Determination of Benzoic Acid and Benzyl Alcohol in E-Liquids (JUULTM Pods) by Isotopic Dilution High-Performance Liquid Chromatography and Tandem Mass Spectrometry
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Arnold, C.: Vaping and Health: What do we Know About E-Cigarettes? Environ. Health Perspect. 122 (2014) A244–249. DOI: 10.1289/ehp.122-A244ArnoldC.Vaping and Health: What do we Know About E-Cigarettes?Environ. Health Perspect.1222014A24424910.1289/ehp.122-A244415420325181730Open DOISearch in Google Scholar
Regan, A.K., G. Promoff, S.R. Dube, and R. Arrazola: Electronic Nicotine Delivery Systems: Adult Use and Awareness of the ‘E-Cigarette’ in the USA; Tob. Control 22 (2013) 19–23. DOI: 10.1136/tobaccocontrol-2011-050044ReganA.K.PromoffG.DubeS.R.ArrazolaR.Electronic Nicotine Delivery Systems: Adult Use and Awareness of the ‘E-Cigarette’ in the USATob. Control222013192310.1136/tobaccocontrol-2011-05004422034071Open DOISearch in Google Scholar
U.S. Department of Health and Human Services (HHS) and Office of the Surgeon General: Facing Addiction in America: The Surgeon General's Report on Alcohol, Drugs, and Health. Washington, DC, USA, 2016. Available at: https://pubmed.ncbi.nlm.nih.gov/28252892/ (accessed November 2021)U.S. Department of Health and Human Services (HHS) and Office of the Surgeon GeneralFacing Addiction in America: The Surgeon General's Report on Alcohol, Drugs, and HealthWashington, DC, USA2016Available at: https://pubmed.ncbi.nlm.nih.gov/28252892/ (accessed November 2021)Search in Google Scholar
Gilbert, A.H.: Smokeless Non-Tobacco Cigarette; U.S. Patent No. 3,200,819 (1965) Brown & Williamson Collection, Bates No. 570328916-570328920. Available at: http://industrydocuments.library.ucsf.edu/tobacco/docs/hzxb0140 (accessed November 11, 2021)GilbertA.H.Smokeless Non-Tobacco CigaretteU.S. Patent No. 3,200,819 (1965) Brown & Williamson Collection, Bates No. 570328916-570328920. Available at: http://industrydocuments.library.ucsf.edu/tobacco/docs/hzxb0140 (accessed November 11, 2021)Search in Google Scholar
Hon, L.: Electronic Atomization Cigarette; U.S. Patent 8,393,331 B2 (2013). Available at: https://docs.google.com/viewer?url=patentimages.storage.googleapis.com/pdfs/US8393331.pdf (accessed November 11, 2021)HonL.Electronic Atomization CigaretteU.S. Patent 8,393,331 B2 (2013). Available at: https://docs.google.com/viewer?url=patentimages.storage.googleapis.com/pdfs/US8393331.pdf (accessed November 11, 2021)Search in Google Scholar
Hohms, S.: Easily Refill Your Juul Pods! How to Refill a Juul Pod Tutorial; YouTube Video, January 26, 2018. Available at: https://www.youtube.com/watch?v=qdg1AZkmlCg (accessed November 2021)HohmsS.Easily Refill Your Juul Pods! How to Refill a Juul Pod TutorialYouTube Video, January 26, 2018. Available at: https://www.youtube.com/watch?v=qdg1AZkmlCg (accessed November 2021)Search in Google Scholar
