<abstract xmlns="http://www.w3.org/1999/xhtml"><p>As high as 20% of the population is thought to have recurrent aphthous stomatitis (RAS), hence, finding new therapeutic agents may be needed. Pomegranate (<italic>Punica granatum</italic>), has been extensively used in the folk medicine of many cultures, as it possesses antioxidant, anti-inflammatory and anti-bacterial properties. In this study, it is hypothesized that a topical form of pomegranate peel extract (PPE) may shorten the duration, accelerate the healing and reduce the pain of RAS patients. The presented randomized, double-blind study was conducted on 56 patients. Herein, 28 patients were advised to apply PPE gel, and the other 28 patients were given placebo gel, twice daily for one week. Efficacy evaluations were made at days 0 (before using the gel), 3, 5 and 7. The mean values of ulcer size, pain and healing duration of ulcers were compared in both groups. PPE gel was significantly effective in reducing the pain (p&lt;0.001), ulcer size (p&lt;0.001), and healing duration of ulcers (p&lt;0.001) over a period of one week. PPE in the form of oral gel can be used in the management of aphthous ulcers.</p></abstract>

As high as 20% of the population is thought to have recurrent aphthous stomatitis (RAS), hence, finding new therapeutic agents may be needed. Pomegranate (Punica granatum), has been extensively used in the folk medicine of many cultures, as it possesses antioxidant, anti-inflammatory and anti-bacterial properties. In this study, it is hypothesized that a topical form of pomegranate peel extract (PPE) may shorten the duration, accelerate the healing and reduce the pain of RAS patients. The presented randomized, double-blind study was conducted on 56 patients. Herein, 28 patients were advised to apply PPE gel, and the other 28 patients were given placebo gel, twice daily for one week. Efficacy evaluations were made at days 0 (before using the gel), 3, 5 and 7. The mean values of ulcer size, pain and healing duration of ulcers were compared in both groups. PPE gel was significantly effective in reducing the pain (p<0.001), ulcer size (p<0.001), and healing duration of ulcers (p<0.001) over a period of one week. PPE in the form of oral gel can be used in the management of aphthous ulcers.

The effects of pomegranate peel extract on recurrent aphthous stomatitis

Department of Biology, Faculty of Science

Pharmaceutical Sciences Research Center, School of Pharmacy

Kermanshah University of Medical Sciences

Advanced Dental Sciences Research Laboratory

Department of Oral and Maxillofacial Medicine

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"The effects of pomegranate peel extract on recurrent aphthous stomatitis"}

As high as 20% of the population is thought to have recurrent aphthous stomatitis (RAS), hence, finding new therapeutic agents may be needed. Pomegranate...

The effects of pomegranate peel extract on recurrent aphthous stomatitis

Data publikacji: 28 wrz 2019

Zakres stron: 115 - 120

Otrzymano: 15 sie 2018

Przyjęty: 11 mar 2019

DOI: https://doi.org/10.2478/cipms-2019-0021

Słowa kluczowe
Antioxidant, pomegranate peel extract, recurrent aphthous stomatitis

© 2019 Sara Darakhshan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The effects of pomegranate peel extract on recurrent aphthous stomatitis

Data publikacji: 28 wrz 2019

Zakres stron: 115 - 120

Otrzymano: 15 sie 2018

Przyjęty: 11 mar 2019

DOI: https://doi.org/10.2478/cipms-2019-0021

Słowa kluczoweAntioxidant, pomegranate peel extract, recurrent aphthous stomatitis

© 2019 Sara Darakhshan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Słowa kluczowe
Antioxidant, pomegranate peel extract, recurrent aphthous stomatitis