<abstract xmlns="http://www.w3.org/1999/xhtml"><p> A method for the quantitative determination of indole and alkylated indoles in cigarette smoke is described. The analysis consists of distributions between n-hexane / methanol-water (4:1); n-hexane / methanol-water (1:2); column chromatography on Florosil and gas chromatographic separation on 20 % Apiezon L at 155°C. Quantitative data are secured by use of C14-labelled indole as internal standard. In the smoke of an 85 mm blended United States cigarette without filter tip were determined 13.9 µg indole, 14.0 µg skatole, 4.2 µg 3-ethylindole, and 0.21 µg 3-n-propylindole. The presence of an admixture of dimethylindoles was tentatively established; their concentration was below 0.03 µg per cigarette</p></abstract>

A method for the quantitative determination of indole and alkylated indoles in cigarette smoke is described. The analysis consists of distributions between n-hexane / methanol-water (4:1); n-hexane / methanol-water (1:2); column chromatography on Florosil and gas chromatographic separation on 20 % Apiezon L at 155°C. Quantitative data are secured by use of C14-labelled indole as internal standard. In the smoke of an 85 mm blended United States cigarette without filter tip were determined 13.9 µg indole, 14.0 µg skatole, 4.2 µg 3-ethylindole, and 0.21 µg 3-n-propylindole. The presence of an admixture of dimethylindoles was tentatively established; their concentration was below 0.03 µg per cigarette

Chemical Studies on Tobacco Smoke: I. The Quantitative Determination of Indoles in Cigarette Smoke

Sloan-Kettering Institute, New York, NY, USA

Contributions to Tobacco & Nicotine Research

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

A method for the quantitative determination of indole and alkylated indoles in cigarette smoke is described. The analysis consists of distributions between...

Chemical Studies on Tobacco Smoke: I. The Quantitative Determination of Indoles in Cigarette Smoke

Data publikacji: 13 cze 2014

Zakres stron: 409 - 414

DOI: https://doi.org/10.2478/cttr-2013-0134

© Beiträge zur Tabakforschung International

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.