<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. <italic>KLOTHO</italic> and <italic>ARNTL</italic> genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of <italic>KLOTHO</italic> and <italic>ARNTL</italic> genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between <italic>KLOTHO</italic> and <italic>ARNTL</italic> methylation and the hypertensive phenotype. Moreover, we could not find a direct association between <italic>KLOTHO</italic> and <italic>ARNTL</italic> methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated <italic>KLOTHO</italic> hypertensive patients and the unmethylated <italic>KLOTHO</italic> control subjects for potassium (K).</p>
</abstract>

Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. KLOTHO and ARNTL genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of KLOTHO and ARNTL genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between KLOTHO and ARNTL methylation and the hypertensive phenotype. Moreover, we could not find a direct association between KLOTHO and ARNTL methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated KLOTHO hypertensive patients and the unmethylated KLOTHO control subjects for potassium (K).

Determination of the Relationship Between DNA Methylation Status of <italic>KLOTHO</italic> and <italic>ARNTL</italic> Genes With Hypertension

Department of Molecular Biology and Genetics, Faculty of Arts and Sciences

Department of Biostatistics, Faculty of Medicine

Department of Cardiovascular Surgery, Dr Burhan Nalbantoglu State Hospital

Balkan Journal of Medical Genetics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Determination of the Relationship Between DNA Methylation Status of  and  Genes With Hypertension

Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. KLOTHO and ARNTL genes play an...

Determination of the Relationship Between DNA Methylation Status of KLOTHO and ARNTL Genes With Hypertension

Article Category: Original Article

Data publikacji: 12 mar 2024

Zakres stron: 41 - 50

DOI: https://doi.org/10.2478/bjmg-2023-0024

Słowa kluczowe
Methylation, Hypertension,

© 2023 M Osum et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Determination of the Relationship Between DNA Methylation Status of KLOTHO and ARNTL Genes With Hypertension

Article Category: Original Article

Data publikacji: 12 mar 2024

Zakres stron: 41 - 50

DOI: https://doi.org/10.2478/bjmg-2023-0024

Słowa kluczoweMethylation, Hypertension,

© 2023 M Osum et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
Methylation, Hypertension,