Off-label Therapy of Hypogonadotropic Hypogonadism in a 35-year-old Male Patient Using Clomiphene Citrate – A Case Study

1 Ide V, Vanderschueren D, Antonio L. Molecular Sciences Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy 2020. https://doi.org/10.3390/ijms22010021. Search in Google Scholar

2 Salonia A et al. Paediatric and adult-onset male hypogonadism HHS Public Access. Nat Rev Dis Prim 2020; 5. https://doi.org/10.1038/s41572-019-0087-y. Search in Google Scholar

3 Corona G et al. European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology. Andrology 2020; 8(5): 970–987. https://doi.org/10.1111/andr.12770. Search in Google Scholar

4 Bhasin S et al. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society* Clinical Practice Guideline. J Clin Endocrinol Metab 2018; 103(5): 1715–1744. https://doi.org/10.1210/jc.2018-00229. Search in Google Scholar

5 Wang C, Swerdloff RS. Testosterone Replacement Therapy in Hypogonadal Men. Endocrinol Metab Clin North Am 2022; 51: 77–98. https://doi.org/10.1016/j.ecl.2021.11.005. Search in Google Scholar

6 Pozza C et al. Testicular ultrasound score: A new proposal for a scoring system to predict testicular function. Andrology 2020; 8(5): 1051–1063. https://doi.org/10.1111/andr.12822. Search in Google Scholar

7 Fukuhara N, Nishiyama M, Iwasaki Y. Update in Pathogenesis, Diagnosis, and Therapy of Prolactinoma. Cancers (Basel) 2022; 14(15). https://doi.org/10.3390/cancers14153604. Search in Google Scholar

8 Corona G. et al. Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: A systematic review and meta-analysis. Eur J Endocrinol 2013; 168(6): 829–843. https://doi.org/10.1530/EJE-12-0955. Search in Google Scholar

9 Huijben M, Lock MTWT, de Kemp VF, de Kort LMO, van Breda HMK. Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis. Andrology 2022; 10(3): 451–469. https://doi.org/10.1111/andr.13146. Search in Google Scholar

10 Auriemma RS, Pirchio R, De Alcubierre D, Pivonello R, Colao A. At the Cutting Edge Dopamine Agonists: From the 1970s to Today. Neuroendocrinology 2019; 109: 34–41. https://doi.org/10.1159/000499470. Search in Google Scholar

11 Rastrelli G, Corona G, Mannucci E, Maggi M. Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study. Andrology 2014; 2(6): 794–808. https://doi.org/10.1111/andr.262. Search in Google Scholar

12 Dwyer AA, Raivio T, Pitteloud N. Gonadotrophin replacement for induction of fertility in hypogonadal men. Best Pract Res Clin Endocrinol Metab 2015; 29(1): 91–103, Jan. https://doi.org/10.1016/J.BEEM.2014.10.005. Search in Google Scholar

13 Liu PY, Wishart SM, Handelsman DJ. A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Recombinant Human Chorionic Gonadotropin on Muscle Strength and Physical Function and Activity in Older Men with Partial Age-Related Androgen Deficiency; 2002 [online]. https://academic.oup.com/jcem/article/87/7/3125/2846669. Access: 07 April 2023. Search in Google Scholar

14 European Medicines Agency. Assessment Report EnCyzix 2018; 44, January [online]. https://www.ema.europa.eu/en/documents/assessment-report/encyzix-epar-public-assessment-report_en.pdf. Search in Google Scholar

15 Expert Opinion Comment 2022; 48: 850–856. https://doi.org/10.1590/S1677-5538.IBJU.2021.0724. Search in Google Scholar

16 Marconi M, Souper R, Hartmann J, Alvarez M, Fuentes I, Guarda FJ. Clomiphene citrate treatment for late onset hypogonadism: rise and fall. Int Braz J Urol 2016; 42: 1190–1194. https://doi.org/10.1590/S1677-5538.IBJU.2016.0112. Search in Google Scholar

17 Awouters M, Vanderschueren D, Antonio L. Aromatase inhibitors and selective estrogen receptor modulators: Unconventional therapies for functional hypogonadism? Andrology 2020; 8(6): 1590–1597. https://doi.org/10.1111/andr.12725. Search in Google Scholar