<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Background:</bold> Gastritis is a progressive disease that evolves from a non-atrophic to an atrophic state and progresses through intestinal metaplasia, even leading to gastric cancer. Gastritis is defined by an inflammatory process of the mucosal lining of the stomach.
<bold>Aim:</bold> We aimed to identify any association between <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>)-positive gastritis and simple inflammatory markers derived from a complete blood count such as the platelet-to-lymphocyte ratio (PLR).
<bold>Material and Methods:</bold> We performed a retrospective case-control study in which we included patients who underwent an upper digestive endoscopy with biopsy between January 2019 and December 2020 and were diagnosed with gastritis. <italic>H. pylori</italic> status was determined from the histopathological examination, and complete blood count was performed from venous blood samples. The final study group included 125 patients with <italic>H. pylori</italic>-positive chronic gastritis, and the control group was made up by 207 patients without <italic>H. pylori</italic> infection.
<bold>Results:</bold> We found a higher value of the PLR in <italic>H. pylori</italic>-positive patients than in the control group, but the difference was not significant statistically.
<bold>Conclusions:</bold> PLR levels could be a predictor of inflammation in <italic>H. pylori</italic> infection, but an extensive study is needed to confirm this theory.
</abstract>

Background: Gastritis is a progressive disease that evolves from a non-atrophic to an atrophic state and progresses through intestinal metaplasia, even leading to gastric cancer. Gastritis is defined by an inflammatory process of the mucosal lining of the stomach.
Aim: We aimed to identify any association between Helicobacter pylori (H. pylori)-positive gastritis and simple inflammatory markers derived from a complete blood count such as the platelet-to-lymphocyte ratio (PLR).
Material and Methods: We performed a retrospective case-control study in which we included patients who underwent an upper digestive endoscopy with biopsy between January 2019 and December 2020 and were diagnosed with gastritis. H. pylori status was determined from the histopathological examination, and complete blood count was performed from venous blood samples. The final study group included 125 patients with H. pylori-positive chronic gastritis, and the control group was made up by 207 patients without H. pylori infection.
Results: We found a higher value of the PLR in H. pylori-positive patients than in the control group, but the difference was not significant statistically.
Conclusions: PLR levels could be a predictor of inflammation in H. pylori infection, but an extensive study is needed to confirm this theory.

A Link Between Platelet-to-Lymphocyte Ratio and <italic>Helicobacter pylori</italic> Infection

Department of Gastroenterology, Faculty of Medicine

“George Emil Palade” University of Medicine, Pharmacy, Science and Technology

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A Link Between Platelet-to-Lymphocyte Ratio and  Infection

Background: Gastritis is a progressive disease that evolves from a non-atrophic to an atrophic state and progresses through intestinal metaplasia, even leading...

A Link Between Platelet-to-Lymphocyte Ratio and Helicobacter pylori Infection

Data publikacji: 18 lut 2022

Zakres stron: 182 - 184

Otrzymano: 09 wrz 2021

Przyjęty: 13 wrz 2021

DOI: https://doi.org/10.2478/jim-2021-0040

Słowa kluczowe
gastritis, platelet-to-lymphocyte ratio

© 2021 Sergiu Ioan Frandeș et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A Link Between Platelet-to-Lymphocyte Ratio and Helicobacter pylori Infection

Data publikacji: 18 lut 2022

Zakres stron: 182 - 184

Otrzymano: 09 wrz 2021

Przyjęty: 13 wrz 2021

DOI: https://doi.org/10.2478/jim-2021-0040

Słowa kluczowegastritis, platelet-to-lymphocyte ratio

© 2021 Sergiu Ioan Frandeș et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
gastritis, platelet-to-lymphocyte ratio