10−6 | ||
G/G | 13 (15.9%) | 13 (36.1%) | 4.03 | (4.03; 286.7) | |||
G/G | 37 (45.1%) | 2 (5.6%) | 1.00 | ||||
A/G | 36 (43.9%) | 22 (61.1%) | 11.31 | (2.48; 51.61) | 7.1 × 10−6 | ||
A/A | 9 (11.0%) | 12 (33.3%) | 24.67 | (4.67; 130.35) | |||
G/G | 16 (19.5%) | 20 (55.6%) | 1.00 | ||||
A/G | 39 (47.6%) | 15 (41.7%) | 0.13 | (0.13; 0.75) | 8.9 × 10−6 | ||
A/A | 27 (32.9%) | 1 (2.8%) | 0.00 | (0.00; 0.24) | |||
8 | G/G | 46 (56.8%) | 6 (16.7%) | 1.00 | |||
A/G | 31 (38.3%) | 13 (36.1%) | 3.22 | (1.10; 9.37) | 5.7 × 10−8 | ||
A/A | 4 (4.9%) | 17 (47.2%) | 32.58 | (8.18; 129.78) | |||
14 | G/G | 19 (23.2%) | 23 (63.9%) | 1.00 | |||
A/G | 39 (47.6%) | 12 (33.3%) | 0.25 | (0.10; 0.62) | 8.8 × 10−6 | ||
A/A | 24 (29.3%) | 1 (2.8%) | 0.03 | (0.00; 0.28) | |||
16 | G/G | 60 (73.2%) | 8 (23.5%) | 1.00 | |||
A/G | 20 (24.4%) | 22 (64.7%) | 8.25 | (3.18; 21.43) | 3.2 × 10−6 | ||
A/A | 2 (2.4%) | 4 (11.8%) | 15.00 | (2.36; 95.47) | |||
19 | G/G | 56 (68.3%) | 10 (28.6%) | 1.00 | |||
A/G | 15 (18.3%) | 23 (65.7%) | 8.59 | (3.37; 21.89) | 4.8 × 10−6 | ||
A/A | 11 (13.4%) | 2 (5.7%) | 1.02 | (0.20; 5.30) | |||
23 | A/A | 21 (26.2%) | 26 (72.2%) | 1.00 | |||
G/A | 29 (36.2%) | 8 (22.2%) | 0.22 | (0.08; 0.59) | 2.9 × 10−6 | ||
G/G | 30 (37.5%) | 2 (5.6%) | 0.05 | (0.01; 0.25) | |||
37 | G/G | 42 (51.2%) | 4 (11.4%) | 1.00 | |||
A/G | 23 (28.0%) | 29 (82.9%) | 13.24 | (4.14; 42.34) | 1.5 × 10−7 | ||
A/A | 17 (20.7%) | 2 (5.7%) | 1.24 | (0.21; 7.39) |
Chromosomes | Codominant | Dominant | Recessive | Overdominant | Log-additive |
---|---|---|---|---|---|
1 |
|
|
|
||
2 | - |
|
- | - | - |
3 | - | - | |||
8 | |||||
10 | - | - | - | - | |
11 | - | - | - | ||
12 | - | - | - | - | |
13 | - | - | - | ||
14 | - | - | - | ||
15 | - | - | - | - | |
16 | - | - | |||
19 |
|
- | - |
|
- |
22 | - | - | - | - | |
23 | - | - | |||
24 | - | - | - | - | |
28 | - | - | - | - | |
30 | - | - | - | - | |
32 | - | - | - | - | |
34 | - | - | - | ||
35 | - | - | - | ||
37 | - | - | |||
X | - | - | - | - |
CHR | SNP | Genotype | Genotype number (percentage) | OR (95% CI) | P-value | |
---|---|---|---|---|---|---|
Control | Case | |||||
1 | G/G-A/A | 43 (52.4%) | 33 (91.7%) | 0.10 | 9.99 × 10−6 | |
A/G | 39 (47.6%) | 3 (8.3%) | (0.03; 0.35) | |||
8 | G/G-A/A | 71 (86.6%) | 16 (44.4%) | 8.07 | 3.03 × 10−6 | |
A/G | 11 (13.4%) | 20 (55.6%) | (3.23; 20.13) | |||
G/G-A/A | 62 (75.6%) | 10 (30.3%) | 7.13 | 6.16 × 10−6 | ||
A/G | 20 (24.4%) | 23 (69.7%) | (2.91; 17.49) | |||
10 | G/G-A/A | 65 (79.3%) | 13 (36.1%) | 6.76 | 6.52 × 10−6 | |
