<abstract xmlns="http://www.w3.org/1999/xhtml">
<p>The most prevalent type of syndromic obesity is referred to as Prader-Willi Syndrome (PWS), being determined by the lack of expression of paternal genes on chromosome 15q11.2-q13 due to genomic or epigenetic variations, such as DNA and histone methylation or acetylation. The syndrome is frequently associated with behavioral disorders, intellectual deficiencies, short stature, polyphagia, hypogonadism and muscular hypotonia, all stemming from the multiple endocrine dysfunctions characterizing this condition.</p>
<p>Cardiovascular (CV) anomalies can manifest even in the early stages of life, and those with PWS have an elevated risk of early onset cardiovascular diseases. The somatic and behavioral aspects of the syndrome interact intricately to cause this increased risk for CV pathologies. Changes in the GH-IGF axis are seen in most Prader-Willi Syndrome (PWS) patients, irrespective of obesity. Specific cardiovascular features of GHD in adult PWS patients include reduced cardiac mass, decreased ejection fraction, and diminished chronotropic response to dobutamine.</p>
</abstract>

The most prevalent type of syndromic obesity is referred to as Prader-Willi Syndrome (PWS), being determined by the lack of expression of paternal genes on chromosome 15q11.2-q13 due to genomic or epigenetic variations, such as DNA and histone methylation or acetylation. The syndrome is frequently associated with behavioral disorders, intellectual deficiencies, short stature, polyphagia, hypogonadism and muscular hypotonia, all stemming from the multiple endocrine dysfunctions characterizing this condition.
Cardiovascular (CV) anomalies can manifest even in the early stages of life, and those with PWS have an elevated risk of early onset cardiovascular diseases. The somatic and behavioral aspects of the syndrome interact intricately to cause this increased risk for CV pathologies. Changes in the GH-IGF axis are seen in most Prader-Willi Syndrome (PWS) patients, irrespective of obesity. Specific cardiovascular features of GHD in adult PWS patients include reduced cardiac mass, decreased ejection fraction, and diminished chronotropic response to dobutamine.

Cardiovascular Characteristics in Patients with Prader-Willi Syndrome

Department of Internal Medicine I, Faculty of Medicine

University of Medicine and Pharmacy “Grigore T. Popa”

Department of Cardiovascular Rehabilitation

Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Cardiovascular Characteristics in Patients with Prader-Willi Syndrome"}

The most prevalent type of syndromic obesity is referred to as Prader-Willi Syndrome (PWS), being determined by the lack of expression of paternal genes on...

Cardiovascular Characteristics in Patients with Prader-Willi Syndrome

Data publikacji: 29 mar 2024

Zakres stron: 49 - 56

DOI: https://doi.org/10.2478/inmed-2024-0277

Słowa kluczowe
obesity, Prader-Willi syndrome, cardiovascular anomalies, growth-hormone deficiency.

© 2024 Ingrid-Ioana Stafie et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cardiovascular Characteristics in Patients with Prader-Willi Syndrome

Data publikacji: 29 mar 2024

Zakres stron: 49 - 56

DOI: https://doi.org/10.2478/inmed-2024-0277

Słowa kluczoweobesity, Prader-Willi syndrome, cardiovascular anomalies, growth-hormone deficiency.

© 2024 Ingrid-Ioana Stafie et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
obesity, Prader-Willi syndrome, cardiovascular anomalies, growth-hormone deficiency.