Insights into the perspective correlation between vitamin D and regulation of hormones: sex hormones and prolactin

1. Boisen IM, Bøllehuus Hansen L, Mortensen LJ, Lanske B, Juul A, Blomberg Jensen M. Possible influence of vitamin D on male reproduction. J Steroid Biochem Mol Biol. 2017;173:215-22.10.1016/j.jsbmb.2016.09.02327693423 Search in Google Scholar

2. Jones G, Prosser DE, Kaufmann M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys. 2012;523(1):9-18.10.1016/j.abb.2011.11.00322100522 Search in Google Scholar

3. Bouillon R, Carmeliet G, Verlinden L, Van Etten E, Verstuyf A, Luderer HF, et al. Vitamin D and human health: Lessons from vitamin D receptor null mice. Endocr Rev. 2008;29(6):726-76.10.1210/er.2008-0004258338818694980 Search in Google Scholar

4. Alnori H, Alassaf FA, Alfahad M, Qazzaz ME, Jasim M, Abed MN. Vitamin D and immunoglobulin E status in allergic rhinitis patients compared to healthy people. J Med Life. 2020;13(4):463-8.10.25122/jml-2020-0015 Search in Google Scholar

5. Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci. 2004;29(12):664-73.10.1016/j.tibs.2004.10.00515544953 Search in Google Scholar

6. Hoenderop JGJ, Bindels RJM. Is vitamin D indispensable for Ca²⁺ homeostasis: Lessons from knockout mouse models? Nephrol Dial Transplant. 2005;20(5):864-7.10.1093/ndt/gfh58715769827 Search in Google Scholar

7. Ji H-F, Shen L. CYP24A1 mutations in idiopathic infantile hypercalcemia. N Engl J Med. 2011;365(18):1741-3.10.1056/NEJMc111022622047571 Search in Google Scholar

8. Mawhinney M, Mariotti A. Physiology, pathology and pharmacology of the male reproductive system. Periodontol 2000. 2013;61(1):232-51.10.1111/j.1600-0757.2011.00408.x23240952 Search in Google Scholar

9. Jensen MB. Vitamin D and male reproduction. Nat Rev Endocrinol. 2014;10(3):175-86.10.1038/nrendo.2013.26224419359 Search in Google Scholar

10. Cornwall GA. New insights into epididymal biology and function. Hum Reprod Update. 2009;15(2):213-27.10.1093/humupd/dmn055263908419136456 Search in Google Scholar

11. Foster RA. Male Reproductive System. Elsevier Public Health Emergency Collection. 2016;3:465-510.10.1016/B978-0-7020-5319-1.00016-5 Search in Google Scholar

12. O’Donnell L, Meachem SJ, Stanton PG, McLachlan RI. Endocrine regulation of spermatogenesis. In: Knobil and Neill’s physiology of reproduction. Cambridge: Academic Press; 2006:1017-69.10.1016/B978-012515400-0/50026-9 Search in Google Scholar

13. O’Shaughnessy PJ, Monteiro A, Verhoeven G, De Gendt K, Abel MH. Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction. 2010;139(1):177-84.10.1530/REP-09-0377279149519846485 Search in Google Scholar

14. Bolland MJ, Grey A, Horne AM, Reid IR. Testosterone levels following decreases in serum osteocalcin. Calcif Tissue Int. 2013;93(2):133-6.10.1007/s00223-013-9730-x23604689 Search in Google Scholar

15. Mortimer D, Barratt CLR, Björndahl L, de Jager C, Jequier AM, Muller CH. What should it take to describe a substance or product as “sperm-safe”. Hum Reprod Update. 2013;19(Suppl 1):145.10.1093/humupd/dmt00823552271 Search in Google Scholar

16. Yaghjyan L, Colditz GA, Drake B. Vitamin D and mammographic breast density: A systematic review. Cancer Causes Control. 2012;23(1):1-13.10.1007/s10552-011-9851-3364115721984232 Search in Google Scholar

