<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Based on the latest medical research, it is supposed that lichen planus is an inflammatory disorder, associated with autoimmune diseases, hepatitis C infection, oxidative stress or antioxidant deficiency. The purpose of the present work is to determine a panel of serum antioxidants, possibly involved in the development/persistence of the disease. The determination of extracellular antioxidants (bilirubin, uric acid, albumin, iron, transferrin, ferritin, copper, ceruloplasmin, total antioxidant capacity) in patients with lichen planus during exacerbations have revealed a significant reduction in non-enzymatic antioxidant systems. Hepatitis C virus enhances the deficit of antioxidants in patients with lichen planus. Based on these findings, the authors consider that lichen planus is a complex disease of unidentified cause and its pathogenic mechanisms are still incompletely elucidated. It may be speculated that several interconnected mechanisms are involved in the onset and evolution of lichen planus.</p></abstract>

Based on the latest medical research, it is supposed that lichen planus is an inflammatory disorder, associated with autoimmune diseases, hepatitis C infection, oxidative stress or antioxidant deficiency. The purpose of the present work is to determine a panel of serum antioxidants, possibly involved in the development/persistence of the disease. The determination of extracellular antioxidants (bilirubin, uric acid, albumin, iron, transferrin, ferritin, copper, ceruloplasmin, total antioxidant capacity) in patients with lichen planus during exacerbations have revealed a significant reduction in non-enzymatic antioxidant systems. Hepatitis C virus enhances the deficit of antioxidants in patients with lichen planus. Based on these findings, the authors consider that lichen planus is a complex disease of unidentified cause and its pathogenic mechanisms are still incompletely elucidated. It may be speculated that several interconnected mechanisms are involved in the onset and evolution of lichen planus.

Relationship of Lichen Planus, Hepatitis Virus C and Low Level of Total Antioxidant Capacity

Victor Babes Clinical Hospital of Infectious and Tropical Diseases, Dermatology Clinic, Bucharest

Carol Davila Clinical Hospital of Nephrology

Sf Ioan Emergency Hospital, Clinic of Urology

Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Based on the latest medical research, it is supposed that lichen planus is an inflammatory disorder, associated with autoimmune diseases, hepatitis C...

Relationship of Lichen Planus, Hepatitis Virus C and Low Level of Total Antioxidant Capacity

Data publikacji: 31 gru 2018

Zakres stron: 23 - 32

DOI: https://doi.org/10.2478/inmed-2018-0035

Słowa kluczowe
lichen planus, hepatitis C, serum antioxidants

© 2018 Simona Roxana Georgescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Relationship of Lichen Planus, Hepatitis Virus C and Low Level of Total Antioxidant Capacity

Data publikacji: 31 gru 2018

Zakres stron: 23 - 32

DOI: https://doi.org/10.2478/inmed-2018-0035

Słowa kluczowelichen planus, hepatitis C, serum antioxidants

© 2018 Simona Roxana Georgescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Słowa kluczowe
lichen planus, hepatitis C, serum antioxidants