<abstract xmlns="http://www.w3.org/1999/xhtml">

Gastrointestinal parasites which are responsible for soil-transmitted helminthiases cause illness globally. The control of helminthiasis depends on mass distribution of anthelmintics which has been reported for its resistance, toxicity and low efficacy. In this study, anthelmintic potentials of <italic>Gongronema latifolium</italic> and <italic>Picralima nitida</italic> which have wide application in traditional medicine were determined <italic>in vivo</italic> using <italic>Heligmosomoides bakeri</italic> a naturally occurring gastro-intestinal parasite of rodents that is closely related to highly prevalent human nematode parasites.
Extracts of <italic>P. nitida</italic> at 500 mg/kg had higher (<italic>p</italic>&lt; 0.05) chemosuppression (92.45 %) than extracts of <italic>G. latifolium</italic> (65.82 %) and was highly comparable to albendazole (92.61 %). As the dose of the extracts increased from 300 to 500 mg/kg body weight, chemosuppression of 84.91 % and 92.45 % (<italic>P. nitida</italic>) and 43.54 % and 65.82 % (<italic>G. latifolium</italic>) respectively were produced. The extract of <italic>P. nitida</italic> gave deparasitization rates (p&lt;0.05) of 72.60 % and 77.16 % at 300g/kg and 500mg/kg of body weight respectively. The glucose level and protein content reduced (p&lt;0.05) in mice treated with extract of <italic>P. nitida</italic> when compared with extract of <italic>G. latifolium</italic> and untreated mice. Phytochemical screening revealed that <italic>P. nitida</italic> and <italic>G. latifolium</italic> contained flavonoids, alkaloids, saponins, tannins and polyphenols. Acute toxicity studies showed that <italic>Gongronema latifolium</italic> and <italic>Picralima nitida</italic> have no apparent toxic effect in mice even at the dose of 5000 mg/kg.
Extracts of <italic>P. nitida</italic> and <italic>G. latifolium</italic> have anthelmintic properties that are dose-dependent, and this could offer potential lead for the development of safe, effective and affordable anthelmintics.
</abstract>

Gastrointestinal parasites which are responsible for soil-transmitted helminthiases cause illness globally. The control of helminthiasis depends on mass distribution of anthelmintics which has been reported for its resistance, toxicity and low efficacy. In this study, anthelmintic potentials of Gongronema latifolium and Picralima nitida which have wide application in traditional medicine were determined in vivo using Heligmosomoides bakeri a naturally occurring gastro-intestinal parasite of rodents that is closely related to highly prevalent human nematode parasites.
Extracts of P. nitida at 500 mg/kg had higher (p< 0.05) chemosuppression (92.45 %) than extracts of G. latifolium (65.82 %) and was highly comparable to albendazole (92.61 %). As the dose of the extracts increased from 300 to 500 mg/kg body weight, chemosuppression of 84.91 % and 92.45 % (P. nitida) and 43.54 % and 65.82 % (G. latifolium) respectively were produced. The extract of P. nitida gave deparasitization rates (p<0.05) of 72.60 % and 77.16 % at 300g/kg and 500mg/kg of body weight respectively. The glucose level and protein content reduced (p<0.05) in mice treated with extract of P. nitida when compared with extract of G. latifolium and untreated mice. Phytochemical screening revealed that P. nitida and G. latifolium contained flavonoids, alkaloids, saponins, tannins and polyphenols. Acute toxicity studies showed that Gongronema latifolium and Picralima nitida have no apparent toxic effect in mice even at the dose of 5000 mg/kg.
Extracts of P. nitida and G. latifolium have anthelmintic properties that are dose-dependent, and this could offer potential lead for the development of safe, effective and affordable anthelmintics.

<italic>In vivo</italic> anthelmintic potentials of <italic>Gongronema latifolium</italic> and <italic>Picralima nitida</italic> against gastrointestinal parasite (<italic>Heligmosomoides bakeri</italic>)

Department of Physiology and Pharmacology

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 anthelmintic potentials of  and  against gastrointestinal parasite ()

Gastrointestinal parasites which are responsible for soil-transmitted helminthiases cause illness globally. The control of helminthiasis depends on mass...

In vivo anthelmintic potentials of Gongronema latifolium and Picralima nitida against gastrointestinal parasite (Heligmosomoides bakeri)

Data publikacji: 31 gru 2023

Zakres stron: 336 - 347

Otrzymano: 25 paź 2022

Przyjęty: 21 wrz 2023

DOI: https://doi.org/10.2478/helm-2023-0033

Słowa kluczowe
anthelmintic activity

© 2023 F. T. Ojo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In vivo anthelmintic potentials of Gongronema latifolium and Picralima nitida against gastrointestinal parasite (Heligmosomoides bakeri)

Data publikacji: 31 gru 2023

Zakres stron: 336 - 347

Otrzymano: 25 paź 2022

Przyjęty: 21 wrz 2023

DOI: https://doi.org/10.2478/helm-2023-0033

Słowa kluczoweanthelmintic activity

© 2023 F. T. Ojo et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
anthelmintic activity