17. Verstuyf A, Carmeliet G, Bouillon R, Mathieu C. Vitamin D: A pleiotropic hormone. Kidney Int. 2010;78(2):140-5.10.1038/ki.2010.1720182414 Search in Google Scholar

18. Blomberg Jensen M, Nielsen JE, Jørgensen A, Rajpert-De Meyts E, Kristensen DM, Jørgensen N, et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod. 2010;25(5):1303-11.10.1093/humrep/deq02420172873 Search in Google Scholar

19. Aquila S, Guido C, Middea E, Perrotta I, Bruno R, Pellegrino M, et al. Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. Reprod Biol Endocrinol. 2009;7(1):140.10.1186/1477-7827-7-140279426919948036 Search in Google Scholar

20. Niederberger C. Re: Are serum levels of vitamin d associated with semen quality? Results from a cross-sectional study in young healthy men. J Urol. 2012;187(1):240-1.10.1016/j.juro.2011.08.09422153462 Search in Google Scholar

21. Blomberg Jensen M, Lieben L, Nielsen JE, Willems A, Jørgensen A, Juul A, et al. Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: Targeting estrogen signalling. Mol Cell Endocrinol. 2013;377(1-2): 93-102.10.1016/j.mce.2013.06.03623850520 Search in Google Scholar

22. Rosol TJ, Gröne A. Endocrine Glands. Jubb, Kennedy Palmer’s Pathol Domest Anim. 2016;3:269-357.10.1016/B978-0-7020-5319-1.00014-1 Search in Google Scholar

23. Malloy PJ, Tiosano D, Feldman D. Hereditary 1, 25-dihydroxyvitamin-D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor. Mol Genet Metab. 2010;99(1)72-9.10.1016/j.ymgme.2009.09.004 Search in Google Scholar

24. Hammoud AO, Wayne Meikle A, Matthew Peterson C, Stanford J, Gibson M, Carrell DT. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl. 2012; 14(6):855-9.10.1038/aja.2012.77 Search in Google Scholar

25. Lerchbaum E, Pilz S, Trummer C, Schwetz V, Pachernegg O, Heijboer AC, et al. Vitamin D and testosterone in healthy men: A randomized controlled trial. J Clin Endocrinol Metab. 2017;102(11):4292-302.10.1210/jc.2017-01428 Search in Google Scholar

26. Lerchbaum E, Trummer C, Theiler-Schwetz V, Kollmann M, Wölfler M, Heijboer AC, et al. Effects of vitamin D supplementation on androgens in men with low testosterone levels: A randomized controlled trial. Eur J Nutr. 2019;58(8):3135-46.10.1007/s00394-018-1858-z Search in Google Scholar

27. Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf). 2010;73(2):243-8.10.1111/j.1365-2265.2009.03777.x Search in Google Scholar

28. Seftel A. Effect of vitamin D supplementation on testosterone levels in men: Editorial comment. J Urol. 2011;186(1):239-40.10.1016/S0022-5347(11)60339-X Search in Google Scholar

29. Anic GM, Albanes D, Rohrmann S, Kanarek N, Nelson WG, Bradwin G, et al. Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES. Clin Endocrinol (Oxf). 2016;85(2):258-66.10.1111/cen.13062494696626991691 Search in Google Scholar

30. Tak YJ, Lee JG, Kim YJ, Park NC, Kim SS, Lee S, et al. Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study. Asian J Androl. 2015;17(2): 324.10.4103/1008-682X.142137465048425532570 Search in Google Scholar

31. Laczmanski L, Lwow F, Mossakowska M, Puzianowska-Kuznicka M, Szwed M, Kolackov K, et al. Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236). Gene. 2015;559(1):73-6.10.1016/j.gene.2015.01.02225595352 Search in Google Scholar

32. Tirabassi G, Sudano M, Salvio G, Cutini M, Muscogiuri G, Corona G, et al. Vitamin D and male sexual function: A transversal and longitudinal study. Int J Endocrinol. 2018;2018.10.1155/2018/3720813581720829531528 Search in Google Scholar

