Quantitative Analysis of Cigarette Smoke Condensate Monophenols by Reverse-Phase High-Performance Liquid Chromatography

A rapid and quantitative method for the determination of cigarette smoke condensate monophenols using high-performance liquid chromatography (HPLC) was developed. Total particulate matter was collected on cigarette filter tips and Cambridge filter pads. Phenolic compounds were extracted with a 1 N sodium hydroxide solution. Five different brands of filter-tipped cigarettes from the French market were analysed. Their phenol, guaiacol, methylphenols and dimethylphenols levels were determined in comparison with an internal standard, o-chlorophenol. With the same method we compared the phenolic retention efficiency of different cigarette filter tips.