<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Atherosclerosis is the elemental precondition for any cardiovascular disease and the predominant cause of ischemic heart disease that often leads to myocardial infarction. Systemic risk factors play an important role in the starting and progression of atherosclerosis. The complexity of the disease is caused by its multifactorial origin. Besides the traditional risk factors, genetic predisposition is also a strong risk factor. Many studies have intensively researched cardioprotective drugs, which can relieve myocardial ischemia and reperfusion injury, thereby reducing infarct size. A better understanding of abnormal epigenetic pathways in the myocardial pathology may result in new treatment options. Individualized therapy based on genome sequencing is important for an effective future medical treatment. Studies based on multiomics help to better understand the pathophysiological mechanism of several diseases at a molecular level. Epigenomic, transcriptomic, proteomic, and metabolomic research may be essential in detecting the pathological phenotype of myocardial ischemia and ischemic heart failure.</p>
</abstract>

Atherosclerosis is the elemental precondition for any cardiovascular disease and the predominant cause of ischemic heart disease that often leads to myocardial infarction. Systemic risk factors play an important role in the starting and progression of atherosclerosis. The complexity of the disease is caused by its multifactorial origin. Besides the traditional risk factors, genetic predisposition is also a strong risk factor. Many studies have intensively researched cardioprotective drugs, which can relieve myocardial ischemia and reperfusion injury, thereby reducing infarct size. A better understanding of abnormal epigenetic pathways in the myocardial pathology may result in new treatment options. Individualized therapy based on genome sequencing is important for an effective future medical treatment. Studies based on multiomics help to better understand the pathophysiological mechanism of several diseases at a molecular level. Epigenomic, transcriptomic, proteomic, and metabolomic research may be essential in detecting the pathological phenotype of myocardial ischemia and ischemic heart failure.

A Genomic Approach to Characterize the Vulnerable Patient – a Clinical Update

University of Medicine, Pharmacy, Science and Technology

Journal of Interdisciplinary Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Atherosclerosis is the elemental precondition for any cardiovascular disease and the predominant cause of ischemic heart disease that often leads to myocardial...

A Genomic Approach to Characterize the Vulnerable Patient – a Clinical Update

Data publikacji: 11 lis 2019

Zakres stron: 141 - 144

Otrzymano: 28 lip 2019

Przyjęty: 04 wrz 2019

DOI: https://doi.org/10.2478/jim-2019-0023

Słowa kluczowe
coronary artery disease, multiomics, epigenetics, gene sequencing, proteomics

© 2019 Evelin Szabó et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A Genomic Approach to Characterize the Vulnerable Patient – a Clinical Update

Data publikacji: 11 lis 2019

Zakres stron: 141 - 144

Otrzymano: 28 lip 2019

Przyjęty: 04 wrz 2019

DOI: https://doi.org/10.2478/jim-2019-0023

Słowa kluczowecoronary artery disease, multiomics, epigenetics, gene sequencing, proteomics

© 2019 Evelin Szabó et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
coronary artery disease, multiomics, epigenetics, gene sequencing, proteomics