A/G | 17 (20.7%) | 23 (63.9%) | (2.85; 16.06) | |||
11 | G/G-A/A | 51 (62.2%) | 35 (97.2%) | 0.05 | 7.59 × 10−6 | |
A/G | 31 (37.8%) | 1 (2.8%) | (0.01; 0.36) | |||
19 | G/G-A/A | 67 (81.7%) | 12 (34.3%) | 8.56 | 7.49 × 10−7 | |
A/G | 15 (18.3%) | 23 (65.7%) | (3.50; 20.95) | |||
37 | A/A-G/G | 57 (69.5%) | 9 (25.0%) | 6.84 | 5.72 × 10−6 | |
G/A | 25 (30.5%) | 27 (75.0%) | (2.81; 16.64) | |||
G/G-A/A | 59 (72.0%) | 6 (17.1%) | 12.4 | 2.14 × 10−8 | ||
A/G | 23 (28.0%) | 29 (82.9%) | (4.55; 33.78) | |||
X | G/G-A/A | 62 (75.6%) | 11 (31.4%) | 6.76 | 6.79 × 10−6 | |
A/G | 20 (24.4%) | 24 (68.6%) | (2.82; 16.20) |
CHR | SNP | Genotype | Genotype number (percentage) | OR (95% CI) | P-value | |
---|---|---|---|---|---|---|
Control | Case | |||||
1 | A/A-G/A | 54 (65.9%) | 36 (100%) | 0 | 9.24 × 10−6 | |
G/G | 28 (34.1%) | 0 (0%) | 0 | |||
3 | C/C-A/C | 49 (59.8%) | 34 (97.1%) | 0.04 | 3.70 × 10−6 | |
A/A | 33 (40.2%) | 1 (2.9%) | (0.01; 0.33) | |||
8 | G/G-A/G | 77 (95.1%) | 19 (52.8%) | 17.22 | 9.55 × 10−8 | |
A/A | 4 (4.9%) | 17 (47.2%) | (5.19; 57.15) | |||
11 | A/A-G/A | 49 (59.8%) | 35 (97.2%) | 0.04 | 2.67 × 10−6 | |
G/G | 33 (40.2%) | 1 (2.8%) | (0.01; 0.33) | |||
22 | G/G-A/G | 50 (61.0%) | 34 (97.1%) | 0.05 | 6.19 × 10−6 | |
A/A | 32 (39.0%) | 1 (2.9%) | (0.01; 0.35) | |||
34 | A/A-G/A | 69 (84.1%) | 15 (41.7%) | 7.43 | 4.35 × 10−6 | |
G/G | 13 (15.9%) | 21 (58.3%) | (3.05; 18.08) | |||
35 | G/G-A/G | 81 (98.8%) | 26 (72.2%) | 31.15 | 8.60 ×10−6 | |
A/A | 1 (1.2%) | (27.8%) | (3.81; 255.00) |
CHR | SNP | Genotype | OR | 95% CI | P-value |
---|---|---|---|---|---|
1 | 0, 1, 2 | 4.66 | (2.17; 9.99) | 9.95 × 10−6 | |
0, 1, 2 | 4.21 | (2.11; 8.37) | 5.17 × 10−6 | ||
0, 1, 2 | 0.23 | (0.12; 0.46) | 2.40 × 10−6 | ||
0, 1, 2 | 3.25 | (1.87; 5.67) | 8.34 × 10−6 | ||
3 | 0, 1, 2 | 0.23 | (0.11; 0.47) | 4.23 × 10−6 | |
0, 1, 2 | 0.28 | (0.15; 0.52) | 8.86 × 10−6 | ||
8 | 0, 1, 2 | 5.46 | (2.76; 10.81) | 1.60 × 10−8 | |
13 | 0, 1, 2 | 5.39 | (2.50; 11.61) | 2.19 × 10−6 | |
14 | 0, 1, 2 | 0.22 | (0.11; 0.45) | 1.62 × 10−6 | |
0, 1, 2 | 0.23 | (0.12; 0.46) | 2.89 × 10−6 | ||
16 | 0, 1, 2 | 5.87 | (2.65; 13.03) | 1.16 × 10−6 | |
23 | 0, 1, 2 | 0.23 | (0.12; 0.45) | 4.49 × 10−7 | |
24 | 0, 1, 2 | 4.78 | (2.27; 10.08) | 6.34 × 10−6 | |
30 | 0, 1, 2 | 3.39 | (1.91; 6.03) | 6.58 × 10−6 | |
34 | 0, 1, 2 | 3.92 | (2.07; 7.41) | 2.84 × 10−6 | |
35 | 0, 1, 2 | 0.22 | (0.10; 0.46) | 2.81 × 10−6 | |
37 | 0, 1, 2 | 0.26 | (0.13; 0.51) | 9.59 × 10−6 |