Collins, L., A.M. Glasser, H. Abudayyeh, J.L. Pearson, and A.C. Villanti: E-Cigarette Marketing and Communication: How E-Cigarette Companies Market E-Cigarettes and the Public Engages with E-Cigarette Information; Nicotine Tob. Res. 21 (2019) 21, 14–24. DOI: 10.1093/ntr/ntx284CollinsL.GlasserA.M.AbudayyehH.PearsonJ.L.VillantiA.C.E-Cigarette Marketing and Communication: How E-Cigarette Companies Market E-Cigarettes and the Public Engages with E-Cigarette InformationNicotine Tob. Res.21201921,142410.1093/ntr/ntx284661016529315420Open DOISearch in Google Scholar
Lee, S.J., V.W. Rees, N. Yossefy, K.M. Emmons, and A.S.L. Tan: Youth and Young Adult Use of Pod-Based Electronic Cigarettes from 2015 to 2019: A Systematic Review; JAMA Pediatr. 174 (2020) 714–720. DOI: 10.1001/jamapediatrics.2020.0259LeeS.J.ReesV.W.YossefyN.EmmonsK.M.TanA.S.L.Youth and Young Adult Use of Pod-Based Electronic Cigarettes from 2015 to 2019: A Systematic ReviewJAMA Pediatr.174202071472010.1001/jamapediatrics.2020.0259786373332478809Open DOISearch in Google Scholar
Ramamurthi, D., C. Chau, and R.K. Jackler: JUUL and Other Stealth Vaporisers: Hiding the Habit from Parents and Teachers; Tob. Control 28 (2019) 610–6. DOI: 10.1136/tobaccocontrol-2018-054455RamamurthiD.ChauC.JacklerR.K.JUUL and Other Stealth Vaporisers: Hiding the Habit from Parents and TeachersTob. Control282019610610.1136/tobaccocontrol-2018-05445530219794Open DOISearch in Google Scholar
Strombotne, K., J. Buckell, and J.L. Sindelar: Do JUUL and E-Cigarette Flavours Change Risk Perceptions of Adolescents? Evidence from a National Survey; Tob. Control 30 (2020) 199–205. DOI: 10.1136/tobaccocontrol-2019-055394StrombotneK.BuckellJ.SindelarJ.L.Do JUUL and E-Cigarette Flavours Change Risk Perceptions of Adolescents? Evidence from a National SurveyTob. Control30202019920510.1136/tobaccocontrol-2019-055394757275832300029Open DOISearch in Google Scholar
Carroll Chapman, S.L. and L.-T. Wu: E-Cigarette Prevalence and Correlates of Use among Adolescents Versus Adults: A Review and Comparison; J. Psychiatr. Res. 54 (2014) 43–54. DOI: 10.1016/j.jpsychires.2014.03.005Carroll ChapmanS.L.WuL.-T.E-Cigarette Prevalence and Correlates of Use among Adolescents Versus Adults: A Review and ComparisonJ. Psychiatr. Res.542014435410.1016/j.jpsychires.2014.03.005405556624680203Open DOISearch in Google Scholar
Fahey, M.C., R.A. Krukowski, G.W. Talcott, and M.A. Little: JUUL Targets Military Personnel and Veterans; Tob. Control 23 (2020) e123–e124. DOI: 10.1136/tobaccocontrol-2019-055377FaheyM.C.KrukowskiR.A.TalcottG.W.LittleM.A.JUUL Targets Military Personnel and VeteransTob. Control232020e123e12410.1136/tobaccocontrol-2019-055377810168532398271Open DOISearch in Google Scholar
Krishnan-Sarin, S., A. Jackson, M. Morean, G. Kong, K.W. Bold, D.R. Camenga, D.A. Cavallo, P. Simon, and R. Wu: E-Cigarette Devices Used by High-School Youth; Drug Alcohol Depend. 194 (2019) 395–400. DOI: 10.1016/j.drugalcdep.2018.10.022Krishnan-SarinS.JacksonA.MoreanM.KongG.BoldK.W.CamengaD.R.CavalloD.A.SimonP.WuR.E-Cigarette Devices Used by High-School YouthDrug Alcohol Depend.194201939540010.1016/j.drugalcdep.2018.10.022631247230497057Open DOISearch in Google Scholar
