Neoadjuvant Chemoradiotherapy in the Downstaging of Locally Advanced Rectal Cancer and its Impact on Progression–Free Survival

1. Calvo F. A. et al. Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5–fluorouracil and preoperative chemoradiation, Annals of Oncology, 2006, Vol. 17, N 7, p. 1103–111010.1093/annonc/mdl085Search in Google Scholar

2. Calvo F. A. et al. Pathologic downstaging of T3–4Nx rectal cancer after chemoradiation: 5–fluorouracil vs. Tegafur. International Journal of Radiation Oncology*Biology*Physics, 2001, Vol. 51, N 5, p. 1264–127010.1016/S0360-3016(01)01728-XSearch in Google Scholar

3. Farhat, W. et al. Factors predicting recurrence after curative resection for rectal cancer: a 16–year study. World Journal of Surgical Oncology, 2019, Vol. 17(1), N 173.10.1186/s12957-019-1718-1681954031660992Search in Google Scholar

4. Glynne–Jones, R., Wyrwicz, L., Tiret, E., Brown, G., Rödel, C., Cervantes, A., Arnold, D., on behalf of the ESMO Guidelines Committee. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow–up. Annals of Oncology, 2017, Vol. 28, N 4, p. iv22–iv4010.1093/annonc/mdx22428881920Search in Google Scholar

5. Khan, M. A. S. et al. Significance of R1 resection margin in colon cancer resections in the modern era. Colorectal disease, 2015, Vol. 17, N 11, p.943–95310.1111/codi.1296025808496Search in Google Scholar

6. Mignanelli, E. D. et al. Downstaging after chemoradiotherapy for locally advanced rectal cancer: is there more (tumor) than meets the eye? Diseases of the Colon and Rectum, 2010, Vol.53, N 3, p. 251–25610.1007/DCR.0b013e3181bcd3cc20173469Search in Google Scholar

7. NCCN Clinical Practice Guidelines in Oncology: Rectal cancer. 2019 – (atsauce 20.03.2019). Pieejams: https://www.nccn.org/professionals/physician_gls/default.aspxSearch in Google Scholar

8. Pahlman L. Radiochemotherapy as an adjuvant treatment for rectal cancer. Recent Results in Cancer Research, 1998, N 146, p.141–151.10.1007/978-3-642-71967-7_139670257Search in Google Scholar

9. Pavlova, J. et al. Pirmsoperācijas staru terapija un ķīmijterapija – lokāli izplatīta taisnās zarnas vēža veiksmīgas ārstēšanas stūrakmens. Latvijas ārsts, 2017, Nr. 7, 33–38.lpp. 3Search in Google Scholar

10. Quah, H. M. et al. Pathologic stage is most prognostic of disease–free survival in locally advanced rectal cancer patients after preoperative chemoradiation. Cancer, 2008, Vol. 113, N 1, p. 57–6410.1002/cncr.2351618442099Search in Google Scholar

11. Rödel, C. et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. Jorunal of Clinical Oncology, 2005, Vol. 23, N 34, p. 8688–869610.1200/JCO.2005.02.132916246976Search in Google Scholar

12. Sirohi, B. et al. Down–staging following neoadjuvant chemo–radiotherapy for locally advanced rectal cancer: Does timing of surgery really matter? Indian journal of medical and paediatric oncology: official journal of Indian Society of Medical & Paediatric Oncology, 2014, Vol. 35, N 4, p. 263–26610.4103/0971-5851.144986426427125538402Search in Google Scholar

13. Statistikas dati par pacientu skaitu sadalījumā pa reǵioniem, lokalizācijas veidiem, dzimuma un vecuma grupām no 2001.gada līdz 2017.gadam – (atsauce 20.03.2019). Pieejams: https://www.spkc.gov.lv/lv/statistika–un–petijumi/statistika/veselibas–aprupes–statistika1Search in Google Scholar

14. Ward, S. E., et al. The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer. British journal of cancer, 2006, Vol. 95, N 1, p.27–3410.1038/sj.bjc.6603215236049816804526Search in Google Scholar