33. Wang N, Han B, Li Q, Chen Y, Chen Y, Xia F, et al. Vitamin D is associated with testosterone and hypogonadism in Chinese men: results from a cross-sectional SPECT-China study. Reprod Biol Endocrinol. 2015;13(1):1-7.10.1186/s12958-015-0068-2450417726177638 Search in Google Scholar

34. Lee DM, Tajar A, Pye SR, Boonen S, Vanderschueren D, Bouillon R, et al. Association of hypogonadism with vitamin D status: the European male ageing study. Eur J Endocrinol. 2012;166(1):77.10.1530/EJE-11-074322048968 Search in Google Scholar

35. Jensen MB, Lawaetz JG, Andersson AM, Petersen JH, Nordkap L, Bang AK, et al. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Hum Reprod. 2016;31(8):1875-85.10.1093/humrep/dew15227496946 Search in Google Scholar

36. Ali SAA, Zainab ARAS, Hussain KAD. Impact of vitamin D on male Iraqi patients with infertility. Ann Trop Med Public Heal. 2020;23(20):232-40.10.36295/ASRO.2020.232240 Search in Google Scholar

37. Seftel AD. Re: Association of hypogonadism with vitamin D status: The European male ageing study. J Urol. 2012;188(2):544.10.1016/j.juro.2012.03.09722784744 Search in Google Scholar

38. Nimptsch K, Platz EA, Willett WC, Giovannucci E. Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol (Oxf). 2012;77(1):106-12.10.1111/j.1365-2265.2012.04332.x371234822220644 Search in Google Scholar

39. Costa RR, Reis RI dos, Aguiar JF, Varanda WA. Luteinizing hormone (LH) acts through PKA and PKC to modulate T-type calcium currents and intracellular calcium transients in mice Leydig cells. Cell Calcium. 2011;49(3):191-9.10.1016/j.ceca.2011.02.00321367452 Search in Google Scholar

40. Sonnenberg J, Christakos S, Krey LC. 1,25-dihydr oxyvitamin D3 treatment results in increased choline acetyltransferase activity in specific brain nuclei. Endocrinology. 1986;118(4):1433-9.10.1210/endo-118-4-14333753932 Search in Google Scholar

41. Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1α,25(OH) 2 vitamin D3: Genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. 2011;25(4):543-59.10.1016/j.beem.2011.05.01021872797 Search in Google Scholar

42. Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE, et al. Endocrine regulation of male fertility by the skeleton. Cell. 2011; 144(5):796-809.10.1016/j.cell.2011.02.004305278721333348 Search in Google Scholar

43. Zanatta L, Bouraïma-Lelong H, Delalande C, Silva FRMB, Carreau S. Regulation of aromatase expression by 1α,25(OH)2 vitamin D3 in rat testicular cells. Reprod Fertil Dev. 2011;23(5):725-35.10.1071/RD1016321635821 Search in Google Scholar

44. Dennis NA, Houghton LA, Jones GT, Van Rij AM, Morgan K, McLennan IS. The level of serum anti-müllerian hormone correlates with vitamin D status in men and women but not in boys. J Clin Endocrinol Metab. 2012;97(7):2450-5.10.1210/jc.2012-121322508713 Search in Google Scholar

45. Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, et al. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res. 2010;42(10):754-7.10.1055/s-0030-126283720711952 Search in Google Scholar

46. Clarke BL, Khosla S. Female reproductive system and bone. Arch Biochem Biophys. 2010;503(1):118-28.10.1016/j.abb.2010.07.006294297520637179 Search in Google Scholar

47. Christensen A, Bentley GE, Cabrera R, Ortega HH, Perfito N, Wu TJ, et al. Hormonal regulation of female reproduction. Horm Metab Res. 2012;44(8):587-91.10.1055/s-0032-1306301364736322438212 Search in Google Scholar