Willett, J.G., M. Bennett, E.C. Hair, H. Xiao, M.S. Greenberg, E. Harvey, J. Cantrell, and D. Vallone: Recognition, Use and Perceptions of JUUL among Youth and Young Adults; Tob. Control 28 (2019) 115–116. DOI: 10.1136/tobaccocontrol-2018-054273WillettJ.G.BennettM.HairE.C.XiaoH.GreenbergM.S.HarveyE.CantrellJ.ValloneD.Recognition, Use and Perceptions of JUUL among Youth and Young AdultsTob. Control28201911511610.1136/tobaccocontrol-2018-05427329669749Open DOISearch in Google Scholar
Huang, J., Z. Duan, J. Kwok, S. Binns, L.E. Vera, Y. Kim, G. Szczypka, and S.L. Emery: Vaping Versus JUULing: How the Extraordinary Growth and Marketing of JUUL Transformed the US Retail E-Cigarette Market; Tob. Control 28 (2019) 146–151. DOI: 10.1136/tobaccocontrol-2018-054382HuangJ.DuanZ.KwokJ.BinnsS.VeraL.E.KimY.SzczypkaG.EmeryS.L.Vaping Versus JUULing: How the Extraordinary Growth and Marketing of JUUL Transformed the US Retail E-Cigarette MarketTob. Control28201914615110.1136/tobaccocontrol-2018-054382627462929853561Open DOISearch in Google Scholar
Pankow, J.F.: A Consideration of the Role of Gas/Particle Partitioning in the Deposition of Nicotine and Other Tobacco Smoke Compounds in the Respiratory Tract; Chem. Res. Toxicol. 14 (2001) 1465–1481. DOI: 10.1021/tx0100901PankowJ.F.A Consideration of the Role of Gas/Particle Partitioning in the Deposition of Nicotine and Other Tobacco Smoke Compounds in the Respiratory TractChem. Res. Toxicol.1420011465148110.1021/tx010090111712903Open DOISearch in Google Scholar
Bowen, A. and C. Xing: Nicotine Salt Formulations for Aerosol Devices and Methods Thereof; U.S. Patent 9,215,895 B2 (2015). Available at: https://patentimages.storage.googleapis.com/e2/9a/99/5a55ed883b0523/US9215895.pdf (accessed November 11, 2021)BowenA.XingC.Nicotine Salt Formulations for Aerosol Devices and Methods ThereofU.S. Patent 9,215,895 B2 (2015). Available at: https://patentimages.storage.googleapis.com/e2/9a/99/5a55ed883b0523/US9215895.pdf (accessed November 11, 2021)Search in Google Scholar
Duell, A.K., J.F. Pankow, and D.H. Peyton: Free-Base Nicotine Determination in Electronic Cigarette Liquids by 1H NMR Spectroscopy; Chem. Res. Toxicol. 31 (2018) 431–434. DOI: 10.1021/acs.chemrestox.8b00097DuellA.K.PankowJ.F.PeytonD.H.Free-Base Nicotine Determination in Electronic Cigarette Liquids by 1H NMR SpectroscopyChem. Res. Toxicol.31201843143410.1021/acs.chemrestox.8b00097600873629775302Open DOISearch in Google Scholar
O’Connell, G., J.D. Pritchard, C. Prue, J. Thompson, T. Verron, D. Graff, and T. Walele: A Randomised, Open-Label, Cross-Over Clinical Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes with Nicotine Salt Formulations in US Adult Smokers; Intern. Emerg. Med. 14 (2019) 853–861. DOI: 10.1007/s11739-019-02025-3O’ConnellG.PritchardJ.D.PrueC.ThompsonJ.VerronT.GraffD.WaleleT.A Randomised, Open-Label, Cross-Over Clinical Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes with Nicotine Salt Formulations in US Adult SmokersIntern. Emerg. Med.14201985386110.1007/s11739-019-02025-3672214530712148Open DOISearch in Google Scholar
