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SCM-198 Can Regulate Autophagy Through the Bax/Bcl-2/TLR4 Pathway to Alleviate Renal Ischemia-Reperfusion Injury

Ersen Eraslan
Ersen Eraslan
, 
Burak Bircan
Burak Bircan
, 
Ayhan Tanyeli
Ayhan Tanyeli
, 
Mustafa Can Güler
Mustafa Can Güler
, 
Yasin Bayır
Yasin Bayır
 oraz 
Serdar Altun
Serdar Altun
   | 21 paź 2021
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Article Category: Research article
Data publikacji: 21 paź 2021
Zakres stron: 161 - 169
DOI: https://doi.org/10.2478/ebtj-2021-0025
Słowa kluczowe
© 2021 Ersen Eraslan, Burak Bircan, Ayhan Tanyeli, Mustafa Can Güler, Yasin Bayır, Serdar Altun, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

SCM-198 chemical structure.
SCM-198 chemical structure.

Figure 2

Effects of SCM-198 on kidney functions. (A) Urea and (B) Cre levels. *P<0.05 compared to the control and DMSO groups, ϕP<0.05 compared to the I/R group.
Effects of SCM-198 on kidney functions. (A) Urea and (B) Cre levels. *P<0.05 compared to the control and DMSO groups, ϕP<0.05 compared to the I/R group.

Figure 3

Effects of SCM- 198 on inflammatory cytokines. (A) TNF-α, (B) IL-1β and (C) IL- 18 levels. *P<0.05 compared to control and DMSO groups, ϕP<0.05 compared to I/R group.
Effects of SCM- 198 on inflammatory cytokines. (A) TNF-α, (B) IL-1β and (C) IL- 18 levels. *P<0.05 compared to control and DMSO groups, ϕP<0.05 compared to I/R group.

Figure 4

Changes in kidney damage biomarkers in the kidney I/ R model (A) NGAL, (B) KIM-1, and (C) PCX levels. *P<0.05 compared to control and DMSO groups, ϕP<0.05 compared to I/R group.
Changes in kidney damage biomarkers in the kidney I/ R model (A) NGAL, (B) KIM-1, and (C) PCX levels. *P<0.05 compared to control and DMSO groups, ϕP<0.05 compared to I/R group.

Figure 5

(A) Control group, LC3B immunonegativity (B) DMSO group, LC3B immunonegativity (C) I/R group, moderate LC3B immunopositivity was observed in renal tubule epithelial cells (arrowhead), (D) SCM-198 group, mild LC3B immunopositivity was detected in renal tubular epithelial cells (arrowhead).
(A) Control group, LC3B immunonegativity (B) DMSO group, LC3B immunonegativity (C) I/R group, moderate LC3B immunopositivity was observed in renal tubule epithelial cells (arrowhead), (D) SCM-198 group, mild LC3B immunopositivity was detected in renal tubular epithelial cells (arrowhead).

Figure 6

(A) Control group, Beclin-1 immunonegativity, (B) DMSO group, Beclin-1 immunonegativity, (C) I/R group, moderate Beclin-1 immunopositivity in renal tubule epithelial cells (arrowhead), (D) SCM -198 group, mild Beclin-1 immunopositivity in renal tubule epithelial cells (arrowhead).
(A) Control group, Beclin-1 immunonegativity, (B) DMSO group, Beclin-1 immunonegativity, (C) I/R group, moderate Beclin-1 immunopositivity in renal tubule epithelial cells (arrowhead), (D) SCM -198 group, mild Beclin-1 immunopositivity in renal tubule epithelial cells (arrowhead).

Figure 7

(A) Control group, TLR4 immunonegativity, (B) DMSO group, TLR4 immunonegativity, (C) I/R group, moderate TLR4 immunopositivity in renal tubule epithelial cells (arrowhead), (D) SCM-198 group, mild TLR4 immunopositivity in renal tubule epithelial cells (arrowhead).
(A) Control group, TLR4 immunonegativity, (B) DMSO group, TLR4 immunonegativity, (C) I/R group, moderate TLR4 immunopositivity in renal tubule epithelial cells (arrowhead), (D) SCM-198 group, mild TLR4 immunopositivity in renal tubule epithelial cells (arrowhead).

Figure 8

(A) Control group, Bax immunonegativity, (B) DMSO group, Bax immunonegativity, (C) I/R group, moderate Bax immunopositivity in renal tubule epithelial cells (arrowhead), (D) SCM-198 group, mild Bax immunopositivity in renal tubule epithelial cells (arrowhead).
(A) Control group, Bax immunonegativity, (B) DMSO group, Bax immunonegativity, (C) I/R group, moderate Bax immunopositivity in renal tubule epithelial cells (arrowhead), (D) SCM-198 group, mild Bax immunopositivity in renal tubule epithelial cells (arrowhead).

Figure 9

(A) Control group, severe Bcl-2 immunopositivity in renal tubule epithelial cells (arrowhead), (B) DMSO group, severe Bcl-2 immunopositivity in renal tubule epithelial cells (arrowhead), (C) I/R group, mild Bcl-2 immunopositivity in renal tubule epithelial cells, (D) SCM-198 group, moderate Bcl-2 immunopositivity in renal tubule epithelial cells (arrowhead).
(A) Control group, severe Bcl-2 immunopositivity in renal tubule epithelial cells (arrowhead), (B) DMSO group, severe Bcl-2 immunopositivity in renal tubule epithelial cells (arrowhead), (C) I/R group, mild Bcl-2 immunopositivity in renal tubule epithelial cells, (D) SCM-198 group, moderate Bcl-2 immunopositivity in renal tubule epithelial cells (arrowhead).

Figure 10

IHC scoring in renal tubule cells (A) LC3B, (B) Beclin-1, (C) TLR4, (D) Bax and (E) Bcl-2. *P<0.05 compared to control and DMSO groups, ϕP<0.05 compared to I/R group.
IHC scoring in renal tubule cells (A) LC3B, (B) Beclin-1, (C) TLR4, (D) Bax and (E) Bcl-2. *P<0.05 compared to control and DMSO groups, ϕP<0.05 compared to I/R group.
eISSN:
2564-615X
Język:
Angielski
Częstotliwość wydawania:
4 razy w roku
Dziedziny czasopisma:
Life Sciences, Genetics, Biotechnology, Bioinformatics, other
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