A Study of Methods to Identify Industry-University-Research Institution Cooperation Partners based on Innovation Chain Theory
, , , , oraz | 22 cze 2018
O artykule
Article Category: Research Paper
Data publikacji: 22 cze 2018
Zakres stron: 38 - 61
Otrzymano: 17 lis 2017
Przyjęty: 03 maj 2018
DOI: https://doi.org/10.2478/jdis-2018-0008
Słowa kluczowe
© 2018 Walter de Gruyter GmbH, Berlin/Boston, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
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GEV types in domestic China.
| No. | Manufacturers | Genetically Engineered Vaccine | Province |
|---|---|---|---|
| 1 | Beijing Tiantan Biological Products Co., Ltd. | Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) | Beijing |
| 2 | Shenzhen Kangtai Biological Products Co., Ltd. | Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) | Guangdong |
| 3 | Hualan Biolocical Engineering, Inc. | Recombinant Hepatitis B Vaccine (Hansenula polymorpha) | Henan |
| 4 | Dalian Hissen Bio-pharm.Co., Ltd. | Recombinant Hepatitis B Vaccine (Hansenula polymorpha) | Liaoning |
| 5 | Beijing Waldorf Shield Biotechnology Co., Ltd. | Recombinant Hepatitis B Vaccine (CHO cell) | Beijing |
| 6 | Lanzhou Institute of Biological Products Co., Ltd. | Recombinant Hepatitis B Vaccine (CHO cell) | Gansu |
| 7 | NCPC GeneTech Biotechnology Development Co., Ltd. | Recombinant Hepatitis B Vaccine (CHO cell) | Hebei |
| 8 | Wuhan Institute of Biological Products Research Co., Ltd. | Recombinant Hepatitis B Vaccine (CHO cell) | Hubei |
| 9 | Xiamen Innovax Biotech Co., Ltd. | Recombinant Hepatitis E Vaccine (Escherichia coli) | Fujian |
| 10 | Shanghai United Cell Biotechnology Co., Ltd. | Recombinant B subunit / bacterial cholera vaccine (enteric-coated capsule) | Shanghai |
Evaluation indexes of institutional competitiveness based on innovation chain.
| First-level indexes | Innovation target | Category | Participate subjects | Second-level indexes |
|---|---|---|---|---|
| Basic research | Problems→Theory | technology | University, R&D institutes | research papers |
| Application research | Theory→Appliaction | technology | University, R&D institutes | patents |
| Transfer and Transformation | Appliaction→Production | technology | University, R&D institutes, enterprises | technological achievements amount |
| Commercialization | Production→Marketing | economic | enterprises | goods amount |
| Industrialization | Marketing→Industry | economic | Production subject, sales subject | industrial scale |
Types of vaccine production enterprises in domestic China.
| Genetically Engineered Vaccine | Vaccine manufacturer |
|---|---|
| Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) | Shenzhen Kangtai Biological Products Co., Ltd., Beijing Tiantan Biological Products Co., Ltd., Glaxo Smith Kline |
| Recombinant Hepatitis B Vaccine (Hansenula polymorpha) | Hualan Biolocical Engineering, Inc., Dalian Hissen Bio-pharm. Co., Ltd., Berna Biotech AG |
| Recombinant Hepatitis B Vaccine (CHO cell) | NCPC GeneTech Biotechnology Development Co., Ltd., Beijing Waldorf Shield Biotechnology Co., Ltd. |
| Recombinant B subunit / bacterial cholera vaccine (enteric-coated capsule) | Shanghai United Cell Biotechnology Co., Ltd. |
| Recombinant hepatitis E vaccine (Escherichia coli) | Xiamen Innovax Biotech Co., Ltd. |
Publication of SCI papers of domestic GEV by the amount of top19 institutions.
