Simplified Diagnosis of Urosepsis by Emergency Ultrasound Combined with Clinical Scores and Biomarkers
, , , , , , , , oraz | 30 sty 2024
O artykule
Article Category: Research Article
Data publikacji: 30 sty 2024
Zakres stron: 30 - 37
Otrzymano: 04 lis 2023
Przyjęty: 10 gru 2023
DOI: https://doi.org/10.2478/jccm-2024-0006
Słowa kluczowe
© 2024 Alice Nicoleta Dragoescu et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Fig. 1.
Fig. 2.
Fig. 3.
Patient demographic and biological parameters and scores with comparison between those with sepsis and septic shock.
| Age (years) | 63.4 ±15.1 | 61.7 ±15.7 | 70.3 ±10.2 | 0.015 |
| Sex (M/F) | 52/24 | 43/18 | 9/6 | 0.433 |
| SOFA score | 6.1 ± 3.2 | 5.3 ± 2.3 | 9.4 ± 2.9 | < 0.001 |
| NEWS | 9.8 ± 2.9 | 9.1 ± 2.3 | 12.6 ± 3.4 | 0.0013 |
| GCS | 12.4 ±1.7 | 12.7 ±1.6 | 11.2 ±1.7 | 0.005 |
| MAP (mmHg) | 80 ± 11 | 83 ± 9 | 67 ± 6 | < 0.001 |
| HR (beats/min) | 82 ± 18 | 78 ± 13 | 98 ± 28 | 0.019 |
| RR (breaths/min) | 23 ± 7 | 23 ± 7 | 23 ± 7 | 0.027 |
| WBC (×103/mm3) | 18 [15–22] | 17 [14–20] | 21 [19–23] | 0.412 |
| NEU (×103/mm3) | 15 [13–18] | 14 [12–17] | 18 [15–19] | 0.313 |
| LYM (×103/mm3) | 1.6 [1.2–2.1] | 1.6 [1.3–2.1] | 1.5 [1.2–1.8] | 0.596 |
| NLR | 10.3 ± 3.2 | 9.8 ± 3.0 | 12.2 ± 3.4 | 0.023 |
| PLT (×103/mm3) | 133 ± 49 | 140 ± 50 | 108 ± 32 | 0.042 |
| C-Reactive Protein (mg/l) | 124 [92–145] | 124 [94–143] | 136 [79–153] | 0.697 |
| Procalcitonin (PCT) (ng/ml) | 13.0 ±5.7 | 11.8 ±4.6 | 18.0 ±7.4 | 0.007 |
| ESR (mm/h) | 40.4 ±16.4 | 38.9 ±16.9 | 42.3 ±14.9 | 0.587 |
| Lactate (mmol/l) | 1.8 ± 1.4 | 1.6 ± 1.2 | 2.7 ± 1.8 | 0.039 |
| Creatinine (mg/dl) | 1.9 ± 1.3 | 1.9 ± 1.4 | 2.1 ± 1.1 | 0.619 |
| Bilirubin (mg/dl) | 1.8 ± 1.0 | 1.7 ± 1.0 | 2.2 ± 0.9 | 0.085 |
Comparison of AUC values with standard error (SE), 95%CI of AUC, Sensitivity (Sn), Specificity (Sp), cut-off value and statistical significance (p) for all analysed parameters: SOFA - Sequential Organ Failure Assessment, NEWS - National Early Warning Score, PCT – procalcitonin, NLR - neutrophil-to-lymphocyte ratio, CRP – C-reactive protein.
| SOFA | 0.874 | 0.043 | 0.778 to 0.939 | 87% | 72% | 6 | <0.0001 |
| NEWS | 0.791 | 0.065 | 0.682 to 0.876 | 67% | 74% | 10 | <0.0001 |
| PCT | 0.743 | 0.080 | 0.629 to 0.836 | 67% | 74% | 13.6 | |
| NLR | 0.717 | 0.072 | 0.603 to 0.815 | 80% | 62% | 9.9 | |
| CRP | 0.543 | 0.099 | 0.425 to 0.658 | 67% | 59% | 127 | 0.664 |