48. McKenna MJ, Murray B. Vitamin D deficiency. Endocrinol Diabetes 2014;9781461486(3):293-304.10.1007/978-1-4614-8684-8_23 Search in Google Scholar

49. Sun W, Xie H, Ji J, Zhou X, Goltzman D, Miao D. Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus. Am J Physiol Endocrinol Metab. 2010;299(6):E928-35.10.1152/ajpendo.00378.201020807842 Search in Google Scholar

50. Hodgins MB, Murad S. 1,25-Dihydroxycholecalciferol stimulates conversion of androstenedione into oestrone by human skin fibroblasts in culture. J Endocrinol. 1986;110(1):R1-4.10.1677/joe.0.110R001 Search in Google Scholar

51. Aspell N, Lawlor B, O’Sullivan M. Is there a role for Vitamin D in supporting cognitive function as we age? Proc Nutr Soc. 2018; 77(2):124-34.10.1017/S002966511700415329233204 Search in Google Scholar

52. Abadia L, Gaskins AJ, Chiu YH, Williams PL, Keller M, Wright DL, et al. Serum 25-hydroxyvitamin D concentrations and treatment outcomes of women undergoing assisted reproduction. Am J Clin Nutr. 2016;104(3):729-35.10.3945/ajcn.115.126359499729327465382 Search in Google Scholar

53. Aleyasin A, Hosseini MA, Mahdavi A, Safdarian L, Fallahi P, Mohajeri MR, et al. Predictive value of the level of vitamin D in follicular fluid on the outcome of assisted reproductive technology. Eur J Obstet Gynecol Reprod Biol. 2011;159(1):132-7.10.1016/j.ejogrb.2011.07.00621835540 Search in Google Scholar

54. Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod. 2012;27(11):3321-7.10.1093/humrep/des28022914766 Search in Google Scholar

55. Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014;101(2):447-52.10.1016/j.fertnstert.2013.10.00824210230 Search in Google Scholar

56. Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG, et al. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Arch Gynecol Obstet. 2009;280(4):559-63.10.1007/s00404-009-0958-719214546 Search in Google Scholar

57. Chang EM, Kim YS, Won HJ, Yoon TK, Lee WS. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab. 2014;99(7):2526-32.10.1210/jc.2013-387324742123 Search in Google Scholar

58. Lorenzen M, Boisen IM, Mortensen LJ, Lanske B, Juul A, Blomberg Jensen M. Reproductive endocrinology of vitamin D. Mol Cell Endocrinol. 2017;453:103-12.10.1016/j.mce.2017.03.02328342856 Search in Google Scholar

59. Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014;99(6):E1137-45.10.1210/jc.2013-4161403773824628555 Search in Google Scholar

60. Merhi ZO, Seifer DB, Weedon J, Adeyemi O, Holman S, Anastos K, et al. Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women’s interagency HIV study. Fertil Steril. 2012;98(1):228-34.10.1016/j.fertnstert.2012.03.029338912522494925 Search in Google Scholar

61. Drakopoulos P, Van De Vijver A, Schutyser V, Milatovic S, Anckaert E, Schiettecatte J, et al. The effect of serum Vitamin D levels on ovarian reserve markers: A prospective cross-sectional study. Hum Reprod. 2017;32(1):208-14.10.1093/humrep/dew304 Search in Google Scholar

62. Neville G, Martyn F, Kilbane M, O’Riordan M, Wingfield M, McKenna M, et al. Vitamin D status and fertility outcomes during winter among couples undergoing in vitro fertilization/intracytoplasmic sperm injection. Int J Gynecol Obstet. 2016;135(2): 172-6.10.1016/j.ijgo.2016.04.01827530219 Search in Google Scholar

63. Sertoglu E, Uyanik M, Kayadibi H. A biochemical view: Vitamin D levels do not affect in vitro fertilization outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol. 2015;212(3):411.10.1016/j.ajog.2014.11.02225460840 Search in Google Scholar