| No. | institution | Province | Number of papers | citations | Cited amount of average article | Number of CNCI |
|---|---|---|---|---|---|---|
| 1 | Chinese Academy of Sciences | Beijing | 26 | 240 | 9.23 | 0.96 |
| 2 | Chinese Academy of Agricultural Sciences | Beijing | 25 | 219 | 8.76 | 0.87 |
| 3 | Chinese Academy of Military Medical Sciences | Beijing | 12 | 124 | 10.33 | 0.69 |
| 4 | The Fourth Military Medical University | Shaanxi | 12 | 68 | 5.67 | 0.39 |
| 5 | Huazhong University of Science and Technology | Hubei | 10 | 79 | 7.90 | 0.48 |
| 6 | Shanghai Jiao Tong University | Shanghai | 9 | 91 | 10.11 | 0.41 |
| 7 | Zhejiang University | Zhejiang | 9 | 67 | 7.44 | 0.93 |
| 8 | Shanghai Institutes for Biological Sciences | Shanghai | 8 | 109 | 13.63 | 1.07 |
| 9 | Sichuan University | Sichuan | 8 | 37 | 4.63 | 0.36 |
| 10 | Peking University | Beijing | 7 | 52 | 7.43 | 0.52 |
| 11 | The Second Military Medical University | Shanghai | 7 | 42 | 6.00 | 0.71 |
| 12 | Huazhong Agricultural University | Hubei | 5 | 58 | 11.60 | 0.73 |
| 13 | China Medical University | Liaoning | 5 | 38 | 7.60 | 0.73 |
| 14 | South China Agricultural University | Guangdong | 4 | 51 | 12.75 | 1.53 |
| 15 | Jilin Agricultural University | Jilin | 4 | 47 | 11.75 | 1.45 |
| 16 | Central South University | Hunan | 4 | 42 | 10.50 | 0.6 |
| 17 | China Agricultural University | Beijing | 3 | 46 | 15.33 | 0.7 |
| 18 | Chongqing Medical University | Chongqing | 3 | 38 | 12.67 | 0.49 |
| 19 | The National Center for Nanoscience and Technology of China | Beijing | 1 | 54 | 54.00 | 6.23 |
Major GEV patents owners in domestic China (institutions have more than 10 patents).
| No. | Patent agencies | Province | Number of Patents |
|---|---|---|---|
| 1 | Fudan University | SH | 51 |
| 2 | Third Military Medical University | CQ | 45 |
| 3 | Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences | GS | 39 |
| 4 | Harbin Veterinary Research Institute, CAAS | HL | 29 |
| 5 | Society for Microbiology of Military Medical College | BJ | 21 |
| 6 | Huazhong Agricultural University | HB | 21 |
| 7 | Nanjing Agricultural University | JS | 19 |
| 8 | The Fourth Military Medical University | SN | 18 |
| 9 | Aventis Pasteur Company | GD | 17 |
| 10 | Institute of Basic Medical Sciences, Academy of Military Medical Sciences | BJ | 17 |
| 11 | Jiangsu Academy of Agricultural Sciences | JS | 17 |
| 12 | Beijing Kaiyin Biological Technology Co., Ltd. | BJ | 16 |
| 13 | Jilin University | JL | 16 |
| 14 | The Second Military Medical University | SH | 16 |
| 15 | Sichuan Agricultural University | SC | 16 |
| 16 | Institute of medical biology of Chinese Academy of Sciences | BJ | 13 |
| 17 | Merial Co., Ltd. | JX | 13 |
| 18 | Pulaike Biological Engineering Co., Ltd. | HN | 13 |
| 19 | Shanghai Human Genome Research Center | SH | 13 |
| 20 | South China Agricultural University | GD | 13 |
| 21 | Wuhan University | HB | 12 |
| 22 | Institute of Microbiology, Chinese Academy of Sciences | BJ | 11 |
| 23 | China Agricultural University | BJ | 11 |
| 24 | Xiamen University | FJ | 11 |
| 25 | Zhejiang University | ZJ | 11 |
| 26 | Institute of Medical Biotechnology of Chinese Academy of Medical Sciences | BJ | 10 |
| 27 | Yuanlun Biotechnology Co., Ltd. | CQ | 10 |
| 28 | Center for Parasitic Diseases Control and Prevention | SH | 10 |
| 29 | Institute of Military Veterinary Medicine, Academy of Military Medical Sciences | JL | 10 |
| 30 | Shanghai Veterinary Research Institute, CAAS | SH | 10 |
| 31 | Zhongshan University | GD | 10 |
GEV Production of enterprise with relevant patents.