Pankow, J.F., K. Kim, K.J. McWhirter, W. Luo, J.O. Escobedo, R.M. Strongin, A.K. Duell, and D.H. Peyton: Benzene Formation in Electronic Cigarettes; PLoS One; 12 (2017) e0173055. DOI: 10.1371/journal.pone.0173055PankowJ.F.KimK.McWhirterK.J.LuoW.EscobedoJ.O.StronginR.M.DuellA.K.PeytonD.H.Benzene Formation in Electronic CigarettesPLoS One122017e017305510.1371/journal.pone.0173055534221628273096Open DOISearch in Google Scholar
Stephens, W.E.: Comparing the Cancer Potencies of Emissions from Vapourised Nicotine Products Including E-Cigarettes With Those of Tobacco Smoke; Tob. Control (2017). DOI: 10.1136/tobaccocontrol-2017-053808StephensW.E.Comparing the Cancer Potencies of Emissions from Vapourised Nicotine Products Including E-Cigarettes With Those of Tobacco SmokeTob. Control201710.1136/tobaccocontrol-2017-05380828778971Open DOISearch in Google Scholar
Dwyer, J.B., R.S. Broide, and F.M. Leslie: Nicotine and Brain Development; Birth Defects Res. C Embryo Today 84 (2008) 30–44. DOI: 10.1002/bdrc.20118DwyerJ.B.BroideR.S.LeslieF.M.Nicotine and Brain DevelopmentBirth Defects Res. C Embryo Today842008304410.1002/bdrc.2011818383130Open DOISearch in Google Scholar
Ren, M. and S. Lotfipour: Nicotine Gateway Effects on Adolescent Substance Use; West. J. Emerg. Med. 20 (2019) 696–709. DOI: 10.5811/westjem.2019.7.41661RenM.LotfipourS.Nicotine Gateway Effects on Adolescent Substance UseWest. J. Emerg. Med.20201969670910.5811/westjem.2019.7.41661675418631539325Open DOISearch in Google Scholar
Yuan, M., S.J. Cross, S.E. Loughlin, and F.M. Leslie: Nicotine and the Adolescent Brain; J. Physiol. 593 (2015) 3397–3412. DOI: 10.1113/JP270492YuanM.CrossS.J.LoughlinS.E.LeslieF.M.Nicotine and the Adolescent BrainJ. Physiol.59320153397341210.1113/JP270492456057326018031Open DOISearch in Google Scholar
Benowitz, N.L. and A.D. Burbank: Cardiovascular Toxicity of Nicotine: Implications for Electronic Cigarette Use; Trends Cardiovasc. Med. 26 (2016) 515–523. DOI: 10.1016/j.tcm.2016.03.001BenowitzN.L.BurbankA.D.Cardiovascular Toxicity of Nicotine: Implications for Electronic Cigarette UseTrends Cardiovasc. Med.26201651552310.1016/j.tcm.2016.03.001495854427079891Open DOISearch in Google Scholar
Benowitz, N.L. and J.B. Fraiman: Cardiovascular Effects of Electronic Cigarettes; Nat. Rev. Cardiol. 14 (2017) 447–56. DOI: 10.1038/nrcardio.2017.36BenowitzN.L.FraimanJ.B.Cardiovascular Effects of Electronic CigarettesNat. Rev. Cardiol.1420174475610.1038/nrcardio.2017.36551913628332500Open DOISearch in Google Scholar
Gottlieb, H.E., V. Kotlyar, and A. Nudelman: NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities; J. Org. Chem. 62 (1997) 7512–7515. DOI: 10.1021/jo971176vGottliebH.E.KotlyarV.NudelmanA.NMR Chemical Shifts of Common Laboratory Solvents as Trace ImpuritiesJ. Org. Chem.6219977512751510.1021/jo971176v11671879Open DOISearch in Google Scholar
