Diagnostic performance of point-of-care ultrasonography (POC-US) in haemophilia joint health: a comparative study with MRI

Diagnostic performance of POC-US for evaluation

	SYNOVIAL HYPERTROPHY	CARTILAGE ABNORMALITY	BONY ABNORMALITY
True positive	32	6	6
True negative	11	34	38
False positive	1	0	0
False negative	1	5	1
Sensitivity	96.9	54.5	85.7
Specificity	91.6	100.0	100.0
PPV	96.9	100.0	100.0
NPV	91.6	87.1	97.4
Diagnostic accuracy	95.5	88.8	97.7
Kappa value	0.89	0.64	0.91

Participant demographics (N=42)

AGE GROUP (YEARS)	NUMBER (N (%))
10–19	18 (42.8%)
20–29	18 (42.8%)
30–39	4 (9.5%)
40–49	2 (4.7%)
Mean ± S.D	21.2 ±7.6
HAEMOPHILIA TYPE
Haemophilia A	35 (83.3%)
Haemophilia B	7 (16.6%)
HAEMOPHILIA SEVERITY
Severe	24 (57.1%)
Moderate	10 (23.8%)
Mild	8 (19%)
FAMILY HISTORY
Positive	24 (57.1%)
Negative	18 (42.8%)

Point-of-care ultrasound (POC-US) results for knee and ankle joints in the study cohort (n=42)

	SYNOVIAL HYPERTROPHY	CARTILAGE ABNORMALITY	BONY ABNORMALITY
Knee	30	6	6
Ankle	3	0	0
Total	33	6	6

Magnetic resonance imaging (MRI) results for knee and ankle joints in the study cohort (n=42)

	SYNOVIAL HYPERTROPHY	CARTILAGE ABNORMALITY	BONY ABNORMALITY
Knee	30	10	6
Ankle	3	1	1
Total	33	11	7

Comparision of the POC-US and MRI findings of the involved knee and ankle joints

		KNEES (N =)		ANKLES (N =)		OVERALL (N =)
		MRI−	MRI+	MRI−	MRI+	MRI−	MRI+
Synovial hypertrophy	POC-US−	11	1	0	0	11	1
	POC-US+	1	29	0	3	1	32
Bone irregularities	POC-US−	35	1	3	0	38	1
	POC-US+	0	6	0	0	0	6
Cartilage abnormalities	POC-US−	31	5	3	0	34	5
	POC-US+	0	6	0	0	0	6