| Vaccine manufacturer | Number of genetically engineered vaccine patents | Number of genetically engineered vaccine |
|---|---|---|
| Liaoning Chengda Co., Ltd. | 2 | 0 |
| Liaoning Yisheng BioPharma Co., Ltd. | 3 | 0 |
| Xiamen Innovax Biotech Co., Ltd. | 3 | 1 |
| Changchun BCHT Biotechnology Co. | 2 | 0 |
Category types of IURC in GEV innovation chain in domestic China.
| Basic research | Applied research | Transfer and transformation | Commercialization and industrialization |
|---|---|---|---|
| Research institutes | Research institutes | enterprise | Enterprise |
| Agricultural University | Agricultural University | N/A | N/A |
| comprehensive research | comprehensive research | N/A | N/A |
| university | university | ||
| N/A | enterprise | N/A | N/A |
Total proportion of GEV commercialization scale in domestic China (2007–2015).
| No. | Vaccine manufacturer | Genetically Engineered Vaccine | Proportion of scale | Region (Country) |
|---|---|---|---|---|
| 1 | Shenzhen Kangtai Biological Products Co., Ltd. | Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) | 33.7% | Guangdong |
| 2 | Beijing Tiantan Biological Products Co., Ltd. | Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) | 24.3% | Beijing |
| 3 | Dalian Hissen Bio-pharm.Co., Ltd. | Recombinant Hepatitis B Vaccine (Hansenula polymorpha) | 19.7% | Liaoning |
| 4 | NCPC GeneTech Biotechnology Development Co., Ltd. | Recombinant Hepatitis B Vaccine (CHO cell) | 12.7% | Hebei |
| 5 | Glaxo Smith Kline | Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) | 3.9% | Belgium |
| 6 | Hualan Biolocical Engineering, Inc. | Recombinant Hepatitis B Vaccine (Hansenula polymorpha) | 2.5% | Hennan |
| 7 | Shanghai United Cell Biotechnology Co., Ltd. | Recombinant B subunit / bacterial cholera vaccine (enteric-coated capsule) | 1.8 | Shanghai |
| 8 | Beijing Waldorf Shield Biotechnology Co., Ltd. | Recombinant Hepatitis B Vaccine (CHO cell) | 0.9 | Beijing |
| 9 | Berna Biotech AG | Recombinant Hepatitis B Vaccine (Hansenula polymorpha) | 0.4 | Switzerland |
| 10 | Xiamen Innovax Biotech Co., Ltd. | Recombinant Hepatitis E Vaccine (Escherichia coli) | 0.1 | Fujian |
The spatial distribution of GEV institutions in domestic China.
| Region | Basic Research Institute | Applied Research Institute | Commercialization and industrialization organization |
|---|---|---|---|
| Guangdong | South China Agricultural University | Aventis Pasteur Company South China Agricultural University Zhongshan University | Shenzhen Kangtai Biological Products Co., Ltd. |
| Beijing | Chinese Academy of Sciences Academy of Military Medical Sciences Chinese Academy of Agricultural Sciences Peking University The National Center for Nanoscience and Technology, Chinese Academy of Sciences | Institute of Microbiology of Military Medical College Institute of Basic Medical Sciences, Military Medical College Beijing Kaiyin Biological Technology Co., Ltd. Institute of medical biology of Chinese Academy of Sciences Institute of Microbiology, Chinese Academy of Sciences China Agricultural University Institute of Medical Biotechnology of Chinese Academy of Medical Sciences | Beijing Tiantan Biological Products Co., Ltd. Beijing Waldorf Shield Biotechnology Co., Ltd. |
| Liaoning | China Medical University | N/A | Dalian Hissen Bio-pharm. Co., Ltd. |
| Heibei | N/A | N/A | NCPC GeneTech Biotechnology Development Co., Ltd. |
| Henan | N/A | Pulaike Biological Engineering Co., Ltd. | Hualan Biolocical Engineering, Inc. |
| Shanghai | Shanghai Jiao Tong University Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences | Fudan University The Second Military Medical University Shanghai Human Genome Research Center Center for Parasitic Diseases Control and Prevention | Shanghai United Cell Biotechnology Co., Ltd. |
| The Second Military Medical University | Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences | ||
| Fujian | N/A | Xiamen University | Xiamen Innovax Biotech Co., Ltd. |