European Commission, Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR): Final Opinion on Additives Used in Tobacco Products (Opinion 1). Tobacco Additives I; European Union, 2016. ISSN: 1831-4783, DOI: 10.2875/437307European Commission, Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR)Final Opinion on Additives Used in Tobacco Products (Opinion 1). Tobacco Additives IEuropean Union2016ISSN: 1831-4783,10.2875/437307Open DOISearch in Google Scholar
Westgard, O.J.: Basic Quality Control Practices: Training in Statistical Quality Control for Health Care Laboratories; 4th Edition, Westgard Quality Inc., Madison, WI, USA, 2016. ISBN: 1-886958-30-0WestgardO.J.Basic Quality Control Practices: Training in Statistical Quality Control for Health Care Laboratories4th EditionWestgard Quality Inc.Madison, WI, USA2016ISBN: 1-886958-30-0Search in Google Scholar
Stanfill, S.B., R.E. Croucher, P.C. Gupta, J.G. Lisko, T.S. Lawler, P. Kuklenyik, M. Dahiya, B. Duncan, J.B. Kimbrell, E.H. Peuchen, and C.H. Watson: Chemical Characterization of Smokeless Tobacco Products from South Asia: Nicotine, Unprotonated Nicotine, Tobacco-Specific N’-Nitrosamines, and Flavor Compounds; Food Chem. Toxicol. 118 (2018) 626–634. DOI: 10.1016/j.fct.2018.05.004StanfillS.B.CroucherR.E.GuptaP.C.LiskoJ.G.LawlerT.S.KuklenyikP.DahiyaM.DuncanB.KimbrellJ.B.PeuchenE.H.WatsonC.H.Chemical Characterization of Smokeless Tobacco Products from South Asia: Nicotine, Unprotonated Nicotine, Tobacco-Specific N’-Nitrosamines, and Flavor CompoundsFood Chem. Toxicol.118201862663410.1016/j.fct.2018.05.00429746936Open DOISearch in Google Scholar
Stanfill, S.B., L.T. Jia, D.L. Ashley, and C.H. Watson: Rapid and Chemically Selective Nicotine Quantification in Smokeless Tobacco Products Using GC-MS; J. Chromatogr. Sci. 47 (2009) 902–909. DOI: 10.1093/chromsci/47.10.902StanfillS.B.JiaL.T.AshleyD.L.WatsonC.H.Rapid and Chemically Selective Nicotine Quantification in Smokeless Tobacco Products Using GC-MSJ. Chromatogr. Sci.47200990290910.1093/chromsci/47.10.90219930803Open DOISearch in Google Scholar
Omaiye, E.E., K.J. McWhirter, W. Luo, J.F. Pankow, and P. Talbot: High-Nicotine Electronic Cigarette Products: Toxicity of JUUL Fluids and Aerosols Correlates Strongly with Nicotine and Some Flavor Chemical Concentrations; Chem. Res. Toxicol 32 (2019) 1058–1069. DOI: 10.1021/acs.chemrestox.8b00381OmaiyeE.E.McWhirterK.J.LuoW.PankowJ.F.TalbotP.High-Nicotine Electronic Cigarette Products: Toxicity of JUUL Fluids and Aerosols Correlates Strongly with Nicotine and Some Flavor Chemical ConcentrationsChem. Res. Toxicol3220191058106910.1021/acs.chemrestox.8b00381657966730896936Open DOISearch in Google Scholar
International Agency for Research on Cancer (IARC): Chemical Agents and Related Occupations. A Review of Human Carcinogens. Monographs on the Evaluation of Carcinogenic Risks to Humans; Vol. 100F. IARC, Lyon, France, 2012.International Agency for Research on Cancer (IARC)Chemical Agents and Related Occupations. A Review of Human Carcinogens. Monographs on the Evaluation of Carcinogenic Risks to HumansVol. 100F.IARCLyon, France2012Search in Google Scholar