No. | Substance name | VIP | P | Variation trend | Detection mode |
---|---|---|---|---|---|
1 | L-glutamate | 1.906599493 | 9.39957E−06 | ↑ | NEG |
2 | L-alanine | 1.870339069 | 9.66197E−05 | ↑ | NEG |
3 | Glycerol 3-phosphate | 1.813604415 | 0.001128205 | ↑ | NEG |
4 | Succinate | 1.790389164 | 0.000554729 | ↑ | NEG |
5 | 20-hydroxy-PGE2 | 1.786772601 | 2.17846E−05 | ↑ | NEG |
6 | Fosfomycin | 1.779219395 | 0.002655475 | ↑ | NEG |
7 | 3-methyluridine | 1.764311315 | 0.000277439 | ↑ | NEG |
8 | N-acetyl-L-alanine | 1.720196947 | 0.000240845 | ↑ | NEG |
9 | Choline | 1.877285980 | 2.37754E−07 | ↑ | POS |
10 | Trigonelline | 1.822938835 | 0.001548866 | ↑ | POS |
11 | Ile-asn | 1.806880095 | 1.10469E−05 | ↑ | POS |
12 | Arachidonic acid (peroxide free) | 1.772611472 | 0.001126785 | ↑ | POS |
13 | S-methyl-5′-thioadenosine | 1.770146402 | 0.000360333 | ↑ | POS |
14 | Creatinine | 1.751825211 | 5.23436E−05 | ↑ | POS |
15 | L-histidinol | 1.74002669 | 0.000841015 | ↑ | POS |
16 | Guanidine acetic acid | 1.698257167 | 0.000546455 | ↑ | POS |
17 | Cytosine | 1.662976359 | 0.000112223 | ↑ | POS |
18 | Inosine | 1.481481111 | 0.002446273 | ↓ | NEG |
19 | Adenine | 1.792517828 | 0.001575227 | ↑ | NEG |
20 | Hypoxanthine | 1.730804616 | 0.00067303 | ↑ | POS |
No. | Variety | Age (years) | Gender | Spaying status | Tumour type | Disease stage |
---|---|---|---|---|---|---|
T-1 | Chinese pastoral cat | 10 | Female | Unspayed | Mammary gland carcinoma | Without metastasis |
T-2 | Chinese pastoral cat | 10 | Female | Unspayed | Mammary gland carcinoma | Without metastasis |
T-3 | Chinese pastoral cat | 9 | Female | Unspayed | Mammary gland carcinoma | Without metastasis |
T-4 | Chinese pastoral cat | 9 | Female | Unspayed | Mammary gland carcinoma | Without metastasis |
T-5 | Chinese pastoral cat | 8 | Female | Unspayed | Mammary gland carcinoma | Without metastasis |
T-6 | Chinese pastoral cat | 7 | Female | Unspayed | Mammary gland carcinoma | Without metastasis |
C-1 | Chinese pastoral cat | 10 | Female | Unspayed | Healthy control | / |
C-2 | Chinese pastoral cat | 9 | Female | Unspayed | Healthy control | / |
C-3 | Chinese pastoral cat | 9 | Female | Unspayed | Healthy control | / |
C-4 | Chinese pastoral cat | 8 | Female | Unspayed | Healthy control | / |
C-5 | Chinese pastoral cat | 8 | Female | Unspayed | Healthy control | / |
C-6 | Chinese pastoral cat | 8 | Female | Unspayed | Healthy control | / |
Substance name | LC-MS non-target metabolomics results | MRM target metabolomics results | ||||
---|---|---|---|---|---|---|
Fold change | VIP | P | Variation trend (T C) | T group final concentration (average) | C group final concentration (average) | |
S-methyl-5′-thioadesine | 2.879152807 | 1.770146402 | 0.000360333 | ↑ | 0.011 | 0.003 |
Creatinine | 1.632513451 | 1.751825211 | 5.23436E−05 | ↑ | 42.117 | 10.13 |
Cytosine | 1.981265029 | 1.662976359 | 0.000112223 | ↑ | 1.383 | 0.49 |
Choline | 1.836734369 | 1.877285980 | 2.37754E−07 | ↑ | 4.381 | 0.71 |
Betaine nicotinate | ||||||
(Trigonelline) | 3.178675095 | 1.822938835 | 0.001548866 | ↑ | 1.915 | 0.32 |
L-alanine | 1.891848591 | 1.870339069 | 9.66197E−05 | ↑ | 190.229 | 94.83 |
L-glutamic acid | 5.129593730 | 1.533880516 | 0.019410600 | ↑ | 30.959 | 3.65 |