<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Circadian rhythm refers to the daily physiologically fluctuating patterns of systemic processes that occur within a circa 24-hour timeframe, independently of external factors. There is evidence that in time, external and internal cycle misalignment leads to severe health consequences, resulting in the development of cardiometabolic disturbances. Desynchronized hormonal fluctuations along with daily specific macronutrient utilization patterns are also discussed, which by consequence, are all predictors of metabolic syndrome. The aim of this paper is to provide insight on the circadian clock’s organization throughout the human body and to explain the underlying genetic background. By understanding these well-established molecular mechanisms and processes, we believe this paper will provide accuracy regarding the importance of the circadian clock’s integrity and will highlight its role in the etiopathology of cardiometabolic syndrome.</p>
</abstract>

Circadian rhythm refers to the daily physiologically fluctuating patterns of systemic processes that occur within a circa 24-hour timeframe, independently of external factors. There is evidence that in time, external and internal cycle misalignment leads to severe health consequences, resulting in the development of cardiometabolic disturbances. Desynchronized hormonal fluctuations along with daily specific macronutrient utilization patterns are also discussed, which by consequence, are all predictors of metabolic syndrome. The aim of this paper is to provide insight on the circadian clock’s organization throughout the human body and to explain the underlying genetic background. By understanding these well-established molecular mechanisms and processes, we believe this paper will provide accuracy regarding the importance of the circadian clock’s integrity and will highlight its role in the etiopathology of cardiometabolic syndrome.

The Circadian Axis and Cardiometabolic Syndrome

“George Emil Palade” University of Medicine

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Circadian Axis and Cardiometabolic Syndrome"}

Circadian rhythm refers to the daily physiologically fluctuating patterns of systemic processes that occur within a circa 24-hour timeframe, independently of...

The Circadian Axis and Cardiometabolic Syndrome

Data publikacji: 07 lis 2022

Zakres stron: 47 - 55

Otrzymano: 06 sie 2022

Przyjęty: 05 wrz 2022

DOI: https://doi.org/10.2478/jim-2022-0017

Słowa kluczowe
circadian rhythm, cardiometabolic syndrome, diabetes, clock gene, hormonal fluctuation

© 2022 Boglárka Varga et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Circadian Axis and Cardiometabolic Syndrome

Data publikacji: 07 lis 2022

Zakres stron: 47 - 55

Otrzymano: 06 sie 2022

Przyjęty: 05 wrz 2022

DOI: https://doi.org/10.2478/jim-2022-0017

Słowa kluczowecircadian rhythm, cardiometabolic syndrome, diabetes, clock gene, hormonal fluctuation

© 2022 Boglárka Varga et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
circadian rhythm, cardiometabolic syndrome, diabetes, clock gene, hormonal fluctuation