64. Paffoni A, Ferrari S, Viganò P, Pagliardini L, Papaleo E, Candiani M, et al. Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles. J Clin Endocrinol Metab. 2014;99(11):E2372-6.10.1210/jc.2014-180225121462 Search in Google Scholar

65. Hu KL, Gan K, Wang R, Li W, Wu Q, Zheng B, et al. Vitamin D supplementation prior to in vitro fertilisation in women with polycystic ovary syndrome: A protocol of a multicentre randomised, double-blind, placebo-controlled clinical trial. BMJ Open. 2020; 10(12):e041409.10.1136/bmjopen-2020-041409772509733293396 Search in Google Scholar

66. Mnallah S, Berjeb KK, Khrouf M, Chtourou S, Elloumi H, Bahri O, et al. Impact of vitamin D deficiency on ICSI outcomes. JFIV Reprod Med Genet. 2017;5(2). Search in Google Scholar

67. Gregerson KA. Prolactin: Structure, function, and regulation of secretion. Knobil Neill’s Physiol Reprod. 2006:1703-26.10.1016/B978-012515400-0/50037-3 Search in Google Scholar

68. Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 1998;19(3):225-68.10.1210/edrv.19.3.0334 Search in Google Scholar

69. Horseman ND. Prolactin. Berlin: Springer Science & Business Media; 2012. Search in Google Scholar

70. Bernichtein S, Touraine P, Goffin V. New concepts in prolactin biology. J Endocrinol. 2010;206(1):1-11.10.1677/JOE-10-0069 Search in Google Scholar

71. Abed MN, Alassaf FA, Qazzaz ME, Alfahad M, Jasim MHM. Insights into the perspective correlation between vitamin D and regulation of hormones: Thyroid and Parathyroid Hormones. Clin Rev Bone Miner Metab. 2021;1-7. Search in Google Scholar

72. Cabrera-Reyes EA, Limón-Morales O, Rivero-Segura NA, Camacho-Arroyo I, Cerbón M. Prolactin function and putative expression in the brain. Endocrine. 2017;57(2):199-213.10.1007/s12020-017-1346-x Search in Google Scholar

73. Phillipps HR, Yip SH, Grattan DR. Patterns of prolactin secretion. Mol Cell Endocrinol. 2020;502:110679.10.1016/j.mce.2019.110679 Search in Google Scholar

74. Saki F, Sadeghian F, Kasaee SR, Koohpeyma F, Ranjbar Omrani GH. Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats. Arch Gynecol Obstet. 2020; 302(1):265-71.10.1007/s00404-020-05567-6 Search in Google Scholar

75. Haug E, Pedersen JI, Gautvik KM. Effects of vitamin D3 metabolites on PRL and GH production in rat pituitary cells. J Steroid Biochem. 1982;17(3):65-79.10.1016/0022-4731(82)90544-1 Search in Google Scholar

76. Tornquist K. Effect of 1,25-dihydroxyvitamin D3 on rat pituitary prolactin release. Acta Endocrinol (Copenh). 1987;116(4):459-64.10.1530/acta.0.1160459 Search in Google Scholar

77. Törnquist K. 1, 25-Dihydroxycholecalciferol enhances both the bombesin-induced transient in intracellular free ca2+ and the bombesin-induced secretion of prolactin in GH4C1 pituitary cells. Endocrinology. 1991;128(4):2175-82.10.1210/endo-128-4-21751900787 Search in Google Scholar

78. Welt CK. Patient education: Absent or irregular periods (Beyond the Basics);2020. Search in Google Scholar

79. Ali M, Mirza L. Morbid obesity due to prolactinoma and significant weight loss after dopamine agonist treatment. AACE Clin Case Reports. 2021;7(3):204-6.10.1016/j.aace.2021.01.004816512634095489 Search in Google Scholar

80. Wark JD, Tashjian AH. Vitamin D stimulates prolactin synthesis by GH4C1 cells incubated in chemically defined medium. Endocrinology. 1982;111(5):1755-7.10.1210/endo-111-5-17556897037 Search in Google Scholar